{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:48:43Z","timestamp":1775058523791,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Evidence of small-bowel capsule endoscopy (SBCE) for evaluating lesions in Crohn\u2019s disease (CD) is lacking. We aimed to clarify the effectiveness and safety of SBCE in a large sample of patients with CD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This multicenter prospective registration study recorded the clinical information and SBCE results of patients with definitive CD (d-CD) or suspected CD (s-CD). The primary outcomes were the rates of successful assessment of disease activity using SBCE, definitive diagnosis of CD, and adverse events. Secondary outcomes were the assessment of SBCE findings in patients with d-CD and s-CD and factors affecting SBCE incompletion and retention; and tertiary outcomes included the association between clinical disease activity or blood examination, endoscopic disease activity, ileal CD, and the questionnaire assessment of patient acceptance of SBCE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 544 patients analyzed, 541 underwent SBCE with 7 (1.3%) retention cases. Of 468 patients with d-CD, 97.6% could be evaluated for endoscopic activity. Of 76 patients with s-CD, 15.8% were diagnosed with \u2018confirmed CD\u2019. CD lesions were more frequently observed in the ileum and were only seen in the jejunum in 3.4% of the patients. Male sex and stenosis were risk factors for incomplete SBCE, and high C-reactive protein levels and stenosis were risk factors for capsule retention. In L1 (Montreal classification) patients, clinical remission was associated with endoscopic remission but showed low specificity and accuracy. The answers to the acceptability questionnaire showed the minimal invasiveness and tolerability of SBCE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>SBCE is practical and safe in patients with CD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00535-023-02017-3","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T17:01:51Z","timestamp":1689958911000},"page":"1003-1014","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn\u2019s disease in Japan (SPREAD-J study)"],"prefix":"10.1007","volume":"58","author":[{"given":"Toshiyuki","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohachi","family":"Nanjjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Hiraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-3240","authenticated-orcid":false,"given":"Masayuki","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the SPREAD-J group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Akutagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Omiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kakimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Sagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotake","family":"Sakuraba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Shinzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Takao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Torisu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konosuke","family":"Nakamichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihiro","family":"Fuijya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimasa","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuicihiro","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Wagatsuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"2017_CR1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769\u201378.","journal-title":"Lancet"},{"key":"2017_CR2","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres J, Mehandru S, Colombel JF, et al. Crohn\u2019s disease. Lancet. 2017;389:1741\u201355.","journal-title":"Lancet"},{"key":"2017_CR3","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","volume":"160","author":"D Turner","year":"2021","unstructured":"Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021;160:1570\u201383.","journal-title":"Gastroenterology"},{"key":"2017_CR4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1053\/j.gastro.2007.05.051","volume":"133","author":"KF Fr\u00f8slie","year":"2007","unstructured":"Fr\u00f8slie KF, Jahnsen J, Moum BA, et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology. 