{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:27:39Z","timestamp":1791080859863,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:00:00Z","timestamp":1282003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s00535-010-0297-2","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T04:02:17Z","timestamp":1281931337000},"page":"232-241","source":"Crossref","is-referenced-by-count":38,"title":["Lymphotropic HCV strain can infect human primary na\u00efve CD4+ cells and affect their proliferation and IFN-\u03b3 secretion activity"],"prefix":"10.1007","volume":"46","author":[{"given":"Yasuteru","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kakazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koju","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Shiina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Wakui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Obara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooru","family":"Shimosegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"issue":"8","key":"297_CR1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJM199908193410802","volume":"341","author":"MJ Alter","year":"1999","unstructured":"Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, Moyer LA, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med. 1999;341(8):556\u201362.","journal-title":"N Engl J Med"},{"issue":"1","key":"297_CR2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00945025","volume":"19","author":"KM Chang","year":"1997","unstructured":"Chang KM, Rehermann B, Chisari FV. Immunopathology of hepatitis C. Springer Semin Immunopathol. 1997;19(1):57\u201368.","journal-title":"Springer Semin Immunopathol"},{"issue":"2","key":"297_CR3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2141.1994.tb05036.x","volume":"88","author":"C Ferri","year":"1994","unstructured":"Ferri C, Caracciolo F, Zignego AL, La Civita L, Monti M, Longombardo G, et al. Hepatitis C virus infection in patients with non-Hodgkin\u2019s lymphoma. Br J Haematol. 1994;88(2):392\u20134.","journal-title":"Br J Haematol"},{"issue":"7","key":"297_CR4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI200420515","volume":"113","author":"D Accapezzato","year":"2004","unstructured":"Accapezzato D, Francavilla V, Paroli M, Casciaro M, Chircu LV, Cividini A, et al. Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest. 2004;113(7):963\u201372.","journal-title":"J Clin Invest"},{"issue":"12","key":"297_CR5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S1473-3099(07)70289-X","volume":"7","author":"T Manigold","year":"2007","unstructured":"Manigold T, Racanelli V. T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infect Dis. 2007;7(12):804\u201313.","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"297_CR6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tim.2007.02.006","volume":"15","author":"SD Blackburn","year":"2007","unstructured":"Blackburn SD, Wherry EJ. IL-10, T cell exhaustion and viral persistence. Trends Microbiol. 2007;15(4):143\u20136.","journal-title":"Trends Microbiol"},{"issue":"2","key":"297_CR7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2567.2008.02829.x","volume":"125","author":"ZQ Yao","year":"2008","unstructured":"Yao ZQ, Prayther D, Trabue C, Dong ZP, Moorman J. Differential regulation of SOCS-1 signalling in B and T lymphocytes by hepatitis C virus core protein. Immunology. 2008;125(2):197\u2013207.","journal-title":"Immunology"},{"issue":"Pt 6","key":"297_CR8","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1099\/vir.0.80882-0","volume":"86","author":"P Bare","year":"2005","unstructured":"Bare P, Massud I, Parodi C, Belmonte L, Garcia G, Nebel MC, et al. Continuous release of hepatitis C virus (HCV) by peripheral blood mononuclear cells and B-lymphoblastoid cell-line cultures derived from HCV-infected patients. J Gen Virol. 2005;86(Pt 6):1717\u201327.","journal-title":"J Gen Virol"},{"issue":"1","key":"297_CR9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1309\/33TAJLB748KLMXVG","volume":"119","author":"Y Hu","year":"2003","unstructured":"Hu Y, Shahidi A, Park S, Guilfoyle D, Hirshfield I. Detection of extrahepatic hepatitis C virus replication by a novel, highly sensitive, single-tube nested polymerase chain reaction. Am J Clin Pathol. 