{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:25:17Z","timestamp":1786980317820,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,7,24]],"date-time":"2010-07-24T00:00:00Z","timestamp":1279929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00535-010-0292-7","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T01:46:01Z","timestamp":1279849561000},"page":"1228-1234","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study"],"prefix":"10.1007","volume":"45","author":[{"given":"Hiroaki","family":"Kusunoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Shiotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,24]]},"reference":[{"key":"292_CR1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagerada JR, et al. Functional gastrointestinal disorders. Gastroenterology. 2006;130:1466\u201379.","journal-title":"Gastroenterology"},{"key":"292_CR2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1053\/j.gastro.2005.10.019","volume":"130","author":"G Karamanolis","year":"2006","unstructured":"Karamanolis G, Caenepeel P, Arts J, Tack J. Association of predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia. Gastroenterology. 2006;130:296\u2013303.","journal-title":"Gastroenterology"},{"key":"292_CR3","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1023\/A:1018803129779","volume":"43","author":"AO Quartero","year":"1998","unstructured":"Quartero AO, De Wit NJ, Lodder AC, Numans ME, Smout AJPM, Hoes AW. Disturbed solid-phase gastric emptying in functional dyspepsia. A meta-analysis. Dig Dis Sci. 1998;43:2028\u201333.","journal-title":"Dig Dis Sci"},{"key":"292_CR4","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/j.1365-2036.2006.02930.x","volume":"23","author":"BDJ Elzen Van Den","year":"2006","unstructured":"Van Den Elzen BDJ, Boeckxstaens GEE. A critical view on impaired accommodation as therapeutic target for functional dyspepsia. Aliment Pharmacol Ther. 2006;23:1499\u2013510.","journal-title":"Aliment Pharmacol Ther"},{"key":"292_CR5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1053\/j.gastro.2004.05.030","volume":"127","author":"J Tack","year":"2004","unstructured":"Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology. 2004;127:1239\u201355.","journal-title":"Gastroenterology"},{"key":"292_CR6","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0016-5085(98)70012-5","volume":"115","author":"J Tack","year":"1998","unstructured":"Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology. 1998;115:1346\u201352.","journal-title":"Gastroenterology"},{"key":"292_CR7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1540\/jsmr1965.26.161","volume":"26","author":"T Kanaizumi","year":"1990","unstructured":"Kanaizumi T, Nakano H, Matsui T, Ishikawa H, Shimizu R, Paku S, et al. Effect of AS-4370 on gastric emptying: double-blind clinical pharmacological study. Nippon Heikatsukin Gakkai Zasshi. 1990;26:161\u201374.","journal-title":"Nippon Heikatsukin Gakkai Zasshi"},{"key":"292_CR8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s005350200150","volume":"37","author":"J Endo","year":"2002","unstructured":"Endo J, Nomura M, Morishita S, Uemura N, Inoue S, Kishi S, et al. Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. J Gastroenterol. 2002;37:888\u201395.","journal-title":"J Gastroenterol"},{"key":"292_CR9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3109\/00365529409094860","volume":"29","author":"J Fijimura","year":"1994","unstructured":"Fijimura J, Haruma K, Hata J, Yamanaka H, Sumii K, Kajiyama G. Quantitation of duodenogastric reflux and antral motility by color Doppler ultrasonography. Scand J Gastroenterol. 1994;29:897\u2013902.","journal-title":"Scand J Gastroenterol"},{"key":"292_CR10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2036.1997.128298000.x","volume":"11","author":"E Okamoto","year":"1997","unstructured":"Okamoto E, Haruma K, Hata J, Tani H, Sumii K, Kajiyama G. Effects of octreotide, a somatostatin analogue, on gastric function evaluated by real-time ultrasonography. Aliment Pharmacol Ther. 1997;11:177\u201384.","journal-title":"Aliment Pharmacol Ther"},{"key":"292_CR11","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1046\/j.1440-1746.2000.02251.x","volume":"15","author":"H Kusunoki","year":"2000","unstructured":"Kusunoki H, Haruma K, Hata J, Tani H, Okamoto E, Sumii K, et al. Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia. J Gastroenterol Hepatol. 2000;15:1022\u20137.","journal-title":"J Gastroenterol Hepatol"},{"issue":"Suppl 2","key":"292_CR12","first-page":"A433","volume":"130","author":"H Kusunoki","year":"2006","unstructured":"Kusunoki H, Haruma K, Hata J, Kamada T, Sato M, Tanaka T, et al. Influence of Helicobacter pylori infection on gastrointestinal motility of dyspeptic patients\u2014real-time ultrasonographic study. Gastroenterology. 