{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:34:02Z","timestamp":1782398042326,"version":"3.54.5"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00535-016-1183-3","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T11:05:10Z","timestamp":1455879910000},"page":"409-420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Host\u2013virus interactions in hepatitis B and hepatitis C infection"],"prefix":"10.1007","volume":"51","author":[{"given":"Sachiyo","family":"Yoshio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"1183_CR1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1172\/JCI39133","volume":"119","author":"B Rehermann","year":"2009","unstructured":"Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009;119:1745\u201354.","journal-title":"J Clin Invest"},{"key":"1183_CR2","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/S0140-6736(14)60220-8","volume":"384","author":"C Trepo","year":"2014","unstructured":"Trepo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384:2053\u201363.","journal-title":"Lancet"},{"key":"1183_CR3","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.4049\/jimmunol.163.4.2314","volume":"163","author":"DG Doherty","year":"1999","unstructured":"Doherty DG, Norris S, Madrigal-Estebas L, et al. The human liver contains multiple populations of NK cells, T cells, and CD3+ CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J Immunol. 1999;163:2314\u201321.","journal-title":"J Immunol"},{"key":"1183_CR4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.pathol.1.110304.100230","volume":"1","author":"LG Guidotti","year":"2006","unstructured":"Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006;1:23\u201361.","journal-title":"Annu Rev Pathol"},{"key":"1183_CR5","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","volume":"343","author":"J Lucifora","year":"2014","unstructured":"Lucifora J, Xia Y, Reisinger F, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014;343:1221\u20138.","journal-title":"Science"},{"issue":"Suppl 1","key":"1183_CR6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/liv.12749","volume":"35","author":"C Ferrari","year":"2015","unstructured":"Ferrari C. HBV and the immune response. Liver Int. 2015;35[Suppl 1]:121\u20138.","journal-title":"Liver Int"},{"key":"1183_CR7","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1073\/pnas.0401771101","volume":"101","author":"S Wieland","year":"2004","unstructured":"Wieland S, Thimme R, Purcell RH, et al. Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci USA. 2004;101:6669\u201374.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1183_CR8","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.284.5415.825","volume":"284","author":"LG Guidotti","year":"1999","unstructured":"Guidotti LG, Rochford R, Chung J, et al. Viral clearance without destruction of infected cells during acute HBV infection. Science. 1999;284:825\u20139.","journal-title":"Science"},{"key":"1183_CR9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cell.2015.03.005","volume":"161","author":"LG Guidotti","year":"2015","unstructured":"Guidotti LG, Inverso D, Sironi L, et al. Immunosurveillance of the liver by intravascular effector CD8(+) T cells. Cell. 2015;161:486\u2013500.","journal-title":"Cell"},{"key":"1183_CR10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/gut.2008.163600","volume":"58","author":"P Fisicaro","year":"2009","unstructured":"Fisicaro P, Valdatta C, Boni C, et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut. 2009;58:974\u201382.","journal-title":"Gut"},{"key":"1183_CR11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.immunol.19.1.65","volume":"19","author":"LG Guidotti","year":"2001","unstructured":"Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol. 2001;19:65\u201391.","journal-title":"Annu Rev Immunol"},{"key":"1183_CR12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/imr.12090","volume":"255","author":"L Golden-Mason","year":"2013","unstructured":"Golden-Mason L, Rosen HR. Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013;255:68\u201381.","journal-title":"Immunol Rev"},{"key":"1183_CR13","doi-asserted-by":"crossref","unstructured":"Xia Y, Stadler D, Lucifora J, et al. Interferon-gamma and tumor necrosis factor-alpha produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis. Gastroenterology 2016;15:194\u2013205.","DOI":"10.1053\/j.gastro.2015.09.026"},{"key":"1183_CR14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jhep.2008.05.017","volume":"49","author":"Z Zhang","year":"2008","unstructured":"Zhang Z, Zou ZS, Fu JL, et al. Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure. J Hepatol. 