2003;119(1):95\u2013100.","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"297_CR10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood-2002-03-0818","volume":"101","author":"J Laporte","year":"2003","unstructured":"Laporte J, Bain C, Maurel P, Inchauspe G, Agut H, Cahour A. Differential distribution and internal translation efficiency of hepatitis C virus quasi species present in dendritic and liver cells. Blood. 2003;101(1):52\u20137.","journal-title":"Blood"},{"issue":"6","key":"297_CR11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1086\/432957","volume":"192","author":"Y Li","year":"2005","unstructured":"Li Y, Wang X, Douglas SD, Metzger DS, Woody G, Zhang T, et al. CD8+ T cell depletion amplifies hepatitis C virus replication in peripheral blood mononuclear cells. J Infect Dis. 2005;192(6):1093\u2013101.","journal-title":"J Infect Dis"},{"issue":"3","key":"297_CR12","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1128\/JVI.77.3.2134-2146.2003","volume":"77","author":"VM Sung","year":"2003","unstructured":"Sung VM, Shimodaira S, Doughty AL, Picchio GR, Can H, Yen TS, et al. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J Virol. 2003;77(3):2134\u201346.","journal-title":"J Virol"},{"issue":"1","key":"297_CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.virol.2006.11.009","volume":"361","author":"Y Kondo","year":"2007","unstructured":"Kondo Y, Sung VM, Machida K, Liu M, Lai MM. Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines. Virology. 2007;361(1):161\u201373.","journal-title":"Virology"},{"issue":"5","key":"297_CR14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1086\/596739","volume":"199","author":"Y Kondo","year":"2009","unstructured":"Kondo Y, Machida K, Liu HM, Ueno Y, Kobayashi K, Wakita T, et al. Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6. J Infect Dis. 2009;199(5):726\u201336.","journal-title":"J Infect Dis"},{"issue":"5734","key":"297_CR15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","volume":"309","author":"BD Lindenbach","year":"2005","unstructured":"Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, Liu CC, et al. Complete replication of hepatitis C virus in cell culture. Science. 2005;309(5734):623\u20136.","journal-title":"Science"},{"issue":"7","key":"297_CR16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1268","volume":"11","author":"T Wakita","year":"2005","unstructured":"Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med. 2005;11(7):791\u20136.","journal-title":"Nat Med"},{"issue":"5","key":"297_CR17","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1038\/nprot.2006.395","volume":"1","author":"T Kato","year":"2006","unstructured":"Kato T, Date T, Murayama A, Morikawa K, Akazawa D, Wakita T. Cell culture and infection system for hepatitis C virus. Nat Protoc. 2006;1(5):2334\u20139.","journal-title":"Nat Protoc"},{"issue":"2","key":"297_CR18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/hep.510290223","volume":"29","author":"F Negro","year":"1999","unstructured":"Negro F, Krawczynski K, Quadri R, Rubbia-Brandt L, Mondelli M, Zarski JP, et al. Detection of genomic- and minus-strand of hepatitis C virus RNA in the liver of chronic hepatitis C patients by strand-specific semiquantitative reverse-transcriptase polymerase chain reaction. Hepatology. 1999;29(2):536\u201342.","journal-title":"Hepatology"},{"issue":"16","key":"297_CR19","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1128\/JVI.78.16.8835-8843.2004","volume":"78","author":"K Machida","year":"2004","unstructured":"Machida K, Cheng KT, Sung VM, Lee KJ, Levine AM, Lai MM. Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes. J Virol. 2004;78(16):8835\u201343.","journal-title":"J Virol"},{"issue":"10","key":"297_CR20","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1128\/JVI.02286-07","volume":"82","author":"HJ Harris","year":"2008","unstructured":"Harris HJ, Farquhar MJ, Mee CJ, Davis C, Reynolds GM, Jennings A, et al. CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. J Virol. 2008;82(10):5007\u201320.","journal-title":"J Virol"},{"issue":"1","key":"297_CR21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/JVI.01443-07","volume":"82","author":"S Molina","year":"2008","unstructured":"Molina S, Castet V, Pichard-Garcia L, Wychowski C, Meurs E, Pascussi JM, et al. Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent. J Virol. 