{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:22:48Z","timestamp":1791944568505,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00535-018-1507-6","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T05:28:43Z","timestamp":1537075723000},"page":"249-260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Capsule endoscopy findings for the diagnosis of Crohn\u2019s disease: a nationwide case\u2013control study"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-509X","authenticated-orcid":false,"given":"Motohiro","family":"Esaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ohmiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Washio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shojiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutomo","family":"Togashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihito","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaharu","family":"Nouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ashizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Omori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Fuyuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Umeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukunori","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"1507_CR1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1055\/s-0034-1391855","volume":"47","author":"M Pennazio","year":"2015","unstructured":"Pennazio M, Spada C, Eliakim R, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2015;47:352\u201376.","journal-title":"Endoscopy"},{"key":"1507_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","volume":"11","author":"F Gomollon","year":"2017","unstructured":"Gomollon F, Dignass A, Annese V, et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 1: diagnosis and medical management. J Crohns Colitis. 2017;11:3\u201325.","journal-title":"J Crohns Colitis"},{"key":"1507_CR3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","volume":"152","author":"RA Enns","year":"2017","unstructured":"Enns RA, Hookey L, Armstrong D, et al. Clinical practice guidelines for the use of video capsule endoscopy. Gastroenterology. 2017;152:497\u2013514.","journal-title":"Gastroenterology"},{"key":"1507_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00535-018-1439-1","volume":"53","author":"K Matsuoka","year":"2018","unstructured":"Matsuoka K, Kobayashi T, Ueno F, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 2018;53:303\u201353.","journal-title":"J Gastroenterol"},{"key":"1507_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10620-011-1894-5","volume":"57","author":"IM Gralnek","year":"2012","unstructured":"Gralnek IM, Cohen SA, Ephrath H, et al. Small bowel capsule endoscopy impacts diagnosis and management of pediatric inflammatory bowel disease: a prospective study. Dig Dis Sci. 2012;57:465\u201371.","journal-title":"Dig Dis Sci"},{"key":"1507_CR6","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1002\/ibd.20509","volume":"14","author":"A Efthymiou","year":"2008","unstructured":"Efthymiou A, Viazis N, Mantzaris G, et al. Does clinical response correlate with mucosal healing in patients with Crohn\u2019s disease of the small bowel? A prospective, case-series study using wireless capsule endoscopy. Inflamm Bowel Dis. 2008;14:1542\u20137.","journal-title":"Inflamm Bowel Dis"},{"key":"1507_CR7","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.crohns.2014.09.005","volume":"8","author":"B Hall","year":"2014","unstructured":"Hall B, Holleran G, Chin JL, et al. A prospective 52\u00a0week mucosal healing assessment of small bowel Crohn\u2019s disease as detected by capsule endoscopy. J Crohns Colitis. 2014;8:1601\u20139.","journal-title":"J Crohns Colitis"},{"key":"1507_CR8","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1136\/gut.2005.081851","volume":"55","author":"A Bourreille","year":"2006","unstructured":"Bourreille A, Jarry M, D\u2019Halluin PN, et al. Wireless capsule endoscopy versus ileocolonoscopy for the diagnosis of postoperative recurrence of Crohn\u2019s disease: a prospective study. Gut. 2006;55:978\u201383.","journal-title":"Gut"},{"key":"1507_CR9","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1002\/ibd.20199","volume":"13","author":"L Biancone","year":"2007","unstructured":"Biancone L, Calabrese E, Petruzziello C, et al. Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn\u2019s disease. Inflamm Bowel Dis. 2007;13:1256\u201365.","journal-title":"Inflamm Bowel Dis"},{"key":"1507_CR10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/jgh.12411","volume":"29","author":"M Esaki","year":"2014","unstructured":"Esaki M, Matsumoto T, Watanabe K, et al. Use of capsule endoscopy in patients with Crohn\u2019s disease in Japan: a multicenter survey. J Gastroenterol Hepatol. 2014;29:96\u2013101.","journal-title":"J Gastroenterol Hepatol"},{"key":"1507_CR11","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/S1542-3565(05)00483-0","volume":"3","author":"R Marmo","year":"2005","unstructured":"Marmo R, Rotondano G, Piscopo R, et al. Capsule endoscopy versus enteroclysis in the detection of small-bowel involvement in Crohn\u2019s disease: a prospective trial. Clin Gastroenterol Hepatol. 2005;3:772\u20136.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1507_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.gie.2005.06.026","volume":"62","author":"E Dubcenco","year":"2005","unstructured":"Dubcenco E, Jeejeeghoy KN, Petroniene R, et al. Capsule endoscopy findings in patients with established and suspected small-bowel Crohn\u2019s disease: correlation with radiologic, endoscopic, and histological findings. Gastrointest Endosc. 2005;62:538\u201344.","journal-title":"Gastrointest Endosc"},{"key":"1507_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.gie.2008.02.017","volume":"68","author":"CA Solem","year":"2008","unstructured":"Solem CA, Loftus EV Jr, Fletcher JG, et al. Small-bowel imaging in Crohn\u2019s disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc. 2008;68:255\u201366.","journal-title":"Gastrointest Endosc"},{"key":"1507_CR14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.dld.2004.03.011","volume":"36","author":"R Eliakim","year":"2004","unstructured":"Eliakim R, Suissa A, Yassin K, et al. Wireless capsule endoscopy compared to barium follow-through and computerized tomography in patients with suspected Crohn\u2019s disease\u2014final report. Dig Liver Dis. 2004;36:519\u201322.","journal-title":"Dig Liver Dis"},{"key":"1507_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1148\/radiol.2381050296","volume":"238","author":"AK Hara","year":"2006","unstructured":"Hara AK, Leighton JA, Heigh RI, et al. Crohn\u2019s disease of the small bowel: preliminary comparison of CT enterography, capsule endoscopy, small-bowel follow-through and ileoscopy. Radiology. 2006;238:128\u201334.","journal-title":"Radiology"},{"key":"1507_CR16","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/ajg.2009.713","volume":"105","author":"PM Dionisio","year":"2010","unstructured":"Dionisio PM, Gurudu SR, Leighton JA, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn\u2019s disease: a meta-analysis. Am J Gastroenterol. 2010;105:1240\u20138.","journal-title":"Am J Gastroenterol"},{"key":"1507_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1542-3565(03)00289-1","volume":"2","author":"WS Mow","year":"2004","unstructured":"Mow WS, Lo SK, Targan SR, et al. Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease. Clin Gastroenterol Hepatol. 2004;2:31\u201340.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1507_CR18","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1007\/BF02237231","volume":"43","author":"T Yao","year":"2000","unstructured":"Yao T, Matsui T, Hiwatashi N. Crohn\u2019s disease in Japan: diagnostic criteria and epidemiology. Dis Colon Rectum. 2000;43:S85\u201393.","journal-title":"Dis Colon Rectum"},{"key":"1507_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00535-013-0798-x","volume":"49","author":"T Hisabe","year":"2014","unstructured":"Hisabe T, Hirai F, Matsui T, et al. Evaluation of diagnostic criteria for Crohn\u2019s disease in Japan. J Gastroenterol. 2014;49:93\u20139.","journal-title":"J Gastroenterol"},{"key":"1507_CR20","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.3748\/wjg.v13.i24.3279","volume":"13","author":"S Saibeni","year":"2007","unstructured":"Saibeni S, Rondonotti E, Iozzelli A, et al. Imaging of the small bowel in Crohn\u2019s disease: a review of old and new techniques. World J Gastroenterol. 