{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:28:12Z","timestamp":1791444492515,"version":"4.3.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s00535-012-0588-x","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T08:36:55Z","timestamp":1334565415000},"page":"1186-1197","source":"Crossref","is-referenced-by-count":27,"title":["Rabeprazole reduces the recurrence risk of peptic ulcers associated with low-dose aspirin in patients with cardiovascular or cerebrovascular disease: a prospective randomized active-controlled trial"],"prefix":"10.1007","volume":"47","author":[{"name":"Care Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sanuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Kutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Hayakumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-ichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kuwayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Miyaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinao","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"588_CR1","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.2169\/internalmedicine.49.3824","volume":"49","author":"I Tamura","year":"2010","unstructured":"Tamura I, Fujita T, Tsumura H, Morita Y, Toyonaga T, Hirano S, et al. Low-dose aspirin-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease. Intern Med. 2010;49:2537\u201345.","journal-title":"Intern Med"},{"key":"588_CR2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s00535-009-0074-2","volume":"44","author":"M Nakayama","year":"2009","unstructured":"Nakayama M, Iwakiri R, Hara M, Ootani H, Shimoda R, Tsunada S, et al. Low-dose aspirin is a prominent cause of bleeding ulcers in patients who underwent emergency endoscopy. J Gastroenterol. 2009;44:912\u20138.","journal-title":"J Gastroenterol"},{"key":"588_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-152-1-201001050-00179","volume":"152","author":"JJ Sung","year":"2010","unstructured":"Sung JJ, Lau JY, Ching JY, Wu JC, Lee YT, Chiu PW, et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2010;152:1\u20139.","journal-title":"Ann Intern Med"},{"key":"588_CR4","doi-asserted-by":"crossref","unstructured":"Garcia Rodriguez LA, Cea-Soriano L, Martin-Merino E, Johansson S. Discontinuation of low dose aspirin and risk of myocardial infarction: case\u2013control study in UK primary care. BMJ. 2011;343:d4094.","DOI":"10.1136\/bmj.d4094"},{"key":"588_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1185\/030079907X162656","volume":"23","author":"A Lanas","year":"2007","unstructured":"Lanas A, Scheiman J. Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin. 2007;23:163\u201373.","journal-title":"Curr Med Res Opin"},{"key":"588_CR6","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa012877","volume":"346","author":"KC Lai","year":"2002","unstructured":"Lai KC, Lam SK, Chu KM, Wong BC, Hui WM, Hu WH, et al. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med. 2002;346:2033\u20138.","journal-title":"N Engl J Med"},{"key":"588_CR7","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1111\/j.1572-0241.2008.01995.x","volume":"103","author":"N Yeomans","year":"2008","unstructured":"Yeomans N, Lanas A, Labenz J, Van Zanten SV, Van Rensburg C, R\u00e1cz I, et al. Efficacy of esomeprazole (20\u00a0mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. Am J Gastroenterol. 2008;103:2465\u201373.","journal-title":"Am J Gastroenterol"},{"key":"588_CR8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0140-6736(09)61246-0","volume":"374","author":"AS Taha","year":"2009","unstructured":"Taha AS, McCloskey C, Prasad R, Bezlyak V. Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. Lancet. 2009;374:119\u201325.","journal-title":"Lancet"},{"key":"588_CR9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.gastro.2009.09.063","volume":"138","author":"FH Ng","year":"2010","unstructured":"Ng FH, Wong SY, Lam KF, Chu WH, Chan P, Ling YH, et al. Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions. Gastroenterology. 2010;138:82\u20138.","journal-title":"Gastroenterology"},{"key":"588_CR10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00228-008-0538-y","volume":"64","author":"S Shi","year":"2008","unstructured":"Shi S, Klotz U. Proton pump inhibitors: an update of their clinical use and pharmacokinetics. Eur J Clin Pharmacol. 2008;64:935\u201351.","journal-title":"Eur J Clin Pharmacol"},{"key":"588_CR11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2133\/dmpk.20.153","volume":"20","author":"T Furuta","year":"2005","unstructured":"Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A, Ishizaki T. Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies. Drug Metab Pharmacokinet. 