{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:40Z","timestamp":1791216460358,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00535-013-0766-5","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T22:24:53Z","timestamp":1363040693000},"page":"1392-1400","source":"Crossref","is-referenced-by-count":68,"title":["Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease"],"prefix":"10.1007","volume":"48","author":[{"given":"Katsutoshi","family":"Tokushige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Tobari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kogiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Shiratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takushi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"766_CR1","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/hep.1840220616","volume":"22","author":"MR Teli","year":"1995","unstructured":"Teli MR, James OFW, Burt AD, Bennet MK, Day CP. The natural history of nonalcoholic fatty liver: follow-up study. Hepatology. 1995;22:1714\u20139.","journal-title":"Hepatology"},{"key":"766_CR2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/jhep.2003.50193","volume":"37","author":"BA Neuschwander-Tetri","year":"2003","unstructured":"Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis; summary of an AASLD single topic conference. Hepatology. 2003;37:1202\u201319.","journal-title":"Hepatology"},{"key":"766_CR3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","volume":"129","author":"LA Adams","year":"2005","unstructured":"Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113\u201321.","journal-title":"Gastroenterology"},{"key":"766_CR4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1440-1746.2009.05806.x","volume":"24","author":"E Hashimoto","year":"2009","unstructured":"Hashimoto E, Farrell GC. Will non-invasive markers replace liver biopsy for diagnosing and staging fibrosis in non-alcoholic steatohepatitis? J Gastroenterol Hepatol. 2009;24:501\u20133.","journal-title":"J Gastroenterol Hepatol"},{"key":"766_CR5","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/hep.24268","volume":"53","author":"ZM Younossi","year":"2011","unstructured":"Younossi ZM, Stepanova M, Rafiq N, Makhlouf H, Younoszai Z, Agrawal R, et al. Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology. 2011;53:1874\u201382.","journal-title":"Hepatology"},{"key":"766_CR6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","volume":"457","author":"A Sreekumar","year":"2009","unstructured":"Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457:910\u20134.","journal-title":"Nature"},{"key":"766_CR7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/brain\/awm304","volume":"13","author":"M Bogdanov","year":"2008","unstructured":"Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS, et al. Metabolomic profiling to develop blood biomarkers for Parkinson\u2019s disease. Brain. 2008;13:389\u201396.","journal-title":"Brain"},{"key":"766_CR8","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/ac0481001","volume":"77","author":"C Wang","year":"2005","unstructured":"Wang C, Kong H, Guan Y, Yang J, Gu J, Yang S, et al. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography\/electrospray mass spectrometry and multivariate statistical analysis. Anal Chem. 2005;77:4108\u201316.","journal-title":"Anal Chem"},{"key":"766_CR9","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1161\/CIRCULATIONAHA.105.569137","volume":"112","author":"MS Sabatine","year":"2005","unstructured":"Sabatine MS, Liu E, Morrow DA, Heller E, McCarroll R, Wiegand R, et al. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation. 2005;112:3868\u201375.","journal-title":"Circulation"},{"issue":"Suppl 2","key":"766_CR10","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.placenta.2010.12.001","volume":"32","author":"AE Heazell","year":"2011","unstructured":"Heazell AE, Brown M, Worton SA, Dunn WB. Review: the effects of oxygen on normal and pre-eclamptic placental tissue\u2013insights from metabolomics. Placenta. 2011;32(Suppl 2):S119\u201324.","journal-title":"Placenta"},{"key":"766_CR11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.metabol.2010.03.006","volume":"60","author":"SC Kalhan","year":"2011","unstructured":"Kalhan SC, Guo L, Edmison J, Dasarathy S, McCullough AJ, Hanson RW, et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism. 2011;60:404\u201313.","journal-title":"Metabolism"},{"key":"766_CR12","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/hep.23229","volume":"50","author":"P Puri","year":"2009","unstructured":"Puri P, Wiest MM, Cheung O, Mirsahi F, Sargent C, Min HK, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology. 2009;50:1827\u201338.","journal-title":"Hepatology"},{"key":"766_CR13","first-page":"2512","volume":"6","author":"J Barr","year":"2012","unstructured":"Barr J, Caballeria J, Martinez-Arranz I, Dominguez-Diez A, Alonso C, Muntane J, et al. Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression. J Proteome Res. 2012;6:2512\u201332.","journal-title":"J Proteome Res"},{"key":"766_CR14","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","volume":"94","author":"EM Brunt","year":"1999","unstructured":"Brunt EM, Janney CG, Di Biscrglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staining the histological lesions. Am J Gastroenterol. 1999;94:2467\u201374.","journal-title":"Am J Gastroenterol"},{"key":"766_CR15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2001-12925","volume":"21","author":"EM Brunt","year":"2001","unstructured":"Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis. 2001;21:3\u201316.","journal-title":"Semin Liver Dis"},{"key":"766_CR16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0676.1995.tb00110.x","volume":"15","author":"K Inoue","year":"1995","unstructured":"Inoue K, Hirohara J, Nakano T, Seki T, Sasaki H, Higuchi K, et al. Prediction of prognosis of primary biliary cirrhosis in Japan. Liver. 