2008;82(1):569\u201374.","journal-title":"J Virol"},{"issue":"19","key":"297_CR22","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1073\/pnas.0402253101","volume":"101","author":"EG Cormier","year":"2004","unstructured":"Cormier EG, Tsamis F, Kajumo F, Durso RJ, Gardner JP, Dragic T. CD81 is an entry coreceptor for hepatitis C virus. Proc Natl Acad Sci USA. 2004;101(19):7270\u20134.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"297_CR23","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1086\/425425","volume":"190","author":"T Kanto","year":"2004","unstructured":"Kanto T, Inoue M, Miyatake H, Sato A, Sakakibara M, Yakushijin T, et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis. 2004;190(11):1919\u201326.","journal-title":"J Infect Dis"},{"issue":"9","key":"297_CR24","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.4049\/jimmunol.162.9.5584","volume":"162","author":"T Kanto","year":"1999","unstructured":"Kanto T, Hayashi N, Takehara T, Tatsumi T, Kuzushita N, Ito A, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol. 1999;162(9):5584\u201391.","journal-title":"J Immunol"},{"issue":"13","key":"297_CR25","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1128\/JVI.02582-07","volume":"82","author":"K Machida","year":"2008","unstructured":"Machida K, Kondo Y, Huang JY, Chen YC, Cheng KT, Keck Z, et al. Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. J Virol. 2008;82(13):6711\u201320.","journal-title":"J Virol"},{"issue":"4","key":"297_CR26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1053\/j.gastro.2005.02.006","volume":"128","author":"W Lin","year":"2005","unstructured":"Lin W, Choe WH, Hiasa Y, Kamegaya Y, Blackard JT, Schmidt EV, et al. Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology. 2005;128(4):1034\u201341.","journal-title":"Gastroenterology"},{"issue":"17","key":"297_CR27","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1128\/JVI.00751-09","volume":"83","author":"T Kanda","year":"2009","unstructured":"Kanda T, Steele R, Ray R, Ray RB. Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice. J Virol. 2009;83(17):8463\u20139.","journal-title":"J Virol"},{"issue":"4","key":"297_CR28","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1053\/j.gastro.2005.12.039","volume":"130","author":"S Pal","year":"2006","unstructured":"Pal S, Sullivan DG, Kim S, Lai KK, Kae J, Cotler SJ, et al. Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Gastroenterology. 2006;130(4):1107\u201316.","journal-title":"Gastroenterology"},{"issue":"6805","key":"297_CR29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/35037728","volume":"407","author":"PH Krammer","year":"2000","unstructured":"Krammer PH. CD95\u2019s deadly mission in the immune system. Nature. 2000;407(6805):789\u201395.","journal-title":"Nature"},{"issue":"20","key":"297_CR30","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1093\/emboj\/19.20.5418","volume":"19","author":"TH Holmstrom","year":"2000","unstructured":"Holmstrom TH, Schmitz I, Soderstrom TS, Poukkula M, Johnson VL, Chow SC, et al. MAPK\/ERK signaling in activated T cells inhibits CD95\/Fas-mediated apoptosis downstream of DISC assembly. EMBO J. 2000;19(20):5418\u201328.","journal-title":"EMBO J"},{"issue":"3","key":"297_CR31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1053\/j.gastro.2005.12.030","volume":"130","author":"SK Nanda","year":"2006","unstructured":"Nanda SK, Herion D, Liang TJ. The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity. Gastroenterology. 2006;130(3):794\u2013809.","journal-title":"Gastroenterology"},{"issue":"10","key":"297_CR32","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/379253","volume":"188","author":"Y Miyasaka","year":"2003","unstructured":"Miyasaka Y, Enomoto N, Kurosaki M, Sakamoto N, Kanazawa N, Kohashi T, et al. Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells. J Infect Dis. 2003;188(10):1537\u201344.","journal-title":"J Infect Dis"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-010-0297-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-010-0297-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-010-0297-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T21:24:11Z","timestamp":1685741051000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-010-0297-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,17]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["297"],"URL":"https:\/\/doi.org\/10.1007\/s00535-010-0297-2","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,17]]}}}