{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:30:38Z","timestamp":1783780238307,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T00:00:00Z","timestamp":1425081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00535-015-1054-3","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T15:49:56Z","timestamp":1425052196000},"page":"1054-1068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice"],"prefix":"10.1007","volume":"50","author":[{"given":"Kazutaka","family":"Tanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Taura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Toriguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Iwaisako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Asagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,28]]},"reference":[{"key":"1054_CR1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"SL Friedman","year":"2008","unstructured":"Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134:1655\u201369.","journal-title":"Gastroenterology"},{"key":"1054_CR2","first-page":"1407","volume":"55","author":"K Murata","year":"2008","unstructured":"Murata K, Ito K, Yoneda K, et al. Splenectomy improves liver function in patients with liver cirrhosis. Hepatogastroenterology. 2008;55:1407\u201311.","journal-title":"Hepatogastroenterology"},{"key":"1054_CR3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1872-034X.2010.00688.x","volume":"40","author":"S Imura","year":"2010","unstructured":"Imura S, Shimada M, Utsunomiya T, et al. Impact of splenectomy in patients with liver cirrhosis: results from 18 patients in a single center experience. Hepatol Res. 2010;40:894\u2013900.","journal-title":"Hepatol Res"},{"key":"1054_CR4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1072-7515(99)00294-X","volume":"190","author":"Y Sugawara","year":"2000","unstructured":"Sugawara Y, Yamamoto J, Shimada K, et al. Splenectomy in patients with hepatocellular carcinoma and hypersplenism. J Am Coll Surg. 2000;190:446\u201350.","journal-title":"J Am Coll Surg"},{"key":"1054_CR5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1440-1746.2008.05497.x","volume":"24","author":"M Watanabe","year":"2009","unstructured":"Watanabe M, Murata S, Hashimoto I, et al. Platelets contribute to the reduction of liver fibrosis in mice. J Gastroenterol Hepatol. 2009;24:78\u201389.","journal-title":"J Gastroenterol Hepatol"},{"key":"1054_CR6","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1053\/j.gastro.2010.02.054","volume":"138","author":"T Kodama","year":"2010","unstructured":"Kodama T, Takehara T, Hikita H, et al. Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice. Gastroenterology. 2010;138:2487\u201398.","journal-title":"Gastroenterology"},{"key":"1054_CR7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1440-1746.2002.02667.x","volume":"17","author":"T Akahoshi","year":"2002","unstructured":"Akahoshi T, Hashizume M, Tanoue K, et al. Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor \u03b2-1. J Gastroenterol Hepatol. 2002;17:59\u201365.","journal-title":"J Gastroenterol Hepatol"},{"issue":"94","key":"1054_CR8","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1073\/pnas.94.20.10663","volume":"30","author":"Z Shi","year":"1997","unstructured":"Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci U S A. 1997;30(94):10663\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1054_CR9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2010.10.044","volume":"55","author":"E Patsenker","year":"2011","unstructured":"Patsenker E, Schneider V, Ledermann M, et al. Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis. J Hepatol. 2011;55:388\u201398.","journal-title":"J Hepatol"},{"key":"1054_CR10","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1016\/j.transproceed.2010.10.013","volume":"42","author":"LJ Laan van der","year":"2010","unstructured":"van der Laan LJ, Hudson M, McPherson S, et al. Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus. Transplant Proc. 2010;42:4573\u20137.","journal-title":"Transplant Proc"},{"key":"1054_CR11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","volume":"51","author":"K Taura","year":"2010","unstructured":"Taura K, Miura K, Iwaisako K, et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010;51:1027\u201336.","journal-title":"Hepatology"},{"key":"1054_CR12","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1053\/j.gastro.2011.01.040","volume":"140","author":"Y Popov","year":"2011","unstructured":"Popov Y, Sverdlov DY, Sharma AK, et al. Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology. 2011;140:1642\u201352.","journal-title":"Gastroenterology"},{"key":"1054_CR13","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/j.gastro.2008.07.065","volume":"135","author":"K Taura","year":"2008","unstructured":"Taura K, De Minicis S, Seki E, et al. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008;135:1729\u201338.","journal-title":"Gastroenterology"},{"key":"1054_CR14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/labinvest.2009.3","volume":"89","author":"J Arias-Diaz","year":"2009","unstructured":"Arias-Diaz J, Ildefonso JA, Mu\u00f1oz JJ, et al. Both tacrolimus and sirolimus decrease Th1\/Th2 ratio, and increase regulatory T lymphocytes in the liver after ischemia\/reperfusion. Lab Investig. 2009;89:433\u20135.","journal-title":"Lab Investig"},{"key":"1054_CR15","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI24798","volume":"115","author":"TI Novobrantseva","year":"2005","unstructured":"Novobrantseva TI, Majeau GR, Amatucci A, et al. Attenuated liver fibrosis in the absence of B cells. J Clin Investig. 2005;115:3072\u201382.","journal-title":"J Clin Investig"},{"key":"1054_CR16","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.4049\/jimmunol.164.10.5337","volume":"164","author":"IO Farah","year":"2000","unstructured":"Farah IO, Mola PW, Kariuki TM, et al. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-\u03b2 and IL-4. J Immunol. 2000;164:5337\u201343.","journal-title":"J Immunol"},{"key":"1054_CR17","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.4049\/jimmunol.166.5.2944","volume":"166","author":"JF Subra","year":"2001","unstructured":"Subra JF, Cautain B, Xystrakis E, et al. The balance between CD45RChigh and CD45RClow CD4 T cells in rats is intrinsic to bone marrow-derived cells and is genetically controlled. J Immunol. 2001;166:2944\u201352.","journal-title":"J Immunol"},{"key":"1054_CR18","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/intimm\/4.8.923","volume":"4","author":"H Nishimura","year":"1992","unstructured":"Nishimura H, Hattori S, Abe M, et al. Differential expression of three CD45 alternative structures on murine T cells: exon 6-dependent epitope as a marker for functional heterogeneity of CD4+\u00a0T cells. Int Immunol. 1992;4:923\u201330.","journal-title":"Int Immunol"},{"key":"1054_CR19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(97)00313-X","volume":"407","author":"M Okabe","year":"1997","unstructured":"Okabe M, Ikawa M, Kominami K, et al. \u2018Green mice\u2019 as a source of ubiquitous green cells. FEBS Lett. 1997;407:313\u20139.","journal-title":"FEBS Lett"},{"key":"1054_CR20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/hep.1840100508","volume":"10","author":"MJ Czaja","year":"1989","unstructured":"Czaja MJ, Weiner FR, Takahashi S, et al. \u03b3-Interferon treatment inhibits collagen deposition in murine schistosomiasis. Hepatology. 1989;10:795\u2013800.","journal-title":"Hepatology"},{"key":"1054_CR21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.510230538","volume":"23","author":"GS Baroni","year":"1996","unstructured":"Baroni GS, D\u2019Ambrosio L, Curto P, et al. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology. 1996;23:1189\u201399.","journal-title":"Hepatology"},{"key":"1054_CR22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","volume":"4","author":"TA Wynn","year":"2004","unstructured":"Wynn TA. Fibrotic disease and the TH1\/TH2 paradigm. Nat Rev Immunol. 2004;4:583\u201394.","journal-title":"Nat Rev Immunol"},{"key":"1054_CR23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4049\/jimmunol.153.2.753","volume":"153","author":"AW Cheever","year":"1994","unstructured":"Cheever AW, Williams ME, Wynn TA, et al. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol. 1994;153:753\u20139.","journal-title":"J Immunol"},{"key":"1054_CR24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/301527a0","volume":"301","author":"GC Bosma","year":"1983","unstructured":"Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301:527\u201330.","journal-title":"Nature"},{"key":"1054_CR25","doi-asserted-by":"crossref","unstructured":"Roh YS, Park S, Lim CW, et al. Depletion of Foxp3+\u00a0regulatory T cells promotes profibrogenic milieu of cholestasis-induced liver injury. Dig Dis Sci. 2014. doi: 10.1007\/s10620-014-3438-2 .","DOI":"10.1007\/s10620-014-3438-2"},{"key":"1054_CR26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","volume":"325","author":"FK Swirski","year":"2009","unstructured":"Swirski FK, Nahrendorf M, Etzrodt M, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325:612\u20136.","journal-title":"Science"},{"key":"1054_CR27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-065X.1984.tb00480.x","volume":"78","author":"ES Vitetta","year":"1984","unstructured":"Vitetta ES, Brooks K, Chen YW, et al. T-cell-derived lymphokines that induce IgM and IgG secretion in activated murine B cells. Immunol Rev. 1984;78:137\u201357.","journal-title":"Immunol Rev"},{"key":"1054_CR28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1988.tb00739.x","volume":"102","author":"RL Coffman","year":"1988","unstructured":"Coffman RL, Seymour BW, Lebman DA, et al. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev. 1988;102:5\u201328.","journal-title":"Immunol Rev"},{"key":"1054_CR29","first-page":"1119","volume":"19","author":"A Vierucci","year":"1977","unstructured":"Vierucci A, De Martino M, Novembre E, et al. Effect of the serum of patients with cholestasis on lymphocyte E rosette formation. Ann Sclavo. 1977;19:1119\u201329.","journal-title":"Ann Sclavo"},{"key":"1054_CR30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02887818","volume":"12","author":"H Li","year":"1992","unstructured":"Li H, Xiong ST, Zhang SX, et al. Interleukin 2 production and its relationship with T lymphocyte subsets in patients with obstructive jaundice. J Tongji Med Univ. 1992;12:164\u20138.","journal-title":"J Tongji Med Univ"},{"key":"1054_CR31","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.1004077","volume":"187","author":"SC Katz","year":"2011","unstructured":"Katz SC, Ryan K, Ahmed N, et al. Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis. J Immunol. 2011;187:1150\u20136.","journal-title":"J Immunol"},{"key":"1054_CR32","first-page":"7","volume":"60","author":"BE Chaignaud","year":"1994","unstructured":"Chaignaud BE, White JG, Nie CH, et al. Splenocytes from bile duct ligated rats do not elicit a normal immune response in the intact host. Am Surg. 1994;60:7\u201311.","journal-title":"Am Surg"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-015-1054-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-015-1054-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-015-1054-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:41:19Z","timestamp":1691440879000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-015-1054-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,28]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["1054"],"URL":"https:\/\/doi.org\/10.1007\/s00535-015-1054-3","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,28]]}}}