2005;20:153\u201367.","journal-title":"Drug Metab Pharmacokinet"},{"key":"588_CR12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00535-004-1417-7","volume":"39","author":"M Kusano","year":"2004","unstructured":"Kusano M, Shimoyama Y, Sugimoto S, Kawamura O, Maeda M, Minashi K, et al. Development and evaluation of FSSG: frequency scale for the symptoms of GERD. J Gastroenterol. 2004;39:888\u201391.","journal-title":"J Gastroenterol"},{"key":"588_CR13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00535-011-0397-7","volume":"46","author":"K Sugano","year":"2011","unstructured":"Sugano K, Matsumoto Y, Itabashi T, Abe S, Sasaki N, Ashida K, et al. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. J Gastroenterol. 2011;46:724\u201335.","journal-title":"J Gastroenterol"},{"key":"588_CR14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/j.gastro.2004.05.001","volume":"127","author":"L Laine","year":"2004","unstructured":"Laine L, Maller ES, Yu C, Quan H, Simon T. Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. Gastroenterology. 2004;127:395\u2013402.","journal-title":"Gastroenterology"},{"key":"588_CR15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.dld.2004.05.011","volume":"36","author":"A Pilott","year":"2004","unstructured":"Pilott A, Franceschi M, Longo MG, Scarcelli C, Orsitto G, Perri F, et al. Helicobacter pylori infection and the prevention of peptic ulcer with proton pump inhibitors in elderly subjects taking low-dose aspirin. Dig Liver Dis. 2004;36:666\u201370.","journal-title":"Dig Liver Dis"},{"key":"588_CR16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2036.2002.01230.x","volume":"16","author":"A Lanas","year":"2002","unstructured":"Lanas A, Fuentes J, Benito R, Serrano P, Bajador E, Sainz R. Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin. Aliment Pharmacol Ther. 2002;16:779\u201386.","journal-title":"Aliment Pharmacol Ther"},{"key":"588_CR17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2036.2009.04133.x","volume":"31","author":"J Hart","year":"2010","unstructured":"Hart J, Hawkey CJ, Lanas A, Naesdals J, Talley NJ, Thomson AB, et al. Predictors of gastroduodenal erosions in patients taking low-dose aspirin. Aliment Pharmacol Ther. 2010;31:143\u20139.","journal-title":"Aliment Pharmacol Ther"},{"key":"588_CR18","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJM196706082762308","volume":"276","author":"HW Davenport","year":"1967","unstructured":"Davenport HW. Salicylate damage to the gastric mucosal barrier. N Engl J Med. 1967;276:1307\u201312.","journal-title":"N Engl J Med"},{"key":"588_CR19","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10620-009-0920-3","volume":"55","author":"M Nishino","year":"2010","unstructured":"Nishino M, Sugimoto M, Kodaira C, Yamade M, Shirai N, Ikuma M, et al. Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers. Dig Dis Sci. 2010;55:1627\u201336.","journal-title":"Dig Dis Sci"},{"key":"588_CR20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00535-011-0385-y","volume":"46","author":"K Iijima","year":"2011","unstructured":"Iijima K, Ara N, Abe Y, Koike T, Iwai W, Uno K, et al. Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy. J Gastroenterol. 2011;46:612\u20139.","journal-title":"J Gastroenterol"},{"key":"588_CR21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jacc.2004.11.041","volume":"45","author":"E Ferrari","year":"2005","unstructured":"Ferrari E, Benhamou M, Cerboni P, Marcel B. Coronary syndromes following aspirin withdrawal, a special risk for late stent thrombosis. J Am Coll Cardiol. 2005;45:456\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"588_CR22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1365-2036.2004.01937.x","volume":"19","author":"LG Rossum Van","year":"2004","unstructured":"Van Rossum LG, Laheij RJF, Vlemmix F, Jansen JBMJ, Verheugt FWA. Health-related quality of life in patients with cardiovascular disease\u2014the effect of upper gastrointestinal symptom treatment. Aliment Pharmacol Ther. 2004;19:1099\u2013104.","journal-title":"Aliment Pharmacol Ther"},{"key":"588_CR23","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.3748\/wjg.v16.i42.5342","volume":"16","author":"H Nema","year":"2010","unstructured":"Nema H, Kato M. Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy. World J Gastroenterol. 2010;16:5342\u20136.","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-012-0588-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-012-0588-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-012-0588-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:38:00Z","timestamp":1559097480000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-012-0588-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,17]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["588"],"URL":"https:\/\/doi.org\/10.1007\/s00535-012-0588-x","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,17]]}}}