{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:05:00Z","timestamp":1778670300084,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T00:00:00Z","timestamp":1479340800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00535-016-1287-9","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T11:10:08Z","timestamp":1479381008000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sequential therapy consisting of glucocorticoid infusions followed by granulocyte\u2013monocyte absorptive apheresis in patients with severe alcoholic hepatitis"],"prefix":"10.1007","volume":"52","author":[{"given":"Kazuhiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Naiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mie","family":"Inao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Mochida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"key":"1287_CR1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1440-1746.1995.tb01339.x","volume":"10","author":"A Takada","year":"1995","unstructured":"Takada A, Tsutsumi M. A Japanese study group for alcoholic liver disease. National survey of alcoholic liver diseases. J Gatroenterol Hepatol. 1995;10:509\u201316.","journal-title":"J Gatroenterol Hepatol"},{"key":"1287_CR2","first-page":"41","volume":"18","author":"G Bird","year":"1993","unstructured":"Bird G, Koskinas J, Portmann B, et al. Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology. 1993;18:41\u20134.","journal-title":"Hepatology"},{"key":"1287_CR3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0741-8329(02)00207-0","volume":"27","author":"AA Nanji","year":"2002","unstructured":"Nanji AA. Role of Kupffer cells in alcoholic hepatitis. Alcohol. 2002;27:13\u20135.","journal-title":"Alcohol"},{"key":"1287_CR4","doi-asserted-by":"crossref","first-page":"172S","DOI":"10.1097\/01.alc.0000189278.30237.e9","volume":"29","author":"H Fukui","year":"2005","unstructured":"Fukui H. Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure. Alcohol Clin Exp Res. 2005;29:172S\u20139S.","journal-title":"Alcohol Clin Exp Res"},{"key":"1287_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.1840090302","volume":"9","author":"CJ MacClain","year":"1989","unstructured":"MacClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349\u201351.","journal-title":"Hepatology"},{"key":"1287_CR6","first-page":"G605","volume":"275","author":"RG Thurman","year":"1998","unstructured":"Thurman RG. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol. 1998;275:G605\u201311.","journal-title":"Am J Physiol"},{"key":"1287_CR7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0741-8329(02)00200-8","volume":"27","author":"H Jaeschke","year":"2002","unstructured":"Jaeschke H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol. 2002;27:23\u20137.","journal-title":"Alcohol"},{"key":"1287_CR8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0168-8278(01)00289-6","volume":"36","author":"P Mathurin","year":"2002","unstructured":"Mathurin P, Mendenhall CL, Carithers RL Jr, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol. 2002;36:480\u20137.","journal-title":"J Hepatol"},{"key":"1287_CR9","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMoa1412278","volume":"372","author":"MR Thursz","year":"2015","unstructured":"Thursz MR, Richardson P, Allison M, et al. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med. 2015;372:1619\u201328.","journal-title":"N Engl J Med"},{"key":"1287_CR10","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1097\/01.ALC.0000078607.32247.9D","volume":"27","author":"Y Tsuji","year":"2003","unstructured":"Tsuji Y, Kumashiro R, Ishii K, et al. Severe alcoholic hepatitis successfully treated by leukocytapheresis: a case report. Alcohol Clin Exp Res. 2003;27:26S\u201331S.","journal-title":"Alcohol Clin Exp Res"},{"key":"1287_CR11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2169\/internalmedicine.45.1456","volume":"45","author":"K Okubo","year":"2006","unstructured":"Okubo K, Yoshizawa K, Okiyama W, et al. Severe alcoholic hepatitis with extremely high neutrophil count successfully treated by granulocytapheresis. Intern Med. 2006;45:155\u20138.","journal-title":"Intern Med"},{"key":"1287_CR12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.hepres.2006.06.016","volume":"36","author":"R Kumashiro","year":"2006","unstructured":"Kumashiro R, Koga Y, Kuwahara R, et al. Granulocytapheresis (GCAP) for severe alcoholic hepatitis\u2014a preliminary report. Hepatol Res. 2006;36:229\u201336.","journal-title":"Hepatol Res"},{"key":"1287_CR13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/MEG.0b013e328332a360","volume":"22","author":"JM Morris","year":"2010","unstructured":"Morris JM, Dickson S, Neilson M, et al. Granulocytapheresis in the treatment of severe alcoholic hepatitis: a case series. Eur J Gastroenterol Hepatol. 