{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:15:08Z","timestamp":1777709708249,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s00535-015-1081-0","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T15:38:55Z","timestamp":1429717135000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Gastric atrophy and xanthelasma are markers for predicting the development of early gastric cancer"],"prefix":"10.1007","volume":"51","author":[{"given":"Akira","family":"Sekikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Sada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiko","family":"Marui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gensho","family":"Tanke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Henmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Tsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"1081_CR1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1200\/JCO.2005.05.2308","volume":"24","author":"F Kamangar","year":"2006","unstructured":"Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24:2137\u201350.","journal-title":"J Clin Oncol"},{"key":"1081_CR2","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893\u2013917.","journal-title":"Int J Cancer"},{"key":"1081_CR3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1523-5378.2011.00889.x","volume":"16","author":"T Matsuo","year":"2011","unstructured":"Matsuo T, Ito M, Takata S, et al. Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese. Helicobacter. 2011;16:415\u20139.","journal-title":"Helicobacter"},{"key":"1081_CR4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000339176","volume":"86","author":"S Ono","year":"2012","unstructured":"Ono S, Kato M, Suzuki M, et al. Frequency of Helicobacter pylori-negative gastric cancer and gastric mucosal atrophy in a Japanese endoscopic submucosal dissection series including histological, endoscopic and serological atrophy. Digestion. 2012;86:59\u201365.","journal-title":"Digestion"},{"key":"1081_CR5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","volume":"325","author":"J Parsonnet","year":"1991","unstructured":"Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter Pylori infection and risk of gastric carcinoma. N Engl J Med. 1991;325:1127\u201331.","journal-title":"N Engl J Med"},{"key":"1081_CR6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","volume":"345","author":"N Uemura","year":"2001","unstructured":"Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter Pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784\u20139.","journal-title":"N Engl J Med"},{"key":"1081_CR7","doi-asserted-by":"crossref","unstructured":"Yamaji Y, Mitsushima T, ikuma H, et al. Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis 5732 Japanese subjects. Gut 2001;49:335-340.","DOI":"10.1136\/gut.49.3.335"},{"key":"1081_CR8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","volume":"134","author":"AC Vries De","year":"2008","unstructured":"De Vries AC, van Grieken NC, Looman CW, et al. Gastric cancer risk in patients with premalignancy lesions: a nationwide cohort study in the Netherlands. Gastroenterology. 2008;134:945\u201352.","journal-title":"Gastroenterology"},{"key":"1081_CR9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00535-006-1924-9","volume":"42","author":"S Take","year":"2007","unstructured":"Take S, Mizuo M, Ishiki K, et al. Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer disease. J Gastroenterol. 2007;42:21\u20137.","journal-title":"J Gastroenterol"},{"key":"1081_CR10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s101200050005","volume":"1","author":"F Kitahara","year":"1998","unstructured":"Kitahara F, Shimazaki R, Sato T, et al. Severe atrophic gastritis with Helicobacter pylori infection and gastric cancer. Gastric Cancer. 1998;1:118\u201324.","journal-title":"Gastric Cancer"},{"key":"1081_CR11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ijc.11680","volume":"109","author":"H Ohata","year":"2004","unstructured":"Ohata H, Kitauchi S, Yoshimura N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 2004;109:138\u201343.","journal-title":"Int J Cancer"},{"key":"1081_CR12","doi-asserted-by":"crossref","unstructured":"Ikeda F, Doi Y, Yonemoto K, et al. Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection: a population-based cohort study. Gastroenterology 2009;136:1234-1241.","DOI":"10.1053\/j.gastro.2008.12.045"},{"key":"1081_CR13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-0031-1297969","volume":"120","author":"T Tian","year":"2012","unstructured":"Tian T, Zhang LQ, Ma XH, et al. Diabetes mellitus and incidence and mortality of gastric cancer: a meta-analysis. Exp Clin Endocrinol Diabetes. 2012;120:217\u201323.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1081_CR14","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3748\/wjg.v19.i6.936","volume":"19","author":"JM Yoon","year":"2013","unstructured":"Yoon JM, Son KY, Eom CS, et al. Pre-existing diabetes mellitus increases the risk of gastric cancer: a meta-analysis. World J Gastroenterol. 2013;19:936\u201345.","journal-title":"World J Gastroenterol"},{"key":"1081_CR15","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.3748\/wjg.v19.i40.6902","volume":"19","author":"S Shimoyama","year":"2013","unstructured":"Shimoyama S. Diabetes mellitus carries a risk of gastric cancer: a meta-analysis. World J Gastroenterol. 2013;19:6902\u201310.","journal-title":"World J Gastroenterol"},{"key":"1081_CR16","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.ejca.2014.05.020","volume":"50","author":"A Sekikawa","year":"2014","unstructured":"Sekikawa A, Fukui H, Maruo T, et al. Diabetes mellitus increases the risk of early gastric cancer development. Eur J Cancer. 