{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:50:25Z","timestamp":1790610625266,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["21H03178"],"award-info":[{"award-number":["21H03178"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00535-021-01848-2","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T12:02:27Z","timestamp":1642248147000},"page":"144-155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Autoimmune gastritis induces aberrant DNA methylation reflecting its carcinogenic potential"],"prefix":"10.1007","volume":"57","author":[{"given":"Chihiro","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemi","family":"Akahane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Yamamichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuta","family":"Tomida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutake","family":"Yamamichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3405-7817","authenticated-orcid":false,"given":"Toshikazu","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"1848_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/BF01071995","volume":"18","author":"RG Strickland","year":"1973","unstructured":"Strickland RG, Mackay IR. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis. 1973;18:426\u201340.","journal-title":"Am J Dig Dis"},{"key":"1848_CR2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrgastro.2013.101","volume":"10","author":"WL Neumann","year":"2013","unstructured":"Neumann WL, Coss E, Rugge M, et al. Autoimmune atrophic gastritis\u2013pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol. 2013;10:529\u201341.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1848_CR3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-020-0187-8","volume":"6","author":"MV Lenti","year":"2020","unstructured":"Lenti MV, Rugge M, Lahner E, et al. Autoimmune gastritis. Nat Rev Dis Primers. 2020;6:56.","journal-title":"Nat Rev Dis Primers"},{"key":"1848_CR4","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1016\/j.cgh.2015.05.040","volume":"13","author":"G Murphy","year":"2015","unstructured":"Murphy G, Dawsey SM, Engels EA, et al. Cancer risk after pernicious anemia in the US elderly population. Clin Gastroenterol Hepatol. 2015;13:2282-2289 e1-4.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1848_CR5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/apt.12177","volume":"37","author":"L Vannella","year":"2013","unstructured":"Vannella L, Lahner E, Osborn J, et al. Systematic review: gastric cancer incidence in pernicious anaemia. Aliment Pharmacol Ther. 2013;37:375\u201382.","journal-title":"Aliment Pharmacol Ther"},{"key":"1848_CR6","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/den.13500","volume":"32","author":"S Terao","year":"2020","unstructured":"Terao S, Suzuki S, Yaita H, et al. Multicenter study of autoimmune gastritis in Japan: clinical and endoscopic characteristics. Dig Endosc. 2020;32:364\u201372.","journal-title":"Dig Endosc"},{"key":"1848_CR7","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1053\/j.gastro.2020.09.058","volume":"160","author":"WM Grady","year":"2021","unstructured":"Grady WM, Yu M, Markowitz SD. Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer. Gastroenterology. 2021;160:690\u2013709.","journal-title":"Gastroenterology"},{"key":"1848_CR8","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1056\/NEJMra1805035","volume":"383","author":"SE Bates","year":"2020","unstructured":"Bates SE. Epigenetic therapies for cancer. N Engl J Med. 2020;383:650\u201363.","journal-title":"N Engl J Med"},{"key":"1848_CR9","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1053\/j.gastro.2015.07.011","volume":"149","author":"Y Okugawa","year":"2015","unstructured":"Okugawa Y, Grady WM, Goel A. Epigenetic alterations in colorectal cancer: emerging biomarkers. Gastroenterology. 2015;149:1204-1225 e12.","journal-title":"Gastroenterology"},{"key":"1848_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpg.2014.11.001","volume":"29","author":"H Nakagawa","year":"2015","unstructured":"Nakagawa H, Whelan K, Lynch JP. Mechanisms of Barrett\u2019s oesophagus: intestinal differentiation, stem cells, and tissue models. Best Pract Res Clin Gastroenterol. 2015;29:3\u201316.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"1848_CR11","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1158\/1078-0432.CCR-05-2096","volume":"12","author":"T Maekita","year":"2006","unstructured":"Maekita T, Nakazawa K, Mihara M, et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res. 2006;12:989\u201395.","journal-title":"Clin Cancer Res"},{"key":"1848_CR12","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1136\/gutjnl-2014-307094","volume":"64","author":"K Asada","year":"2015","unstructured":"Asada K, Nakajima T, Shimazu T, et al. Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study. Gut. 2015;64:388\u201396.","journal-title":"Gut"},{"key":"1848_CR13","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1136\/gutjnl-2016-313387","volume":"66","author":"M Maeda","year":"2017","unstructured":"Maeda M, Nakajima T, Oda I, et al. High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study. Gut. 2017;66:1721\u20133.","journal-title":"Gut"},{"key":"1848_CR14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s10120-020-01117-w","volume":"24","author":"HJ Kim","year":"2021","unstructured":"Kim HJ, Kim N, Kim HW, et al. Promising aberrant DNA methylation marker to predict gastric cancer development in individuals with family history and long-term effects of H. pylori eradication on DNA methylation. Gastric Cancer. 