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Perioperative hemodynamics and clinical outcomes were compared between the Groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence of hypotension during anesthesia requiring repeated treatment with vasoconstrictors was higher in Group C than Group W (<jats:italic>p<\/jats:italic>\u2009=\u20090.0052). Blood pressure during anesthesia was generally lower in Group C than Group W (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) despite significantly more doses of ephedrine and phenylephrine administrated in Group C (<jats:italic>p<\/jats:italic>\u2009=\u20090.0246 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0327, respectively). The incidence of postoperative hypertension did not differ between Groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.3793). Estimated glomerular filtration rate (eGFR) on the preoperative day did not differ between Groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.7045), while eGFR was slightly lower in Group C than Group W on the first and third postoperative days (<jats:italic>p<\/jats:italic>\u2009=\u20090.0400 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0088, respectively), although clinically relevant acute kidney injury did not develop.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Continuing ARB\/CCB combination tablets preoperatively in patients undergoing minor surgery increased the incidence of hypotension during anesthesia, increased requirements of vasoconstrictors to treat hypotension, and might deteriorate postoperative renal function, albeit slightly. These results suggest that withholding ARB\/CCB tablets preoperatively is preferable to continuing them.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration<\/jats:title>\n                <jats:p>This trial is registered with the Japan Registry of Clinical Trials (jRCT) at Japanese Ministry of Health, Labour, and Welfare (Trial ID: jRCT1031190027).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00540-022-03053-8","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:02:43Z","timestamp":1646485363000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Continuing versus withholding angiotensin receptor blocker (ARB)\/calcium channel blocker (CCB) combination tablets during perioperative periods in patients undergoing minor surgery: a single-blinded randomized controlled trial"],"prefix":"10.1007","volume":"36","author":[{"given":"Kazuyo","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-2281","authenticated-orcid":false,"given":"Masakazu","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kudoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maho","family":"Kakemizu-Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Kawagoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"3053_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/hr.2013.80","volume":"37","author":"K Shimamoto","year":"2014","unstructured":"Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, Ito S, Itoh H, Iwao H, Kai H, Kario K, Kashihara N, Kawano Y, Kim-Mitsuyama S, Kimura G, Kohara K, Komuro I, Kumagai H, Matsuura H, Miura K, Morishita R, Naruse M, Node K, Ohya Y, Rakugi H, Saito I, Saitoh S, Shimada K, Shimosawa T, Suzuki H, Tamura K, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Umemura S, Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension. 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