{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:55:53Z","timestamp":1782888953903,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474164"],"award-info":[{"award-number":["82474164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"DOI":"10.1007\/s00535-026-02474-6","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:20:42Z","timestamp":1782883242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["METTL3\/FTO drives ferroptosis in colorectal cancer by targeting m6A modification of MUC1 mRNA and YTHDF2-dependent SLC7A11\/GSH pathway"],"prefix":"10.1007","author":[{"given":"Zili","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"issue":"1","key":"2474_CR1","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A. Cancer statistics, 2025. CA Cancer J Clin. 2025;75(1):10\u201345.","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"2474_CR2","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1007\/s00535-025-02281-5","volume":"60","author":"F Du","year":"2025","unstructured":"Du F, Ji X, Su J, Liu C, Wang J, Ning T, et al. The pivotal role of SFRP2 in promoting glycolysis and progression in the high-risk group based on the glycometabolism prognostic model for colorectal cancer. J Gastroenterol. 2025;60(11):1400\u201313.","journal-title":"J Gastroenterol"},{"issue":"1","key":"2474_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02166-w","volume":"23","author":"Q Xie","year":"2024","unstructured":"Xie Q, Liu X, Liu R, Pan J, Liang J. Cellular mechanisms of combining innate immunity activation with PD-1\/PD-L1 blockade in treatment of colorectal cancer. Mol Cancer. 2024;23(1):252.","journal-title":"Mol Cancer"},{"issue":"19","key":"2474_CR4","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1158\/0008-5472.CAN-24-1620","volume":"84","author":"C Rolfo","year":"2024","unstructured":"Rolfo C, Russo A. The Next Frontier for Colorectal Cancer Screening: Blood-Based Tests. Cancer Res. 2024;84(19):3128\u20139.","journal-title":"Cancer Res"},{"key":"2474_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2026.158221","volume":"156","author":"J Sheng","year":"2026","unstructured":"Sheng J, An Q, Yu F, Xiao Y, Ding H, Wu L, et al. Lycorine suppresses DPP3-mediated Nrf2 signaling, thereby reducing SLC7A11 levels to trigger ferroptosis in colorectal cancer cells. Phytomedicine. 2026;156:158221.","journal-title":"Phytomedicine"},{"issue":"7","key":"2474_CR6","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.devcel.2025.02.004","volume":"60","author":"WC Lee","year":"2025","unstructured":"Lee WC, Dixon SJ. Mechanisms of ferroptosis sensitization and resistance. Dev Cell. 2025;60(7):982\u201393.","journal-title":"Dev Cell"},{"issue":"4","key":"2474_CR7","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41556-025-01640-x","volume":"27","author":"GI Lancaster","year":"2025","unstructured":"Lancaster GI, Murphy AJ. GPX4 methylation puts a brake on ferroptosis. Nat Cell Biol. 2025;27(4):556\u20137.","journal-title":"Nat Cell Biol"},{"issue":"7939","key":"2474_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","volume":"612","author":"R Kim","year":"2022","unstructured":"Kim R, Hashimoto A, Markosyan N, Tyurin VA, Tyurina YY, Kar G, et al. Ferroptosis of tumour neutrophils causes immune suppression in cancer. Nature. 2022;612(7939):338\u201346.","journal-title":"Nature"},{"issue":"3","key":"2474_CR9","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.molcel.2023.01.006","volume":"83","author":"E Sendinc","year":"2023","unstructured":"Sendinc E, Shi Y. RNA m6A methylation across the transcriptome. Mol Cell. 2023;83(3):428\u201341.","journal-title":"Mol Cell"},{"issue":"1","key":"2474_CR10","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1038\/s41467-025-59346-5","volume":"16","author":"N Katoku-Kikyo","year":"2025","unstructured":"Katoku-Kikyo N, Kawakami H, Cantor M, Kawakami Y, Kikyo N. METTL14 regulates chondrogenesis through the GDF5-RUNX-extracellular matrix gene axis during limb development. Nat Commun. 