2007;133:412\u201322.","journal-title":"Gastroenterology"},{"key":"2017_CR5","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/ajg.2009.713","volume":"105","author":"PM Dionisio","year":"2010","unstructured":"Dionisio PM, Gurudu SR, Leighton JA, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn\u2019s disease: a meta-analysis. Am J Gastroenterol. 2010;105:1240\u20138.","journal-title":"Am J Gastroenterol"},{"key":"2017_CR6","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.dld.2017.04.013","volume":"49","author":"U Kopylov","year":"2017","unstructured":"Kopylov U, Yung DE, Engel T, et al. Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn\u2019s disease: systematic review and meta-analysis. Dig Liver Dis. 2017;49:854\u201363.","journal-title":"Dig Liver Dis"},{"key":"2017_CR7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.gie.2009.09.031","volume":"71","author":"Z Liao","year":"2010","unstructured":"Liao Z, Gao R, Xu C, et al. Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review. Gastrointest Endosc. 2010;71:280\u20136.","journal-title":"Gastrointest Endosc"},{"key":"2017_CR8","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1111\/j.1572-0241.2006.00761.x","volume":"101","author":"AS Cheifetz","year":"2006","unstructured":"Cheifetz AS, Kornbluth AA, Legnani P, et al. The risk of retention of the capsule endoscope in patients with known or suspected Crohn\u2019s disease. Am J Gastroenterol. 2006;101:2218\u201322.","journal-title":"Am J Gastroenterol"},{"key":"2017_CR9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s00330-010-1976-3","volume":"21","author":"E Casciani","year":"2011","unstructured":"Casciani E, Masselli G, Di Nardo G, et al. MR enterography versus capsule endoscopy in paediatric patients with suspected Crohn\u2019s disease. Eur Radiol. 2011;21:823\u201331.","journal-title":"Eur Radiol"},{"key":"2017_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cgh.2010.10.019","volume":"9","author":"MD Jensen","year":"2011","unstructured":"Jensen MD, Nathan T, Rafaelsen SR, et al. Diagnostic accuracy of capsule endoscopy for small bowel Crohn\u2019s disease is superior to that of MR enterography or CT enterography. Clin Gastroenterol Hepatol. 2011;9:124\u20139.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2017_CR11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10620-011-1894-5","volume":"57","author":"IM Gralnek","year":"2012","unstructured":"Gralnek IM, Cohen SA, Ephrath H, et al. Small bowel capsule endoscopy impacts diagnosis and management of pediatric inflammatory bowel disease: a prospective study. Dig Dis Sci. 2012;57:465\u201371.","journal-title":"Dig Dis Sci"},{"key":"2017_CR12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1136\/gut.2004.040055","volume":"54","author":"WA Voderholzer","year":"2005","unstructured":"Voderholzer WA, Beinhoelzl J, Rogalla P, et al. Small bowel involvement in Crohn\u2019s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis. Gut. 2005;54:369\u201373.","journal-title":"Gut"},{"key":"2017_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/518718","volume":"2012","author":"CM H\u00f6\u00f6g","year":"2012","unstructured":"H\u00f6\u00f6g CM, Bark L\u00c5, Arkani J, et al. Capsule retentions and incomplete capsule endoscopy examinations: an analysis of 2300 examinations. Gastroenterol Res Pract. 2012;2012: 518718.","journal-title":"Gastroenterol Res Pract"},{"key":"2017_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","volume":"152","author":"RA Enns","year":"2017","unstructured":"Enns RA, Hookey L, Armstrong D, et al. Clinical practice guidelines for the use of video capsule endoscopy. Gastroenterology. 2017;152:497\u2013514.","journal-title":"Gastroenterology"},{"key":"2017_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1055\/a-1973-3796","volume":"55","author":"M Pennazio","year":"2023","unstructured":"Pennazio M, Rondonotti E, Despott EJ, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2014update 2922. Endoscopy. 