2006;130(Suppl 2):A433.","journal-title":"Gastroenterology"},{"key":"292_CR13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1136\/gut.51.6.781","volume":"51","author":"EP Bouras","year":"2002","unstructured":"Bouras EP, Delgado-Aros S, Camilleri M, Castillo EJ, Burton DD, Thomforde GM, et al. SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Gut. 2002;51:781\u20136.","journal-title":"Gut"},{"key":"292_CR14","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1111\/j.1572-0241.2001.05264.x","volume":"96","author":"DY Kim","year":"2001","unstructured":"Kim DY, Dolgado-Aros S, Camilleri M, Samsom M, Murray JA, O\u2019Connor MK, et al. Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia. Am J Gastroenterol. 2001;96:3099\u2013105.","journal-title":"Am J Gastroenterol"},{"key":"292_CR15","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1136\/gut.52.11.1548","volume":"52","author":"BDJ Elzen Van Den","year":"2003","unstructured":"Van Den Elzen BDJ, Bennink RJ, Wieringa RE, Tytgat GNJ, Boeckxstaens GEE. Fundic accommodation assessed by SPECT scanning comparison with the gastric barostat. Gut. 2003;52:1548\u201354.","journal-title":"Gut"},{"key":"292_CR16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF01540334","volume":"34","author":"R Jian","year":"1989","unstructured":"Jian R, Ducrot F, Ruskone A, Chaussade S, Rambaud JC, Modigliani R, et al. Symptomatic, radionuclide and therapeutic assessment of chronic idiopathic dyspepsia: a double-blind placebo-controlled evaluation of cisapride. Dig Dis Sci. 1989;34:657\u201364.","journal-title":"Dig Dis Sci"},{"key":"292_CR17","doi-asserted-by":"crossref","first-page":"G278","DOI":"10.1152\/ajpgi.00086.2003","volume":"286","author":"J Tack","year":"2004","unstructured":"Tack J, Broeckaert D, Coulie B, Janssens J. The influence of cisapride on gastric tone and the perception of gastric distension. Am J Physiol Gastrointest Liver Physiol. 2004;286:G278\u201384.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"292_CR18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1046\/j.1365-2036.2003.01775.x","volume":"18","author":"J Tack","year":"2003","unstructured":"Tack J, Vos R, Janssens J, Salter J, Jauffret S, Vandeplassche G. Influence of tegaserod on proximal gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther. 2003;18:1031\u20137.","journal-title":"Aliment Pharmacol Ther"},{"key":"292_CR19","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0016-5085(03)00287-7","volume":"124","author":"MP Caldarella","year":"2003","unstructured":"Caldarella MP, Azpiroz F, Malagerada JR. Antro-fundic dysfunctions in functional dyspepsia. Gastroenterology. 2003;124:1220\u20139.","journal-title":"Gastroenterology"},{"key":"292_CR20","doi-asserted-by":"crossref","first-page":"G278","DOI":"10.1152\/ajpgi.00086.2003","volume":"286","author":"K-J Lee","year":"2004","unstructured":"Lee K-J, Vos R, Janssens J, Tack J. Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol. 2004;286:G278\u201384.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"292_CR21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF02213124","volume":"41","author":"OH Gilja","year":"1996","unstructured":"Gilja OH, Hausken T, Wilhelmsen I, Berstad A. Impaired accommodation of proximal stomach to a meal in functional dyspepsia. Dis Dis Sci. 1996;41:689\u201396.","journal-title":"Dis Dis Sci"},{"key":"292_CR22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7863\/jum.1995.14.2.81","volume":"14","author":"OH Gilja","year":"1995","unstructured":"Gilja OH, Hausken T, Wilhelmsen I, \u00d8degaard S, Berstad A. Monitoring postprandial size of the proximal stomach by ultrasonography. J Ultrasound Med. 1995;14:81\u20139.","journal-title":"J Ultrasound Med"},{"key":"292_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/00365529309090256","volume":"28","author":"LP Duan","year":"1993","unstructured":"Duan LP, Zheng ZT, Li YN. A study of gastric emptying in non-ulcer dyspepsia using a new ultrasonographic metod. Scand J Gastroenterol. 1993;28:355\u201360.","journal-title":"Scand J Gastroenterol"},{"key":"292_CR24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/gut.34.2.173","volume":"34","author":"R Ricci","year":"1993","unstructured":"Ricci R, Bontempo I, Corazziari E, La Bella A, Torsoli A. Real time ultrasonography of the gastric antrum. Gut. 1993;34:173\u20136.","journal-title":"Gut"},{"key":"292_CR25","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1007\/s00535-009-0113-z","volume":"44","author":"Y Matsumoto","year":"2009","unstructured":"Matsumoto Y, Ito M, Tsuge M, Matsuo T, Tanaka S, Haruma K, et al. Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach. J Gastroenterol. 2009;44:1118\u201324.","journal-title":"J Gastroenterol"},{"key":"292_CR26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1254\/jjp.77.53","volume":"77","author":"T Yoshikawa","year":"1998","unstructured":"Yoshikawa T, Yoshida N, Mine Y, Hosoki K. Affinity of mosapride citrate, a new gastroprokinetic agent, for 5-HT4 receptors in guinea pig ileum. Jpn J Pharmacol. 