{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:03:17Z","timestamp":1790758997303,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s00535-022-01929-w","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T05:02:56Z","timestamp":1666846976000},"page":"53-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17\u03b2-hydroxysteroid dehydrogenase 13 expression"],"prefix":"10.1007","volume":"58","author":[{"given":"Norihiro","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-4400","authenticated-orcid":false,"given":"Kenya","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nagoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Setsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yokoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroteru","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Soki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Inamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiro","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatsune","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kousaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Tachiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"1929_CR1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/gutjnl-2017-315691","volume":"67","author":"SH Ibrahim","year":"2018","unstructured":"Ibrahim SH, Hirsova P, Gores GJ. Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation. Gut. 2018;67:963\u201372.","journal-title":"Gut"},{"key":"1929_CR2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"M Eslam","year":"2020","unstructured":"Eslam M, Newsome PN, Sarin SK, et al. A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement. J Hepatol. 2020;73:202\u20139.","journal-title":"J Hepatol"},{"key":"1929_CR3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","volume":"53","author":"Y Sumida","year":"2018","unstructured":"Sumida Y, Yoneda M. Current and future pharmacological therapies for NAFLD\/NASH. J Gastroenterol. 2018;53:362\u201376.","journal-title":"J Gastroenterol"},{"key":"1929_CR4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","volume":"149","author":"P Angulo","year":"2015","unstructured":"Angulo P, Kleiner DE, Dam-Larsen S, et al. Liver Fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology. 2015;149:389-97.e10.","journal-title":"Gastroenterology"},{"key":"1929_CR5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","volume":"575","author":"P Ramachandran","year":"2019","unstructured":"Ramachandran P, Dobie R, Wilson-Kanamori JR, et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 2019;575:512\u20138.","journal-title":"Nature"},{"key":"1929_CR6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jhbp.245","volume":"22","author":"E Seki","year":"2015","unstructured":"Seki E, Brenner DA. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobil Pancreat Sci. 2015;22:512\u20138.","journal-title":"J Hepatobil Pancreat Sci"},{"key":"1929_CR7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jhep.2007.05.015","volume":"47","author":"OA Gressner","year":"2007","unstructured":"Gressner OA, Lahme B, Demirci I, et al. Differential effects of TGF-beta on connective tissue growth factor (CTGF\/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol. 2007;47:699\u2013710.","journal-title":"J Hepatol"},{"key":"1929_CR8","volume":"5","author":"H Abe","year":"2016","unstructured":"Abe H, Kamimura K, Kobayashi Y, et al. Effective prevention of liver fibrosis by liver-targeted hydrodynamic gene delivery of matrix metalloproteinase-13 in a rat liver fibrosis model. Mol Ther Nucleic Acids. 2016;5: e276.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1929_CR9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1758-2946-5-30","volume":"5","author":"F Napolitano","year":"2013","unstructured":"Napolitano F, Zhao Y, Moreira VM, et al. Drug repositioning: a machine-learning approach through data integration. J Cheminform. 2013;5:30.","journal-title":"J Cheminform"},{"key":"1929_CR10","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1016\/j.toxlet.2013.05.448","volume":"221","author":"M Nakashima","year":"2013","unstructured":"Nakashima M, Tachiki H, Enomoto H, et al. Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-mouse with highly humanized liver. Toxicol Lett. 2013;221:S194.","journal-title":"Toxicol Lett"},{"key":"1929_CR11","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1016\/j.toxlet.2014.06.902","volume":"229","author":"M Nakashima","year":"2014","unstructured":"Nakashima M, Enomoto H, Tachiki H, et al. Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse\u00ae with highly humanized liver. Toxicol Lett. 2014;229:S235.","journal-title":"Toxicol Lett"},{"key":"1929_CR12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1124\/dmd.111.040923","volume":"40","author":"S Sanoh","year":"2012","unstructured":"Sanoh S, Horiguchi A, Sugihara K, et al. Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver. Drug Metab Dispos. 2012;40:322\u20138.","journal-title":"Drug Metab Dispos"},{"key":"1929_CR13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1248\/jhs.55.325","volume":"55","author":"T Sakuma","year":"2009","unstructured":"Sakuma T, Kawasaki Y, Jarukamjorn K, et al. Sex differences of drug-metabolizing enzyme: Female predominant expression of human and mouse cytochrome P450 3A isoforms. J Health Sci. 2009;55:325\u201337.","journal-title":"J Health Sci"},{"key":"1929_CR14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.mri.2016.03.009","volume":"34","author":"T Yamada","year":"2016","unstructured":"Yamada T, Obata A, Kashiwagi Y, et al. Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice. Magn Res Imaging. 2016;34:724\u20139.","journal-title":"Magn Res Imaging"},{"key":"1929_CR15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12079-009-0043-9","volume":"3","author":"DR Brigstock","year":"2009","unstructured":"Brigstock DR. Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J Cell Commun Signal. 2009;3:5\u201318.","journal-title":"J Cell Commun Signal"},{"key":"1929_CR16","first-page":"4995","volume":"29","author":"T Vrekoussis","year":"2009","unstructured":"Vrekoussis T, Chaniotis V, Navrozoglou I, et al. Image analysis of breast cancer immunohistochemistry-stained sections using ImageJ: an RGB-based model. Anticancer Res. 2009;29:4995\u20138.","journal-title":"Anticancer Res"},{"key":"1929_CR17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/hepr.12819","volume":"47","author":"A Iwata","year":"2016","unstructured":"Iwata A, Kamada Y, Ebisutani Y, et al. Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models. Hepatol Res. 2016;47:902\u20139.","journal-title":"Hepatol Res"},{"key":"1929_CR18","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.4049\/jimmunol.1302821","volume":"192","author":"E Sierra-Filardi","year":"2014","unstructured":"Sierra-Filardi E, Nieto C, Dom\u00ednguez-Soto A, et al. CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2\/CCR2-dependent gene expression profile. J Immunol. 2014;192:3858\u201367.","journal-title":"J Immunol"},{"key":"1929_CR19","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.29885","volume":"68","author":"T Lan","year":"2018","unstructured":"Lan T, Li C, Yang G, et al. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Hepatology. 2018;68:1070\u201386.","journal-title":"Hepatology"},{"key":"1929_CR20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","volume":"147","author":"F Marra","year":"2014","unstructured":"Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology. 2014;147:577\u201394.","journal-title":"Gastroenterology"},{"key":"1929_CR21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jaut.2010.09.003","volume":"35","author":"E Hintermann","year":"2010","unstructured":"Hintermann E, Bayer M, Pfeilschifter JM, et al. CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J Autoimmun. 2010;35:424\u201335.","journal-title":"J Autoimmun"},{"key":"1929_CR22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jhep.2016.02.004","volume":"64","author":"D Schmidt-Arras","year":"2016","unstructured":"Schmidt-Arras D, Rose-John S. IL-6 pathway in the liver: From physiopathology to therapy. J Hepatol. 2016;64:1403\u201315.","journal-title":"J Hepatol"},{"key":"1929_CR23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13287-019-1204-2","volume":"10","author":"X Rong","year":"2019","unstructured":"Rong X, Liu J, Yao X, et al. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt\/\u03b2-catenin pathway. Stem Cell Res Ther. 2019;10:98.","journal-title":"Stem Cell Res Ther"},{"key":"1929_CR24","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1038\/s41598-018-25526-1","volume":"8","author":"B Mezquita","year":"2018","unstructured":"Mezquita B, Mezquita P, Pau M, et al. All-trans-retinoic acid activates the pro-invasive Src-YAP-interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action. Sci Rep. 2018;8:7047.","journal-title":"Sci Rep"},{"key":"1929_CR25","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/hep.30350","volume":"69","author":"Y Ma","year":"2019","unstructured":"Ma Y, Belyaeva OV, Brown PM, et al. 17-Beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histologic features of nonalcoholic fatty liver disease. Hepatology. 2019;69:1504\u201319.","journal-title":"Hepatology"},{"key":"1929_CR26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2018.10.014","volume":"489","author":"W Su","year":"2019","unstructured":"Su W, Mao Z, Liu Y, et al. Role of HSD17B13 in the liver physiology and pathophysiology. Mol Cell Endocrinol. 2019;489:119\u201325.","journal-title":"Mol Cell Endocrinol"},{"key":"1929_CR27","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/hep.31229","volume":"72","author":"S Sookoian","year":"2020","unstructured":"Sookoian S, Pirola CJ, Valenti L, et al. Genetic pathways in nonalcoholic fatty liver disease: insights from systems biology. Hepatology. 