2008;49:396\u2013406.","journal-title":"J Hepatol"},{"key":"1183_CR15","doi-asserted-by":"crossref","unstructured":"Yoshio S, Sugiyama M, Shoji H, et al. Indoleamine-2, 3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B. Hepatology 2016;63:83\u201394.","DOI":"10.1002\/hep.28282"},{"key":"1183_CR16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.it.2012.10.001","volume":"34","author":"DH Munn","year":"2013","unstructured":"Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013;34:137\u201343.","journal-title":"Trends Immunol"},{"key":"1183_CR17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jhep.2010.07.014","volume":"54","author":"JI Riezu-Boj","year":"2011","unstructured":"Riezu-Boj JI, Larrea E, Aldabe R, et al. Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection. J Hepatol. 2011;54:422\u201331.","journal-title":"J Hepatol"},{"key":"1183_CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molmed.2003.11.003","volume":"10","author":"DH Munn","year":"2004","unstructured":"Munn DH, Mellor AL. IDO and tolerance to tumors. Trends Mol Med. 2004;10:15\u20138.","journal-title":"Trends Mol Med"},{"key":"1183_CR19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499\u2013511.","journal-title":"Nat Rev Immunol"},{"key":"1183_CR20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol. 2004;5:730\u20137.","journal-title":"Nat Immunol"},{"key":"1183_CR21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.immuni.2014.12.016","volume":"42","author":"S Sato","year":"2015","unstructured":"Sato S, Li K, Kameyama T, et al. The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus. Immunity. 2015;42:123\u201332.","journal-title":"Immunity"},{"key":"1183_CR22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/JVI.02008-08","volume":"83","author":"H Guo","year":"2009","unstructured":"Guo H, Jiang D, Ma D, et al. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol. 2009;83:847\u201358.","journal-title":"J Virol"},{"key":"1183_CR23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.molcel.2014.03.040","volume":"54","author":"X Cai","year":"2014","unstructured":"Cai X, Chiu YH, Chen ZJ. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell. 2014;54:289\u201396.","journal-title":"Mol Cell"},{"key":"1183_CR24","doi-asserted-by":"crossref","unstructured":"Dansako H, Ueda Y, Okumura N, et al. The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly. FEBS J 2016;283:144\u201356.","DOI":"10.1111\/febs.13563"},{"key":"1183_CR25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/hep.22751","volume":"49","author":"J Wu","year":"2009","unstructured":"Wu J, Meng Z, Jiang M, et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology. 2009;49:1132\u201340.","journal-title":"Hepatology"},{"key":"1183_CR26","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.4049\/jimmunol.0903874","volume":"185","author":"C Wei","year":"2010","unstructured":"Wei C, Ni C, Song T, et al. The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol. 2010;185:1158\u201368.","journal-title":"J Immunol"},{"key":"1183_CR27","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1099\/vir.0.020552-0","volume":"91","author":"S Yu","year":"2010","unstructured":"Yu S, Chen J, Wu M, et al. Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1\/IKKepsilon and DDX3. J Gen Virol. 2010;91:2080\u201390.","journal-title":"J Gen Virol"},{"key":"1183_CR28","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1128\/JVI.02760-14","volume":"89","author":"Y Liu","year":"2015","unstructured":"Liu Y, Li J, Chen J, et al. Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways. J Virol. 2015;89:2287\u2013300.","journal-title":"J Virol"},{"key":"1183_CR29","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1053\/j.gastro.2011.02.057","volume":"140","author":"M Lutgehetmann","year":"2011","unstructured":"Lutgehetmann M, Bornscheuer T, Volz T, et al. Hepatitis B virus limits response of human hepatocytes to interferon-alpha in chimeric mice. Gastroenterology. 2011;140:2074\u201383.","journal-title":"Gastroenterology"},{"key":"1183_CR30","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jhep.2015.07.014","volume":"63","author":"S Luangsay","year":"2015","unstructured":"Luangsay S, Gruffaz M, Isorce N, et al. Early inhibition of hepatocyte innate responses by hepatitis B virus. J Hepatol. 2015;63:1314\u201322.","journal-title":"J Hepatol"},{"key":"1183_CR31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2013.00057","volume":"4","author":"MK Maini","year":"2013","unstructured":"Maini MK, Peppa D. NK cells: a double-edged sword in chronic hepatitis B virus infection. Front Immunol. 2013;4:57.","journal-title":"Front Immunol"},{"key":"1183_CR32","doi-asserted-by":"crossref","unstructured":"Oliviero B, Varchetta S, Paudice E, et al. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 2009;137:1151\u201360.","DOI":"10.1053\/j.gastro.2009.05.047"},{"key":"1183_CR33","doi-asserted-by":"crossref","first-page":"e1001227","DOI":"10.1371\/journal.ppat.1001227","volume":"6","author":"D Peppa","year":"2010","unstructured":"Peppa D, Micco L, Javaid A, et al. Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS Pathog. 2010;6:e1001227.","journal-title":"PLoS Pathog"},{"key":"1183_CR34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fimmu.2014.00258","volume":"5","author":"A Schuch","year":"2014","unstructured":"Schuch A, Hoh A, Thimme R. The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection. Front Immunol. 2014;5:258.","journal-title":"Front Immunol"},{"key":"1183_CR35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jhep.2010.07.009","volume":"54","author":"ET Tjwa","year":"2011","unstructured":"Tjwa ET, van Oord GW, Hegmans JP, et al. Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B. J Hepatol. 2011;54:209\u201318.","journal-title":"J Hepatol"},{"key":"1183_CR36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20121172","volume":"210","author":"D Peppa","year":"2013","unstructured":"Peppa D, Gill US, Reynolds G, et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J Exp Med. 2013;210:99\u2013114.","journal-title":"J Exp Med"},{"key":"1183_CR37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2249.2002.01943.x","volume":"130","author":"HF Lohr","year":"2002","unstructured":"Lohr HF, Pingel S, Bocher WO, et al. Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B\u2014restoration by exogenous interleukin-12. Clin Exp Immunol. 2002;130:107\u201314.","journal-title":"Clin Exp Immunol"},{"key":"1183_CR38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hep.21048","volume":"43","author":"A Untergasser","year":"2006","unstructured":"Untergasser A, Zedler U, Langenkamp A, et al. Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection. Hepatology. 2006;43:539\u201347.","journal-title":"Hepatology"},{"key":"1183_CR39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/clim.2002.5245","volume":"104","author":"S Beckebaum","year":"2002","unstructured":"Beckebaum S, Cicinnati VR, Dworacki G, et al. Reduction in the circulating pDC1\/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection. Clin Immunol. 2002;104:138\u201350.","journal-title":"Clin Immunol"},{"key":"1183_CR40","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.micinf.2009.02.008","volume":"11","author":"Q Xie","year":"2009","unstructured":"Xie Q, Shen HC, Jia NN, et al. Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9. Microbes Infect. 2009;11:515\u201323.","journal-title":"Microbes Infect"},{"key":"1183_CR41","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.molimm.2009.04.031","volume":"46","author":"Y Xu","year":"2009","unstructured":"Xu Y, Hu Y, Shi B, et al. HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol Immunol. 2009;46:2640\u20136.","journal-title":"Mol Immunol"},{"issue":"1586\u20131596","key":"1183_CR42","first-page":"e8","volume":"143","author":"J Martinet","year":"2012","unstructured":"Martinet J, Dufeu-Duchesne T, Bruder Costa J, et al. Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection. Gastroenterology. 2012;143(1586\u20131596):e8.","journal-title":"Gastroenterology"},{"key":"1183_CR43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2567.2008.02896.x","volume":"126","author":"ML Op den Brouw","year":"2009","unstructured":"Op den Brouw ML, Binda RS, van Roosmalen MH, et al. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus. Immunology. 2009;126:280\u20139.","journal-title":"Immunology"},{"key":"1183_CR44","first-page":"295","volume":"14","author":"SM Akbar","year":"2004","unstructured":"Akbar SM, Furukawa S, Hasebe A, et al. Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrierer. Int J Mol Med. 2004;14:295\u20139.","journal-title":"Int J Mol Med"},{"key":"1183_CR45","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/hep.25879","volume":"56","author":"J Martinet","year":"2012","unstructured":"Martinet J, Leroy V, Dufeu-Duchesne T, et al. Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection. Hepatology. 2012;56:1706\u201318.","journal-title":"Hepatology"},{"key":"1183_CR46","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1172\/JCI66043","volume":"123","author":"AJ Gehring","year":"2013","unstructured":"Gehring AJ, Haniffa M, Kennedy PT, et al. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J Clin Invest. 