{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:07:22Z","timestamp":1791284842468,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2021YFA0910100"],"award-info":[{"award-number":["2021YFA0910100"]}]},{"name":"Healthy Zhejiang One Million People Cohort","award":["K-20230085"],"award-info":[{"award-number":["K-20230085"]}]},{"name":"Post-doctoral Innovative Talent Support Program","award":["BX2023375"],"award-info":[{"award-number":["BX2023375"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304946"],"award-info":[{"award-number":["82304946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473489"],"award-info":[{"award-number":["82473489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403546"],"award-info":[{"award-number":["82403546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR21H280001"],"award-info":[{"award-number":["LR21H280001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["ZCLQN25H1602"],"award-info":[{"award-number":["ZCLQN25H1602"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Medicine and Health Science Fund of Zhejiang Province Health Commission","award":["2025KY047"],"award-info":[{"award-number":["2025KY047"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023N743560"],"award-info":[{"award-number":["2023N743560"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00535-025-02305-0","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:04:36Z","timestamp":1759896276000},"page":"1496-1512","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of integrin \u03b13 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake"],"prefix":"10.1007","volume":"60","author":[{"given":"Weiwei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"issue":"3","key":"2305_CR1","first-page":"264","volume":"71","author":"SS Joshi","year":"2021","unstructured":"Joshi SS, Badgwell BD. Current treatment and recent progress in gastric cancer. CA Cancer J Clin. 2021;71(3):264\u201379.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2305_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"W-L Guan","year":"2023","unstructured":"Guan W-L, He Y, Xu R-H. Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol. 2023;16(1):57.","journal-title":"J Hematol Oncol"},{"issue":"2","key":"2305_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.6004\/jnccn.2022.0008","volume":"20","author":"JA Ajani","year":"2022","unstructured":"Ajani JA, D\u2019amico TA, Bentrem DJ, et al. Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology [J]. J Natl Compr Canc Netw. 2022;20(2):167\u201392.","journal-title":"J Natl Compr Canc Netw"},{"issue":"8","key":"2305_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41571-021-00492-2","volume":"18","author":"Y Nakamura","year":"2021","unstructured":"Nakamura Y, Kawazoe A, Lordick F, et al. Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm [J]. Nat Rev Clin Oncol. 2021;18(8):473\u201387.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"2305_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41573-021-00284-4","volume":"21","author":"RJ Slack","year":"2022","unstructured":"Slack RJ, Macdonald SJF, Roper JA, et al. Emerging therapeutic opportunities for integrin inhibitors [J]. Nat Rev Drug Discov. 2022;21(1):60\u201378.","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"2305_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a004994","volume":"3","author":"ID Campbell","year":"2011","unstructured":"Campbell ID, Humphries MJ. Integrin structure, activation, and interactions [J]. Cold Spring Harb Perspect Biol. 2011;3(3):1.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"2305_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","volume":"8","author":"X Pang","year":"2023","unstructured":"Pang X, He X, Qiu Z, et al. Targeting integrin pathways: mechanisms and advances in therapy [J]. Signal Transduct Target Ther. 2023;8(1):1.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"2305_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","volume":"35","author":"J Cooper","year":"2019","unstructured":"Cooper J, Giancotti FG. Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance [J]. Cancer Cell. 2019;35(3):347\u201367.","journal-title":"Cancer Cell"},{"key":"2305_CR9","doi-asserted-by":"publisher","first-page":"588066","DOI":"10.3389\/fcell.2020.588066","volume":"8","author":"EJ Park","year":"2020","unstructured":"Park EJ, Myint PK, Ito A, et al. Integrin-ligand interactions in inflammation, cancer, and metabolic disease: insights into the multifaceted roles of an emerging ligand Irisin. Front Cell Dev Biol. 2020;8:588066.","journal-title":"Front Cell Dev Biol"},{"issue":"36","key":"2305_CR10","doi-asserted-by":"publisher","first-page":"e2309907","DOI":"10.1002\/smll.202309907","volume":"20","author":"C Xiao","year":"2024","unstructured":"Xiao C, Xie N, Shu Q, et al. Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin-Mediated Cell-ECM Interactions [J]. Small. 2024;20(36):e2309907.","journal-title":"Small"},{"issue":"2","key":"2305_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41580-024-00777-1","volume":"26","author":"MR Chastney","year":"2025","unstructured":"Chastney MR, Kaivola J, Lepp\u00e4nen V-M, et al. The role and regulation of integrins in cell migration and invasion. Nat Rev Mol Cell Biol. 2025;26(2):147\u201367.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2305_CR12","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.2147\/OTT.S201675","volume":"12","author":"Y Jiao","year":"2019","unstructured":"Jiao Y, Li Y, Liu S, et al. ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer [J]. Onco Targets Ther. 2019;12:4141\u201352.","journal-title":"Onco Targets Ther"},{"key":"2305_CR13","doi-asserted-by":"publisher","first-page":"e926800","DOI":"10.12659\/MSM.926800","volume":"26","author":"C Feng","year":"2020","unstructured":"Feng C, Jin X, Han Y, et al. Expression and prognostic analyses of ITGA3, ITGA5, and ITGA6 in head and neck squamous cell carcinoma. Med Sci Monit. 2020;26:e926800.","journal-title":"Med Sci Monit"},{"issue":"4","key":"2305_CR14","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/annonc\/mdq542","volume":"22","author":"M Scartozzi","year":"2011","unstructured":"Scartozzi M, Loretelli C, Bearzi I, et al. Allele polymorphisms of tumor integrins correlate with peritoneal carcinosis capability of gastric cancer cells in radically resected patients. Ann Oncol. 2011;22(4):897\u2013902.","journal-title":"Ann Oncol"},{"key":"2305_CR15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.077","author":"M Liu","year":"2021","unstructured":"Liu M, Zhang Y, Yang J, et al. Zinc-dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer [J]. Gastroenterology. 2021. https:\/\/doi.org\/10.1053\/j.gastro.2020.12.077.","journal-title":"Gastroenterology"},{"key":"2305_CR16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.038","author":"M Liu","year":"2020","unstructured":"Liu M, Zhang Y, Yang J, et al. ZIP4 increases expression of transcription factor ZEB1 to promote integrin \u03b13\u03b21 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic cancer cells [J]. Gastroenterology. 2020. https:\/\/doi.org\/10.1053\/j.gastro.2019.10.038.","journal-title":"Gastroenterology"},{"issue":"7","key":"2305_CR17","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1053\/j.gastro.2024.07.038","volume":"167","author":"X Cheng","year":"2024","unstructured":"Cheng X, Dai E, Wu J, et al. Atlas of metastatic gastric cancer links ferroptosis to disease progression and immunotherapy response [J]. Gastroenterology. 2024;167(7):1345\u201357.","journal-title":"Gastroenterology"},{"issue":"4","key":"2305_CR18","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.7150\/ijbs.80324","volume":"19","author":"C Hu","year":"2023","unstructured":"Hu C, Zu D, Xu J, et al. Polyphyllin B suppresses gastric tumor growth by modulating iron metabolism and inducing ferroptosis [J]. Int J Biol Sci. 2023;19(4):1063\u201379.","journal-title":"Int J Biol Sci"},{"key":"2305_CR19","first-page":"370","volume":"8","author":"F Liu","year":"2017","unstructured":"Liu F, Cheng Z, Li X, et al. A novel Pak1\/ATF2\/miR-132 signaling axis is involved in the hematogenous metastasis of gastric cancer cells. Mol Ther. 2017;8:370\u201382.","journal-title":"Mol Ther"},{"issue":"1","key":"2305_CR20","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1038\/s41467-022-30447-9","volume":"13","author":"Y Cheng","year":"2022","unstructured":"Cheng Y, Shen Z, Gao Y, et al. Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas [J]. Nat Commun. 