2020;72:330\u201346.","journal-title":"Hepatology"},{"key":"1929_CR28","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/liv.14411","volume":"40","author":"S Stender","year":"2020","unstructured":"Stender S, Romeo S. HSD17B13 as a promising therapeutic target against chronic liver disease. Liver Int. 2020;40:756\u20137.","journal-title":"Liver Int"},{"key":"1929_CR29","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1002\/jcp.26372","volume":"233","author":"W Yang","year":"2018","unstructured":"Yang W, Han W, Qin A, et al. The emerging role of Hippo signaling pathway in regulating osteoclast formation. J Cell Physiol. 2018;233:4606\u201317.","journal-title":"J Cell Physiol"},{"key":"1929_CR30","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1755-1536-5-S1-S24","volume":"5","author":"KE Lipson","year":"2012","unstructured":"Lipson KE, Wong C, Teng Y, et al. CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis. Fibrogenesis Tissue Rep. 2012;5:S24.","journal-title":"Fibrogenesis Tissue Rep"},{"key":"1929_CR31","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1158\/0008-5472.CAN-17-3844","volume":"78","author":"Y Makino","year":"2018","unstructured":"Makino Y, Hikita H, Kodama T, et al. CTGF mediates tumor-stroma interactions between hepatoma cells and hepatic stellate cells to accelerate HCC progression. Cancer Res. 2018;78:4902\u201314.","journal-title":"Cancer Res"},{"key":"1929_CR32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbalip.2011.05.004","volume":"1821","author":"JL Napoli","year":"2012","unstructured":"Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152\u201367.","journal-title":"Biochim Biophys Acta"},{"key":"1929_CR33","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1073\/pnas.1802279115","volume":"115","author":"XY Qin","year":"2018","unstructured":"Qin XY, Suzuki H, Honda M, et al. Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. Proc Natl Acad Sci U S A. 2018;115:4969\u201374.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1929_CR34","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jcp.25921","volume":"233","author":"H Shimizu","year":"2018","unstructured":"Shimizu H, Tsubota T, Kanki K, et al. All-trans retinoic acid ameliorates hepatic stellate cell activation via suppression of thioredoxin interacting protein expression. J Cell Physiol. 2018;233:607\u201316.","journal-title":"J Cell Physiol"},{"key":"1929_CR35","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/eji.201142322","volume":"42","author":"KA Lee","year":"2012","unstructured":"Lee KA, Song YC, Kim GY, et al. Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells. Eur J Immunol. 2012;42:1685\u201394.","journal-title":"Eur J Immunol"},{"key":"1929_CR36","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1073\/pnas.1410741111","volume":"111","author":"W Su","year":"2014","unstructured":"Su W, Wang Y, Jia X, et al. Comparative proteomic study reveals 17\u03b2-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2014;111:11437\u201342.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1929_CR37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jcmgh.2020.07.006","volume":"11","author":"A Saeed","year":"2021","unstructured":"Saeed A, Bartuzi P, Heegsma J, et al. Impaired hepatic vitamin a metabolism in NAFLD mice leading to vitamin a accumulation in hepatocytes. Cell Mol Gastroenterol Hepatol. 2021;11:309-325.e3.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1929_CR38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ygcen.2016.02.028","volume":"241","author":"R Verma","year":"2017","unstructured":"Verma R, Krishna A. Effect of letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: both in vivo and in vitro study. Gen Comp Endocrinol. 2017;241:57\u201368.","journal-title":"Gen Comp Endocrinol"},{"key":"1929_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2019.04.008","volume":"489","author":"M Poutanen","year":"2019","unstructured":"Poutanen M, Penning TM. Biology and clinical relevance of hydroxysteroid (17\u03b2) dehydrogenase enzymes. Mol Cell Endocrinol. 2019;489:1\u20132.","journal-title":"Mol Cell Endocrinol"},{"key":"1929_CR40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/abbi.2000.1747","volume":"377","author":"T Sakuma","year":"2000","unstructured":"Sakuma T, Takai M, Endo Y, et al. A novel female-specific member of the CYP3A gene subfamily in the mouse liver. Arch Biochem Biophys. 2000;377:153\u201362.","journal-title":"Arch Biochem Biophys"},{"key":"1929_CR41","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0003-9861(02)00329-6","volume":"404","author":"T Sakuma","year":"2002","unstructured":"Sakuma T, Endo Y, Mashino M, et al. Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones. Arch Biochem Biophys. 