1998;77:53\u20139.","journal-title":"Jpn J Pharmacol"},{"key":"292_CR27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0022-3565(25)24782-6","volume":"257","author":"N Yoshida","year":"1991","unstructured":"Yoshida N, Ito T, Karasawa T, Itoh Z. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J Pharmacol Exp Ther. 1991;257:781\u20137.","journal-title":"J Pharmacol Exp Ther"},{"key":"292_CR28","doi-asserted-by":"crossref","first-page":"G727","DOI":"10.1152\/ajpcell.1986.251.5.C727","volume":"251","author":"F Azpiroz","year":"1986","unstructured":"Azpiroz F, Malagerada JR. Vagally mediated gastric relaxation induced by intestinal nutrients in the dog. Am J Physiol. 1986;251:G727\u201335.","journal-title":"Am J Physiol"},{"key":"292_CR29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/351477a0","volume":"351","author":"KMW Desai","year":"1991","unstructured":"Desai KMW, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature. 1991;351:477\u20139.","journal-title":"Nature"},{"key":"292_CR30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF00171343","volume":"348","author":"AL Meulemans","year":"1993","unstructured":"Meulemans AL, Helsen LF, Schuurkes JA. The role of nitric oxide (NO) in 5-TH induced relaxations of the guinea-pig stomach. Naunyn Schmiedebergs Arch Pharmacol. 1993;348:424\u201330.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"292_CR31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s005350070056","volume":"35","author":"T Taniyama","year":"2000","unstructured":"Taniyama T, Makimoto N, Furuichi A, Yamashita Y, Nagase Y, Kaibara M, et al. Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine 4 receptor, in gastrointestinal motility. J Gastroenterol. 2000;35:575\u201382.","journal-title":"J Gastroenterol"},{"key":"292_CR32","first-page":"163","volume-title":"The stomach, pylorus and duodenum","author":"D Kumar","year":"1988","unstructured":"Kumar D, Gustavsson S. An illustrated guide to gastrointestinal motility. In: Richter HM, editor. The stomach, pylorus and duodenum. New York: Wiley; 1988. p. 163\u201374."},{"key":"292_CR33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0016-5085(19)33428-6","volume":"61","author":"RR Dozois","year":"1971","unstructured":"Dozois RR, Kelly KA, Code CF. Effect of distal antrectomy on gastric emptying of liquids and solids. Gastroenterology. 1971;61:675\u201381.","journal-title":"Gastroenterology"},{"key":"292_CR34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/gut.33.2.184","volume":"33","author":"V Stanghellini","year":"1992","unstructured":"Stanghellini V, Ghidini C, Maccarini MR, Paparo GF, Corinaldesi R, Barbara L. Fasting and postprandial gastrointestinal motility in ulcer and nonulcer dyspepsia. Gut. 1992;33:184\u201390.","journal-title":"Gut"},{"key":"292_CR35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/00042737-199511000-00007","volume":"7","author":"R Burbera","year":"1995","unstructured":"Burbera R, Feinle C, Read NW. Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia. Eur J Gastroenterol Hepatol. 1995;7:1051\u20137.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"292_CR36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0016-5085(99)70171-X","volume":"116","author":"M Samsom","year":"1999","unstructured":"Samsom M, Verhagen MA, Van Berge Henegouwen GP, Smout AJ. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology. 1999;116:515\u201320.","journal-title":"Gastroenterology"},{"key":"292_CR37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/00365529850170784","volume":"33","author":"KA Undeland","year":"1998","unstructured":"Undeland KA, Hausken T, Gilja OH, Aanderud S, Berstad A. Gastric meal accommodation studied by ultrasound in diabetes. Scand J Gastroenterol. 1998;33:236\u201341.","journal-title":"Scand J Gastroenterol"},{"key":"292_CR38","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gut.42.6.814","volume":"42","author":"H Mertz","year":"1998","unstructured":"Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut. 1998;42:814\u201322.","journal-title":"Gut"},{"key":"292_CR39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/gut.42.6.823","volume":"42","author":"GA Salet","year":"1998","unstructured":"Salet GA, Samsom M, Roelof JM, van Berge Henegouwen GP, Smout AJ, Akkermans LM. Responses to gastric distension in function. Gut. 1998;42:823\u20139.","journal-title":"Gut"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-010-0292-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-010-0292-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-010-0292-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T02:54:44Z","timestamp":1740279284000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-010-0292-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,24]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["292"],"URL":"https:\/\/doi.org\/10.1007\/s00535-010-0292-7","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,24]]}}}