2013;123:3766\u201376.","journal-title":"J Clin Invest"},{"key":"1183_CR47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.imlet.2015.10.007","volume":"168","author":"D Yu","year":"2015","unstructured":"Yu D, Liu H, Shi S, et al. A novel dendritic-cell-targeting DNA vaccine for hepatitis B induces T cell and humoral immune responses and potentiates the antivirus activity in HBV transgenic mice. Immunol Lett. 2015;168:293\u20139.","journal-title":"Immunol Lett"},{"key":"1183_CR48","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/hep.25875","volume":"56","author":"C Ji","year":"2012","unstructured":"Ji C, Sastry KS, Tiefenthaler G, et al. Targeted delivery of interferon-alpha to hepatitis B virus-infected cells using T-cell receptor-like antibodies. Hepatology. 2012;56:2027\u201338.","journal-title":"Hepatology"},{"key":"1183_CR49","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1053\/j.gastro.2013.04.047","volume":"145","author":"K Krebs","year":"2013","unstructured":"Krebs K, Bottinger N, Huang LR, et al. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology. 2013;145:456\u201365.","journal-title":"Gastroenterology"},{"key":"1183_CR50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/hep.26654","volume":"59","author":"S Lv","year":"2014","unstructured":"Lv S, Wang J, Dou S, et al. Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection. Hepatology. 2014;59:385\u201394.","journal-title":"Hepatology"},{"key":"1183_CR51","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ni.2573","volume":"14","author":"LR Huang","year":"2013","unstructured":"Huang LR, Wohlleber D, Reisinger F, et al. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol. 2013;14:574\u201383.","journal-title":"Nat Immunol"},{"key":"1183_CR52","doi-asserted-by":"crossref","unstructured":"Lanford RE, Guerra B, Chavez D, et al. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 2013;144:1508\u201317, 1517 e1\u201310.","DOI":"10.1053\/j.gastro.2013.02.003"},{"issue":"1576\u20131585","key":"1183_CR53","first-page":"e4","volume":"143","author":"P Fisicaro","year":"2012","unstructured":"Fisicaro P, Valdatta C, Massari M, et al. Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV. Gastroenterology. 2012;143(1576\u20131585):e4.","journal-title":"Gastroenterology"},{"key":"1183_CR54","doi-asserted-by":"crossref","first-page":"e1003856","DOI":"10.1371\/journal.ppat.1003856","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Zhang E, Ma Z, et al. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog. 2014;10:e1003856.","journal-title":"PLoS Pathog"},{"key":"1183_CR55","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/hep.1840360704","volume":"36","author":"JH Hoofnagle","year":"2002","unstructured":"Hoofnagle JH. Course and outcome of hepatitis C. Hepatology. 2002;36:S21\u20139.","journal-title":"Hepatology"},{"key":"1183_CR56","doi-asserted-by":"crossref","first-page":"235","DOI":"10.7326\/0003-4819-158-4-201302190-00003","volume":"158","author":"P Duggal","year":"2013","unstructured":"Duggal P, Thio CL, Wojcik GL, et al. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013;158:235\u201345.","journal-title":"Ann Intern Med"},{"key":"1183_CR57","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.2217\/pgs.09.121","volume":"10","author":"A Rauch","year":"2009","unstructured":"Rauch A, Gaudieri S, Thio C, et al. Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics. 2009;10:1819\u201337.","journal-title":"Pharmacogenomics"},{"key":"1183_CR58","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.172.3.1333","volume":"172","author":"G Ferlazzo","year":"2004","unstructured":"Ferlazzo G, Munz C. NK cell compartments and their activation by dendritic cells. J Immunol. 2004;172:1333\u20139.","journal-title":"J Immunol"},{"key":"1183_CR59","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1097670","volume":"305","author":"SI Khakoo","year":"2004","unstructured":"Khakoo SI, Thio CL, Martin MP, et al. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 2004;305:872\u20134.","journal-title":"Science"},{"key":"1183_CR60","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.molimm.2008.06.004","volume":"45","author":"V Romero","year":"2008","unstructured":"Romero V, Zuniga J, Azocar J, et al. Genetic interactions of KIR and G1\u00a0M immunoglobulin allotypes differ in obese from non-obese individuals with type 2 diabetes. Mol Immunol. 2008;45:3857\u201362.","journal-title":"Mol Immunol"},{"key":"1183_CR61","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","volume":"41","author":"Y Tanaka","year":"2009","unstructured":"Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 2009;41:1105\u20139.","journal-title":"Nat Genet"},{"key":"1183_CR62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","volume":"461","author":"D Ge","year":"2009","unstructured":"Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461:399\u2013401.","journal-title":"Nature"},{"key":"1183_CR63","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","volume":"41","author":"V Suppiah","year":"2009","unstructured":"Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 2009;41:1100\u20134.","journal-title":"Nat Genet"},{"key":"1183_CR64","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nature08463","volume":"461","author":"DL Thomas","year":"2009","unstructured":"Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461:798\u2013801.","journal-title":"Nature"},{"key":"1183_CR65","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/hep.26770","volume":"59","author":"S Wieland","year":"2014","unstructured":"Wieland S, Makowska Z, Campana B, et al. Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver. Hepatology. 2014;59:2121\u201330.","journal-title":"Hepatology"},{"key":"1183_CR66","doi-asserted-by":"crossref","unstructured":"Park HSE, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, et al. IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection. Hepatology 2012; 56:2060\u201370.","DOI":"10.1002\/hep.25897"},{"key":"1183_CR67","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.coi.2011.07.007","volume":"23","author":"SV Kotenko","year":"2011","unstructured":"Kotenko SV. IFN-lambdas. Curr Opin Immunol. 2011;23:583\u201390.","journal-title":"Curr Opin Immunol"},{"key":"1183_CR68","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","volume":"41","author":"Y Tanaka","year":"2009","unstructured":"Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 2009;41:1105\u20139.","journal-title":"Nat Genet"},{"key":"1183_CR69","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/hep.23912","volume":"52","author":"TJ Urban","year":"2010","unstructured":"Urban TJ, Thompson AJ, Bradrick SS, et al. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology. 2010;52:1888\u201396.","journal-title":"Hepatology"},{"key":"1183_CR70","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","volume":"449","author":"R Medzhitov","year":"2007","unstructured":"Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449:819\u201326.","journal-title":"Nature"},{"key":"1183_CR71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(01)00456-1","volume":"106","author":"YJ Liu","year":"2001","unstructured":"Liu YJ. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell. 2001;106:259\u201362.","journal-title":"Cell"},{"key":"1183_CR72","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20092618","volume":"207","author":"LF Poulin","year":"2010","unstructured":"Poulin LF, Salio M, Griessinger E, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010;207:1261\u201371.","journal-title":"J Exp Med"},{"key":"1183_CR73","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1084\/jem.20092720","volume":"207","author":"H Lauterbach","year":"2010","unstructured":"Lauterbach H, Bathke B, Gilles S, et al. Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med. 2010;207:2703\u201317.","journal-title":"J Exp Med"},{"key":"1183_CR74","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/hep.26182","volume":"57","author":"S Yoshio","year":"2013","unstructured":"Yoshio S, Kanto T, Kuroda S, et al. Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-lambda in response to hepatitis C virus. Hepatology. 2013;57:1705\u201315.","journal-title":"Hepatology"},{"key":"1183_CR75","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1073\/pnas.1002301107","volume":"107","author":"K Takahashi","year":"2010","unstructured":"Takahashi K, Asabe S, Wieland S, et al. Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci USA. 2010;107:7431\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1183_CR76","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00535-015-1056-1","volume":"50","author":"S Hiramine","year":"2015","unstructured":"Hiramine S, Sugiyama M, Furusyo N, et al. A thymine-adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus. J Gastroenterol. 2015;50:1069\u201377.","journal-title":"J Gastroenterol"},{"key":"1183_CR77","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ni.2758","volume":"15","author":"AP McFarland","year":"2014","unstructured":"McFarland AP, Horner SM, Jarret A, et al. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. Nat Immunol. 2014;15:72\u20139.","journal-title":"Nat Immunol"},{"key":"1183_CR78","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/hep.20592","volume":"41","author":"A Ulsenheimer","year":"2005","unstructured":"Ulsenheimer A, Gerlach JT, Jung MC, et al. Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection. Hepatology. 2005;41:643\u201351.","journal-title":"Hepatology"},{"key":"1183_CR79","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00535-014-1023-2","volume":"50","author":"Y Aoki","year":"2015","unstructured":"Aoki Y, Sugiyama M, Murata K, et al. Association of serum IFN-lambda3 with inflammatory and fibrosis markers in patients with chronic hepatitis C virus infection. J Gastroenterol. 