2025;16(1):4072.","journal-title":"Nat Commun"},{"issue":"9","key":"2474_CR11","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1016\/j.apsb.2024.05.025","volume":"14","author":"AT Kao","year":"2024","unstructured":"Kao AT, Cabanlong CV, Padilla K, Xue X. Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment. Acta Pharm Sin B. 2024;14(9):3785\u2013801.","journal-title":"Acta Pharm Sin B"},{"issue":"4","key":"2474_CR12","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s43018-023-00715-8","volume":"5","author":"H Zheng","year":"2024","unstructured":"Zheng H, Liu J, Cheng Q, Zhang Q, Zhang Y, Jiang L, et al. Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance. Nat Cancer. 2024;5(4):572\u201389.","journal-title":"Nat Cancer"},{"issue":"9","key":"2474_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202508541","volume":"13","author":"J Wang","year":"2026","unstructured":"Wang J, Dai X, Liu H, Hua S, Chang H, Sun H, et al. HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11\/GPX4. Adv Sci (Weinh). 2026;13(9):e08541.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"2474_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12943-024-02144-2","volume":"23","author":"JX Shi","year":"2024","unstructured":"Shi JX, Zhang ZC, Yin HZ, Piao XJ, Liu CH, Liu QJ, et al. RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy. Mol Cancer. 2024;23(1):225.","journal-title":"Mol Cancer"},{"issue":"3","key":"2474_CR15","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jtho.2023.12.014","volume":"19","author":"A Yalamanchali","year":"2024","unstructured":"Yalamanchali A, Hassan KA. MUC1-C: the Occam razor of osimertinib resistance? J Thorac Oncol. 2024;19(3):370\u20132.","journal-title":"J Thorac Oncol"},{"key":"2474_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103509","volume":"80","author":"Q Pang","year":"2025","unstructured":"Pang Q, Zhou S, Wang Y, Pan H, Wang Z, Qin X, et al. GAMG alleviates liver fibrosis through inducing ferroptosis in inflammatory macrophages via the IRF1\/SLC7A11 signaling pathway. Redox Biol. 2025;80:103509.","journal-title":"Redox Biol"},{"key":"2474_CR17","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.2147\/JIR.S402592","volume":"16","author":"H Wang","year":"2023","unstructured":"Wang H, Sun Y, Xiao FJ, Zhao X, Zhang WY, Xia YJ, et al. Mesenchymal Stem Cells Ameliorate DSS-Induced Experimental Colitis by Modulating the Gut Microbiota and MUC-1 Pathway. J Inflamm Res. 2023;16:2023\u201339.","journal-title":"J Inflamm Res"},{"issue":"30","key":"2474_CR18","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1038\/s41388-021-01899-y","volume":"40","author":"M Hagiwara","year":"2021","unstructured":"Hagiwara M, Fushimi A, Yamashita N, Bhattacharya A, Rajabi H, Long MD, et al. MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells. Oncogene. 2021;40(30):4930\u201340.","journal-title":"Oncogene"},{"issue":"1","key":"2474_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41420-023-01772-9","volume":"10","author":"T Daimon","year":"2024","unstructured":"Daimon T, Bhattacharya A, Wang K, Haratake N, Nakashoji A, Ozawa H, et al. MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells. Cell Death Discov. 2024;10(1):9.","journal-title":"Cell Death Discov"},{"issue":"8","key":"2474_CR20","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1007\/s12033-024-01250-2","volume":"67","author":"W Chen","year":"2025","unstructured":"Chen W, Liu C, He Y, Jiang T, Chen Q, Zhang H, et al. ALKBH5-Mediated m6A Modification Drives Apoptosis in Renal Tubular Epithelial Cells by Negatively Regulating MUC1. Mol Biotechnol. 2025;67(8):3255\u201367.","journal-title":"Mol Biotechnol"},{"key":"2474_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2026.157912","volume":"153","author":"Y Sun","year":"2026","unstructured":"Sun Y, Zhuang Y, Cheng K, Wei Y, Li M, Xuan J, et al. YTHDF2-orchestrated m6A methylation of BECN1 induces Scoparone-mediated hepatic stellate cell ferroptosis to attenuate liver fibrosis. Phytomedicine. 