{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:45:06Z","timestamp":1784133906410,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fk0210060"],"award-info":[{"award-number":["19fk0210060"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fk0210047"],"award-info":[{"award-number":["19fk0210047"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fk0210058"],"award-info":[{"award-number":["19fk0210058"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant-in-Aid for Scientific Research","award":["19K08415"],"award-info":[{"award-number":["19K08415"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["19H03635"],"award-info":[{"award-number":["19H03635"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00535-020-01715-6","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T14:02:36Z","timestamp":1596895356000},"page":"990-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-7676","authenticated-orcid":false,"given":"Mina","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutoshi","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Takeichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Kawai-Kitahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyako","family":"Murakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Itsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishin","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei","family":"Kakinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Asahina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Ochanomizu Liver Conference Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"1715_CR1","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S0140-6736(16)30579-7","volume":"388","author":"JD Stanaway","year":"2016","unstructured":"Stanaway JD, Flaxman AD, Naghavi M, et al. The global burden of viral hepatitis from 1990 to 2013: findings from the global burden of disease study 2013. Lancet. 2016;388:1081\u20138.","journal-title":"Lancet"},{"key":"1715_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","volume":"70","author":"SK Asrani","year":"2019","unstructured":"Asrani SK, Devarbhavi H, Eaton J, et al. Burden of liver diseases in the world. J Hepatol. 2019;70:151\u201371.","journal-title":"J Hepatol"},{"key":"1715_CR3","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/hepr.13417","volume":"49","author":"J Tanaka","year":"2019","unstructured":"Tanaka J, Akita T, Ko K, et al. Countermeasures against viral hepatitis B and C in Japan: an epidemiological point of view. Hepatol Res. 2019;49:990\u20131002.","journal-title":"Hepatol Res"},{"key":"1715_CR4","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","volume":"349","author":"T Poynard","year":"1997","unstructured":"Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet. 1997;349:825\u201332.","journal-title":"Lancet"},{"key":"1715_CR5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-132-7-200004040-00002","volume":"132","author":"Y Shiratori","year":"2000","unstructured":"Shiratori Y, Imazeki F, Moriyama M, et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med. 2000;132:517\u201324.","journal-title":"Ann Intern Med"},{"key":"1715_CR6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/cncr.10662","volume":"95","author":"H Hamada","year":"2002","unstructured":"Hamada H, Yatsuhashi H, Yano K, et al. Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C. Cancer. 2002;95:331\u20139.","journal-title":"Cancer"},{"key":"1715_CR7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.23691","volume":"52","author":"Y Asahina","year":"2010","unstructured":"Asahina Y, Tsuchiya K, Tamaki N, et al. Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection. Hepatology. 2010;52:518\u201327.","journal-title":"Hepatology"},{"key":"1715_CR8","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/hep.26442","volume":"58","author":"Y Asahina","year":"2013","unstructured":"Asahina Y, Tsuchiya K, Nishimura T, et al. \u03b1-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology. 2013;58:1253\u201362.","journal-title":"Hepatology"},{"key":"1715_CR9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.7326\/0003-4819-123-8-199510150-00008","volume":"123","author":"SC Gumber","year":"1995","unstructured":"Gumber SC, Chopra S. Hepatitis C: a multifaceted disease Review of extrahepatic manifestations. Ann Intern Med. 1995;123:615\u201320.","journal-title":"Ann Intern Med"},{"key":"1715_CR10","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jhep.2017.05.028","volume":"67","author":"H Nagata","year":"2017","unstructured":"Nagata H, Nakagawa M, Asahina Y, et al. Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. J Hepatol. 2017;67:933\u20139.","journal-title":"J Hepatol"},{"key":"1715_CR11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jhep.2017.10.012","volume":"68","author":"H Nagata","year":"2018","unstructured":"Nagata H, Nakagawa M, Asahina Y. Imaging basis of AFP and WFA + M2BP as indicators of the risk of HCC after SVR. J Hepatol. 2018;68:607\u20138.","journal-title":"J Hepatol"},{"key":"1715_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/hep.21669","volume":"46","author":"A Vallet-Pichard","year":"2007","unstructured":"Vallet-Pichard A, Mallet V, Nalpas B, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 2007;46:32\u20136.","journal-title":"Hepatology"},{"key":"1715_CR13","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/hep.24105","volume":"53","author":"ZH Lin","year":"2011","unstructured":"Lin ZH, Xin YN, Dong QJ, et al. Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology. 2011;53:726\u201336.","journal-title":"Hepatology"},{"key":"1715_CR14","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1002\/hep.1840190629","volume":"19","author":"VJ Desmet","year":"1994","unstructured":"Desmet VJ, Gerber M, Hoofnagle JH, et al. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology. 1994;19:1513\u201320.","journal-title":"Hepatology"},{"key":"1715_CR15","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/srep01065","volume":"3","author":"A Kuno","year":"2013","unstructured":"Kuno A, Ikehara Y, Tanaka Y, et al. A serum \u201csweet-doughnut\u201d protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis. Sci Rep. 2013;3:1065.","journal-title":"Sci Rep"},{"key":"1715_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"S van Buuren","year":"2011","unstructured":"van Buuren S, Groothuis-Oudshoorn K. Mice: multivariate imputation by chained equations in R. J Stat Softw. 