{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:08:20Z","timestamp":1784005700917,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Health Labour Sciences Research Grant","award":["201415102A"],"award-info":[{"award-number":["201415102A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s00535-016-1209-x","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T05:59:43Z","timestamp":1460613583000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan"],"prefix":"10.1007","volume":"52","author":[{"given":"Erika","family":"Kuwahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagamu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Nagahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"issue":"3","key":"1209_CR1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ajg.2009.727","volume":"105","author":"A Kornbluth","year":"2010","unstructured":"Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501\u201323.","journal-title":"Am J Gastroenterol"},{"issue":"18","key":"1209_CR2","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","volume":"365","author":"S Danese","year":"2011","unstructured":"Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011;365(18):1713\u201325.","journal-title":"N Engl J Med"},{"issue":"6","key":"1209_CR3","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","volume":"140","author":"J Cosnes","year":"2011","unstructured":"Cosnes J, Gower-Rousseau C, Seksik P, et al. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1785\u201394.","journal-title":"Gastroenterology"},{"issue":"1","key":"1209_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1751-2980.2008.00355.x","volume":"10","author":"K Goh","year":"2009","unstructured":"Goh K, Xiao SD. Inflammatory bowel disease: a survey of the epidemiology in Asia. J Dig Dis. 2009;10(1):1\u20136.","journal-title":"J Dig Dis"},{"issue":"7","key":"1209_CR5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00535-009-0057-3","volume":"44","author":"K Asakura","year":"2009","unstructured":"Asakura K, Nishiwaki Y, Inoue N, et al. Prevalence of ulcerative colitis and Crohn\u2019s disease in Japan. J Gastroenterol. 2009;44(7):659\u201365.","journal-title":"J Gastroenterol"},{"issue":"Suppl 8","key":"1209_CR6","first-page":"1","volume":"30","author":"N Morita","year":"1995","unstructured":"Morita N, Toki S, Hirohashi T, et al. Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991. J Gastroenterol. 1995;30(Suppl 8):1\u20134.","journal-title":"J Gastroenterol"},{"issue":"5","key":"1209_CR7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","volume":"3","author":"S Danese","year":"2004","unstructured":"Danese S, Sans M, Fiocchi C. Inflammatory bowel disease: the role of environmental factors. Autoimmun Rev. 2004;3(5):394\u2013400.","journal-title":"Autoimmun Rev"},{"issue":"4","key":"1209_CR8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00365520802600961","volume":"44","author":"IC Solberg","year":"2009","unstructured":"Solberg IC, Lygren I, Jahnsen J, et al. Clinical course during the first 10\u00a0years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study). Scand J Gastroenterol. 2009;44(4):431\u201340.","journal-title":"Scand J Gastroenterol"},{"issue":"8","key":"1209_CR9","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1111\/j.1572-0241.2007.01265.x","volume":"102","author":"O Hoie","year":"2007","unstructured":"Hoie O, Wolters F, Riis L, et al. Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007;102(8):1692\u2013701.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"1209_CR10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ajg.2008.38","volume":"104","author":"MJ Romberg-Camps","year":"2009","unstructured":"Romberg-Camps MJ, Dagnelie PC, Kester AD, et al. Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease. Am J Gastroenterol. 2009;104(2):371\u201383.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"1209_CR11","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/BF02064985","volume":"40","author":"S Futami","year":"1995","unstructured":"Futami S, Aoyama N, Honsako Y, et al. HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci. 1995;40(4):814\u20138.","journal-title":"Dig Dis Sci"},{"issue":"13","key":"1209_CR12","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1097\/01.MIB.0000437567.12067.e7","volume":"19","author":"DG Walker","year":"2013","unstructured":"Walker DG, Williams HR, Bancil AS, et al. Ethnicity differences in genetic susceptibility to ulcerative colitis: a comparison of Indian asians and white northern Europeans. Inflamm Bowel Dis. 2013;19(13):2888\u201394.","journal-title":"Inflamm Bowel Dis"},{"issue":"4947","key":"1209_CR13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","volume":"2","author":"SC Truelove","year":"1955","unstructured":"Truelove SC, Witts LJ. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955;2(4947):1041\u20138.","journal-title":"Br Med J"},{"issue":"Suppl A","key":"1209_CR14","doi-asserted-by":"crossref","first-page":"5A","DOI":"10.1155\/2005\/269076","volume":"19","author":"MS Silverberg","year":"2005","unstructured":"Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol Journal canadien de gastroenterologie. 2005;19(Suppl A):5A\u201336A.","journal-title":"Can J Gastroenterol Journal canadien de gastroenterologie"},{"issue":"3","key":"1209_CR15","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/MIB.0b013e31827e78be","volume":"19","author":"A Lasson","year":"2013","unstructured":"Lasson A, Simren M, Stotzer PO, et al. Fecal calprotectin levels predict the clinical course in patients with new onset of ulcerative colitis. Inflamm Bowel Dis. 2013;19(3):576\u201381.","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"1209_CR16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/gast.2001.20912","volume":"120","author":"A Bitton","year":"2001","unstructured":"Bitton A, Peppercorn MA, Antonioli DA, et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology. 2001;120(1):13\u201320.","journal-title":"Gastroenterology"},{"issue":"10","key":"1209_CR17","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/bjs.7135","volume":"97","author":"AG Wibmer","year":"2010","unstructured":"Wibmer AG, Kroesen AJ, Grone J, et al. Predictors of permanent ileostomy after restorative proctocolectomy. Br J Surg. 2010;97(10):1561\u20136.","journal-title":"Br J Surg"},{"issue":"7","key":"1209_CR18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/DCR.0b013e3181db7029","volume":"53","author":"JA Canedo","year":"2010","unstructured":"Canedo JA, Pinto RA, McLemore EC, et al. Restorative proctectomy with ileal pouch-anal anastomosis in obese patients. Dis Colon Rectum. 2010;53(7):1030\u20134.","journal-title":"Dis Colon Rectum"},{"key":"1209_CR19","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1476-511X-10-204","volume":"10","author":"LG Teixeira","year":"2011","unstructured":"Teixeira LG, Leonel AJ, Aguilar EC, et al. The combination of high-fat diet-induced obesity and chronic ulcerative colitis reciprocally exacerbates adipose tissue and colon inflammation. Lipids Health Dis. 2011;10:204.","journal-title":"Lipids Health Dis"},{"issue":"10","key":"1209_CR20","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1097\/MIB.0b013e31829cf401","volume":"19","author":"JW Harper","year":"2013","unstructured":"Harper JW, Sinanan MN, Zisman TL. Increased body mass index is associated with earlier time to loss of response to infliximab in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(10):2118\u201324.","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"1209_CR21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/1319-3767.80383","volume":"17","author":"S Azad","year":"2011","unstructured":"Azad S, Sood N, Sood A. Biological and histological parameters as predictors of relapse in ulcerative colitis: a prospective study. Saudi J Gastroenterol. 2011;17(3):194\u20138.","journal-title":"Saudi J Gastroenterol"},{"issue":"9","key":"1209_CR22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00535-012-0558-3","volume":"47","author":"E Kuwahara","year":"2012","unstructured":"Kuwahara E, Asakura K, Nishiwaki Y, et al. Effects of family history on inflammatory bowel disease characteristics in Japanese patients. J Gastroenterol. 2012;47(9):961\u20138.","journal-title":"J Gastroenterol"},{"issue":"5","key":"1209_CR23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2036.2008.03772.x","volume":"28","author":"A Lau","year":"2008","unstructured":"Lau A, Chande N, Ponich T, et al. Predictive factors associated with immunosuppressive agent use in ulcerative colitis: a case-control study. Aliment Pharmacol Ther. 2008;28(5):606\u201313.","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"1209_CR24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/gut.2005.088732","volume":"56","author":"P Rutgeerts","year":"2007","unstructured":"Rutgeerts P, Vermeire S, Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut. 2007;56(4):453\u20135.","journal-title":"Gut"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1209-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-016-1209-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1209-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1209-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:40:19Z","timestamp":1559083219000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-016-1209-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,13]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["1209"],"URL":"https:\/\/doi.org\/10.1007\/s00535-016-1209-x","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,13]]}}}