{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:12:37Z","timestamp":1792131157963,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82104257"],"award-info":[{"award-number":["82104257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82230018"],"award-info":[{"award-number":["82230018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82300642"],"award-info":[{"award-number":["82300642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Pujiang Program","award":["2022PJD015"],"award-info":[{"award-number":["2022PJD015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00535-024-02145-4","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T09:02:24Z","timestamp":1723712544000},"page":"1037-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Corynoline protects chronic pancreatitis via binding to PSMA2 and alleviating pancreatic fibrosis"],"prefix":"10.1007","volume":"59","author":[{"given":"Pengyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-7475","authenticated-orcid":false,"given":"Lianghao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"2145_CR1","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1001\/jama.2019.19411","volume":"322","author":"VK Singh","year":"2019","unstructured":"Singh VK, Yadav D, Garg PK. Diagnosis and management of chronic pancreatitis: a review. JAMA. 2019;322:2422.","journal-title":"JAMA"},{"key":"2145_CR2","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJMcp1809396","volume":"386","author":"SS Vege","year":"2022","unstructured":"Vege SS, Chari ST. Chronic pancreatitis. N Engl J Med. 2022;386:869\u201378.","journal-title":"N Engl J Med"},{"key":"2145_CR3","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1089\/ars.2011.4079","volume":"15","author":"M Apte","year":"2011","unstructured":"Apte M, Pirola R, Wilson J. The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells. Antioxid Redox Signal. 2011;15:2711\u201322.","journal-title":"Antioxid Redox Signal"},{"key":"2145_CR4","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1016\/j.cgh.2009.07.038","volume":"7","author":"A Masamune","year":"2009","unstructured":"Masamune A, Watanabe T, Kikuta K, et al. Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis. Clin Gastroenterol Hepatol. 2009;7:S48-54.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2145_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","volume":"121","author":"T Higashi","year":"2017","unstructured":"Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27\u201342.","journal-title":"Adv Drug Deliv Rev"},{"key":"2145_CR6","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","volume":"14","author":"T Tsuchida","year":"2017","unstructured":"Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14:397\u2013411.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2145_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.apsb.2019.11.008","volume":"10","author":"P Ramakrishnan","year":"2020","unstructured":"Ramakrishnan P, Loh WM, Gopinath SCB, et al. Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer. Acta Pharm Sin B. 2020;10:399\u2013413.","journal-title":"Acta Pharm Sin B"},{"key":"2145_CR8","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/hep.31749","volume":"74","author":"T Lan","year":"2021","unstructured":"Lan T, Yu Y, Zhang J, et al. Cordycepin ameliorates nonalcoholic steatohepatitis by activation of the AMP-activated protein kinase signaling pathway. Hepatology. 2021;74:686\u2013703.","journal-title":"Hepatology"},{"key":"2145_CR9","doi-asserted-by":"publisher","first-page":"112404","DOI":"10.1016\/j.jep.2019.112404","volume":"249","author":"Y Wei","year":"2020","unstructured":"Wei Y, Wu Y, Feng K, et al. Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-beta\/smads pathway. J Ethnopharmacol. 2020;249:112404.","journal-title":"J Ethnopharmacol"},{"key":"2145_CR10","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.119.042559","volume":"141","author":"K Schimmel","year":"2020","unstructured":"Schimmel K, Jung M, Foinquinos A, et al. Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction. Circulation. 2020;141:751\u201367.","journal-title":"Circulation"},{"key":"2145_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.intimp.2017.04.029","volume":"48","author":"Y Liu","year":"2017","unstructured":"Liu Y, Song M, Zhu G, et al. Corynoline attenuates LPS-induced acute lung injury in mice by activating Nrf2. Int Immunopharmacol. 2017;48:96\u2013101.","journal-title":"Int Immunopharmacol"},{"key":"2145_CR12","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1002\/ptr.6719","volume":"34","author":"C Yi","year":"2020","unstructured":"Yi C, Li X, Chen S, et al. Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress. Phytother Res. 2020;34:2766.","journal-title":"Phytother Res"},{"key":"2145_CR13","doi-asserted-by":"publisher","first-page":"113075","DOI":"10.1016\/j.biopha.2022.113075","volume":"150","author":"M Wang","year":"2022","unstructured":"Wang M, Luo W, Yu T, et al. Corynoline protects ang II-induced hypertensive heart failure by increasing PPARalpha and Inhibiting NF-kappaB pathway. Biomed Pharmacother. 2022;150:113075.","journal-title":"Biomed Pharmacother"},{"key":"2145_CR14","doi-asserted-by":"publisher","first-page":"7158","DOI":"10.1038\/ncomms8158","volume":"6","author":"J Xue","year":"2015","unstructured":"Xue J, Sharma V, Hsieh MH, et al. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun. 2015;6:7158.","journal-title":"Nat Commun"},{"key":"2145_CR15","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1053\/j.gastro.2012.12.043","volume":"144","author":"MM Lerch","year":"2013","unstructured":"Lerch MM, Gorelick FS. Models of acute and chronic pancreatitis. Gastroenterology. 2013;144:1180\u201393.","journal-title":"Gastroenterology"},{"key":"2145_CR16","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12906-015-0789-y","volume":"15","author":"Z Lin","year":"2015","unstructured":"Lin Z, Zheng LC, Zhang HJ, et al. Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells. BMC Complement Altern Med. 2015;15:259.","journal-title":"BMC Complement Altern Med"},{"key":"2145_CR17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41401-021-00666-9","volume":"43","author":"PY Wang","year":"2022","unstructured":"Wang PY, Feng JY, Zhang Z, et al. The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway. Acta Pharmacol Sin. 2022;43:367\u201375.","journal-title":"Acta Pharmacol Sin"},{"key":"2145_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/9780470559277.ch110180","volume":"3","author":"B Lomenick","year":"2011","unstructured":"Lomenick B, Jung G, Wohlschlegel JA, et al. Target identification using drug affinity responsive target stability (DARTS). Curr Protoc Chem Biol. 2011;3:163\u201380.","journal-title":"Curr Protoc Chem Biol"},{"key":"2145_CR19","doi-asserted-by":"publisher","first-page":"e1095","DOI":"10.1002\/ctm2.1095","volume":"12","author":"D Jia","year":"2022","unstructured":"Jia D, Liu C, Zhu Z, et al. Novel transketolase inhibitor oroxylin A suppresses the non-oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient-derived organoids. Clin Transl Med. 2022;12:e1095.","journal-title":"Clin Transl Med"},{"key":"2145_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41573-019-0040-5","volume":"19","author":"X Zhao","year":"2020","unstructured":"Zhao X, Kwan JYY, Yip K, et al. Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020;19:57\u201375.","journal-title":"Nat Rev Drug Discov"},{"key":"2145_CR21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41392-022-01070-3","volume":"7","author":"M Zhao","year":"2022","unstructured":"Zhao M, Wang L, Wang M, et al. Targeting fibrosis, mechanisms and cilinical trials. Signal Transduct Target Ther. 2022;7:206.","journal-title":"Signal Transduct Target Ther"},{"key":"2145_CR22","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","volume":"173","author":"M Liu","year":"2021","unstructured":"Liu M, de Juan Abad BL, Cheng K. Cardiac fibrosis: myofibroblast-mediated pathological regulation and drug delivery strategies. Adv Drug Deliv Rev. 2021;173:504\u201319.","journal-title":"Adv Drug Deliv Rev."},{"key":"2145_CR23","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.immuni.2022.06.001","volume":"55","author":"X Yang","year":"2022","unstructured":"Yang X, Chen J, Wang J, et al. Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis. Immunity. 2022;55:1185\u201399.","journal-title":"Immunity"},{"key":"2145_CR24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.2147\/JIR.S299298","volume":"14","author":"Q Wang","year":"2021","unstructured":"Wang Q, Wang H, Jing Q, et al. Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via Targeting of stellate Cell PPAR-gamma. J Inflamm Res. 2021;14:461\u201377.","journal-title":"J Inflamm Res"},{"key":"2145_CR25","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","volume":"12","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Ouyang Z, Du H, et al. New opportunities and challenges of natural products research: when target identification meets single-cell multiomics. Acta Pharm Sin B. 2022;12:4011\u201339.","journal-title":"Acta Pharm Sin B"},{"key":"2145_CR26","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.cell.2017.12.006","volume":"172","author":"I Piazza","year":"2018","unstructured":"Piazza I, Kochanowski K, Cappelletti V, et al. A Map of protein-metabolite interactions reveals principles of chemical communication. Cell. 2018;172:358\u201372.","journal-title":"Cell"},{"key":"2145_CR27","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cmet.2021.02.007","volume":"33","author":"S Chen","year":"2021","unstructured":"Chen S, Liu X, Peng C, et al. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metab. 2021;33:565\u201380.","journal-title":"Cell Metab"},{"key":"2145_CR28","doi-asserted-by":"crossref","unstructured":"H. Fukasawa., Y. Fujigaki., T. Yamamoto., et al. Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis. Current Medicinal Chemistry. 2012; 19: 893\u2013900.","DOI":"10.2174\/092986712799034941"},{"key":"2145_CR29","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.redox.2013.01.004","volume":"1","author":"T Jung","year":"2013","unstructured":"Jung T, Grune T. The proteasome and the degradation of oxidized proteins: part I-structure of proteasomes. Redox Biol. 2013;1:178\u201382.","journal-title":"Redox Biol"},{"key":"2145_CR30","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev-biochem-062917-011931","volume":"87","author":"JAM Bard","year":"2018","unstructured":"Bard JAM, Goodall EA, Greene ER, et al. Structure and function of the 26S proteasome. Annu Rev Biochem. 2018;87:697\u2013724.","journal-title":"Annu Rev Biochem"},{"key":"2145_CR31","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1053\/j.gastro.2012.09.059","volume":"144","author":"H Huang","year":"2013","unstructured":"Huang H, Liu Y, Daniluk J, et al. Activation of nuclear factor-\u03baB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology. 2013;144:202\u201310.","journal-title":"Gastroenterology"},{"key":"2145_CR32","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1111\/jcmm.14833","volume":"24","author":"H Chen","year":"2020","unstructured":"Chen H, Tan P, Qian B, et al. Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-\u03baB (p65)\/IL-6 signalling pathway. J Cell Mol Med. 2020;24:1488\u2013503.","journal-title":"J Cell Mol Med"},{"key":"2145_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1044-579X(02)00096-2","volume":"13","author":"S Amit","year":"2003","unstructured":"Amit S, Ben-Neriah Y. NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach. Semin Cancer Biol. 2003;13:15\u201328.","journal-title":"Semin Cancer Biol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-024-02145-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-024-02145-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-024-02145-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T10:03:34Z","timestamp":1729591414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-024-02145-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["2145"],"URL":"https:\/\/doi.org\/10.1007\/s00535-024-02145-4","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]},"assertion":[{"value":"1 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}