{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:20:59Z","timestamp":1777292459238,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T00:00:00Z","timestamp":1331942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We propose a morphological classification of intraductal papillary neoplasm of the bile duct (IPN\u2010B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 16 patients with IPN\u2010B who had undergone surgical resection was conducted. These 16 cases were classified into three types based on the primary lesion's anatomical location: branch duct type (6 cases), main duct type (5 cases) and mixed type (5 cases). In this paper we have analyzed the characteristics of IPN\u2010B according to our new classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All branch duct type IPN\u2010B was located in the left lobe and 5 of them were resected by left hepatectomy without extrahepatic bile duct resection (EBDR). On the other hand, all patients with main duct and mixed type IPN\u2010B underwent EBDR in addition to hepatectomy or pancreatoduodenectomy. Microscopically, 2 of 6 patients with branch duct type IPN\u2010B had no malignant component and, in the remaining 4 patients, cancer invasion was restricted to within the ductal wall. There were no cases of branch duct type IPN\u2010B with lymph node metastasis and superficial intraductal tumor spread. In contrast, all patients with main duct and mixed duct type IPN\u2010B had the malignant component. In all cases, lymph node metastasis was not observed, but superficial intraductal tumor spread was frequently found in extrahepatic bile duct lesions: 3 of main duct type and 3 of mixed type. Four patients with superficial intraductal spread had non\u2010curative resection due to a cancer\u2010positive ductal margin. Most patients with IPN\u2010B obtained a good prognosis, but two patients with a cancer\u2010positive ductal margin developed local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our classification vividly reflects clinical and pathological characteristics of IPN\u2010B and is useful to determine appropriate surgical strategy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-012-0513-y","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T09:27:27Z","timestamp":1331890047000},"page":"165-172","source":"Crossref","is-referenced-by-count":14,"title":["Proposal for a morphological classification of intraductal papillary neoplasm of the bile duct (IPN\u2010B)"],"prefix":"10.1002","volume":"20","author":[{"given":"Hiroyuki","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Azumi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kishiwada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Isaji","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine  Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28199"},{"key":"e_1_2_5_3_1","first-page":"851","article-title":"Biliary papillary neoplasm of the liver","volume":"17","author":"Nakanuma Y","year":"2002","journal-title":"Histol Histopathol."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20031"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880301)61:5<941::AID-CNCR2820610514>3.0.CO;2-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217636.40050.54"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2008.03.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00256.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2008.03.002"},{"key":"e_1_2_5_10_1","first-page":"45","article-title":"Intraductal Papillary Neoplasm of Bile Duct (IPN\u2010B). 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