2002;404:234\u201342.","journal-title":"Arch Biochem Biophys"},{"key":"1929_CR42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/jc.2013-2851","volume":"99","author":"B Delvoux","year":"2014","unstructured":"Delvoux B, D\u2019Hooghe T, Kyama C, et al. Inhibition of type 1 17\u03b2-hydroxysteroid dehydrogenase impairs the synthesis of 17\u03b2-estradiol in endometriosis lesions. J Clin Endocrinol Metab. 2014;99:276\u201384.","journal-title":"J Clin Endocrinol Metab"},{"key":"1929_CR43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jsbmb.2017.06.009","volume":"172","author":"XQ Wang","year":"2017","unstructured":"Wang XQ, Aka JA, Li T, et al. Inhibition of 17\u03b2-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. J Steroid Biochem Mol Biol. 2017;172:188\u201397.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1929_CR44","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","volume":"378","author":"NS Abul-Husn","year":"2018","unstructured":"Abul-Husn NS, Cheng X, Li AH, et al. A protein-truncating HSD17B13 variant and protection from chronic liver disease. N Engl J Med. 2018;378:1096\u2013106.","journal-title":"N Engl J Med"},{"key":"1929_CR45","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/apt.15738","volume":"51","author":"B Carlsson","year":"2020","unstructured":"Carlsson B, Lind\u00e9n D, Brol\u00e9n G, et al. Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2020;51:1305\u201320.","journal-title":"Aliment Pharmacol Ther"},{"key":"1929_CR46","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1152\/ajpendo.00310.2016","volume":"312","author":"W Su","year":"2017","unstructured":"Su W, Peng J, Li S, et al. Liver X receptor alpha induces 17\u03b2-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab. 2017;312:E357\u201367.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1929_CR47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/hep.30799","volume":"71","author":"H Gellert-Kristensen","year":"2020","unstructured":"Gellert-Kristensen H, Nordestgaard BG, Tybjaerg-Hansen A, et al. High risk of fatty liver disease amplifies the alanine transaminase-lowering effect of a HSD17B13 variant. Hepatology. 2020;71:56\u201366.","journal-title":"Hepatology"},{"key":"1929_CR48","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132158","volume":"5","author":"PK Luukkonen","year":"2020","unstructured":"Luukkonen PK, Tukiainen T, Juuti A, et al. Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight. 2020;5: e132158.","journal-title":"JCI Insight"},{"key":"1929_CR49","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107400","volume":"204","author":"N Isoherranen","year":"2019","unstructured":"Isoherranen N, Zhong G. Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases. Pharmacol Ther. 2019;204: 107400.","journal-title":"Pharmacol Ther"},{"key":"1929_CR50","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.3390\/ijms23105544","volume":"23","author":"M Wang","year":"2022","unstructured":"Wang M, Li J, Li H, et al. Down-regulating the high level of 17-beta-hydroxysteroid dehydrogenase 13 plays a therapeutic role for non-alcoholic fatty liver disease. Int J Mol Sci. 2022;23:5544.","journal-title":"Int J Mol Sci"},{"key":"1929_CR51","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/hep.31517","volume":"73","author":"Y Ma","year":"2021","unstructured":"Ma Y, Brown PM, Lin DD, et al. Hsd17b13 deficiency does not protect mice from obesogenic diet injury. Hepatology. 2021;73:1701\u201316.","journal-title":"Hepatology"},{"key":"1929_CR52","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/hep.1840380424","volume":"38","author":"R Wolbold","year":"2003","unstructured":"Wolbold R, Klein K, Burk O, et al. Sex is a major determinant of CYP3A4 expression in human liver. Hepatology. 2003;38:978\u201388.","journal-title":"Hepatology"},{"key":"1929_CR53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","volume":"73","author":"QM Anstee","year":"2020","unstructured":"Anstee QM, Darlay R, Cockell S, et al. Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort. J Hepatol. 2020;73:505\u201315.","journal-title":"J Hepatol"},{"key":"1929_CR54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-019-0212-0","volume":"17","author":"M Eslam","year":"2020","unstructured":"Eslam M, George J. Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology. Nat Rev Gastroenterol Hepatol. 2020;17:40\u201352.","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-022-01929-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-022-01929-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-022-01929-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:52:09Z","timestamp":1673365929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-022-01929-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1929"],"URL":"https:\/\/doi.org\/10.1007\/s00535-022-01929-w","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"7 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}