{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:36:50Z","timestamp":1780054610677,"version":"3.54.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T00:00:00Z","timestamp":1487980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2014\/15\/N\/NZ4\/04564"],"award-info":[{"award-number":["UMO-2014\/15\/N\/NZ4\/04564"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00535-017-1323-4","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T05:15:39Z","timestamp":1487999739000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage"],"prefix":"10.1007","volume":"53","author":[{"given":"Marcin","family":"Magierowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Hubalewska-Mazgaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Magierowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmara","family":"Wojcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Sliwowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Kwiecien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Brzozowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,25]]},"reference":[{"key":"1323_CR1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0016-5085(89)80056-3","volume":"96","author":"G Kauffman","year":"1989","unstructured":"Kauffman G. Aspirin-induced gastric mucosal injury: lessons learned from animal models. Gastroenterology. 1989;96:606\u201314.","journal-title":"Gastroenterology"},{"key":"1323_CR2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00042737-199306000-00004","volume":"5","author":"N Hudson","year":"1993","unstructured":"Hudson N, Hawkey CJ. Non-steroidal anti-inflammatory drug associated upper gastrointestinal ulceration and complications. Eur J Gastroenterol Hepatol. 1993;5:412\u20139.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"1323_CR3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2036.2007.03348.x","volume":"26","author":"I Bjarnason","year":"2007","unstructured":"Bjarnason I, Scarpignato C, Takeuchi K, et al. Determinants of the short-term gastric damage caused by NSAIDs in man. Aliment Pharmacol Ther. 2007;26(1):95\u2013106.","journal-title":"Aliment Pharmacol Ther"},{"key":"1323_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrgastro.2011.97","volume":"8","author":"C Sostres","year":"2011","unstructured":"Sostres C, Lanas A. Gastrointestinal effects of aspirin. Nat Rev Gastroenterol Hepatol. 2011;8:385\u201394. doi: 10.1038\/nrgastro.2011.97 .","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1323_CR5","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2005.07.060","volume":"129","author":"S Fiorucci","year":"2005","unstructured":"Fiorucci S, Antonelli E, Distrutti E, et al. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology. 2005;129:1210\u201324.","journal-title":"Gastroenterology"},{"key":"1323_CR6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5604\/17322693.1038356","volume":"67","author":"M Magierowski","year":"2013","unstructured":"Magierowski M, Jasnos K, Kwiecien S, et al. Role of hydrogen sulfide in the physiology of gastrointestinal tract and in the mechanism of gastroprotection. Postepy Hig Med Dosw. 2013;67:150\u20136.","journal-title":"Postepy Hig Med Dosw"},{"key":"1323_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/j.gastro.2014.04.041","volume":"147","author":"G Farrugia","year":"2014","unstructured":"Farrugia G, Szurszewski JH. Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. Gastroenterology. 2014;147:303\u201313.","journal-title":"Gastroenterology"},{"key":"1323_CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5604\/17322693.1087527","volume":"68","author":"K Jasnos","year":"2014","unstructured":"Jasnos K, Magierowski M, Kwiecien S, Brzozowski T. Carbon monoxide in human physiology-its role in the gastrointestinal tract. Postepy Hig Med Dosw. 2014;68:101\u20139.","journal-title":"Postepy Hig Med Dosw"},{"issue":"37","key":"1323_CR9","doi-asserted-by":"publisher","first-page":"13559","DOI":"10.1073\/pnas.1413390111","volume":"111","author":"KL Flannigan","year":"2014","unstructured":"Flannigan KL, Agbor TA, Blackler RW, et al. Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis. Proc Natl Acad Sci U S A. 2014;111(37):13559\u201364. doi: 10.1073\/pnas.1413390111 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1323_CR10","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.3390\/molecules20059099","volume":"20","author":"M Magierowski","year":"2015","unstructured":"Magierowski M, Magierowska K, Kwiecien S, et al. Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules. 2015;20(5):9099\u2013123.","journal-title":"Molecules"},{"issue":"2","key":"1323_CR11","first-page":"169","volume":"66","author":"Z Jin","year":"2015","unstructured":"Jin Z, Chan H, Ning J, et al. The role of hydrogen sulfide in pathologies of the vital organs and its clinical application. J Physiol Pharmacol. 2015;66(2):169\u201379.","journal-title":"J Physiol Pharmacol"},{"issue":"3","key":"1323_CR12","first-page":"319","volume":"66","author":"K Gyires","year":"2015","unstructured":"Gyires K, Toth VE, Zadori ZS. Gastric mucosal protection: from the periphery to the central nervous system. J Physiol Pharmacol. 2015;66(3):319\u201329.","journal-title":"J Physiol Pharmacol"},{"issue":"4","key":"1323_CR13","first-page":"505","volume":"66","author":"M Romerowicz-Misielak","year":"2015","unstructured":"Romerowicz-Misielak M, Oren DA, Sowa-Kucma M, et al. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. J Physiol Pharmacol. 2015;66(4):505.","journal-title":"J Physiol Pharmacol"},{"issue":"6","key":"1323_CR14","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1111\/j.1476-5381.2009.00611.x","volume":"159","author":"JL Wallace","year":"2010","unstructured":"Wallace JL, Caliendo G, Santagada V, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br J Pharmacol. 2010;159(6):1236\u201346. doi: 10.1111\/j.1476-5381.2009.00611.x .","journal-title":"Br J Pharmacol"},{"issue":"21","key":"1323_CR15","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.2174\/1381612821666150514105413","volume":"21","author":"KL Flannigan","year":"2015","unstructured":"Flannigan KL, Wallace JL. Hydrogen sulfide-based anti-inflammatory and chemopreventive therapies: an experimental approach. Curr Pharm Des. 2015;21(21):3012\u201322.","journal-title":"Curr Pharm Des"},{"issue":"2","key":"1323_CR16","doi-asserted-by":"publisher","first-page":"e0147289","DOI":"10.1371\/journal.pone.0147289","volume":"11","author":"M Paul-Clark","year":"2016","unstructured":"Paul-Clark M, Elsheikh W, Kirkby N, et al. Profound chemopreventative effects of a hydrogen sulfide-releasing NSAID in the APCMin\/+\u00a0mouse model of intestinal tumorigenesis. PLoS ONE. 2016;11(2):e0147289. doi: 10.1371\/journal.pone.0147289 .","journal-title":"PLoS ONE"},{"key":"1323_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.phrs.2016.11.001","volume":"114","author":"M Magierowski","year":"2016","unstructured":"Magierowski M, Magierowska K, Hubalewska-Mazgaj M, et al. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage. Pharmacol Res. 2016;114:235\u201350. doi: 10.1016\/j.phrs.2016.11.001 .","journal-title":"Pharmacol Res"},{"issue":"2","key":"1323_CR18","first-page":"143","volume":"63","author":"S Kwiecien","year":"2012","unstructured":"Kwiecien S, Konturek PC, Sliwowski Z, et al. Interaction between selective cyclooxygenase inhibitors and capsaicin-sensitive afferent sensory nerves in pathogenesis of stress-induced gastric lesions. Role of oxidative stress. J Physiol Pharmacol. 2012;63(2):143\u201351.","journal-title":"J Physiol Pharmacol"},{"issue":"3","key":"1323_CR19","doi-asserted-by":"publisher","first-page":"e0118972","DOI":"10.1371\/journal.pone.0118972","volume":"10","author":"M Magierowski","year":"2015","unstructured":"Magierowski M, Jasnos K, Kwiecien S, et al. Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. PLoS ONE. 2015;10(3):e0118972. doi: 10.1371\/journal.pone.0118972 .","journal-title":"PLoS ONE"},{"key":"1323_CR20","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1161\/hh0202.104530","volume":"90","author":"R Motterlini","year":"2002","unstructured":"Motterlini R, Clark JE, Foresti R, et al. