{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:51:12Z","timestamp":1785261072026,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy and safety of ultrasound (US)\u2010guided percutaneous argon\u2010helium cryoablation for hepatocellular carcinoma (HCC) and determine appropriate indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed outcomes of 300 HCC patients who underwent US\u2010guided percutaneous cryoablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 223 tumors (mean diameter 7.2 \u00b1 2.8 cm) in 165 patients were incompletely ablated, while 185 tumors (mean diameter 5.6 \u00b1 0.8 cm, <jats:italic>P<\/jats:italic> = 0.0001 vs. incomplete ablation) in 135 patients were completely ablated. Nineteen patients (6.3%) developed serious complications while in hospital, including cryoshock syndrome in six patients, hepatic bleeding in five, stress\u2010induced gastric bleeding in four, liver abscess in one and intestinal fistulas in one. Two patients died because of liver failure. The median follow\u2010up was 36.7 months (range 6\u201363 months). The local tumor recurrence rate was 31%, and was related to tumor size (<jats:italic>P<\/jats:italic> = 0.029) and tumor location (<jats:italic>P<\/jats:italic> = 0.037). The mean survival duration of patients with early, intermediate and advanced HCC (Barcelona Clinic Liver Cancer staging system) was 45.7 \u00b1 3.8, 28.4 \u00b1 1.2 and 17.7 \u00b1 0.6 months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>US\u2010guided percutaneous cryoablation is a relatively safe and effective therapy for selected HCC patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-011-0490-6","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T09:20:50Z","timestamp":1324372850000},"page":"674-684","source":"Crossref","is-referenced-by-count":54,"title":["Outcomes of ultrasound\u2010guided percutaneous argon\u2010helium cryoablation of hepatocellular carcinoma"],"prefix":"10.1002","volume":"19","author":[{"given":"Yongping","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Therapeutic Research for Hepatocellular Carcinoma Beijing 302nd Hospital  Beijing 100039 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