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The etiology of BA is still unclear, although there is some evidence pointing to viral, toxic, and multiple genetic factors. For new therapeutic options other than liver transplantation to be developed, a greater understanding of the pathogenesis of BA is indispensable. The fact that the pathology of BA develops during a period of biliary growth and remodeling suggests an involvement of developmental anomalies. Recent studies indicate an association of the etiology of BA with some genetic factors such as laterality genes, epigenetic regulation and\/or microRNA function. In this paper, we present an overview of recent advances in the understanding of the disease focusing on bile duct developmental anomaly.<\/jats:p>","DOI":"10.1007\/s00534-013-0604-4","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T09:18:01Z","timestamp":1365412681000},"page":"459-464","source":"Crossref","is-referenced-by-count":32,"title":["Etiology of biliary atresia as a developmental anomaly: recent advances"],"prefix":"10.1002","volume":"20","author":[{"given":"Kazuaki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Pharmacology National Research Institute for Child Health and Development  2\u201010\u20101 Okura Setagaya\u2010ku Tokyo 157\u20108538 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Tanoue","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Research Institute for Child Health and Development  2\u201010\u20101 Okura 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