{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:03:44Z","timestamp":1793556224305,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100019949","name":"FUJIFILM Toyama Chemical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019949","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AI Medical Service Inc."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00535-024-02199-4","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T17:19:13Z","timestamp":1734110353000},"page":"416-429","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse"],"prefix":"10.1007","volume":"60","author":[{"given":"Kei","family":"Nishioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-8389","authenticated-orcid":false,"given":"Haruei","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eikichi","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Minoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko M.","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"2199_CR1","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","volume":"369","author":"DC Baumgart","year":"2007","unstructured":"Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007;369:1641\u201357. https:\/\/doi.org\/10.1016\/S0140-6736(07)60751-X.","journal-title":"Lancet"},{"key":"2199_CR2","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1056\/NEJMra0804647","volume":"361","author":"C Abraham","year":"2009","unstructured":"Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med. 2009;361:2066\u201378. https:\/\/doi.org\/10.1056\/NEJMra0804647.","journal-title":"N Engl J Med"},{"key":"2199_CR3","first-page":"294","volume":"27","author":"WE Ek","year":"2014","unstructured":"Ek WE, D\u2019Amato M, Halfvarson J. The history of genetics in inflammatory bowel disease. Ann of Gastroenterol. 2014;27:294\u2013303.","journal-title":"Ann of Gastroenterol"},{"key":"2199_CR4","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet. 2017;389:1756\u201370. https:\/\/doi.org\/10.1016\/S0140-6736(16)32126-2.","journal-title":"Lancet"},{"key":"2199_CR5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1309\/XLXKJ84C3JCW3RCH","volume":"122","author":"ME Robert","year":"2004","unstructured":"Robert ME, Skacel M, Ullman T, et al. Patterns of colonic involvement at initial presentation in ulcerative colitis. a retrospective study of 46 newly diagnosed cases. Am J Clin Pathol. 2004;122:94\u20139.","journal-title":"Am J Clin Pathol"},{"key":"2199_CR6","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","volume":"402","author":"C Le Berre","year":"2023","unstructured":"Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis. Lancet. 2023;402:571\u201384. https:\/\/doi.org\/10.1016\/S0140-6736(23)00966-2.","journal-title":"Lancet"},{"key":"2199_CR7","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1111\/apt.15767","volume":"51","author":"S Sagami","year":"2020","unstructured":"Sagami S, Kobayashi T, Aihara K, et al. Transperineal ultrasound predicts endoscopic and histological healing in ulcerative colitis. Aliment Pharmacol Ther. 2020;51:1373\u201383. https:\/\/doi.org\/10.1111\/apt.15767.","journal-title":"Aliment Pharmacol Ther"},{"issue":"16","key":"2199_CR8","doi-asserted-by":"publisher","first-page":"9344","DOI":"10.3390\/ijms23169344","volume":"23","author":"B Katsandegwaza","year":"2022","unstructured":"Katsandegwaza B, Horsnell W, Smith K. Inflammatory bowel disease: a review of pre-clinical murine models of human disease. Int J Mol Sci. 2022;23(16):9344.","journal-title":"Int J Mol Sci"},{"key":"2199_CR9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s10620-010-1286-2","volume":"56","author":"H Ogino","year":"2011","unstructured":"Ogino H, Nakamura K, Ihara E, et al. CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci. 2011;56:376\u201386. https:\/\/doi.org\/10.1007\/s10620-010-1286-2.","journal-title":"Dig Dis Sci"},{"key":"2199_CR10","doi-asserted-by":"publisher","first-page":"13743","DOI":"10.1038\/s41598-021-92870-0","volume":"11","author":"Y Nishihara","year":"2021","unstructured":"Nishihara Y, Ogino H, Tanaka M, et al. Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. Sci Rep. 2021;11:13743. https:\/\/doi.org\/10.1038\/s41598-021-92870-0.","journal-title":"Sci Rep"},{"issue":"1844\u20131854","key":"2199_CR11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.049","volume":"139","author":"BP Willing","year":"2010","unstructured":"Willing BP, Dicksved J, Halfvarson J, et al. A Pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology. 2010;139(1844\u20131854): e1. https:\/\/doi.org\/10.1053\/j.gastro.2010.08.049.","journal-title":"Gastroenterology"},{"key":"2199_CR12","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114\u201320. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170.","journal-title":"Bioinformatics"},{"key":"2199_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 2011;12:323. https:\/\/doi.org\/10.1186\/1471-2105-12-323.","journal-title":"BMC Bioinformatics"},{"key":"2199_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616.","journal-title":"Bioinformatics"},{"key":"2199_CR15","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1007\/s10620-019-5470-8","volume":"64","author":"K Komori","year":"2019","unstructured":"Komori K, Ihara E, Minoda Y, et al. The altered mucosal barrier function in the duodenum plays a role in the pathogenesis of functional dyspepsia. Dig Dis Sci. 2019;64:3228\u201339. https:\/\/doi.org\/10.1007\/s10620-019-5470-8.","journal-title":"Dig Dis Sci"},{"key":"2199_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/coa.12332","volume":"40","author":"H Koizumi","year":"2015","unstructured":"Koizumi H, Suzuki H, Ohbuchi T, et al. Increased permeability of the epithelium of middle ear cholesteatoma. Clin Otolaryngol. 2015;40:106\u201314. https:\/\/doi.org\/10.1111\/coa.12332.","journal-title":"Clin Otolaryngol"},{"key":"2199_CR17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00535-016-1221-1","volume":"52","author":"Y Iboshi","year":"2017","unstructured":"Iboshi Y, Nakamura K, Fukaura K, et al. Increased IL-17A\/IL-17F expression ratio represents the key mucosal T helper\/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis. J Gastroenterol. 