{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:59:45Z","timestamp":1781344785005,"version":"3.54.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Anesth"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The influence of anesthetic interactions on motor-evoked potentials in infants has rarely been reported. In infants, adding a small dose of sevoflurane to propofol-based total intravenous anesthesia is reasonable for reducing propofol administration. We collected preliminary data regarding the effect of low-dose sevoflurane in propofol-based total intravenous anesthesia on motor-evoked potentials in infants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This pilot interventional study included 10 consecutive infants requiring motor-evoked potentials between January 2023 and March 2024. The motor-evoked potential amplitudes in the upper and lower extremities were recorded twice when general anesthesia was maintained using (1) propofol-based total intravenous anesthesia and (2) 0.1\u20130.15 age-adjusted minimum alveolar concentration sevoflurane\u2009+\u2009propofol-based total intravenous anesthesia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The motor-evoked potential amplitude in the right upper extremity was not significantly different after the addition of a small dose of sevoflurane [192 (75.3\u2013398) \u03bcV, 121 (57.7\u2013304) \u03bcV, <jats:italic>P<\/jats:italic>\u2009=\u20090.19]. All the motor-evoked potential amplitudes in the right lower extremity (quadriceps femoris, anterior tibialis, and gastrocnemius muscles) were significantly attenuated by adding a small dose of sevoflurane (median [interquartile range]: 47.9 [35.4\u2013200] \u03bcV, 25.2 [12.4\u201355.3] \u03bcV, <jats:italic>P<\/jats:italic>\u2009=\u20090.014; 74.2 [51.9\u2013232] \u03bcV, 31.2 [2.7\u201364] \u03bcV, <jats:italic>P<\/jats:italic>\u2009=\u20090.0039; 29.8 [20\u2013194] \u03bcV, 9.9 [3.8\u201392.4] \u03bcV, <jats:italic>P<\/jats:italic>\u2009=\u20090.0039, respectively). Similar results were observed in the left lower extremities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Adding even 0.1\u20130.15 age-adjusted minimum alveolar concentration sevoflurane to propofol-based total intravenous anesthesia attenuated the motor-evoked potential amplitudes in the lower extremities. A further prospective interventional study with an appropriate sample size is required to investigate the study hypothesis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00540-024-03436-z","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:20:36Z","timestamp":1733052036000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of low-dose sevoflurane with propofol-based anesthesia on motor-evoked potentials in infants: a single-arm crossover pilot study"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-9815","authenticated-orcid":false,"given":"Taiki","family":"Kojima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nakahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kurimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"3436_CR1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00004691-199805000-00005","volume":"15","author":"TB Sloan","year":"1998","unstructured":"Sloan TB. Anesthetic effects on electrophysiologic recordings. J Clin Neurophysiol. 1998;15:217\u201326.","journal-title":"J Clin Neurophysiol"},{"key":"3436_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00381-009-1023-3","volume":"26","author":"T Sloan","year":"2010","unstructured":"Sloan T, Sloan T. Anesthesia and intraoperative neurophysiological monitoring in children. Childs Nerv Syst. 2010;26:227\u201335.","journal-title":"Childs Nerv Syst"},{"key":"3436_CR3","doi-asserted-by":"publisher","DOI":"10.1055\/a-2103-7381","author":"S Tanaka","year":"2024","unstructured":"Tanaka S, Yamamoto K, Yoshida S, Tomio R, Fujimoto T, Osaka M, Ishikawa T, Shimizu T, Akao N, Nishimatsu T. Anesthetic fade in intraoperative transcranial motor-evoked potential monitoring is mainly due to decreased synaptic transmission at the neuromuscular junction by propofol accumulation. 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