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VO<jats:sub>2<\/jats:sub> and VCO<jats:sub>2<\/jats:sub> were measured at different intervals: upon awakening (T1), 15\u00a0min after tracheal intubation (T2), and 1\u00a0h after T2 (T3). Oxygen delivery (DO<jats:sub>2<\/jats:sub>) was calculated simultaneously with these measurements. VO<jats:sub>2<\/jats:sub> was ascertained using an indirect calorimeter and further calculated using vital signs, among other factors. DO<jats:sub>2<\/jats:sub> was derived from cardiac output and arterial blood gas analysis performed with an arterial pressure-based cardiac output measurement system.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>VO<jats:sub>2<\/jats:sub>, VCO<jats:sub>2<\/jats:sub>, and DO<jats:sub>2<\/jats:sub> decreased significantly from T1 to T2 and T3 [VO<jats:sub>2<\/jats:sub>\/body surface area (BSA) (ml\/min\/m<jats:sup>2<\/jats:sup>): T1, 130 (122\u2013146); T2, 107 (83\u2013139); T3, 97 (93\u2013121); <jats:italic>p<\/jats:italic>\u2009=\u20090.011], [VCO<jats:sub>2<\/jats:sub>\/BSA (ml\/min\/m<jats:sup>2<\/jats:sup>): T1, 115 (105\u2013129); T2, 90 (71\u2013107); T3, 81 (69\u2013101); <jats:italic>p<\/jats:italic>\u2009=\u20090.011], [DO<jats:sub>2<\/jats:sub>\/BSA (ml\/min\/m<jats:sup>2<\/jats:sup>): T1, 467 (395\u2013582); T2, 347 (286\u2013392); T3, 382 (238\u2013414); <jats:italic>p<\/jats:italic>\u2009=\u20090.0020]. Among the study subjects, a subset exhibited minimal reduction in VCO<jats:sub>2<\/jats:sub>. Although the respiratory frequency was titrated on the basis of end-tidal CO<jats:sub>2<\/jats:sub> levels, there was no significant difference between the groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>General anesthetic induction with remimazolam decreased VO<jats:sub>2<\/jats:sub>, VCO<jats:sub>2<\/jats:sub>, and DO<jats:sub>2<\/jats:sub>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00540-024-03362-0","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:02:24Z","timestamp":1717675344000},"page":"622-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in oxygen supply\u2013demand balance during induction of general anesthesia: an exploratory study using remimazolam"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-8077","authenticated-orcid":false,"given":"Kenya","family":"Yarimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Nakane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneyuki","family":"Kawamae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"2","key":"3362_CR1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s005400200011","volume":"16","author":"K Hirota","year":"2002","unstructured":"Hirota K. 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