2007;13:3279\u201387.","journal-title":"World J Gastroenterol"},{"key":"1507_CR21","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1053\/j.gastro.2007.09.001","volume":"133","author":"S Nikolaus","year":"2007","unstructured":"Nikolaus S, Schreiber S. Diagnostics of inflammatory bowel disease. Gastroenterology. 2007;133:1670\u201389.","journal-title":"Gastroenterology"},{"key":"1507_CR22","first-page":"895","volume":"40","author":"F Hirai","year":"2005","unstructured":"Hirai F, Yano Y, Ohara J, et al. Long-term clinical course of Crohn\u2019s disease of aphthous type. Stomach Intest. 2005;40:895\u2013910 (Japanese with English abstract).","journal-title":"Stomach Intest"},{"key":"1507_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00535-011-0501-z","volume":"47","author":"Y Maehata","year":"2012","unstructured":"Maehata Y, Esaki M, Morishita T, et al. Small bowel injury induced by selective cyclooxygenase-2 inhibitors: a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam. J Gastroenterol. 2012;47:387\u201393.","journal-title":"J Gastroenterol"},{"key":"1507_CR24","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.cgh.2015.10.022","volume":"14","author":"W Washio","year":"2016","unstructured":"Washio W, EsakiM Maehata Y, et al. Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial. Clin Gastroenterol Hepatol. 2016;14:809\u201315.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1507_CR25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1365-2036.2007.03556.x","volume":"27","author":"IM Gralnek","year":"2008","unstructured":"Gralnek IM, Defranchis R, Seidman E, et al. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther. 2008;27:146\u201354.","journal-title":"Aliment Pharmacol Ther"},{"key":"1507_CR26","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.gie.2008.04.016","volume":"69","author":"C Brotz","year":"2009","unstructured":"Brotz C, Nandi N, Conn M, et al. A validation study of three grading systems to evaluate small-bowel cleansing for wireless capsule endoscopy: a quantitative index, a qualitative evaluation, and an overall adequacy assessment. Gastrointest Endosc. 2009;69:262\u201370.","journal-title":"Gastrointest Endosc"},{"key":"1507_CR27","first-page":"212","volume-title":"Statistical methods for rates and proportions","author":"JL Fleiss","year":"1981","unstructured":"Fleiss JL. The measurement of interobserver agreement. In: Fleiss JL, editor. Statistical methods for rates and proportions. New York: John Wiley; 1981. p. 212\u201336."},{"key":"1507_CR28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159\u201374.","journal-title":"Biometrics"},{"key":"1507_CR29","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1038\/ajg.2010.203","volume":"105","author":"GA Doherty","year":"2010","unstructured":"Doherty GA, Moss AC, Cheifetz AS. Capsule endoscopy in suspected Crohn\u2019s disease: \u201cyield\u201d does not equal \u201cdiagnosis\u201d. Am J Gastroenterol. 2010;105:2111.","journal-title":"Am J Gastroenterol"},{"key":"1507_CR30","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1038\/ajg.2009.404","volume":"104","author":"M Tukey","year":"2009","unstructured":"Tukey M, Pleskow D, Legnani P, et al. The utility of capsule endoscopy in patients with suspected Crohn\u2019s disease. Am J Gastroenterol. 2009;104:2734\u20139.","journal-title":"Am J Gastroenterol"},{"key":"1507_CR31","first-page":"1481","volume":"36","author":"M Yorioka","year":"2001","unstructured":"Yorioka M, Yao T, Sakurai T, et al. Endoscopic findings in duodenum of Crohn\u2019s disease patients. Stomach Intest. 2001;36:1481\u20137 (Japanese with English abstract).","journal-title":"Stomach Intest"},{"key":"1507_CR32","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.3748\/wjg.v16.i26.3299","volume":"16","author":"C Petruzziello","year":"2010","unstructured":"Petruzziello C, Onali S, Calabrese E, et al. Wireless capsule endoscopy and proximal small bowel lesions in Crohn\u2019s disease. World J Gastroenterol. 