1995;15:70\u20137.","journal-title":"Liver"},{"key":"766_CR17","first-page":"1257","volume":"60","author":"P Scheuer","year":"1967","unstructured":"Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967;60:1257\u201360.","journal-title":"Proc R Soc Med"},{"key":"766_CR18","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1021\/ac900675k","volume":"81","author":"T Soga","year":"2009","unstructured":"Soga T, Igarashi K, Ito C, Mizobuchi K, Zimmermann HP, Tomita M. Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry. Anal Chem. 2009;81:6165\u201374.","journal-title":"Anal Chem"},{"key":"766_CR19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1248\/yakushi1947.98.7_880","volume":"98","author":"N Awata","year":"1978","unstructured":"Awata N, Yamamoto K, Sugimoto I. Absorption, excretion and metabolism of dehydroepiandrosterone sulfate in rabbits. Yakugaku Zasshi. 1978;98:880\u20135.","journal-title":"Yakugaku Zasshi"},{"key":"766_CR20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.metabol.2010.07.027","volume":"60","author":"T Kasumov","year":"2011","unstructured":"Kasumov T, Edmison JM, Dasarathy S, Bennett C, Lopez R, Kalhan SC. Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease. Metabolism. 2011;60:776\u201381.","journal-title":"Metabolism"},{"key":"766_CR21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/hep.22063","volume":"47","author":"M Charlton","year":"2008","unstructured":"Charlton M, Angulo P, Chalasani N, Merriman R, Viker K, Charatcharoenwitthaya P, et al. Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. Hepatology. 2008;47:484\u201392.","journal-title":"Hepatology"},{"key":"766_CR22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S1590-8658(03)00416-X","volume":"35","author":"G Bianchi","year":"2003","unstructured":"Bianchi G, Marchesini G, Brunetti N, Manicardi E, Montuschi F, Chianese R, et al. Impaired insulin-mediated amino acid plasma disappearance in non-alcoholic fatty liver disease: a feature of insulin resistance. Dig Liver Dis. 2003;35:722\u20137.","journal-title":"Dig Liver Dis"},{"key":"766_CR23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2010.12.001","volume":"653","author":"MC Mong","year":"2011","unstructured":"Mong MC, Chao CY, Yin MC. Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet. Eur J Pharmacol. 2011;653:82\u20138.","journal-title":"Eur J Pharmacol"},{"key":"766_CR24","doi-asserted-by":"crossref","unstructured":"Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J Nutr 2009;139:63\u20138.","DOI":"10.3945\/jn.108.094771"},{"key":"766_CR25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1053\/j.gastro.2007.05.019","volume":"133","author":"A Nocito","year":"2007","unstructured":"Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, et al. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Gastroenterology. 2007;133:608\u201318.","journal-title":"Gastroenterology"},{"key":"766_CR26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1386-6346(99)00097-2","volume":"18","author":"Y Matsuda","year":"2000","unstructured":"Matsuda Y, Fujita T, Hada T, Higashino K. Comparative study on the correlation of plasma gamma-aminobutyric acid and pipecolic acid with liver function in patients with liver cirrhosis. Hepatol Res. 2000;18:132\u201340.","journal-title":"Hepatol Res"},{"key":"766_CR27","doi-asserted-by":"crossref","unstructured":"Lasco A, Frisina N, Morabito N, Gaudio A, Morini E, Trifiletti A, et al. Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol. 2001;145:457\u201361.","DOI":"10.1530\/eje.0.1450457"},{"key":"766_CR28","first-page":"161","volume":"34","author":"R Hampl","year":"2000","unstructured":"Hampl R, Starka L. Mini review: 16-a-hydrpxylated metabolites of dehydroepiandrosterone and their biological significance. Endrocrine Reg. 2000;34:161\u20133.","journal-title":"Endrocrine Reg"},{"key":"766_CR29","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0022-4731(84)90021-9","volume":"20","author":"J Fishman","year":"1984","unstructured":"Fishman J, Schneider J, Hershcope RJ, Bradlow HL. Increased estrogen-16 alpha-hydroxylase activity in women with breast and endometrial cancer. J Steroid Biochem. 1984;20:1077\u201381.","journal-title":"J Steroid Biochem"},{"key":"766_CR30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.25573","volume":"55","author":"G Fede","year":"2012","unstructured":"Fede G, Spadaro L, Tomaselli T, Privitera G, Germani G, Tsochatzis E, et al. Adrenocortical dysfunction in liver disease: a systematic review. Hepatology. 2012;55:1282\u201391.","journal-title":"Hepatology"},{"key":"766_CR31","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2006.03.005","volume":"44","author":"A Lonardo","year":"2006","unstructured":"Lonardo A, Carani C, Carulli N, Loria P. \u2018Endocrine NAFLD\u2019 a hormonocentric perspective of nonalcoholic fatty liver disease pathogenesis. J Hepatol. 2006;44:1196\u2013207.","journal-title":"J Hepatol"},{"key":"766_CR32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","volume":"317","author":"WE Naugler","year":"2007","unstructured":"Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317:121\u20134.","journal-title":"Science"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-013-0766-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-013-0766-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-013-0766-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T18:51:53Z","timestamp":1553626313000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-013-0766-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,13]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["766"],"URL":"https:\/\/doi.org\/10.1007\/s00535-013-0766-5","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,13]]}}}