2026;153:157912.","journal-title":"Phytomedicine"},{"key":"2474_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102151","volume":"47","author":"M Shen","year":"2021","unstructured":"Shen M, Li Y, Wang Y, Shao J, Zhang F, Yin G, et al. N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells. Redox Biol. 2021;47:102151.","journal-title":"Redox Biol"},{"key":"2474_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101619","volume":"36","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Guo M, Shen M, Kong D, Zhang F, Shao J, et al. The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells. Redox Biol. 2020;36:101619.","journal-title":"Redox Biol"},{"issue":"8","key":"2474_CR24","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","volume":"16","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, et al. RNA-binding protein ZFP36\/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. Autophagy. 2020;16(8):1482\u2013505.","journal-title":"Autophagy"},{"key":"2474_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102971","volume":"69","author":"Y Li","year":"2024","unstructured":"Li Y, Guo M, Qiu Y, Li M, Wu Y, Shen M, et al. Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma. Redox Biol. 2024;69:102971.","journal-title":"Redox Biol"},{"key":"2474_CR26","doi-asserted-by":"publisher","first-page":"D955","DOI":"10.1093\/nar\/gks1111","volume":"41","author":"W Yang","year":"2013","unstructured":"Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013;41:D955\u201361.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"2474_CR27","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s00535-025-02300-5","volume":"60","author":"K Hino","year":"2025","unstructured":"Hino K, Nishina S, Yanatori I. Ferroptosis: biology and role in liver disease. J Gastroenterol. 2025;60(11):1339\u201361.","journal-title":"J Gastroenterol"},{"issue":"1","key":"2474_CR28","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1038\/s41467-025-58992-z","volume":"16","author":"Z Zhao","year":"2025","unstructured":"Zhao Z, He J, Qiu S, Wang L, Huangfu S, Hu Y, et al. Targeting PLK1-CBX8-GPX4 axis overcomes BRAF\/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis. Nat Commun. 2025;16(1):3605.","journal-title":"Nat Commun"},{"issue":"9","key":"2474_CR29","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1158\/0008-5472.CAN-24-1940","volume":"85","author":"Y Lin","year":"2025","unstructured":"Lin Y, Zhang Y, Huang T, Chen J, Li G, Zhang B, et al. Arginine deprivation induces quiescence and confers vulnerability to ferroptosis in colorectal cancer. Cancer Res. 2025;85(9):1663\u201379.","journal-title":"Cancer Res"},{"issue":"1","key":"2474_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12943-023-01782-2","volume":"22","author":"H Zhuang","year":"2023","unstructured":"Zhuang H, Yu B, Tao D, Xu X, Xu Y, Wang J, et al. The role of m6A methylation in therapy resistance in cancer. Mol Cancer. 2023;22(1):91.","journal-title":"Mol Cancer"},{"key":"2474_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217004","volume":"596","author":"Y Bian","year":"2024","unstructured":"Bian Y, Xu S, Gao Z, Ding J, Li C, Cui Z, et al. m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21\/IGF2BP2\/ FOXM1 positive feedback loop. Cancer Lett. 2024;596:217004.","journal-title":"Cancer Lett"},{"key":"2474_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134691","volume":"473","author":"J Feng","year":"2024","unstructured":"Feng J, Zhang P, Chen K, Huang P, Liang X, Dong J, et al. Soot nanoparticles promote ferroptosis in dopaminergic neurons via alteration of m6A RNA methylation in Parkinson\u2019s disease. J Hazard Mater. 2024;473:134691.","journal-title":"J Hazard Mater"},{"key":"2474_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116576","volume":"230","author":"L Song","year":"2024","unstructured":"Song L, Liu H, Yang W, Yin H, Wang J, Guo M, et al. Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders. Biochem Pharmacol. 