2011;45:1\u201367.","journal-title":"J Stat Softw"},{"key":"1715_CR17","doi-asserted-by":"publisher","first-page":"b2393","DOI":"10.1136\/bmj.b2393","volume":"338","author":"JA Sterne","year":"2009","unstructured":"Sterne JA, White IR, Carlin JB, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338:b2393.","journal-title":"BMJ"},{"key":"1715_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696","volume-title":"Multiple imputation for nonresponse in surveys","author":"DB Rubin","year":"1987","unstructured":"Rubin DB. Multiple imputation for nonresponse in surveys. New York: NY John Wiley & Sons; 1987."},{"key":"1715_CR19","unstructured":"Novo AA, Schafer JL. norm: Analysis of multivariate normal datasets with missing values, version 1.0\u20139.5. https:\/\/CRAN.R-project.org\/package=norm. 2013."},{"key":"1715_CR20","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/emboj\/17.6.1606","volume":"17","author":"T Sasaki","year":"1998","unstructured":"Sasaki T, Brakebusch C, Engel J, et al. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. EMBO J. 1998;17:1606\u201313.","journal-title":"EMBO J"},{"key":"1715_CR21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2009.00794.x","volume":"230","author":"NC Henderson","year":"2009","unstructured":"Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009;230:160\u201371.","journal-title":"Immunol Rev"},{"key":"1715_CR22","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","volume":"110","author":"UC Sharma","year":"2004","unstructured":"Sharma UC, Pokharel S, van Brakel TJ, et al. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation. 2004;110:3121\u20138.","journal-title":"Circulation"},{"key":"1715_CR23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2016.06.027","volume":"251","author":"T Sugiura","year":"2016","unstructured":"Sugiura T, Dohi Y, Takase H, et al. Serum levels of Mac-2 binding protein increase with cardiovascular risk and reflect silent atherosclerosis. Atherosclerosis. 2016;251:192\u20136.","journal-title":"Atherosclerosis"},{"key":"1715_CR24","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.numecd.2019.08.008","volume":"29","author":"T Sugiura","year":"2019","unstructured":"Sugiura T, Dohi Y, Takase H, et al. Factors associated with longitudinal changes in serum concentrations of Mac-2 binding protein: a prospective 3-year observational study. Nutr Metab Cardiovasc Dis. 2019;29:1337\u2013444.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1715_CR25","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.jhep.2016.06.011","volume":"65","author":"P Cacoub","year":"2016","unstructured":"Cacoub P, Desbois AC, Isnard-Bagnis C, et al. Hepatitis C virus infection and chronic kidney disease: time for reappraisal. J Hepatol. 2016;65:S82\u201394.","journal-title":"J Hepatol"},{"key":"1715_CR26","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s12072-016-9754-1","volume":"10","author":"H Nagata","year":"2016","unstructured":"Nagata H, Nakagawa M, Nishimura-Sakurai Y, et al. Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy. Hepatol Int. 2016;10:956\u201364.","journal-title":"Hepatol Int"},{"key":"1715_CR27","doi-asserted-by":"crossref","first-page":"e0129053","DOI":"10.1371\/journal.pone.0129053","volume":"10","author":"R Sasaki","year":"2015","unstructured":"Sasaki R, Yamasaki K, Abiru S, et al. Serum Wisteria floribunda agglutinin-positive mac-2 binding protein values predict the development of hepatocellular carcinoma among patients with chronic hepatitis C after sustained virological response. PLoS ONE. 2015;10:e0129053.","journal-title":"PLoS ONE"},{"key":"1715_CR28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jhep.2019.10.005","volume":"72","author":"M Pons","year":"2020","unstructured":"Pons M, Rodr\u00edguez-Tajes S, Esteban JI, et al. Non-invasive prediction of liver-related events in patients with HCV-associated compensated advanced chronic liver disease after oral antivirals. J Hepatol. 2020;72:472\u201380.","journal-title":"J Hepatol"},{"key":"1715_CR29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00535-019-01595-5","volume":"54","author":"K Mizuno","year":"2019","unstructured":"Mizuno K, Toyoda H, Yasuda S, et al. The course of elderly patients with persistent hepatitis C virus infection without hepatocellular carcinoma. J Gastroenterol. 2019;54:829\u201336.","journal-title":"J Gastroenterol"},{"key":"1715_CR30","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1053\/j.gastro.2018.10.033","volume":"156","author":"GN Ioannou","year":"2019","unstructured":"Ioannou GN, Feld JJ. What are the benefits of a sustained virologic response to direct-acting antiviral therapy for hepatitis C virus infection? Gastroenterology. 2019;156:446\u2013460e442.","journal-title":"Gastroenterology"},{"key":"1715_CR31","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1136\/gutjnl-2018-316234","volume":"67","author":"P Cacoub","year":"2018","unstructured":"Cacoub P, Desbois AC, Comarmond C, et al. Impact of sustained virological response on the extrahepatic manifestations of chronic hepatitis C: a meta-analysis. Gut. 2018;67:2025\u201334.","journal-title":"Gut"},{"key":"1715_CR32","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.jhep.2017.02.010","volume":"66","author":"M Ramos-Casals","year":"2017","unstructured":"Ramos-Casals M, Zignego AL, Ferri C, et al. Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection. J Hepatol. 2017;66:1282\u201399.","journal-title":"J Hepatol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-020-01715-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-020-01715-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-020-01715-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T23:23:19Z","timestamp":1628378599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-020-01715-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,8]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1715"],"URL":"https:\/\/doi.org\/10.1007\/s00535-020-01715-6","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,8]]},"assertion":[{"value":"27 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all patients. The Ethical Committee of TMDU or affiliated hospitals participating in the Ochanomizu\u2013Liver Conference Study group approved this study, which was conducted in accordance with the Declaration of Helsinki (confirmation number: G2000-189).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}