2023;55:58\u201395.","journal-title":"Endoscopy"},{"key":"2017_CR16","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1055\/s-0029-1214790","volume":"41","author":"A Bourreille","year":"2009","unstructured":"Bourreille A, Ignjatovic A, Aabakken L, et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy. 2009;41:618\u201337.","journal-title":"Endoscopy"},{"key":"2017_CR17","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00535-021-01784-1","volume":"56","author":"H Nakase","year":"2021","unstructured":"Nakase H, Uchino M, Shinzaki S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 2021;56:489\u2013526.","journal-title":"J Gastroenterol"},{"key":"2017_CR18","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","volume":"70","author":"WR Best","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s disease study. Gastroenterology. 1976;70:439\u201344.","journal-title":"Gastroenterology"},{"key":"2017_CR19","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s10620-007-0084-y","volume":"53","author":"E Gal","year":"2008","unstructured":"Gal E, Geller A, Fraser G, et al. Assessment and validation of the new capsule endoscopy Crohn\u2019s disease activity index (CECDAI). Dig Dis Sci. 2008;53:1933\u20137.","journal-title":"Dig Dis Sci"},{"key":"2017_CR20","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1365-2036.2007.03556.x","volume":"27","author":"IM Gralnek","year":"2008","unstructured":"Gralnek IM, Defranchis R, Seidman E, et al. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther. 2008;27:146\u201354.","journal-title":"Aliment Pharmacol Ther"},{"key":"2017_CR21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749\u201353.","journal-title":"Gut"},{"key":"2017_CR22","unstructured":"Ministry of Health, Labour and Welfare. Grant-in-Aid for Scientific Research on Intractable Diseases, \u201cResearch on Intractable Inflammatory Bowel Disorders\u201d (Suzuki Group), 2020, Diagnostic Criteria and Treatment Guidelines for Ulcerative Colitis and Crohn\u2019s Disease (revised version). http:\/\/www.ibdjapan.org\/. Accessed 10 Dec 2020."},{"key":"2017_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00535-013-0798-x","volume":"49","author":"T Hisabe","year":"2014","unstructured":"Hisabe T, Hirai F, Matsui T, et al. Evaluation of diagnostic criteria for Crohn\u2019s disease in Japan. J Gastroenterol. 2014;49:93\u20139.","journal-title":"J Gastroenterol"},{"key":"2017_CR24","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1097\/MEG.0000000000000194","volume":"26","author":"BJ Hall","year":"2014","unstructured":"Hall BJ, Holleran GE, Smith SM, et al. A prospective 12-week mucosal healing assessment of small bowel Crohn\u2019s disease as detected by capsule endoscopy. Eur J Gastroenterol Hepatol. 2014;26:1253\u20139.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2017_CR25","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.gie.2018.07.035","volume":"88","author":"GY Melmed","year":"2018","unstructured":"Melmed GY, Dubinsky MC, Rubin DT, et al. Utility of video capsule endoscopy for longitudinal monitoring of Crohn\u2019s disease activity in the small bowel: a prospective study. Gastrointest Endosc. 2018;88:947-55.e2.","journal-title":"Gastrointest Endosc"},{"key":"2017_CR26","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.crohns.2014.03.003","volume":"8","author":"E Niv","year":"2014","unstructured":"Niv E, Fishman S, Kachman H, et al. Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn\u2019s disease. J Crohns Colitis. 2014;8:1616\u201323.","journal-title":"J Crohns Colitis"},{"key":"2017_CR27","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.gie.2016.12.024","volume":"85","author":"M Rezapour","year":"2017","unstructured":"Rezapour M, Amadi C, Gerson LB. Retention associated with video capsule endoscopy: systematic review and meta-analysis. Gastrointest Endosc. 2017;85:1157-68.e2.","journal-title":"Gastrointest Endosc"},{"key":"2017_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/jgh.12411","volume":"29","author":"M Esaki","year":"2014","unstructured":"Esaki M, Matsumoto T, Watanabe K, et al. Use of capsule endoscopy in patients with Crohn\u2019s disease in Japan: a multicenter survey. J Gastroenterol Hepatol. 2014;29:96\u2013101.","journal-title":"J Gastroenterol Hepatol"},{"key":"2017_CR29","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/ajg.2012.117","volume":"107","author":"L Peyrin-Biroulet","year":"2012","unstructured":"Peyrin-Biroulet L, Billioud V, D\u2019Haens G, et al. Development of the Paris definition of early Crohn\u2019s disease for disease-modification trials: results of an international expert opinion process. Am J Gastroenterol. 