{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T23:15:25Z","timestamp":1794093325796,"version":"4.8.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23FC1027"],"award-info":[{"award-number":["23FC1027"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00535-025-02295-z","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:29:12Z","timestamp":1756819752000},"page":"1513-1522","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nationwide estimates of patient numbers and prevalence rates of ulcerative colitis and Crohn\u2019s disease in Japan in 2023"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-3717","authenticated-orcid":false,"given":"Anna","family":"Tsutsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Ohfuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakaba","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadakazu","family":"Hisamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"2295_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.pop.2017.07.010","volume":"44","author":"T Sairenji","year":"2017","unstructured":"Sairenji T, Collins KL, Evans DV. An update on inflammatory bowel disease. Prim Care. 2017;44:673\u201392. https:\/\/doi.org\/10.1016\/j.pop.2017.07.010.","journal-title":"Prim Care"},{"key":"2295_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","volume":"5","author":"S Alatab","year":"2020","unstructured":"Alatab S, Sepanlou SG, Ikuta K, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 2020;5:17\u201330. https:\/\/doi.org\/10.1016\/S2468-1253(19)30333-4.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2295_CR3","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769\u201378. https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0.","journal-title":"Lancet"},{"key":"2295_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08940-0","author":"L Hracs","year":"2025","unstructured":"Hracs L, Windsor JW, Gorospe J, et al. Global evolution of inflammatory bowel disease across epidemiologic stages. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08940-0.","journal-title":"Nature"},{"key":"2295_CR5","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1111\/j.1440-1746.2012.07150.x","volume":"27","author":"L Prideaux","year":"2012","unstructured":"Prideaux L, Kamm MA, De Cruz PP, et al. Inflammatory bowel disease in Asia: a systematic review. J Gastroenterol Hepatol. 2012;27:1266\u201380. https:\/\/doi.org\/10.1111\/j.1440-1746.2012.07150.x.","journal-title":"J Gastroenterol Hepatol"},{"key":"2295_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5217\/ir.2016.14.2.111","volume":"14","author":"WK Ng","year":"2016","unstructured":"Ng WK, Wong SH, Ng SC. Changing epidemiological trends of inflammatory bowel disease in Asia. Intest Res. 2016;14:111\u20139. https:\/\/doi.org\/10.5217\/ir.2016.14.2.111.","journal-title":"Intest Res"},{"key":"2295_CR7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/MIB.0000000000000313","volume":"21","author":"HJ Kim","year":"2015","unstructured":"Kim HJ, Hann HJ, Hong SN, et al. Incidence and natural course of inflammatory bowel disease in Korea, 2006\u20132012: a nationwide population-based study. Inflamm Bowel Dis. 2015;21:623\u201330. https:\/\/doi.org\/10.1097\/MIB.0000000000000313.","journal-title":"Inflamm Bowel Dis"},{"key":"2295_CR8","first-page":"3","volume":"62","author":"K Takahashi","year":"2014","unstructured":"Takahashi K, Izumi S, Takeuchi A. Epidemiologic studies with location information and their statistical methods (in Japanese). Proc Inst Stat Math. 2014;62:3\u201324.","journal-title":"Proc Inst Stat Math"},{"key":"2295_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0300580","volume":"19","author":"M Kodama","year":"2024","unstructured":"Kodama M, Okano S, Nojri S, et al. Longitudinal and regional association between dietary factors and prevalence of Crohn\u2019s disease in Japan. PLoS ONE. 2024;19:e0300580. https:\/\/doi.org\/10.1371\/journal.pone.0300580.","journal-title":"PLoS ONE"},{"issue":"Suppl 8","key":"2295_CR10","first-page":"1","volume":"30","author":"N Morita","year":"1995","unstructured":"Morita N, Toki S, Hirohashi T, et al. Incidence and prevalence of inflammatory bowel disease in Japan: Nationwide epidemiological survey during the year 1991. J Gastroenterol. 1995;30(Suppl 8):1\u20134.","journal-title":"J Gastroenterol"},{"key":"2295_CR11","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1007\/s00535-019-01603-8","volume":"54","author":"Y Murakami","year":"2019","unstructured":"Murakami Y, Nishiwaki Y, Oba MS, et al. Estimated prevalence of ulcerative colitis and Crohn\u2019s disease in Japan in 2015: an analysis of a nationwide survey. J Gastroenterol. 2019;54:1070\u20137. https:\/\/doi.org\/10.1007\/s00535-019-01603-8.","journal-title":"J Gastroenterol"},{"key":"2295_CR12","unstructured":"The Ministry of Health, Labour and Welfare. Health and Labour Sciences Research Grant, Research on Epidemiologic Research for Intractable Diseases (Nakamura Group). [A manual of a nationwide epidemiological survey for estimating the number of patients and assessing clinico-epidemiological characteristics of patients with intractable diseases (3rd edition) (in Japanese)]. 