2021;24:302\u201313.","journal-title":"Gastric Cancer"},{"key":"1848_CR15","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1002\/ijc.25274","volume":"127","author":"BG Schneider","year":"2010","unstructured":"Schneider BG, Peng DF, Camargo MC, et al. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer. 2010;127:2588\u201397.","journal-title":"Int J Cancer"},{"key":"1848_CR16","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1172\/JCI124070","volume":"130","author":"H Takeshima","year":"2020","unstructured":"Takeshima H, Niwa T, Yamashita S, et al. TET repression and increased DNMT activity synergistically induce aberrant DNA methylation. J Clin Invest. 2020;130:5370\u20139.","journal-title":"J Clin Invest"},{"key":"1848_CR17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/0016-5085(91)90199-U","volume":"100","author":"TL Fong","year":"1991","unstructured":"Fong TL, Dooley CP, Dehesa M, et al. Helicobacter pylori infection in pernicious anemia: a prospective controlled study. Gastroenterology. 1991;100:328\u201332.","journal-title":"Gastroenterology"},{"key":"1848_CR18","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/j.1523-5378.2003.00187.x","volume":"8","author":"F Presotto","year":"2003","unstructured":"Presotto F, Sabini B, Cecchetto A, et al. Helicobacter pylori infection and gastric autoimmune diseases: is there a link? Helicobacter. 2003;8:578\u201384.","journal-title":"Helicobacter"},{"key":"1848_CR19","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.2169\/internalmedicine.2292-18","volume":"58","author":"T Notsu","year":"2019","unstructured":"Notsu T, Adachi K, Mishiro T, et al. Prevalence of autoimmune gastritis in individuals undergoing medical checkups in Japan. Intern Med. 2019;58:1817\u201323.","journal-title":"Intern Med"},{"key":"1848_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2217\/epi-2017-0093","volume":"10","author":"N Iida","year":"2018","unstructured":"Iida N, Okuda Y, Ogasawara O, et al. MACON: a web tool for computing DNA methylation data obtained by the illumina infinium human DNA methylation BeadArray. Epigenomics. 2018;10:249\u201358.","journal-title":"Epigenomics"},{"key":"1848_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147519","volume":"11","author":"Y Shiwa","year":"2016","unstructured":"Shiwa Y, Hachiya T, Furukawa R, et al. Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols. PLoS ONE. 2016;11: e0147519.","journal-title":"PLoS ONE"},{"key":"1848_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s13148-019-0789-8","volume":"11","author":"S Yamashita","year":"2019","unstructured":"Yamashita S, Nanjo S, Rehnberg E, et al. Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori. Clin Epigenet. 2019;11:191.","journal-title":"Clin Epigenet"},{"key":"1848_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041361","volume":"7","author":"LE Reinius","year":"2012","unstructured":"Reinius LE, Acevedo N, Joerink M, et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE. 2012;7: e41361.","journal-title":"PLoS ONE"},{"key":"1848_CR24","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1038\/srep04092","volume":"4","author":"AR Bateman","year":"2014","unstructured":"Bateman AR, El-Hachem N, Beck AH, et al. Importance of collection in gene set enrichment analysis of drug response in cancer cell lines. Sci Rep. 2014;4:4092.","journal-title":"Sci Rep"},{"key":"1848_CR25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28:27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"1848_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10120-014-0348-0","volume":"18","author":"Y Yoda","year":"2015","unstructured":"Yoda Y, Takeshima H, Niwa T, et al. Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer. 2015;18:65\u201376.","journal-title":"Gastric Cancer"},{"key":"1848_CR27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrgastro.2017.53","volume":"14","author":"N Padmanabhan","year":"2017","unstructured":"Padmanabhan N, Ushijima T, Tan P. How to stomach an epigenetic insult: the gastric cancer epigenome. Nat Rev Gastroenterol Hepatol. 2017;14:467\u201378.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1848_CR28","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.1158\/1078-0432.CCR-03-0622","volume":"10","author":"Y Sun","year":"2004","unstructured":"Sun Y, Deng D, You WC, et al. Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study. Clin Cancer Res. 2004;10:5087\u201393.","journal-title":"Clin Cancer Res"},{"key":"1848_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/32918","volume":"392","author":"P Guilford","year":"1998","unstructured":"Guilford P, Hopkins J, Harraway J, et al. E-cadherin germline mutations in familial gastric cancer. Nature. 1998;392:402\u20135.","journal-title":"Nature"},{"key":"1848_CR30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1349-7006.2006.00136.x","volume":"97","author":"S Yamashita","year":"2006","unstructured":"Yamashita S, Tsujino Y, Moriguchi K, et al. Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2\u2019-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006;97:64\u201371.","journal-title":"Cancer Sci"},{"key":"1848_CR31","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1093\/carcin\/bgq203","volume":"31","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Yamamoto E, Nojima M, et al. Methylation-associated silencing of microRNA-34b\/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 2010;31:2066\u201373.","journal-title":"Carcinogenesis"},{"key":"1848_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/cncr.23989","volume":"115","author":"J Yu","year":"2009","unstructured":"Yu J, Tao Q, Cheng YY, et al. Promoter methylation of the Wnt\/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. Cancer. 2009;115:49\u201360.","journal-title":"Cancer"},{"key":"1848_CR33","doi-asserted-by":"publisher","first-page":"4699","DOI":"10.1038\/sj.onc.1210259","volume":"26","author":"M Nojima","year":"2007","unstructured":"Nojima M, Suzuki H, Toyota M, et al. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene. 2007;26:4699\u2013713.","journal-title":"Oncogene"},{"key":"1848_CR34","first-page":"159","volume":"59","author":"SY Leung","year":"1999","unstructured":"Leung SY, Yuen ST, Chung LP, et al. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res. 1999;59:159\u201364.","journal-title":"Cancer Res"},{"issue":"Suppl 1","key":"1848_CR35","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/hel.12073","volume":"18","author":"M Koch","year":"2013","unstructured":"Koch M, Meyer TF, Moss SF. Inflammation, immunity, vaccines for Helicobacter pylori infection. Helicobacter. 2013;18(Suppl 1):18\u201323.","journal-title":"Helicobacter"},{"key":"1848_CR36","doi-asserted-by":"publisher","first-page":"5101","DOI":"10.3748\/wjg.v18.i36.5101","volume":"18","author":"XQ Xu","year":"2012","unstructured":"Xu XQ, Wang ZH, Liao JX, et al. Predictive value of neutrophil infiltration as a marker of Helicobacter pylori infection. World J Gastroenterol. 2012;18:5101\u20135.","journal-title":"World J Gastroenterol"},{"key":"1848_CR37","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1158\/0008-5472.CAN-09-2755","volume":"70","author":"T Niwa","year":"2010","unstructured":"Niwa T, Tsukamoto T, Toyoda T, et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010;70:1430\u201340.","journal-title":"Cancer Res"},{"key":"1848_CR38","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1158\/0008-5472.CAN-08-0700","volume":"68","author":"KM McGarvey","year":"2008","unstructured":"McGarvey KM, Van Neste L, Cope L, et al. Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. Cancer Res. 2008;68:5753\u20139.","journal-title":"Cancer Res"},{"key":"1848_CR39","doi-asserted-by":"publisher","first-page":"144577","DOI":"10.1016\/j.gene.2020.144577","volume":"742","author":"V Ebrahimi","year":"2020","unstructured":"Ebrahimi V, Soleimanian A, Ebrahimi T, et al. Epigenetic modifications in gastric cancer: focus on DNA methylation. Gene. 2020;742:144577.","journal-title":"Gene"},{"key":"1848_CR40","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1101\/gad.2037511","volume":"25","author":"AM Deaton","year":"2011","unstructured":"Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev. 2011;25:1010\u201322.","journal-title":"Genes Dev"},{"key":"1848_CR41","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s10120-014-0393-8","volume":"18","author":"E Lahner","year":"2015","unstructured":"Lahner E, Esposito G, Pilozzi E, et al. Gastric cancer in patients with type I gastric carcinoids. Gastric Cancer. 2015;18:564\u201370.","journal-title":"Gastric Cancer"},{"key":"1848_CR42","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1158\/0008-5472.CAN-18-2651","volume":"79","author":"G Suarez","year":"2019","unstructured":"Suarez G, Romero-Gallo J, Piazuelo MB, et al. Nod1 imprints inflammatory and carcinogenic responses toward the gastric pathogen Helicobacter pylori. Cancer Res. 2019;79:1600\u201311.","journal-title":"Cancer Res"},{"key":"1848_CR43","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s00535-011-0504-9","volume":"47","author":"M Kodama","year":"2012","unstructured":"Kodama M, Murakami K, Okimoto T, et al. Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication. J Gastroenterol. 2012;47:394\u2013403.","journal-title":"J Gastroenterol"},{"key":"1848_CR44","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/onc.2011.241","volume":"31","author":"M Katsurano","year":"2012","unstructured":"Katsurano M, Niwa T, Yasui Y, et al. Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene. 2012;31:342\u201351.","journal-title":"Oncogene"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-021-01848-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-021-01848-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-021-01848-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T10:13:18Z","timestamp":1650276798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-021-01848-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,15]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1848"],"URL":"https:\/\/doi.org\/10.1007\/s00535-021-01848-2","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,15]]},"assertion":[{"value":"1 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no potential conflicts of interest. All authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights statement"}},{"value":"Informed consent was obtained from all patients to be included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}