2015;50:894\u2013902.","journal-title":"J Gastroenterol"},{"key":"1183_CR80","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1086\/425425","volume":"190","author":"T Kanto","year":"2004","unstructured":"Kanto T, Inoue M, Miyatake H, et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis. 2004;190:1919\u201326.","journal-title":"J Infect Dis"},{"key":"1183_CR81","doi-asserted-by":"crossref","unstructured":"Zhao L, Shields J, Tyrrell DL. Functional changes, increased apoptosis, and diminished nuclear factor-kappaB activity of myeloid dendritic cells during chronic hepatitis C infection. Hum Immunol 2010;71:751\u20136.","DOI":"10.1016\/j.humimm.2010.05.006"},{"key":"1183_CR82","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.4049\/jimmunol.0902522","volume":"184","author":"IG Rodrigue-Gervais","year":"2010","unstructured":"Rodrigue-Gervais IG, Rigsby H, Jouan L, et al. Dendritic cell inhibition is connected to exhaustion of CD8\u00a0+\u00a0T cell polyfunctionality during chronic hepatitis C virus infection. J Immunol. 2010;184:3134\u201344.","journal-title":"J Immunol"},{"key":"1183_CR83","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2001.21212","volume":"120","author":"C Bain","year":"2001","unstructured":"Bain C, Fatmi A, Zoulim F, et al. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology. 2001;120:512\u201324.","journal-title":"Gastroenterology"},{"key":"1183_CR84","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.4049\/jimmunol.162.9.5584","volume":"162","author":"T Kanto","year":"1999","unstructured":"Kanto T, Hayashi N, Takehara T, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol. 1999;162:5584\u201391.","journal-title":"J Immunol"},{"key":"1183_CR85","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.173.10.6072","volume":"173","author":"M Jinushi","year":"2004","unstructured":"Jinushi M, Takehara T, Tatsumi T, et al. Negative regulation of NK cell activities by inhibitory receptor CD94\/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. J Immunol. 2004;173:6072\u201381.","journal-title":"J Immunol"},{"key":"1183_CR86","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1128\/JVI.02671-08","volume":"83","author":"H Liang","year":"2009","unstructured":"Liang H, Russell RS, Yonkers NL, et al. Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells. J Virol. 2009;83:5693\u2013707.","journal-title":"J Virol"},{"key":"1183_CR87","doi-asserted-by":"crossref","unstructured":"Marukian S, Jones CT, Andrus L, et al. Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells. Hepatology 2008;48:1843\u201350.","DOI":"10.1002\/hep.22550"},{"key":"1183_CR88","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/hep.22337","volume":"48","author":"T Ebihara","year":"2008","unstructured":"Ebihara T, Shingai M, Matsumoto M, et al. Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells. Hepatology. 2008;48:48\u201358.","journal-title":"Hepatology"},{"key":"1183_CR89","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/hep.22624","volume":"49","author":"JC Yoon","year":"2009","unstructured":"Yoon JC, Shiina M, Ahlenstiel G, et al. Natural killer cell function is intact after direct exposure to infectious hepatitis C virions. Hepatology. 2009;49:12\u201321.","journal-title":"Hepatology"},{"key":"1183_CR90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/hep.21996","volume":"47","author":"M Shiina","year":"2008","unstructured":"Shiina M, Rehermann B. Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology. 2008;47:385\u201395.","journal-title":"Hepatology"},{"key":"1183_CR91","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.4049\/jimmunol.170.11.5615","volume":"170","author":"A Dolganiuc","year":"2003","unstructured":"Dolganiuc A, Kodys K, Kopasz A, et al. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol. 2003;170:5615\u201324.","journal-title":"J Immunol"},{"key":"1183_CR92","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1053\/jhep.2003.50194","volume":"37","author":"A Ulsenheimer","year":"2003","unstructured":"Ulsenheimer A, Gerlach JT, Gruener NH, et al. Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C. Hepatology. 2003;37:1189\u201398.","journal-title":"Hepatology"},{"key":"1183_CR93","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.1088774","volume":"302","author":"A Grakoui","year":"2003","unstructured":"Grakoui A, Shoukry NH, Woollard DJ, et al. HCV persistence and immune evasion in the absence of memory T cell help. Science. 2003;302:659\u201362.","journal-title":"Science"},{"key":"1183_CR94","doi-asserted-by":"crossref","first-page":"e1003422","DOI":"10.1371\/journal.ppat.1003422","volume":"9","author":"H Kared","year":"2013","unstructured":"Kared H, Fabre T, Bedard N, et al. Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C. PLoS Pathog. 2013;9:e1003422.","journal-title":"PLoS Pathog"},{"key":"1183_CR95","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4049\/jimmunol.169.6.3447","volume":"169","author":"H Wedemeyer","year":"2002","unstructured":"Wedemeyer H, He XS, Nascimbeni M, et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol. 2002;169:3447\u201358.","journal-title":"J Immunol"},{"key":"1183_CR96","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.1840380409","volume":"38","author":"V Leroy","year":"2003","unstructured":"Leroy V, Vigan I, Mosnier JF, et al. Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C. Hepatology. 2003;38:829\u201341.","journal-title":"Hepatology"},{"key":"1183_CR97","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/1521-4141(200103)31:3<894::AID-IMMU894>3.0.CO;2-I","volume":"31","author":"C Prezzi","year":"2001","unstructured":"Prezzi C, Casciaro MA, Francavilla V, et al. Virus-specific CD8(+) T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection. Eur J Immunol. 2001;31:894\u2013906.","journal-title":"Eur J Immunol"},{"key":"1183_CR98","doi-asserted-by":"crossref","unstructured":"Frebel H, Richter K, Oxenius A. How chronic viral infections impact on antigen-specific T-cell responses. Eur J Immunol 2010;40:654\u201363.","DOI":"10.1002\/eji.200940102"},{"key":"1183_CR99","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1128\/JVI.01177-06","volume":"80","author":"S Urbani","year":"2006","unstructured":"Urbani S, Amadei B, Tola D, et al. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol. 2006;80:11398\u2013403.","journal-title":"J Virol"},{"key":"1183_CR100","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1128\/JVI.02474-07","volume":"82","author":"V Kasprowicz","year":"2008","unstructured":"Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, et al. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008;82:3154\u201360.","journal-title":"J Virol"},{"key":"1183_CR101","doi-asserted-by":"crossref","first-page":"e1000313","DOI":"10.1371\/journal.ppat.1000313","volume":"5","author":"N Nakamoto","year":"2009","unstructured":"Nakamoto N, Cho H, Shaked A, et al. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1\/CTLA-4 blockade. PLoS Pathog. 2009;5:e1000313.","journal-title":"PLoS Pathog"},{"key":"1183_CR102","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/hep.20649","volume":"41","author":"JN Stoop","year":"2005","unstructured":"Stoop JN, van der Molen RG, Baan CC, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology. 2005;41:771\u20138.","journal-title":"Hepatology"},{"key":"1183_CR103","first-page":"1437","volume":"38","author":"K Sugimoto","year":"2003","unstructured":"Sugimoto K, Ikeda F, Stadanlick J, et al. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology. 2003;38:1437\u201348.","journal-title":"Hepatology"},{"key":"1183_CR104","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/nm.3408","volume":"19","author":"SH Park","year":"2013","unstructured":"Park SH, Veerapu NS, Shin EC, et al. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med. 2013;19:1638\u201342.","journal-title":"Nat Med"},{"key":"1183_CR105","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/hep.21774","volume":"46","author":"N Forestier","year":"2007","unstructured":"Forestier N, Reesink HW, Weegink CJ, et al. Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology. 2007;46:640\u20138.","journal-title":"Hepatology"},{"issue":"190\u2013200","key":"1183_CR106","first-page":"e2","volume":"149","author":"E Serti","year":"2015","unstructured":"Serti E, Chepa-Lotrea X, Kim YJ, et al. Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function. Gastroenterology. 2015;149(190\u2013200):e2.","journal-title":"Gastroenterology"},{"key":"1183_CR107","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/hep.28155","volume":"62","author":"C Boni","year":"2015","unstructured":"Boni C, Lampertico P, Talamona L, et al. Natural killer cell phenotype modulation and natural killer\/T-cell interplay in nucleos(t)ide analogue-treated hepatitis e antigen-negative patients with chronic hepatitis B. Hepatology. 2015;62:1697\u2013709.","journal-title":"Hepatology"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1183-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-016-1183-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1183-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T23:08:41Z","timestamp":1692227321000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-016-1183-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":107,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1183"],"URL":"https:\/\/doi.org\/10.1007\/s00535-016-1183-3","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}