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Among screened 333\u00a0days, isoflurane was used in 97\u00a0days, while in 187\u00a0days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients\u2019 age (median [interquartile range]) was 64 (60\u201368) years. They were invasively ventilated for 36 [21\u201350] days. End-tidal isoflurane concentrations were high (0.96\u2009\u00b1\u20090.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)\/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5\u2009\u00b1\u20091.4 versus 7.1\u2009\u00b1\u20093.2\u00a0ml\u2219h<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In five patients, the maximum recommended dose of propofol of 4\u00a0mg\u2219hour<jats:sup>\u22121<\/jats:sup>\u2219kg<jats:sup>\u22121<\/jats:sup>ABW was exceeded on several days. On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), as were co-sedatives (7% versus 31%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); daily opioid doses were lower (720 [720\u2013960] versus 1080 [720\u20131620] mg morphine equivalents, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); and RASS scores indicated deeper levels of sedation (\u2212\u00a04.0 [\u2212\u00a04.0 to \u2212\u00a03.0] versus \u2212\u00a03.0 [\u2212\u00a03.6 to \u2212\u00a02.5]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00540-021-02960-6","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T03:35:12Z","timestamp":1624592112000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients\u2014a retrospective chart review"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-0062","authenticated-orcid":false,"given":"Azzeddine","family":"Kermad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Speltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Danziger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Mertke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp M.","family":"Lepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"2960_CR1","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1213\/ane.0000000000004887","volume":"131","author":"D Hanidziar","year":"2020","unstructured":"Hanidziar D, Bittner EA. 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Jacques Speltz, MD: J. Speltz\u2019s presented data are part of his doctoral thesis. Guy Danziger, MD D.E.S.A: none. Thilo Mertke, MD: none. Robert Bals, MD PhD FERS: none Thomas Volk, MD PhD: Received consulting fees from Sedana Medical (Danderyd, Sweden). Philipp Lepper, MD PhD: none. Andreas Meiser, MD PhD: received consulting fees from Sedana Medical (Danderyd, Sweden) and honoraria for lectures from Pall Corporation (Dreieich, Germany).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}