2022;13(1):2724.","journal-title":"Nat Commun"},{"key":"2305_CR21","doi-asserted-by":"publisher","first-page":"105411","DOI":"10.1016\/j.phrs.2020.105411","volume":"165","author":"L Yuan","year":"2021","unstructured":"Yuan L, Mo S-W, Xu Z-Y, et al. P-MEK expression predicts prognosis of patients with adenocarcinoma of esophagogastric junction (AEG) and plays a role in anti-AEG efficacy of Huaier [j]. Pharmacol Res. 2021;165:105411.","journal-title":"Pharmacol Res"},{"key":"2305_CR22","doi-asserted-by":"publisher","first-page":"103519","DOI":"10.1016\/j.redox.2025.103519","volume":"80","author":"C Hu","year":"2025","unstructured":"Hu C, Xu J, Zhang Y, et al. Inhibition of glutathione peroxidase 4 suppresses gastric cancer peritoneal metastasis via regulation of RCC2 homeostasis. Redox Biol. 2025;80:103519.","journal-title":"Redox Biol"},{"issue":"1","key":"2305_CR23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12943-022-01538-4","volume":"21","author":"S Qi","year":"2022","unstructured":"Qi S, Guan X, Zhang J, et al. Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis [J]. Mol Cancer. 2022;21(1):70.","journal-title":"Mol Cancer"},{"issue":"8","key":"2305_CR24","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1038\/s41418-017-0053-8","volume":"25","author":"M Luo","year":"2018","unstructured":"Luo M, Wu L, Zhang K, et al. MiR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma [J]. Cell Death Differ. 2018;25(8):1457\u201372.","journal-title":"Cell Death Differ"},{"issue":"2","key":"2305_CR25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nm.4464","volume":"24","author":"ML Schulte","year":"2018","unstructured":"Schulte ML, Fu A, Zhao P, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models [J]. Nat Med. 2018;24(2):194\u2013202.","journal-title":"Nat Med"},{"issue":"2","key":"2305_CR26","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41419-024-06475-2","volume":"15","author":"R Peng","year":"2024","unstructured":"Peng R, Dong Y, Zheng M, et al. IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism [J]. Cell Death Dis. 2024;15(2):111.","journal-title":"Cell Death Dis"},{"issue":"3","key":"2305_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41575-022-00703-w","volume":"20","author":"M Alsina","year":"2023","unstructured":"Alsina M, Arrazubi V, Diez M, et al. Current developments in gastric cancer: from molecular profiling to treatment strategy [J]. Nat Rev Gastroenterol Hepatol. 2023;20(3):155\u201370.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"10251","key":"2305_CR28","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer. Lancet. 2020;396(10251):635\u201348.","journal-title":"Lancet"},{"key":"2305_CR29","doi-asserted-by":"publisher","first-page":"101080","DOI":"10.1016\/j.drup.2024.101080","volume":"74","author":"G Che","year":"2024","unstructured":"Che G, Yin J, Wang W, et al. Circumventing drug resistance in gastric cancer: a spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics [J]. Drug Resist Updat. 2024;74:101080.","journal-title":"Drug Resist Updat"},{"issue":"8","key":"2305_CR30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","volume":"20","author":"JZ Kechagia","year":"2019","unstructured":"Kechagia JZ, Ivaska J, Roca-Cusachs P. Integrins as biomechanical sensors of the microenvironment [J]. Nat Rev Mol Cell Biol. 2019;20(8):457\u201373.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"2305_CR31","doi-asserted-by":"publisher","first-page":"R536","DOI":"10.1016\/j.cub.2021.01.038","volume":"31","author":"MR Chastney","year":"2021","unstructured":"Chastney MR, Conway JRW, Ivaska J. Integrin adhesion complexes. Curr Biol. 2021;31(10):R536\u201342.","journal-title":"Curr Biol"},{"issue":"5","key":"2305_CR32","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ceb.2012.06.003","volume":"24","author":"J Qin","year":"2012","unstructured":"Qin J, Wu C. ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling. Curr Opin Cell Biol. 2012;24(5):607\u201313.","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"2305_CR33","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.devcel.2013.02.012","volume":"24","author":"H Wolfenson","year":"2013","unstructured":"Wolfenson H, Lavelin I, Geiger B. Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell. 2013;24(5):447\u201358.","journal-title":"Dev Cell"},{"issue":"4","key":"2305_CR34","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1083\/jcb.201609037","volume":"215","author":"Z Sun","year":"2016","unstructured":"Sun Z, Guo SS, F\u00e4ssler R. Integrin-mediated mechanotransduction [J]. J Cell Biol. 2016;215(4):445\u201356.","journal-title":"J Cell Biol"},{"key":"2305_CR35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ceb.2017.01.003","volume":"45","author":"EG Kleinschmidt","year":"2017","unstructured":"Kleinschmidt EG, Schlaepfer DD. Focal adhesion kinase signaling in unexpected places [J]. Curr Opin Cell Biol. 2017;45:24\u201330.","journal-title":"Curr Opin Cell Biol"},{"issue":"10","key":"2305_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.86829","volume":"1","author":"MP Iwanicki","year":"2016","unstructured":"Iwanicki MP, Chen H-Y, Iavarone C, et al. Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition [J]. JCI Insight. 2016;1(10):1.","journal-title":"JCI Insight"},{"issue":"2","key":"2305_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cmet.2019.11.020","volume":"31","author":"HC Yoo","year":"2020","unstructured":"Yoo HC, Park SJ, Nam M, et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells [J]. Cell Metab. 2020;31(2):1.","journal-title":"Cell Metab"},{"issue":"4","key":"2305_CR38","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1165\/rcmb.2022-0339OC","volume":"69","author":"M Choudhury","year":"2023","unstructured":"Choudhury M, Schaefbauer KJ, Kottom TJ, et al. Targeting pulmonary fibrosis by SLC1A5-dependent glutamine transport blockade [J]. Am J Respir Cell Mol Biol. 2023;69(4):441\u201355.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"24","key":"2305_CR39","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1038\/onc.2015.381","volume":"35","author":"M van Geldermalsen","year":"2016","unstructured":"van Geldermalsen M, Wang Q, Nagarajah R, et al. ASCT2\/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer [J]. Oncogene. 2016;35(24):3201\u20138.","journal-title":"Oncogene"},{"key":"2305_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.004","author":"H Weng","year":"2022","unstructured":"Weng H, Huang F, Yu Z, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022. https:\/\/doi.org\/10.1016\/j.ccell.2022.10.004.","journal-title":"Cancer Cell"},{"issue":"7","key":"2305_CR41","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/ijc.29535","volume":"137","author":"M Hassanein","year":"2015","unstructured":"Hassanein M, Qian J, Hoeksema MD, et al. Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer. Int J Cancer. 2015;137(7):1587\u201397.","journal-title":"Int J Cancer"},{"key":"2305_CR42","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00062-2022","author":"X Liu","year":"2022","unstructured":"Liu X, Qin H, Li Z, et al. Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC\/SLC1A5-dependent metabolic pathway. Eur Respir J. 2022. https:\/\/doi.org\/10.1183\/13993003.00062-2022.","journal-title":"Eur Respir J"},{"issue":"1","key":"2305_CR43","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41416-019-0637-9","volume":"122","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Liu R, Shuai Y, et al. ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma [J]. Br J Cancer. 2020;122(1):82\u201393.","journal-title":"Br J Cancer"},{"key":"2305_CR44","doi-asserted-by":"publisher","first-page":"104844","DOI":"10.1016\/j.phrs.2020.104844","volume":"158","author":"H Jiang","year":"2020","unstructured":"Jiang H, Zhang N, Tang T, et al. Target the human Alanine\/Serine\/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy [J]. Pharmacol Res. 2020;158:104844.","journal-title":"Pharmacol Res"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-025-02305-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-025-02305-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-025-02305-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:14:17Z","timestamp":1763550857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-025-02305-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2305"],"URL":"https:\/\/doi.org\/10.1007\/s00535-025-02305-0","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of Zhejiang Cancer Hospital (No.IRB-2023-960). All patients provided written informed consent to participate. This study conformed to the principles outlined in the Declaration of Helsinki (1964 and later version).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The content of this manuscript has not been previously published and is not under consideration for publication elsewhere. All of the authors agree to the content of the paper and their being listed as a co-author of the paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}