2017;52:315\u201326. https:\/\/doi.org\/10.1007\/s00535-016-1221-1.","journal-title":"J Gastroenterol"},{"key":"2199_CR18","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9:799\u2013809. https:\/\/doi.org\/10.1038\/nri2653.","journal-title":"Nat Rev Immunol"},{"key":"2199_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.12","volume":"8","author":"H Ishigami","year":"2017","unstructured":"Ishigami H, Matsumura T, Kasamatsu S, et al. Endoscopy-guided evaluation of duodenal mucosal permeability in functional dyspepsia. Clin Transl Gastroenterol. 2017;8: e83. https:\/\/doi.org\/10.1038\/ctg.2017.12.","journal-title":"Clin Transl Gastroenterol"},{"key":"2199_CR20","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrm.2016.80","volume":"17","author":"C Zihni","year":"2016","unstructured":"Zihni C, Mills C, Matter K, et al. Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol. 2016;17:564\u201380. https:\/\/doi.org\/10.1038\/nrm.2016.80.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2199_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.682614","volume":"12","author":"S \u010cu\u017ei\u0107","year":"2021","unstructured":"\u010cu\u017ei\u0107 S, Antoli\u0107 M, Ognjenovi\u0107 A, et al. Claudins: Beyond tight junctions in human IBD and Murine Models ibid. Front Pharmacol. 2021;12: 682614. https:\/\/doi.org\/10.3389\/fphar.2021.682614.","journal-title":"Front Pharmacol"},{"key":"2199_CR22","doi-asserted-by":"publisher","DOI":"10.4161\/21688370.2014.977176","volume":"3","author":"J Luettig","year":"2015","unstructured":"Luettig J, Rosenthal R, Barmeyer C, et al. Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers. 2015;3: e977176. https:\/\/doi.org\/10.4161\/21688370.2014.977176.","journal-title":"Tissue Barriers"},{"issue":"Suppl 2","key":"2199_CR23","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1111\/j.1440-1746.2008.05405.x","volume":"23","author":"T Oshima","year":"2008","unstructured":"Oshima T, Miwa H, Joh T. Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol. 2008;23(Suppl 2):S146\u201350. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05405.x.","journal-title":"J Gastroenterol Hepatol"},{"key":"2199_CR24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170771","author":"R Ahmad","year":"2023","unstructured":"Ahmad R, Kumar B, Thapa I, et al. Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing. J Clin Invest. 2023. https:\/\/doi.org\/10.1172\/JCI170771.","journal-title":"J Clin Invest"},{"key":"2199_CR25","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/mi.2014.21","volume":"7","author":"R Ahmad","year":"2014","unstructured":"Ahmad R, Chaturvedi R, Olivares-Villagomez D, et al. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol. 2014;7:1340\u201353. https:\/\/doi.org\/10.1038\/mi.2014.21.","journal-title":"Mucosal Immunol"},{"key":"2199_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/mi.2016.128","volume":"10","author":"R Ahmad","year":"2017","unstructured":"Ahmad R, Sorrell MF, Batra SK, et al. Gut permeability and mucosal inflammation: bad, good or context dependent. Mucosal Immunol. 2017;10:307\u201317. https:\/\/doi.org\/10.1038\/mi.2016.128.","journal-title":"Mucosal Immunol"},{"key":"2199_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jcmgh.2017.03.007","volume":"4","author":"E Martini","year":"2017","unstructured":"Martini E, Krug SM, Siegmund B, et al. Mend Your Fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4:33\u201346. https:\/\/doi.org\/10.1016\/j.jcmgh.2017.03.007.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2199_CR28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jcmgh.2020.04.001","volume":"10","author":"L Zuo","year":"2020","unstructured":"Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. Cell Mol Gastroenterol Hepatol. 2020;10:327\u201340. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.04.001.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2199_CR29","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nri3738","volume":"14","author":"AM Mowat","year":"2014","unstructured":"Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14:667\u201385. https:\/\/doi.org\/10.1038\/nri3738.","journal-title":"Nat Rev Immunol"},{"key":"2199_CR30","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1053\/j.gastro.2020.06.038","volume":"159","author":"M Rawat","year":"2020","unstructured":"Rawat M, Nighot M, Al-Sadi R, et al. IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p which degrades occludin mRNA. Gastroenterology. 2020;159:1375\u201389. https:\/\/doi.org\/10.1053\/j.gastro.2020.06.038.","journal-title":"Gastroenterology"},{"key":"2199_CR31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jcmgh.2020.04.001","volume":"10","author":"L Zuo","year":"2020","unstructured":"Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. Clin Mol Gastroenterol Hepatol. 2020;10:327\u201340. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.04.001.","journal-title":"Clin Mol Gastroenterol Hepatol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-024-02199-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-024-02199-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-024-02199-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:12:15Z","timestamp":1742371935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-024-02199-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2199"],"URL":"https:\/\/doi.org\/10.1007\/s00535-024-02199-4","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,13]]},"assertion":[{"value":"3 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"HO belongs to an endowed course supported by Miyarisan Pharmaceutical Co. Ltd., Fujifilm Medical Co. Ltd., Terumo Corporation, FANCL Corporation, and Seiwa Medical Corporation. ME is a consultant for AI Medical Service Inc. The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}