2014;50:2065\u201371.","journal-title":"Eur J Cancer"},{"key":"1081_CR17","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jgh.12512","volume":"29","author":"A Sekikawa","year":"2014","unstructured":"Sekikawa A, Fukui H, Maruo T, et al. Gastric xanthelasma may be a warning sign for the presence of early gastric cancer. J Gastroenterol Hepatol. 2014;29:951\u20136.","journal-title":"J Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"1081_CR18","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","volume":"33","author":"American Diabetes Association","year":"2010","unstructured":"American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diab Care. 2010;33(Suppl 1):S62\u20139.","journal-title":"Diab Care"},{"key":"1081_CR19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0028-1098086","volume":"1","author":"K Kimura","year":"1969","unstructured":"Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 1969;1:87\u201397.","journal-title":"Endoscopy"},{"key":"1081_CR20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/gut.44.5.693","volume":"44","author":"F Kitahara","year":"1999","unstructured":"Kitahara F, Kobayashi K, Sato T, et al. Accuracy of screening for gastric cancer using serum pepsinogen concentration. Gut. 1999;44:693\u20137.","journal-title":"Gut"},{"key":"1081_CR21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/bjc.1988.75","volume":"57","author":"P Shipponen","year":"1988","unstructured":"Shipponen P, Kekki M, Siurala M. Increase risk of gastric cancer in males affects the intestinal type of cancer and is independent of age, location of the tumour and atrophic gastritis. Br J Cancer. 1988;57:332\u20136.","journal-title":"Br J Cancer"},{"key":"1081_CR22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ijc.2910530114","volume":"53","author":"M Tatsuta","year":"1993","unstructured":"Tatsuta M, Iishi H, Nakaizumi A, et al. Fundal atrophic gastritis as a risk factor for gastric cancer. Int J Cancer. 1993;53:70\u20134.","journal-title":"Int J Cancer"},{"key":"1081_CR23","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2004.055400","volume":"54","author":"H Watabe","year":"2005","unstructured":"Watabe H, Mitsushima T, Yamaji Y, et al. Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study. Gut. 2005;54:764\u20138.","journal-title":"Gut"},{"key":"1081_CR24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/gast.1996.v110.pm8566582","volume":"110","author":"E Kaiserling","year":"1996","unstructured":"Kaiserling E, Heine H, Itabe H, et al. Lipid islands in human gastric mucosa: morphological and immunohistochemical findings. Gastroenterology. 1996;110:369\u201374.","journal-title":"Gastroenterology"},{"key":"1081_CR25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/gut.42.3.351","volume":"42","author":"F Farinati","year":"1998","unstructured":"Farinati F, Cardin R, Dagan P, et al. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut. 1998;42:351\u20136.","journal-title":"Gut"},{"key":"1081_CR26","first-page":"743","volume":"48","author":"J Kountouras","year":"2001","unstructured":"Kountouras J, Chatzopoulos D, Zavos C. Reactive oxygen metabolites and upper gastrointestinal diseases. Hepatogastroenterology. 2001;48:743\u201351.","journal-title":"Hepatogastroenterology"},{"key":"1081_CR27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/aje\/kwr418","volume":"175","author":"AM Leufkens","year":"2012","unstructured":"Leufkens AM, van Duijnhoven FJ, Woudt SH, et al. Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol. 2012;175:653\u201363.","journal-title":"Am J Epidemiol"},{"key":"1081_CR28","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.3748\/wjg.v20.i12.3078","volume":"20","author":"R Cardin","year":"2014","unstructured":"Cardin R, Piciocchi M, Bortolami M, et al. Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an intricate pathway. World J Gastroenterol. 2014;20:3078\u201386.","journal-title":"World J Gastroenterol"},{"key":"1081_CR29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cas.12043","volume":"104","author":"K Shikata","year":"2013","unstructured":"Shikata K, Ninomiya T, Kiyohara Y. Diabetes mellitus and cancer risk: review of the epidemiological evidence. Cancer Sci. 2013;104:9\u201314.","journal-title":"Cancer Sci"},{"key":"1081_CR30","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1677\/ERC-09-0087","volume":"16","author":"P Vigneri","year":"2009","unstructured":"Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Endocr Relat Cancer. 2009;16:1103\u201323.","journal-title":"Endocr Relat Cancer"},{"key":"1081_CR31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1172\/JCI112295","volume":"77","author":"M Lorenzi","year":"1986","unstructured":"Lorenzi M, Montisano DF, Toledo S, Barrieux A. High glucose induced DNA damage in cultured human epithelial cells. J Clin Invest. 1986;77:322\u20135.","journal-title":"J Clin Invest"},{"key":"1081_CR32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(96)90013-6","volume":"347","author":"P Dondona","year":"1996","unstructured":"Dondona P, Thusu K, Cook S, et al. Oxidative damage to DNA in diabetes mellitus. Lancet. 1996;347:444\u20135.","journal-title":"Lancet"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-015-1081-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-015-1081-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-015-1081-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T02:40:16Z","timestamp":1559097616000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-015-1081-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["1081"],"URL":"https:\/\/doi.org\/10.1007\/s00535-015-1081-0","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}