{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:41:37Z","timestamp":1790264497068,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012330","name":"Okayama University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012330","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We previously demonstrated that the Kyoto classification of gastritis was useful for judging the status of <jats:italic>Helicobacter pylori<\/jats:italic> infection in a population-based screening program, and that adding <jats:italic>H. pylori<\/jats:italic> antibody test improved its accuracy (UMIN000028629). Here, we tested whether our endoscopic diagnosis of <jats:italic>H. pylori<\/jats:italic> infection status reliably estimated gastric cancer risk in the program.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data were collected from1345 subjects who underwent endoscopic follow-up 4\u00a0years after the end of the registration. We analyzed the association of three diagnostic methods of <jats:italic>H. pylori<\/jats:italic> infection with gastric cancer detection: (1) endoscopic diagnosis based on the Kyoto classification of gastritis; (2) serum diagnosis according to the ABC method (<jats:italic>H. pylori<\/jats:italic> antibody and pepsinogen I and II); and (3) endoscopic diagnosis together with <jats:italic>H. pylori<\/jats:italic> antibody test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During the follow-up, 19 cases of gastric cancer were detected. By Kaplan\u2013Meier analysis, the detection rates of cancer were significantly higher in the past or current <jats:italic>H. pylori<\/jats:italic> infection groups than in the never-infected group with all 3 methods. By the Cox proportional hazards model, the hazard ratio for cancer detection was highest in evaluation with the combined endoscopic diagnosis and the antibody test (method 3; hazard ratio 22.6, 95% confidence interval 2.99\u2013171) among the three methods (the endoscopic diagnosis (method 1); 11.3, 2.58\u201349.8, and the ABC method (method 2); 7.52, 2.49\u201322.7).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Endoscopic evaluation of <jats:italic>H. pylori<\/jats:italic> status with the Kyoto classification of gastritis, especially combined with serum anti-<jats:italic>Helicobacter pylori<\/jats:italic> antibody testing, reliably risk-stratified subjects in a population-based gastric cancer screening program.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00535-023-02010-w","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T04:14:23Z","timestamp":1687320863000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endoscopic evaluation by the Kyoto classification of gastritis combined with serum anti-Helicobacter pylori antibody testing reliably risk-stratifies subjects in a population-based gastric cancer screening program"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-9695","authenticated-orcid":false,"given":"Ryosuke","family":"Hirai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Mitsuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Shimodate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Matsueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motowo","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2010_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/scientificamerican0296-104","volume":"274","author":"MJ Blaser","year":"1996","unstructured":"Blaser MJ. 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