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res. 2002;90:E17\u201324.","journal-title":"Circ Res"},{"issue":"10","key":"1323_CR21","doi-asserted-by":"publisher","first-page":"e0140493","DOI":"10.1371\/journal.pone.0140493","volume":"10","author":"K Magierowska","year":"2015","unstructured":"Magierowska K, Magierowski M, Hubalewska-Mazgaj M, et al. Carbon monoxide (CO) released from tricarbonyldichlororuthenium(II) dimer (CORM-2) in gastroprotection against experimental ethanol-induced gastric damage. PLoS ONE. 2015;10(10):e0140493. doi: 10.1371\/journal.pone.0140493 .","journal-title":"PLoS ONE"},{"issue":"11","key":"1323_CR22","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1007\/s10620-016-4280-5","volume":"61","author":"M Magierowski","year":"2016","unstructured":"Magierowski M, Magierowska K, Szmyd J, et al. Hydrogen sulfide and carbon monoxide protect gastric mucosa compromised by mild stress against alendronate injury. Dig Dis Sci. 2016;61(11):3176\u201389. doi: 10.1007\/s10620-016-4280-5 .","journal-title":"Dig Dis Sci"},{"key":"1323_CR23","first-page":"41","volume":"60","author":"PC Konturek","year":"2009","unstructured":"Konturek PC, Brzozowski T, Engel M, et al. Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. J Physiol Pharmacol. 2009;60:41\u20137.","journal-title":"J Physiol Pharmacol"},{"key":"1323_CR24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0076-6879(96)68040-9","volume":"268","author":"OW Griffith","year":"1996","unstructured":"Griffith OW, Kilbourn RG. Nitric oxide synthase inhibitors: amino acids. Methods Enzymol. 1996;268:375\u201392.","journal-title":"Methods Enzymol"},{"issue":"5","key":"1323_CR25","first-page":"515","volume":"63","author":"S Kwiecien","year":"2012","unstructured":"Kwiecien S, Ptak-Belowska A, Krzysiek-Maczka G, et al. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, interacts with gastric oxidative metabolism and enhances stress-induced gastric lesions. J Physiol Pharmacol. 2012;63(5):515\u201324.","journal-title":"J Physiol Pharmacol"},{"issue":"4","key":"1323_CR26","doi-asserted-by":"publisher","first-page":"E442","DOI":"10.3390\/ijms17040442","volume":"17","author":"K Magierowska","year":"2016","unstructured":"Magierowska K, Magierowski M, Surmiak M, et al. The protective role of carbon monoxide (CO) produced by heme oxygenases and derived from the CO-releasing molecule CORM-2 in the pathogenesis of stress-induced gastric lesions: evidence for non-involvement of nitric oxide (NO). Int J Mol Sci. 2016;17(4):E442. doi: 10.3390\/ijms17040442 .","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1323_CR27","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.3390\/ijms15034946","volume":"15","author":"M Magierowski","year":"2014","unstructured":"Magierowski M, Jasnos K, Sliwowski Z, et al. Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP). Int J Mol Sci. 2014;15(3):4946\u201364. doi: 10.3390\/ijms15034946 .","journal-title":"Int J Mol Sci"},{"key":"1323_CR28","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3:1101\u20138. doi: 10.1038\/nprot.2008.73 .","journal-title":"Nat Protoc"},{"issue":"3","key":"1323_CR29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1254\/jjp.24.363","volume":"24","author":"S Okabe","year":"1974","unstructured":"Okabe S, Takeuchi K, Nakamura K, et al. Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat. Jpn J Pharmacol. 1974;24(3):363\u201371.","journal-title":"Jpn J Pharmacol"},{"issue":"6","key":"1323_CR30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/gut.23.6.536","volume":"23","author":"SJ Konturek","year":"1982","unstructured":"Konturek SJ, Brzozowski T, Piastucki I, et al. Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins. Gut. 1982;23(6):536\u201340.","journal-title":"Gut"},{"issue":"3","key":"1323_CR31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0022-3565(25)11144-0","volume":"261","author":"M Perretti","year":"1992","unstructured":"Perretti M, Mugridge KG, Wallace JL, et al. Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids. J Pharmacol Exp Ther. 1992;261(3):1238\u201347.","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"1323_CR32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1248\/bpb.26.651","volume":"26","author":"Y Pongpiriyadacha","year":"2003","unstructured":"Pongpiriyadacha Y, Matsuda H, Morikawa T, et al. Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action. Biol Pharm Bull. 2003;26(5):651\u20137.","journal-title":"Biol Pharm Bull"},{"issue":"6","key":"1323_CR33","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3748\/wjg.v20.i6.1614","volume":"20","author":"JY Zhang","year":"2014","unstructured":"Zhang JY, Wu QF, Wan Y, et al. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol. 2014;20(6):1614\u201322. doi: 10.3748\/wjg.v20.i6.1614 .","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1323_CR34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/j.gastro.2006.11.042","volume":"132","author":"JL Wallace","year":"2007","unstructured":"Wallace JL, Caliendo G, Santagada V, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007;132(1):261\u201371.","journal-title":"Gastroenterology"},{"key":"1323_CR35","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.1038\/ncomms5381","volume":"5","author":"M Eberhardt","year":"2014","unstructured":"Eberhardt M, Dux M, Namer B, et al. H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun. 2014;5:4381. doi: 10.1038\/ncomms5381 .","journal-title":"Nat Commun"},{"key":"1323_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4377-x","author":"LT Lucetti","year":"2016","unstructured":"Lucetti LT, Silva RO, Santana AP, et al. Nitric oxide and hydrogen sulfide interact when modulating gastric physiological functions in rodents. Dig Dis Sci. 2016. doi: 10.1007\/s10620-016-4377-x .","journal-title":"Dig Dis Sci"},{"key":"1323_CR37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mvr.2016.11.001","volume":"109","author":"S Materazzi","year":"2016","unstructured":"Materazzi S, Zagli G, Nassini R, et al. Vasodilator activity of hydrogen sulfide (H2S) in human mesenteric arteries. Microvasc Res. 2016;109:38\u201344. doi: 10.1016\/j.mvr.2016.11.001 .","journal-title":"Microvasc Res"},{"key":"1323_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.09.010","author":"PM Yang","year":"2016","unstructured":"Yang PM, Huang YT, Zhang YQ, et al. Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase\/Akt mechanism. Vascul Pharmacol. 2016. doi: 10.1016\/j.vph.2016.09.010 .","journal-title":"Vascul Pharmacol"},{"issue":"4","key":"1323_CR39","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1073\/pnas.72.4.1349","volume":"72","author":"J Richardson","year":"1975","unstructured":"Richardson J, Thomas KA, Rubin BH, et al. Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. Proc Natl Acad Sci U S A. 1975;72(4):1349\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1323_CR40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0306-9877(98)90024-X","volume":"50","author":"X Wang","year":"1998","unstructured":"Wang X. A chelate theory for the mechanism of action of aspirin-like drugs. Med Hypotheses. 1998;50(3):239\u201351.","journal-title":"Med Hypotheses"},{"issue":"2","key":"1323_CR41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.freeradbiomed.2006.10.044","volume":"42","author":"EM Park","year":"2007","unstructured":"Park EM, Ramnath N, Yang GY, et al. High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis. Free Radic Biol Med. 2007;42(2):280\u20137.","journal-title":"Free Radic Biol Med"},{"key":"1323_CR42","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1590\/1414-431X20133030","volume":"46","author":"LA Nicolau","year":"2013","unstructured":"Nicolau LA, Silva RO, Damasceno SR, et al. The hydrogen sulfide donor, Lawesson\u2019s reagent, prevents alendronate-induced gastric damage in rats. Braz J Med Biol Res. 2013;46:708\u201314.","journal-title":"Braz J Med Biol Res"},{"key":"1323_CR43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2012.12.007","volume":"700","author":"NR Costa","year":"2013","unstructured":"Costa NR, Silva RO, Nicolau LA, et al. Role of soluble guanylate cyclase activation in the gastroprotective effect of the HO-1\/CO pathway against alendronate-induced gastric damage in rats. Eur J Pharmacol. 2013;700:51\u20139.","journal-title":"Eur J Pharmacol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-017-1323-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-017-1323-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-017-1323-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T18:51:15Z","timestamp":1750013475000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-017-1323-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,25]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1323"],"URL":"https:\/\/doi.org\/10.1007\/s00535-017-1323-4","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,25]]}}}