2024;230:116576.","journal-title":"Biochem Pharmacol"},{"key":"2474_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133692","volume":"467","author":"M Jiang","year":"2024","unstructured":"Jiang M, Han J, Ma Q, Chen X, Xu R, Wang Q, et al. Nicotine-derived NNK promotes CRC progression through activating TMUB1\/AKT pathway in METTL14\/YTHDF2-mediated m6A manner. J Hazard Mater. 2024;467:133692.","journal-title":"J Hazard Mater"},{"issue":"16-18","key":"2474_CR35","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1089\/ars.2023.0291","volume":"40","author":"P Pang","year":"2024","unstructured":"Pang P, Si W, Wu H, Ju J, Liu K, Wang C, et al. YTHDF2 promotes cardiac ferroptosis via degradation of SLC7A11 in cardiac ischemia-reperfusion injury. Antioxid Redox Signal. 2024;40(16\u201318):889\u2013905.","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2474_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00820-x","volume":"18","author":"F Wang","year":"2023","unstructured":"Wang F, Sun Z, Zhang Q, Yang H, Yang G, Yang Q, et al. Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer. Chin Med. 2023;18(1):122.","journal-title":"Chin Med"},{"key":"2474_CR37","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.biopha.2018.08.109","volume":"107","author":"M Guo","year":"2018","unstructured":"Guo M, You C, Dou J. Role of transmembrane glycoprotein mucin 1 (MUC1) in various types of colorectal cancer and therapies: current research status and updates. Biomed Pharmacother. 2018;107:1318\u201325.","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"2474_CR38","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.3390\/cancers15102680","volume":"15","author":"I Radziejewska","year":"2023","unstructured":"Radziejewska I. Galectin-3 and Epithelial MUC1 Mucin-Interactions Supporting Cancer Development. Cancers. 2023;15(10):2680.","journal-title":"Cancers"},{"issue":"1","key":"2474_CR39","first-page":"185","volume":"22","author":"CC Chang","year":"2020","unstructured":"Chang CC, Chao KC, Huang CJ, Hung CS, Wang YC. Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer. Mol Med Rep. 2020;22(1):185\u201392.","journal-title":"Mol Med Rep"},{"key":"2474_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103798","volume":"86","author":"J Yang","year":"2025","unstructured":"Yang J, Lin D, Huang Y, Yin S, Chen M, Sun H, et al. Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis. Redox Biol. 2025;86:103798.","journal-title":"Redox Biol"},{"issue":"1","key":"2474_CR41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13046-024-03032-9","volume":"43","author":"Y Qiao","year":"2024","unstructured":"Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, et al. Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11\/GPX4 expression. J Exp Clin Cancer Res. 2024;43(1):108.","journal-title":"J Exp Clin Cancer Res"},{"key":"2474_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1611299","volume":"16","author":"T Zhang","year":"2025","unstructured":"Zhang T, Gu F, Lin W, Shao H, Jiang A, Guan X. Boosting cancer immunotherapy: drug delivery systems leveraging ferroptosis and immune checkpoint blockade. Front Immunol. 2025;16:1611299.","journal-title":"Front Immunol"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-026-02474-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00535-026-02474-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00535-026-02474-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:20:44Z","timestamp":1782883244000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00535-026-02474-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":42,"alternative-id":["2474"],"URL":"https:\/\/doi.org\/10.1007\/s00535-026-02474-6","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study was approved by the ethical review committee of Nanjing University of Chinese Medicine. Written informed consent was obtained from all enrolled parties.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Patients agree to participate in this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}