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As a probiotic,\n                      <jats:italic>Bifidobacterium bifidum<\/jats:italic>\n                      (\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      ) exhibits unique anti-inflammatory properties; however, whether and how it alleviate MASLD induced by HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      requires further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      MASLD mouse model was constructed by gavage administration with HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      W14 to assess the therapeutic effect of\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01 in vivo. Cell infection models, metabolomics sequencing, and in vitro antibacterial assays were integrated to systematically elucidate the mechanism by which\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01 mitigates HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      W14-induced cell damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01 was able to ameliorate MASLD induced by HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      through a multi-target mechanism. Compared to pair-fed mice, HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      W14 disrupted gut barrier and promoted inflammatory cytokines release. While, supplementation with\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01 reversed these effects by a) restoring intestinal integrity via upregulating tight junction proteins (ZO-1\/Occludin) and mucin protein MUC-2, reducing reactive oxidative stress (ROS) and apoptosis in colonic cells, and b) rescuing hepatic cytochrome P450 2E1 (CYP2E1)-driven oxidative injury (ROS\/Caspase-3) while promoting mitochondrial\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -oxidation, as well as c) directly suppressing HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      proliferation and biofilm formation. Metabolomics and 16S rRNA of fecal samples analyses revealed\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01-mediated metabolic regulation: depletion of toxic branched-chain amino acids (BCAAs) intermediates and restoration of energy homeostasis and antioxidant defense alongside increased short-chain fatty acids (SCFAs)-associated pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings highlight\n                      <jats:italic>B. bifidum<\/jats:italic>\n                      CIP-01 as a novel therapeutic candidate for HiAlc\n                      <jats:italic>Kpn<\/jats:italic>\n                      -induced MASLD, operating through a triad of pathogen suppression, gut\u2013liver axis repair, and metabolic regulation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00535-025-02332-x","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:11:11Z","timestamp":1766585471000},"page":"462-476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bifidobacterium bifidum CIP-01 attenuates metabolic dysfunction-associated steatotic liver disease induced by high-alcohol-producing Klebsiella pneumoniae"],"prefix":"10.1007","volume":"61","author":[{"given":"Xue","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rentao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"2332_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084156","author":"Y Sakurai","year":"2021","unstructured":"Sakurai Y, Kubota N, Yamauchi T, et al. 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