2010;16:3299\u2013304.","journal-title":"World J Gastroenterol"},{"key":"1507_CR33","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1097\/MIB.0b013e31828133c1","volume":"19","author":"M Flamant","year":"2013","unstructured":"Flamant M, Trang C, Maillard O, et al. The prevalence and outcome of jejunal lesions visualized by small bowel capsule endoscopy in Crohn\u2019s disease. Inflamm Bowel Dis. 2013;19:1390\u20136.","journal-title":"Inflamm Bowel Dis"},{"key":"1507_CR34","doi-asserted-by":"publisher","first-page":"e7780","DOI":"10.1097\/MD.0000000000007780","volume":"96","author":"C He","year":"2017","unstructured":"He C, Zhang J, Chen Z, et al. Relationships of capsule endoscopy Lewis score with clinical disease activity indices, C-reactive protein, and small bowel transit time in pediatric and adult patients with small bowel Crohn\u2019s disease. Medicine (Baltimore). 2017;96:e7780.","journal-title":"Medicine (Baltimore)"},{"key":"1507_CR35","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/ajg.2015.221","volume":"110","author":"U Kopylov","year":"2015","unstructured":"Kopylov U, Yablecovitch D, Lahat A, et al. Detection of small bowel mucosal healing and deep remission in patients with known small bowel Crohn\u2019s disease using biomarkers, capsule endoscopy, and imaging. Am J Gastroenterol. 2015;110:1316\u201323.","journal-title":"Am J Gastroenterol"},{"key":"1507_CR36","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3109\/00365521.2012.677953","volume":"47","author":"T Sipponen","year":"2012","unstructured":"Sipponen T, Haapam\u00e4ki J, Savilahti E, et al. Fecal calprotectin and S100A12 have low utility in prediction of small bowel Crohn\u2019s disease detected by wireless capsule endoscopy. Scand J Gastroenterol. 2012;47:778\u201384.","journal-title":"Scand J Gastroenterol"},{"key":"1507_CR37","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3109\/00365521.2014.920915","volume":"49","author":"CM H\u00f6\u00f6g","year":"2014","unstructured":"H\u00f6\u00f6g CM, Bark L, Brostr\u00f6m O, et al. Capsule endoscopic findings correlate with fecal calprotectin and C-reactive protein in patients with suspected small-bowel Crohn\u2019s disease. Scand J Gastroenterol. 2014;49:1084\u201390.","journal-title":"Scand J Gastroenterol"},{"key":"1507_CR38","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1080\/00365521.2016.1253769","volume":"52","author":"AB Shitrit","year":"2017","unstructured":"Shitrit AB, Koslowsky B, Livovsky DM, et al. A prospective study of fecal calprotectin and lactoferrin as predictors of small bowel Crohn\u2019s disease in patients undergoing capsule endoscopy. Scand J Gastroenterol. 2017;52:328\u201333.","journal-title":"Scand J Gastroenterol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00535-018-1507-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-018-1507-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-018-1507-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T10:44:52Z","timestamp":1568976292000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00535-018-1507-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,15]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1507"],"URL":"https:\/\/doi.org\/10.1007\/s00535-018-1507-6","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,15]]},"assertion":[{"value":"10 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Motohiro Esaki received research grants from, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., AbbVie GK, ZERIA Pharmaceutical Co., Ltd., and Asahi Kasei Medical Co., Ltd., and lecture fee from Mitsubishi Tanabe Pharma Corporation and AbbVie GK, outside the submitted work. Takayuki Matsumoto received research grants from Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., and Nippon Kayaku Co., Ltd., and lecture fee from Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., KYORIN Pharmaceutical Co., Ltd., AbbVie GK, Janssen Pharmaceutical K.K., Mochida Pharmaceutical Co., Ltd., Pfizer Inc., Zeria Pharmaceutical Co., Ltd., and AstraZeneca plc, and advisory fee from JIMRO Co., Ltd., Kissei Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd., outside the submitted work. Naoki Ohmiya received research grants from Otsuka Pharamaceutical Factory, Inc., JIMRO Co., Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi Sankyo Company, Limited, Astellas Pharma Inc., Eli Lilly and Company, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., TAIHO Pharmaceutical