{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:48:09Z","timestamp":1791373689789,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Recent studies have revealed that the Glasgow prognostic score (GPS), an inflammation\u2010based prognostic score, is useful for predicting outcome in a variety of cancers. This study sought to investigate the significance of GPS for prognostication of patients who underwent surgery with extrahepatic cholangiocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed a total of 62 patients who underwent resection for extrahepatic cholangiocarcinoma. We calculated the GPS as follows: patients with both an elevated C\u2010reactive protein (&gt;10 mg\/L) and hypoalbuminemia (&lt;35 g\/L) were allocated a score of 2; patients with one or none of these abnormalities were allocated a score of 1 or 0, respectively. Prognostic significance was analyzed by the log\u2010rank test and a Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival rate was 25.5 % at 5 years for all 62 patients. Venous invasion (<jats:italic>p<\/jats:italic> = 0.01), pathological primary tumor category (<jats:italic>p<\/jats:italic> = 0.013), lymph node metastasis category (<jats:italic>p<\/jats:italic> &lt; 0.001), TNM stage (<jats:italic>p<\/jats:italic> &lt; 0.001), and GPS (<jats:italic>p<\/jats:italic> = 0.008) were significantly associated with survival by univariate analysis. A Cox model demonstrated that increased GPS was an independent predictive factor with poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preoperative GPS is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-012-0550-6","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T10:27:34Z","timestamp":1352370454000},"page":"389-395","source":"Crossref","is-referenced-by-count":20,"title":["Inflammation\u2010based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma"],"prefix":"10.1002","volume":"20","author":[{"given":"Yukio","family":"Oshiro","sequence":"first","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Comprehensive Human Sciences University of Tsukuba  1\u20101\u20101 Tennodai Tsukuba 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ohkohchi","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences University of Tsukuba  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