{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:25:23Z","timestamp":1786980323215,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Anesth"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00540-018-2577-6","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T23:26:45Z","timestamp":1542065205000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro"],"prefix":"10.1007","volume":"33","author":[{"given":"Tianci","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongfang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-2097","authenticated-orcid":false,"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"2577_CR1","first-page":"16","volume-title":"World cancer report","author":"D Forman","year":"2014","unstructured":"Forman D, Ferlay J. The global and regional burden of cancer. In: Stewart B, Wild CP, editors. World cancer report. Lyon: International Agency for Research on Cancer; 2014. pp.\u00a016\u201353."},{"key":"2577_CR2","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/ALN.0b013e31829e47fd","volume":"119","author":"LL Benzonana","year":"2013","unstructured":"Benzonana LL, Perry NJ, Watts HR, Yang B, Perry IA, Coombes C, Takata M, Ma D. Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology. 2013;119:593\u2013605.","journal-title":"Anesthesiology"},{"key":"2577_CR3","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/bjc.2014.426","volume":"111","author":"H Huang","year":"2014","unstructured":"Huang H, Benzonana LL, Zhao H, Watts HR, Perry NJ, Bevan C, Brown R, Ma D. Prostate cancer cell malignancy via modulation of HIF-1alpha pathway with isoflurane and propofol alone and in combination. Br J Cancer. 2014;111:1338\u201349.","journal-title":"Br J Cancer"},{"key":"2577_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/anae.13342","volume":"71","author":"SJ Ciechanowicz","year":"2016","unstructured":"Ciechanowicz SJ, Ma D. Anaesthesia for oncological surgery\u2014can it really influence cancer recurrence? Anaesthesia. 2016;71:127\u201331.","journal-title":"Anaesthesia"},{"key":"2577_CR5","doi-asserted-by":"publisher","first-page":"26042","DOI":"10.18632\/oncotarget.8304","volume":"7","author":"M Iwasaki","year":"2016","unstructured":"Iwasaki M, Zhao H, Jaffer T, Unwith S, Benzonana L, Lian Q, Sakamoto A, Ma D. Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells. Oncotarget. 2016;7:26042\u201356.","journal-title":"Oncotarget"},{"key":"2577_CR6","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1097\/00000542-200610000-00008","volume":"105","author":"AK Exadaktylos","year":"2006","unstructured":"Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology. 2006;105:660\u20134.","journal-title":"Anesthesiology"},{"key":"2577_CR7","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/ALN.0b013e31817f5b73","volume":"109","author":"B Biki","year":"2008","unstructured":"Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology. 2008;109:180\u20137.","journal-title":"Anesthesiology"},{"key":"2577_CR8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cct.2008.01.002","volume":"29","author":"DI Sessler","year":"2008","unstructured":"Sessler DI, Ben-Eliyahu S, Mascha EJ, Parat MO, Buggy DJ. Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial. Contemp Clin Trials. 2008;29:517\u201326.","journal-title":"Contemp Clin Trials"},{"key":"2577_CR9","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/00000542-200703000-00014","volume":"106","author":"H Wada","year":"2007","unstructured":"Wada H, Seki S, Takahashi T, Kawarabayashi N, Higuchi H, Habu Y, Sugahara S, Kazama T. Combined spinal and general anesthesia attenuates liver metastasis by preserving TH1\/TH2 cytokine balance. Anesthesiology. 2007;106:499\u2013506.","journal-title":"Anesthesiology"},{"issue":"Suppl 1","key":"2577_CR10","doi-asserted-by":"publisher","first-page":"i39","DOI":"10.1093\/bja\/aeu104","volume":"113","author":"DT Baptista-Hon","year":"2014","unstructured":"Baptista-Hon DT, Robertson FM, Robertson GB, Owen SJ, Rogers GW, Lydon EL, Lee NH, Hales TG. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. Br J Anaesth. 2014;113(Suppl 1):i39\u201348.","journal-title":"Br J Anaesth"},{"key":"2577_CR11","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/ALN.0b013e3182661977","volume":"117","author":"T Piegeler","year":"2012","unstructured":"Piegeler T, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, Minshall RD, Borgeat A. Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade. Anesthesiology. 2012;117:548\u201359.","journal-title":"Anesthesiology"},{"key":"2577_CR12","doi-asserted-by":"publisher","first-page":"26277","DOI":"10.1038\/srep26277","volume":"6","author":"W Xuan","year":"2016","unstructured":"Xuan W, Zhao H, Hankin J, Chen L, Yao S, Ma D. Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro. Sci Rep. 2016;6:26277.","journal-title":"Sci Rep"},{"key":"2577_CR13","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ccr.2014.03.015","volume":"25","author":"HJ Clarke","year":"2014","unstructured":"Clarke HJ, Chambers JE, Liniker E, Marciniak SJ. Endoplasmic reticulum stress in malignancy. Cancer Cell. 2014;25:563\u201373.","journal-title":"Cancer Cell"},{"key":"2577_CR14","doi-asserted-by":"publisher","first-page":"7652","DOI":"10.3390\/ijms12117652","volume":"12","author":"DY Hong","year":"2011","unstructured":"Hong DY, Kwon K, Lee KR, Choi YJ, Goo TW, Yu K, Kim SW, Kwon OY. Lidocaine induces endoplasmic reticulum stress-associated apoptosis in vitro and in vivo. Int J Mol Sci. 2011;12:7652\u201361.","journal-title":"Int J Mol Sci"},{"key":"2577_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.phrs.2015.03.017","volume":"95\u201396","author":"A Bundscherer","year":"2015","unstructured":"Bundscherer A, Malsy M, Gebhardt K, Metterlein T, Plank C, Wiese CH, Gruber M, Graf BM. Effects of ropivacaine, bupivacaine and sufentanil in colon and pancreatic cancer cells in vitro. Pharmacol Res 2015; 95\u201396:126\u201331.","journal-title":"Pharmacol Res"},{"key":"2577_CR16","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.mito.2011.03.010","volume":"12","author":"C Jose","year":"2012","unstructured":"Jose C, Bellance N, Chatelain EH, Benard G, Nouette-Gaulain K, Rossignol R. Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile. Mitochondrion. 2012;12:100\u20139.","journal-title":"Mitochondrion"},{"key":"2577_CR17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ceb.2010.09.007","volume":"23","author":"KT Pfaffenbach","year":"2011","unstructured":"Pfaffenbach KT, Lee AS. The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol. 2011;23:150\u20136.","journal-title":"Curr Opin Cell Biol"},{"key":"2577_CR18","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334:1081\u20136.","journal-title":"Science"},{"key":"2577_CR19","doi-asserted-by":"publisher","first-page":"e05434","DOI":"10.7554\/eLife.05434","volume":"4","author":"AS Mendez","year":"2015","unstructured":"Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife 2015; 4:e05434.","journal-title":"Elife"},{"key":"2577_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ijc.23479","volume":"123","author":"MP Davies","year":"2008","unstructured":"Davies MP, Barraclough DL, Stewart C, Joyce KA, Eccles RM, Barraclough R, Rudland PS, Sibson DR. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer. 2008;123:85\u20138.","journal-title":"Int J Cancer"},{"key":"2577_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1247\/csf.07044","volume":"33","author":"Y Adachi","year":"2008","unstructured":"Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct. 2008;33:75\u201389.","journal-title":"Cell Struct Funct"},{"key":"2577_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.molcel.2010.01.041","volume":"38","author":"K Bourougaa","year":"2010","unstructured":"Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S, Fahraeus R. Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53\/47. Mol Cell. 2010;38:78\u201388.","journal-title":"Mol Cell"},{"key":"2577_CR23","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","volume":"7","author":"D Scheuner","year":"2001","unstructured":"Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001;7:1165\u201376.","journal-title":"Mol Cell"},{"key":"2577_CR24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","volume":"11","author":"S Oyadomari","year":"2004","unstructured":"Oyadomari S, Mori M. Roles of CHOP\/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381\u20139.","journal-title":"Cell Death Differ"},{"key":"2577_CR25","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","volume":"1833","author":"R Sano","year":"2013","unstructured":"Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta. 2013;1833:3460\u201370.","journal-title":"Biochim Biophys Acta"},{"key":"2577_CR26","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ygyno.2012.11.024","volume":"128","author":"K Matsuo","year":"2013","unstructured":"Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA, Yoo EJ, Dubeau L, Lee AS, Lin YG. The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol. 2013;128:552\u20139.","journal-title":"Gynecol Oncol"},{"key":"2577_CR27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10549-014-2967-x","volume":"145","author":"YZ Zheng","year":"2014","unstructured":"Zheng YZ, Cao ZG, Hu X, Shao ZM. The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Res Treat. 2014;145:349\u201358.","journal-title":"Breast Cancer Res Treat"},{"key":"2577_CR28","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/anae.13414","volume":"71","author":"RKY Yasumura","year":"2016","unstructured":"Yasumura RKY, Ochiai R. A comparison of plasma levobupivacaine concentrations following transversus abdominis plane block and rectus sheath block. Anaesthesia. 2016;71:544\u20139.","journal-title":"Anaesthesia"},{"key":"2577_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijoa.2017.04.007","volume":"32","author":"BCR Trabelsi","year":"2017","unstructured":"Trabelsi BCR, Bennasr L, Marzouk SB, Eljebari H, Jebabli N, Sassi MB, Trabelsi S, Maghrebi H. Pharmacokinetics of bupivacaine after bilateral ultrasound-guided transversus abdominis plane block following cesarean delivery under spinal anesthesia. Int J Obstet Anesth 2017;32:17\u201320.","journal-title":"Int J Obstet Anesth"},{"key":"2577_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1445-2197.2012.06210.x","volume":"84","author":"MRTM Thanapal","year":"2014","unstructured":"Thanapal MRTM, Tan AJ, Subramaniam T, Tong JM, Palayan K, Rampal S, Gurunathan R. Pre-emptive intraperitoneal local anaesthesia: an effective method in immediate post-operative pain management and metabolic stress response in laparoscopic appendicectomy, a randomized, double-blinded, placebo-controlled study. ANZ J Surg. 2014;84:47\u201351.","journal-title":"ANZ J Surg"},{"key":"2577_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/SLA.0b013e318221f0cf","volume":"254","author":"AST Kahokehr","year":"2011","unstructured":"Kahokehr AST, Zargar Shoshtari K, Taylor M, Hill AG. Intraperitoneal local anesthetic improves recovery after colon resection: a double-blinded randomized controlled trial. Ann Surg. 2011;254:28\u201338.","journal-title":"Ann Surg"}],"container-title":["Journal of Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00540-018-2577-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-018-2577-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-018-2577-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T19:34:19Z","timestamp":1573587259000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00540-018-2577-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["2577"],"URL":"https:\/\/doi.org\/10.1007\/s00540-018-2577-6","relation":{},"ISSN":["0913-8668","1438-8359"],"issn-type":[{"value":"0913-8668","type":"print"},{"value":"1438-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"25 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}