Co. Ltd., Takeda Pharmaceutical Co., Ltd., Tsumura & Co., KYORIN Pharmaceutical Co., Ltd., and Asahi kasei Pharma, and lecture fee from KYORIN Pharmaceutical Co., Ltd., Fujifilm medical Co., Covidien Japan, EA Pharma Co. Ltd., KYORIN Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Co., Ltd., ZERIA Pharmaceutical Co., Ltd., Astellas Pharma Inc., AbbVie GK, and Mylan Inc, outside the submitted work. Kenji Watanabe received research grants from AbbVie GK, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., Asahi Kasei Medical Co., Ltd., Kyowa Hakko Kirin Co., Ltd, Kyorin Pharmaceutical Co., Ltd, Astellas Pharma Inc, and JIMRO Co., Ltd., and consulting fee from EA Pharma Co., Ltd., Mitsubishi Tanabe Pharma Corporation, AbbVie GK, Kyorin Pharmaceutical Co., Ltd., Asahi Kasei Medical Co. Ltd., Kyowa Hakko Kirin Co., Ltd., Takeda Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Olympus Corporation, Covidien Japan Co., Ltd., Mochida Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K., Pfizer Japan Inc., and Otsuka Pharmaceutical Co., Ltd., and lecture fee from Mitsubishi Tanabe Pharma Corporation, Eisai Co., Ltd, AbbVie GK, Asahi Kasei Medical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Astellas Pharma Inc., JIMRO Co., Ltd., UCB Japan Co., Ltd., Zeria Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Olympus Corporation, Covidien Japan Co., Ltd., and Otsuka Pharmaceutical Co., Ltd., and advisory fee from Takeda Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K., Pfizer Japan Inc., EA Pharma Co., Ltd., Mitsubishi Tanabe Pharma Corporation, and JIMRO Co., Ltd., outside the submitted work. Fumihito Hirai received research grants from AbbVie GK, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., JIMRO Co., Ltd., ZERIA Pharmaceutical Co., Ltd., and Eisai Co., Ltd., and lecture fee from AbbVie GK, EA Pharma Co., Ltd., Eisai Co., Ltd. And Mitsubishi Tanabe Pharma Corporation, outside the submitted work. Atsushi Hirano received research grants from AbbVie GK, and Mitsubishi Tanabe Pharma Corporation, outside the submitted work. Takanari Kitazono received research grants from Daiichi Sankyo Co., Ltd., Takeda Pharmaceutical Co. Ltd., MSD Co., Ltd. Nippon Boehringer Ingelheim Co., Ltd., Sanofi-Aventis Co., Ltd. Pfizer Inc., Bayer yakuhin, Ltd., and Eisai Co., Ltd., and lecture fee from Daiichi Sankyo Co., Ltd., Bayer yakuhin, Ltd., and Chugai Pharmaceutical Co., Ltd., outside the submitted work. Mamoru Watanabe received research grants from Asahi Kasei Medical Co., Ltd., Ajinomoto Co., Inc., AbbVie GK, EA Pharma Co., Ltd., Eisai Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corp., Otsuka Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co. Ltd., Zeria Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Takeda Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Ono Pharmaceutical Co., Ltd., Astellas Pharma Inc., MSD K.K., Dainippon Sumitomo Dainippon Pharma Co., Ltd., Bristol-Myers, K.K, and Chugai Pharmaceutical Co., Ltd., and lecture fees from Mitsubishi Tanabe Pharma Corp., Eisai Co., Ltd., Kyorin Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Ajinomoto Co., Inc., AbbVie GK, Takeda Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co. Ltd., Zeria Pharmaceutical Co., Ltd., Asahi Kasei Medical Co., Ltd., EA Pharma Co., Ltd., Astellas Pharma Inc., Mochida Pharmaceutical Co., Ltd., Janssen Pharmaceutical Co., Ltd., Gilead Sciences, Inc., Celgene Corp., outside the submitted work. Toshiyuki Matsui received research grants from AbbVie GK, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., JIMRO Co., Ltd., ZERIA Pharmaceutical Co., Ltd., Eisai Co., Ltd., Astellas Pharma Inc, and Takeda Pharmaceutical Co. Ltd., and lecture fee from AbbVie GK, and EA Pharma Co., outside the submitted work. Yasuo Suzuki received research grants from AbbVie GK, Mitsubishi Tanabe Pharma Corporation, Ltd., EA Pharma Co., Ltd., JIMRO Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Nippon Kayaku Co., Ltd., and lecture fee from Mitsubishi Tanabe Pharma Corporation, AbbVie GK, EA Pharma Co. Ltd., ZERIA Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., and KYORIN Pharmaceutical Co., Ltd., outside the submitted work. All other authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}