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We aimed to elucidate temporal changes in BE status over a 10-year period using a database derived from repeated endoscopies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 9,741 subjects who underwent screening esophagogastroduodenoscopy in 2014 and at least one follow-up examination by December 2025 were included. Transitions in BE status between the index and final examinations were classified as progression, regression, or no change based on differences in BE length. Logistic regression analyses were performed to investigate factors associated with BE progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up period from the index to final examination was 8.8\u00a0years. Overall, BE\u2009\u2265\u20091\u00a0cm or BE\u2009\u2265\u20092\u00a0cm was newly identified at the final examination in 4.87% and 0.82%, respectively. Progression rates toward longer BE segments remained relatively constant across age groups, ranging from the 30\u00a0s to\u2009\u2265\u200970\u00a0years. Multivariable regression analyses revealed significant associations between reflux esophagitis and BE progression, with higher risks observed for both Los Angeles grade A and grade B or higher esophagitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BE status remained stable in the majority of subjects during approximately nine years of follow-up; however, new BE\u2009\u2265\u20091\u00a0cm and\u2009\u2265\u20092\u00a0cm developed in 4.87% and 0.82% of subjects, respectively. Such progression occurred irrespective of age at baseline, providing evidence supporting flexible, adaptive surveillance strategies for BE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00535-026-02495-1","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:41:47Z","timestamp":1785868907000},"page":"1408-1418","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural history of Barrett\u2019s esophagus over a 10-year period: a longitudinal endoscopic study in a Japanese population"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-1307","authenticated-orcid":false,"given":"Kenta","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Onochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Matsuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2495_CR1","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJMra1314704","volume":"371","author":"SJ Spechler","year":"2014","unstructured":"Spechler SJ, Souza RF. 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