{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:18:25Z","timestamp":1768436305187,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 91529302, No.81572798"],"award-info":[{"award-number":["No. 91529302, No.81572798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00535-017-1329-y","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T05:22:54Z","timestamp":1489728174000},"page":"71-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1\/Rho GTPase signaling pathway"],"prefix":"10.1007","volume":"53","author":[{"given":"Li","family":"Pang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingde","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiqin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-gang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"issue":"4","key":"1329_CR1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaoncol.2015.0735","volume":"1","author":"C Fitzmaurice","year":"2015","unstructured":"Fitzmaurice C, Dicker D, Pain A, et al. The global burden of cancer 2013. JAMA Oncol. 2015;1(4):505\u201327.","journal-title":"JAMA Oncol."},{"issue":"10060","key":"1329_CR2","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1016\/S0140-6736(16)30354-3","volume":"388","author":"E Cutsem Van","year":"2016","unstructured":"Van Cutsem E, Sagaert X, Topal B, et al. Gastric cancer. Lancet. 2016;388(10060):2654\u201364.","journal-title":"Lancet."},{"issue":"1\u20132","key":"1329_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10555-008-9166-3","volume":"28","author":"A Hall","year":"2009","unstructured":"Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev. 2009;28(1\u20132):5\u201314.","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"1329_CR4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc725","volume":"2","author":"E Sahai","year":"2002","unstructured":"Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer. 2002;2(2):133\u201342.","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"1329_CR5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0955-0674(03)00097-8","volume":"15","author":"M Fukata","year":"2003","unstructured":"Fukata M, Nakagawa M, Kaibuchi K. Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol. 2003;15(5):590\u20137.","journal-title":"Curr Opin Cell Biol"},{"issue":"7","key":"1329_CR6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1158\/1541-7786.395.2.7","volume":"2","author":"XL Shi","year":"2004","unstructured":"Shi XL, Gangadharan B, Brass LF, et al. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res. 2004;2(7):395\u2013402.","journal-title":"Mol Cancer Res"},{"issue":"1","key":"1329_CR7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gde.2006.12.002","volume":"17","author":"BD Spiegelberg","year":"2007","unstructured":"Spiegelberg BD, Hamm HE. Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. Curr Opin Genet Dev. 2007;17(1):40\u20134.","journal-title":"Curr Opin Genet Dev"},{"key":"1329_CR8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/1471-2407-10-443","volume":"10","author":"D Fujimoto","year":"2010","unstructured":"Fujimoto D, Hirono Y, Goi T, et al. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer. 2010;10:443.","journal-title":"BMC Cancer"},{"issue":"3","key":"1329_CR9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbrc.2004.01.108","volume":"315","author":"Y Pan","year":"2004","unstructured":"Pan Y, Bi F, Liu N, et al. Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun. 2004;315(3):686\u201391.","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"1329_CR10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1476-4598-13-100","volume":"13","author":"T Du","year":"2014","unstructured":"Du T, Qu Y, Li J, et al. Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK\/Paxillin pathway. Mol Cancer. 2014;13(1):100.","journal-title":"Mol Cancer."},{"issue":"1","key":"1329_CR11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/bbrc.2000.4125","volume":"280","author":"IV Kurochkin","year":"2001","unstructured":"Kurochkin IV, Yonemitsu N, Funahashi SI, et al. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Biochem Biophys Res Commun. 2001;280(1):340\u20137.","journal-title":"Biochem Biophys Res Commun."},{"key":"1329_CR12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0074-7696(08)61054-2","volume":"186","author":"M Hatzfeld","year":"1999","unstructured":"Hatzfeld M. The armadillo family of structural proteins. Int Rev Cytol. 1999;186:179\u2013224.","journal-title":"Int Rev Cytol"},{"issue":"8","key":"1329_CR13","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.7314\/APJCP.2015.16.8.3293","volume":"16","author":"Y Gao","year":"2015","unstructured":"Gao Y, Wu JY, Zeng F, et al. ALEX1 regulates proliferation and apoptosis in breast cancer cells. Asian Pac J Cancer Prev. 2015;16(8):3293\u20139.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"7","key":"1329_CR14","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.1349-7006.2012.02300.x","volume":"103","author":"H Iseki","year":"2012","unstructured":"Iseki H, Takeda A, Andoh T, et al. ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines. Cancer Sci. 2012;103(7):1267\u201371.","journal-title":"Cancer Sci"},{"issue":"5","key":"1329_CR15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2008.09.061","volume":"135","author":"L Zender","year":"2008","unstructured":"Zender L, Xue W, Zuber J, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 2008;135(5):852\u201364.","journal-title":"Cell"},{"key":"1329_CR16","first-page":"906017","volume":"2012","author":"X Liu","year":"2012","unstructured":"Liu X, Tang X, Zhang S, et al. Methylation and expression of retinoblastoma and transforming growth factor-beta1 genes in Epstein-Barr virus-associated and -negative gastric carcinomas. Gastroenterol Res Pract. 2012;2012:906017.","journal-title":"Gastroenterol Res Pract."