2017. Available at: https:\/\/www.jichi.ac.jp\/dph\/nanbyou\/manual_2017.pdf. Accessed 4 June 2025."},{"key":"2295_CR13","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00535-021-01784-1","volume":"56","author":"H Nakase","year":"2021","unstructured":"Nakase H, Uchino M, Shinzaki S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 2021;56:489\u2013526. https:\/\/doi.org\/10.1007\/s00535-021-01784-1.","journal-title":"J Gastroenterol"},{"key":"2295_CR14","unstructured":"The Ministry of Health, Labour and Welfare. Health and Labour Sciences Research Grant, Research on Intractable Inflammatory Bowel Disorders (Hisamatsu Group). [Ulcerative colitis and Crohn\u2019s disease diagnostic criteria and treatment guidelines FY2022 revised edition (in Japanese)]. 2023. Available at: http:\/\/www.ibdjapan.org\/for_medical\/pdf\/doc15.pdf. Accessed 7 December 2023."},{"key":"2295_CR15","first-page":"880","volume":"38","author":"S Hashimoto","year":"1991","unstructured":"Hashimoto S, Fukutomi K, Nagai M, et al. A method of interval estimation for number of patients in the nationwide epidemiological survey on intractable diseases (in Japanese). Jpn J Public Health. 1991;38:880\u20133.","journal-title":"Jpn J Public Health."},{"key":"2295_CR16","unstructured":"The Ministry of Internal Affairs and Communications. Population Estimates by Age (Five-Year Groups) and Sex - October 1, 2023 (Final estimates), March 1, 2024 (Provisional estimates): Population Estimates \/ Monthly Report. In: e-Stat, Portal Site of Official Statistics of Japan. 2024. https:\/\/www.e-stat.go.jp\/en\/stat-search\/files?stat_infid=000040156581. Accessed 4 June 2025."},{"key":"2295_CR17","unstructured":"The Ministry of Health, Labour and Welfare. [Number of recipients of the Specific Medical Expense Subsidy (Designated Intractable Diseases), by age group and disease category: Annual Report on Public Health Administration and Services, FY2023 (in Japanese)]. In: e-Stat, Portal Site of Official Statistics of Japan. 2025. https:\/\/www.e-stat.go.jp\/stat-search\/files?stat_infid=000040217272. Accessed 4 June 2025."},{"key":"2295_CR18","unstructured":"The Ministry of Justice. Act on Medical Care for Patients with Intractable Diseases. In: Japanese Law Translation Database System. 2014. https:\/\/www.japaneselawtranslation.go.jp\/ja\/laws\/view\/3363. Accessed 4 June 2025."},{"key":"2295_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.31662\/jmaj.2021-0038","volume":"4","author":"M Chiba","year":"2021","unstructured":"Chiba M, Morita N, Nakamura A, et al. Increased incidence of inflammatory bowel disease in association with dietary transition (westernization) in Japan. JMA J. 2021;4:347\u201357. https:\/\/doi.org\/10.31662\/jmaj.2021-0038.","journal-title":"JMA J"},{"key":"2295_CR20","unstructured":"The Ministry of Internal Affairs and Communications. Population Estimates by Age (Five-Year Groups) and Sex - October 1, 2019 (Final estimates), March 1, 2020 (Provisional estimates): Population Estimates \/ Monthly Report. In: e-Stat, Portal Site of Official Statistics of Japan. 2020. https:\/\/www.e-stat.go.jp\/en\/stat-search\/files?stat_infid=000031918730. Accessed 4 June 2025."},{"key":"2295_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/jgh.16387","volume":"39","author":"S Yoshida","year":"2024","unstructured":"Yoshida S, Imai S, Fushimi K. Changes in surgery rates among hospitalized patients with inflammatory bowel disease in Japan from 2015 to 2019: A nationwide administrative database analysis. J Gastroenterol Hepatol. 2024;39:272\u20139. https:\/\/doi.org\/10.1111\/jgh.16387.","journal-title":"J Gastroenterol Hepatol"},{"key":"2295_CR22","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00535-022-01907-2","volume":"57","author":"K Matsuoka","year":"2022","unstructured":"Matsuoka K, Fujii T, Okamoto R, et al. Characteristics of adult patients newly diagnosed with Crohn\u2019s disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn\u2019s disease in Japan (iCREST-CD). J Gastroenterol. 2022;57:867\u201378. https:\/\/doi.org\/10.1007\/s00535-022-01907-2.","journal-title":"J Gastroenterol"},{"key":"2295_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00384-023-04417-6","volume":"38","author":"M Yamazaki","year":"2023","unstructured":"Yamazaki M, Chung H, Xu Y, et al. Trends in the prevalence and incidence of ulcerative colitis in Japan and the US. Int J Colorectal Dis. 2023;38:135\u20136. https:\/\/doi.org\/10.1007\/s00384-023-04417-6.","journal-title":"Int J Colorectal Dis"},{"key":"2295_CR24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00535-024-02086-y","volume":"59","author":"D Hirayama","year":"2024","unstructured":"Hirayama D, Hyodo S, Morita K, Nakase H. Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis. J Gastroenterol. 