2010;22:457\u201360.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1287_CR14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s10620-013-2871-y","volume":"59","author":"K Kamimura","year":"2014","unstructured":"Kamimura K, Imai M, Sakamaki A, et al. Granulocytapheresis for the treatment of severe alcoholic hepatitis: a case series and literature review. Dig Dis Sci. 2014;59:482\u20138.","journal-title":"Dig Dis Sci"},{"key":"1287_CR15","doi-asserted-by":"crossref","first-page":"251S","DOI":"10.1097\/01.alc.0000192300.52559.04","volume":"29","author":"Y Horie","year":"2005","unstructured":"Horie Y, Ishii H, Hibi T. Severe alcoholic hepatitis in Japan: prognosis and therapy. Alcohol Clin Exp Res. 2005;29:251S\u20138S.","journal-title":"Alcohol Clin Exp Res"},{"key":"1287_CR16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/msj.20135","volume":"76","author":"H-H Tan","year":"2009","unstructured":"Tan H-H, Virmani S, Martin P. Controversies in the management of alcoholic liver disease. Mt Sinai J Med. 2009;76:484\u201398.","journal-title":"Mt Sinai J Med"},{"key":"1287_CR17","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","volume":"35","author":"SK Ramaiah","year":"2007","unstructured":"Ramaiah SK, Jaeschke H. Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol Pathol. 2007;35:757\u201366.","journal-title":"Toxicol Pathol"},{"key":"1287_CR18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jlb.57.2.317","volume":"57","author":"JL Burton","year":"1995","unstructured":"Burton JL, Kehrli ME Jr, Kapil S, et al. Regulation of L-selectin and CD18 on bovine neutrophils by glucocorticoids: effects of cortisol and dexamethasone. J Leukoc Biol. 1995;57:317\u201325.","journal-title":"J Leukoc Biol"},{"key":"1287_CR19","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0168-8278(01)00190-8","volume":"35","author":"L Spahr","year":"2001","unstructured":"Spahr L, Rubbia-Brandt L, Pugin J, et al. Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood. J Hepatol. 2001;35:582\u20139.","journal-title":"J Hepatol"},{"key":"1287_CR20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2957\/kanzo.34.888","volume":"34","author":"A Takada","year":"1993","unstructured":"Takada A, Okudaira M, Ohta Y, et al. A new diagnostic criteria of alcoholic liver diseases. Acta Hepatol Jpn. 1993;34:888\u201396.","journal-title":"Acta Hepatol Jpn"},{"key":"1287_CR21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2957\/kanzo.55.22","volume":"55","author":"Y Horie","year":"2014","unstructured":"Horie Y, Yamagishi Y, Ebinuma H, et al. Japan alcoholic score can help management of patients with alcoholic hepatitis. Kanzo. 2014;55:22\u201332.","journal-title":"Kanzo"},{"key":"1287_CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-141-1-200407060-00014","volume":"141","author":"PC Minneci","year":"2004","unstructured":"Minneci PC, Deans KJ, Banks SM, et al. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med. 2004;141:47\u201356.","journal-title":"Ann Intern Med"},{"key":"1287_CR23","doi-asserted-by":"crossref","first-page":"e692","DOI":"10.1016\/j.crohns.2013.06.012","volume":"7","author":"R Sacco","year":"2013","unstructured":"Sacco R, Romano A, Mazzoni A, et al. Granulocytapheresis in steroid-dependent and steroid-resistant patients with inflammatory bowel disease: a prospective observational study. J Crohns Colitis. 2013;7:e692\u20137.","journal-title":"J Crohns Colitis"},{"key":"1287_CR24","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.clinre.2011.07.005","volume":"35","author":"Y Horie","year":"2011","unstructured":"Horie Y, Yamagishi Y, Ebinuma H, et al. Therapeutic strategies for severe alcoholic hepatitis. Clin Res Hepatol Gastroenterol. 2011;35:738\u201344.","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"Suppl 2","key":"1287_CR25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1746.2011.07005.x","volume":"27","author":"Y Horie","year":"2012","unstructured":"Horie Y. Granulocytapheresis and plasma exchange for severe alcoholic hepatitis. J Gastroenterol Hepatol. 2012;27(Suppl 2):99\u2013103.","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-016-1287-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1287-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-016-1287-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T18:01:53Z","timestamp":1568570513000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-016-1287-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,17]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["1287"],"URL":"https:\/\/doi.org\/10.1007\/s00535-016-1287-9","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,17]]}}}