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There are no guidelines for living\u2010donor liver transplantation (LDLT) in PPHTN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present our experiences of LDLT in six patients with moderate or severe PPHTN, along with our institutional guidelines. Three had liver cirrhosis and three were non\u2010cirrhotic. Catheterization studies were undertaken before, during and after LDLT, and the mean pulmonary arterial pressure (mPAP), cardiac output (CO), pulmonary vascular resistance and total peripheral resistance (TPR) were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed significant differences in CO and TPR between cirrhotic and non\u2010cirrhotic patients before, during and after LDLT. Cirrhotic patients showed systemic hyperdynamic state. Two cirrhotic patients showed poor responses to pre\u2010transplant treatment, and continued to have increased PAH and poor clinical courses after LDLT. LDLT has an advantage of flexible timing of LT. Currently in our institution, PPHTN patients with mPAP &lt;40 mmHg are registered for LDLT after treatment and catheterization. However, LDLT is performed when mPAP is \u2a7d35 mmHg, leading to improved outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPHTN patients with well\u2010controlled PAH, or secondary PAH resulting from porto\u2010systemic shunts, may be appropriate candidates for LDLT after careful considerations.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-011-0453-y","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T15:50:31Z","timestamp":1321372231000},"page":"638-649","source":"Crossref","is-referenced-by-count":20,"title":["Living\u2010donor liver transplantation for moderate or severe porto\u2010pulmonary hypertension accompanied by pulmonary arterial hypertension: a single\u2010centre experience over 2 decades in Japan"],"prefix":"10.1002","volume":"19","author":[{"given":"Eri","family":"Ogawa","sequence":"first","affiliation":[{"name":"Divisions of Hepato\u2010Pancreato\u2010Biliary and Transplant Surgery, Department of 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