2024;59:389\u2013401. https:\/\/doi.org\/10.1007\/s00535-024-02086-y.","journal-title":"J Gastroenterol"},{"key":"2295_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.70175","volume":"9","author":"M Urushiyama","year":"2025","unstructured":"Urushiyama M, Tarasawa K, Moroi R, et al. Evolving trends in pediatric inflammatory bowel disease management in Japan: a decade of nationwide data. JGH Open. 2025;9:e70175. https:\/\/doi.org\/10.1002\/jgh3.70175.","journal-title":"JGH Open"},{"key":"2295_CR26","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s00535-019-01658-7","volume":"55","author":"A Masamune","year":"2020","unstructured":"Masamune A, Kikuta K, Hamada S, et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. J Gastroenterol. 2020;55:462\u201370. https:\/\/doi.org\/10.1007\/s00535-019-01658-7.","journal-title":"J Gastroenterol"},{"key":"2295_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.2188\/jea.JE20210277","volume":"32","author":"W Fukushima","year":"2022","unstructured":"Fukushima W, Hara M, Kitamura Y, et al. A nationwide epidemiological survey of adolescent patients with diverse symptoms similar to those following human papillomavirus vaccination: background prevalence and incidence for considering vaccine safety in Japan. J Epidemiol. 2022;32:34\u201343. https:\/\/doi.org\/10.2188\/jea.JE20210277.","journal-title":"J Epidemiol"},{"key":"2295_CR28","first-page":"768","volume":"37","author":"S Hashimoto","year":"1990","unstructured":"Hashimoto S, Fukutomi K, Nagai M, et al. A note on methods for estimating the number of patients in the nationwide epidemiological survey on intractable diseases (in Japanese). Jpn J Public Health. 1990;37:768\u201374.","journal-title":"Jpn J Public Health."},{"key":"2295_CR29","doi-asserted-by":"publisher","first-page":"328","DOI":"10.5217\/ir.2023.00012","volume":"21","author":"HH Lee","year":"2023","unstructured":"Lee HH, Park JJ, Lee BI, et al. Diagnosis of inflammatory bowel disease\u2013Asian perspectives: the results of a multinational web-based survey in the 8th Asian organization for Crohn\u2019s and colitis meeting. Intest Res. 2023;21:328\u201338. https:\/\/doi.org\/10.5217\/ir.2023.00012.","journal-title":"Intest Res"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-025-02295-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-025-02295-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-025-02295-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:14:20Z","timestamp":1763550860000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-025-02295-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2295"],"URL":"https:\/\/doi.org\/10.1007\/s00535-025-02295-z","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AT and YM received commissioned research funding from Daiichi Sankyo Company, Limited for the Department of Medical Statistics, Toho University in the past 36\u00a0months. AT also holds stock in AstraZeneca PLC. YM also served on the advisory board for Cardiopoint Japan K.K. in the past 36\u00a0months. KM received research grants and contracts from Mochida Pharmaceutical Co., Ltd., EA Pharma Co., Ltd., AbbVie GK, and Nippon Kayaku Co., Ltd. in the past 36\u00a0months. KM also received consulting fees from Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Company Limited, Janssen Pharmaceutical K.K., AbbVie GK, EA Pharma Co., Ltd., Pfizer Japan Inc., Mochida Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Gilead Sciences K.K., Celltrion Healthcare Japan K.K., Eli Lilly Japan K.K., and Bristol-Myers Squibb K.K. in the past 36\u00a0months. KM also received payments and honoraria from Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Company Limited, Janssen Pharmaceutical K.K., AbbVie GK, EA Pharma Co., Ltd., Pfizer Japan Inc., Mochida Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Zeria Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Gilead Sciences K.K., Celltrion Healthcare Japan K.K., Eli Lilly Japan K.K., and Bristol-Myers Squibb K.K. in the past 36\u00a0months. TH received research grants from Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., AbbVie GK, JIMRO Co., Ltd., Zeria Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., Mochida Pharmaceutical Co., Ltd., Boston Scientific Corporation, and Kissei Pharmaceutical Co., Ltd. in the past 36\u00a0months. TH also received consulting fees from Mitsubishi Tanabe Pharma Corporation, EA Pharma Co., Ltd., AbbVie GK, Janssen Pharmaceutical K.K., Pfizer Inc., Eli Lilly, Gilead Sciences, Bristol-Myers Squibb, and Abivax in the past 36\u00a0months. TH also received lecture fees from Mitsubishi Tanabe Pharma Corporation, AbbVie GK, EA Pharma Co., Ltd., Kyorin Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Janssen Pharmaceutical K.K., Mochida Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., and Kissei Pharmaceutical Co., Ltd. in the past 36\u00a0months.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}