2012;107:1770\u20136.","journal-title":"Am J Gastroenterol"},{"key":"2017_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","volume":"13","author":"C Maaser","year":"2019","unstructured":"Maaser C, Sturm A, Vavricka SR, et al. ECCO-ESGAR guideline for diagnostic assessment in IBD part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019;13:144\u201364.","journal-title":"J Crohns Colitis"},{"key":"2017_CR31","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00535-018-1507-6","volume":"54","author":"M Esaki","year":"2019","unstructured":"Esaki M, Matsumoto T, Ohmiya N, et al. Capsule endoscopy findings for the diagnosis of Crohn\u2019s disease: a nationwide case-control study. J Gastroenterol. 2019;54:249\u201360.","journal-title":"J Gastroenterol"},{"key":"2017_CR32","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.gie.2017.09.011","volume":"86","author":"V Aggarwal","year":"2017","unstructured":"Aggarwal V, Day AS, Connor S, et al. Role of capsule endoscopy and fecal biomarkers in small-bowel Crohn\u2019s disease to assess remission and predict relapse. Gastrointest Endosc. 2017;86:1070\u20138.","journal-title":"Gastrointest Endosc"},{"key":"2017_CR33","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1002\/ibd.20178","volume":"13","author":"MA Denis","year":"2007","unstructured":"Denis MA, Reenaers C, Fontaine F, et al. Assessment of endoscopic activity index and biological inflammatory markers in clinically active Crohn\u2019s disease with normal C-reactive protein serum level. Inflamm Bowel Dis. 2007;13:1100\u20135.","journal-title":"Inflamm Bowel Dis"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-023-02017-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-023-02017-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-023-02017-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:15:17Z","timestamp":1695741317000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-023-02017-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1007\/s00535-023-02017-3","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"assertion":[{"value":"9 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The following authors have no competing interests in this study or its publication: Toshiyuki Sakurai, Takahiro Ito, Katsuyoshi Andoh, Takeshi Yamamura, Sohachi Nanjo, Susumu Osawa, Teruyuki Takeda, Hiroto Hiraga, Shuji Yamamoto, Keiji Ozeki, Shinji Tanaka, and Hisao Tajiri. Teppei Omori received honoraria (lecture fees) from Takeda Pharmaceutical Co. Ltd. Hiroki Tanaka received honoraria (lecture fees) from JIMRO Co. Ltd., AbbVie GK, EA Pharma Co. Ltd., Kyorin Pharmaceutical Co. Ltd., Mochida Pharmaceutical Co. Ltd., Kissei Pharmaceutical Co. Ltd., Eisai Co. Ltd., Mitsubishi Tanabe Pharma Corporation, Janssen Pharmaceutical K.K., Nikkiso Co. Ltd., Nippon Kayaku Co. Ltd., and Takeda Pharmaceutical; and research grants from AbbVie GK, Janssen Pharmaceutical K.K., EA Pharma, and Takeda Pharmaceutical. Katsunori Andoh received honoraria (lecture fees) from Nippon Kayaku Co. Ltd.,\u00a0Janssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma Corporation,\u00a0Takeda\u00a0Pharmaceutical Co. Ltd., AbbVie GK.,\u00a0JIMRO Co. Ltd., EA Pharma Co. Ltd.,\u00a0Kyorin Pharmaceutical Co. Ltd.,\u00a0ZERIA Pharmaceutical Co. Ltd.,\u00a0Aspen Japan K.K., Sandoz K.K. Kenji Watanabe received honoraria (lecture fees) from AbbVie GK, EA Pharma Co. Ltd, Kissei Pharmaceutical Co. Ltd., Pfizer Pharmaceutical Co. Ltd., Takeda Pharmaceutical, Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd., and Mochida Pharmaceutical Co. Ltd.; and research grants from EA Pharma Co. Ltd., Takeda Pharmaceutical, and EP Group Ltd.; a scholarship from AbbVie GK, EA Pharma Co. Ltd., Mitsubishi Tanabe Pharma Corporation, JIMRO Co. Ltd., and Nippon Kayaku Co. Ltd.; an endowed chair from AbbVie GK, EA Pharma Co. Ltd., Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd., ZERIA Pharmaceutical Co. Ltd., JIMRO Co. Ltd, Otsuka Pharmaceutical Factory, Asahi Kasei Medical Co. Ltd., and Mochida Pharmaceutical Co. Ltd. Masayuki Saruta received honoraria (lecture fees) from AbbVie GK, Mitsubishi Tanabe Pharma, Janssen Pharma K.K., and Takeda Pharmaceutical Co. Ltd.; and scholarship\/research grants from EA Pharma Co. Ltd., ZERIA Pharmaceutical Co. Ltd., Kissei Pharmaceutical Co. Ltd., and Mochida Pharmaceutical Co. Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}