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Emergence agitation\u00a0(EA) occurrence was assessed by PAED scale and 5-point agitation scale. Pain was judged using Face, Legs, Activity, Cry, and Consolability (FLACC) scale. The recovery time, extubation time, and post-anesthesia care unit (PACU) stay time were recorded for all three groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Patients administered 1\u00a0\u03bcg\/kg of dexmedetomidine (8.8%) and individuals given 0.3\u00a0mg\/kg of esketamine (11.8%) showed lower incidences of emergence agitation compared to those receiving saline (35.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.009). There was no statistically significant difference in the time to discharge from the PACU among the three groups of patients (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The recovery time and extubation time were notably extended in the dexmedetomidine group (40.88\u2009\u00b1\u200912.95\u00a0min, 42.50\u2009\u00b1\u200913.38\u00a0min) when compared to the saline group (32.56\u2009\u00b1\u200913.05\u00a0min, 33.29\u2009\u00b1\u200911.30\u00a0min; <jats:italic>P<\/jats:italic>\u2009=\u20090.009, <jats:italic>P<\/jats:italic>\u2009=\u20090.010).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Following CO<jats:sub>2<\/jats:sub> pneumoperitoneum in pediatric laparoscopic surgeries, the intravenous administration of 1\u00a0\u03bcg\/kg dexmedetomidine or 0.3\u00a0mg\/kg esketamine effectively lowers EA occurrence without extending PACU time.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00540-024-03410-9","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T15:01:22Z","timestamp":1727622082000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of intravenous different drugs on the prevention of restlessness during recovery period of pediatric laparoscopic surgery: a randomized control trial"],"prefix":"10.1007","volume":"39","author":[{"given":"Zhi-Jie","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Mei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ling","family":"Nong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni-Qiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Xin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Nan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"3410_CR1","first-page":"667","volume":"22","author":"JE Eckenhoff","year":"1961","unstructured":"Eckenhoff JE, Kneale DH, Dripps RD. 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