},{"issue":"6","key":"1329_CR17","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3892\/ijo.2014.2651","volume":"45","author":"T Otsuki","year":"2014","unstructured":"Otsuki T, Fujimoto D, Hirono Y, et al. Thrombin conducts epithelial\u2013mesenchymal transition via proteasea-ctivated receptor1 in human gastric cancer. Int J Oncol. 2014;45(6):2287\u201394.","journal-title":"Int J Oncol"},{"issue":"2","key":"1329_CR18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/ijo.2012.1738","volume":"42","author":"D Fujimoto","year":"2013","unstructured":"Fujimoto D, Hirono Y, Goi T, et al. The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion. Int J Oncol. 2013;42(2):565\u201373.","journal-title":"Int J Oncol"},{"issue":"8","key":"1329_CR19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3748\/wjg.v19.i8.1182","volume":"19","author":"DQ Calcagno","year":"2013","unstructured":"Calcagno DQ, Gigek CO, Chen ES, et al. DNA and histone methylation in gastric carcinogenesis. World J Gastroenterol. 2013;19(8):1182\u201392.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1329_CR20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/nrc3187","volume":"12","author":"N McCarthy","year":"2012","unstructured":"McCarthy N. Epigenetics: worth another look? Nat Rev Cancer. 2012;12(1):2.","journal-title":"Nat Rev Cancer"},{"issue":"20","key":"1329_CR21","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1074\/jbc.M901177200","volume":"284","author":"Z Mou","year":"2009","unstructured":"Mou Z, Tapper AR, Gardner PD. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. J Biol Chem. 2009;284(20):13629\u201340.","journal-title":"J Biol Chem"},{"issue":"1","key":"1329_CR22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/dvdy.20309","volume":"233","author":"CA Smith","year":"2005","unstructured":"Smith CA, McClive PJ, Sinclair AH. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Dev Dyn. 2005;233(1):188\u201393.","journal-title":"Dev Dyn"},{"issue":"8","key":"1329_CR23","first-page":"2281","volume":"62","author":"GF Weber","year":"2002","unstructured":"Weber GF, Bronson RT, Ilagan J, et al. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 2002;62(8):2281\u20136.","journal-title":"Cancer Res"},{"issue":"5285","key":"1329_CR24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1126\/science.274.5285.259","volume":"274","author":"O Lefebvre","year":"1996","unstructured":"Lefebvre O, Chenard MP, Masson R, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science. 1996;274(5285):259\u201362.","journal-title":"Science"},{"issue":"14","key":"1329_CR25","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1158\/0008-5472.CAN-10-1040","volume":"70","author":"JE Talmadge","year":"2010","unstructured":"Talmadge JE, Fidler IJ. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 2010;70(14):5649\u201369.","journal-title":"Cancer Res"},{"issue":"9","key":"1329_CR26","doi-asserted-by":"crossref","first-page":"e25103","DOI":"10.1371\/journal.pone.0025103","volume":"6","author":"SJ Kim","year":"2011","unstructured":"Kim SJ, Shin JY, Lee KD, et al. Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1). PLoS One. 2011;6(9):e25103.","journal-title":"PLoS One"},{"issue":"3","key":"1329_CR27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2004.12.018","volume":"120","author":"A Boire","year":"2005","unstructured":"Boire A, Covic L, Agarwal A, et al. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 2005;120(3):303\u201313.","journal-title":"Cell"},{"issue":"16","key":"1329_CR28","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1038\/sj.onc.1204281","volume":"20","author":"CB Martin","year":"2001","unstructured":"Martin CB, Mahon GM, Klinger MB, et al. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene. 2001;20(16):1953\u201363.","journal-title":"Oncogene"},{"issue":"3","key":"1329_CR29","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/bi027100x","volume":"42","author":"DL Greenberg","year":"2003","unstructured":"Greenberg DL, Mize GJ, Takayama TK. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry. 2003;42(3):702\u20139.","journal-title":"Biochemistry"},{"issue":"2","key":"1329_CR30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrm1587","volume":"6","author":"KL Rossman","year":"2005","unstructured":"Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol. 2005;6(2):167\u201380.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"1329_CR31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","volume":"128","author":"PA Jones","year":"2007","unstructured":"Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128(4):683\u201392.","journal-title":"Cell"},{"key":"1329_CR32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cca.2015.07.001","volume":"448","author":"Y Li","year":"2015","unstructured":"Li Y, Liang J, Hou P. Hypermethylation in gastric cancer. Clin Chim Acta. 2015;448:124\u201332.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1329_CR33","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/epi.15.4","volume":"7","author":"T Tahara","year":"2015","unstructured":"Tahara T, Arisawa T. DNA methylation as a molecular biomarker in gastric cancer. Epigenomics. 2015;7(3):475\u201386.","journal-title":"Epigenomics."},{"issue":"4","key":"1329_CR34","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1158\/0008-5472.CAN-09-2755","volume":"70","author":"T Niwa","year":"2010","unstructured":"Niwa T, Tsukamoto T, Toyoda T, et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010;70(4):1430\u201340.","journal-title":"Cancer Res"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-017-1329-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-017-1329-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-017-1329-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T16:20:03Z","timestamp":1658852403000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-017-1329-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1329"],"URL":"https:\/\/doi.org\/10.1007\/s00535-017-1329-y","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,17]]}}}