{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:39:29Z","timestamp":1773819569975,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Anesth"],"DOI":"10.1007\/s00540-026-03717-9","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:32:38Z","timestamp":1773815558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of perioperative antibiotic usage in the operating room during the 2019 cefazolin shortage in Japan: a multicenter observational study"],"prefix":"10.1007","author":[{"given":"Yoji","family":"Kabasawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-3532","authenticated-orcid":false,"given":"Tomonori","family":"Takazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshie","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiki","family":"Kanemaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Tuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Sakimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"3717_CR1","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1111\/bcp.15842","volume":"89","author":"JK Aronson","year":"2023","unstructured":"Aronson JK, Heneghan C, Ferner RE. Drug shortages. Part 1. definitions and harms. Br J Clin Pharmacol. 2023;89:2950\u20136.","journal-title":"Br J Clin Pharmacol"},{"key":"3717_CR2","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1111\/bcp.15853","volume":"89","author":"JK Aronson","year":"2023","unstructured":"Aronson JK, Heneghan C, Ferner RE. Drug shortages. Part 2: Trends, causes and solutions. Br J Clin Pharmacol. 2023;89:2957\u201363.","journal-title":"Br J Clin Pharmacol"},{"key":"3717_CR3","unstructured":"Ministry of Health Labour and Welfare (Japan). The 33rd Meeting of the Health Sciences Council\u2019s Infectious Diseases Subcommittee Report: \u2018Regarding the Decline in the Supply of Cefazolin\u2019 [In Japanese] 2019. [Available from: https:\/\/www.mhlw.go.jp\/content\/10906000\/000527494.pdf.]"},{"key":"3717_CR4","unstructured":"The Drug Shortages Task Force. Drug Shortages: Root Causes and Potential Solutions. U.S. Food and Drug Administration. 2019. [Available from: https:\/\/www.fda.gov\/media\/131130\/download.]"},{"key":"3717_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00540-023-03217-0","volume":"37","author":"T Takazawa","year":"2023","unstructured":"Takazawa T. Sustainable development goals for Japanese anesthesiologists: how to survive in times of turmoil. J Anesth. 2023;37:499\u2013502.","journal-title":"J Anesth"},{"key":"3717_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2146\/ajhp120568","volume":"70","author":"DW Bratzler","year":"2013","unstructured":"Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70:195\u2013283.","journal-title":"Am J Health Syst Pharm"},{"key":"3717_CR7","unstructured":"Takemasu Y, Kishimoto H, Kubo S, Sakamoto H, Suzuki T, Takahashi K, Hashimoto M, Hotomi M, Matsushita K, Mikamo H, Yamada K, Yamamoto S, Yuzuki Y, Mayumi T, Oka M, Kitagawa Y, Konishi T, Fukushima R, Obara H, Kobayashi M, Takeda S. Practical Guidelines for Appropriate Use of Antimicrobial Agents for Surgical Site Infection Prophylaxis [in Japanese]. City: Jpn Chemother Surg Infect Guideline. 2016."},{"key":"3717_CR8","unstructured":"Nichi-Iko Pharmaceutical Co., Ltd. press release. Cefazolin Sodium Details of Supply Issue:\u00a0Nichi-Iko. 2019 May 13. [Available from: https:\/\/www.nichiiko.co.jp\/english\/press\/detail\/4657\/815\/4541_20190513_CEZ_E.pdf.]"},{"key":"3717_CR9","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1097\/BRS.0000000000003946","volume":"46","author":"H Nakarai","year":"2021","unstructured":"Nakarai H, Yamada K, Tonosu J, Abe H, Watanabe K, Yoshida Y, et al. The impact of cefazolin shortage on surgical site infection following spine surgery in Japan. Spine (Phila Pa 1976). 2021;46:923\u201330.","journal-title":"Spine (Phila Pa 1976)"},{"key":"3717_CR10","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.jos.2022.08.004","volume":"28","author":"S Sugiura","year":"2023","unstructured":"Sugiura S, Shimura H, Fujita K, Ogawa T, Nimura A. Comparison of ceftriaxone and cefazolin as prophylactic antibiotics for surgical site infection in orthopedic upper extremity surgery: the nationwide shortage of cefazolin in March 2019. J Orthop Sci. 2023;28:1018\u201322.","journal-title":"J Orthop Sci"},{"key":"3717_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10101247","author":"A Uda","year":"2021","unstructured":"Uda A, Onuma K, Shigemura K, Kitagawa K, Yan Y, Osawa K, et al. Impact of cefazolin shortage on clinical outcomes of adult patients with bacteremia caused by methicillin-susceptible Staphylococcus aureus in a tertiary care university hospital. Antibiotics. 2021. https:\/\/doi.org\/10.3390\/antibiotics10101247.","journal-title":"Antibiotics"},{"key":"3717_CR12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1186\/s13104-019-4849-0","volume":"12","author":"J Komagamine","year":"2019","unstructured":"Komagamine J, Yabuki T, Hiraiwa T. A trend in prevalence of antimicrobial use and appropriateness of antimicrobial therapy in an acute care hospital from 2018 to 2019: repeated prevalence surveys in Japan. BMC Res Notes. 2019;12:811.","journal-title":"BMC Res Notes"},{"key":"3717_CR13","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1186\/s12913-021-07139-z","volume":"21","author":"R Koizumi","year":"2021","unstructured":"Koizumi R, Kusama Y, Asai Y, Yoshiaki G, Muraki Y, Ohmagari N. Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials. BMC Health Serv Res. 2021;21:1118.","journal-title":"BMC Health Serv Res"},{"key":"3717_CR14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jgar.2022.06.010","volume":"30","author":"D Miyamori","year":"2022","unstructured":"Miyamori D, Kamitani T, Kashiyama S, Ito M, Ohge H, Yamamoto Y. Bacterial susceptibility changes post national shortage of first cephalosporin in Japan: a longitudinal retrospective database study using interrupted time series analysis. J Glob Antimicrob Resist. 2022;30:348\u201353.","journal-title":"J Glob Antimicrob Resist"},{"key":"3717_CR15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jiph.2023.01.021","volume":"16","author":"H Nagano","year":"2023","unstructured":"Nagano H, Shin JH, Kunisawa S, Fushimi K, Nagao M, Imanaka Y. Impact of the cefazolin shortage on the selection and cost of parenteral antibiotics during the supply disruption period in Japan: a controlled interrupted time series analysis. J Infect Public Health. 2023;16:467\u201373.","journal-title":"J Infect Public Health"},{"key":"3717_CR16","unstructured":"Ministry of Health Labour and Welfare (Japan). Measures for Ensuring the Stable Supply of Cefazolin Sodium Injection [In Japanese] Tokyo: MHLW. 2019 [Available from: https:\/\/www.mhlw.go.jp\/content\/10900000\/000498133.pdf.]"},{"key":"3717_CR17","unstructured":"Ministry of Health Labour and Welfare (Japan). Summary of the Stakeholders\u2019 Meeting on Measures for the Stable Supply of Medical Pharmaceuticals [In Japanese] Tokyo: MHLW. 2020 [Available from: https:\/\/www.mhlw.go.jp\/content\/10807000\/000676422.pdf.]"},{"key":"3717_CR18","unstructured":"Ministry of Health Labour and Welfare (Japan). Materials for the 9th Meeting of the Pharmaceutical and Medical Device System Subcommittee, Health Science Council, FY2024: NHLW. 2024\u00a0[Available from: https:\/\/www.mhlw.go.jp\/content\/11121000\/001340513.pdf.]"}],"container-title":["Journal of Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03717-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00540-026-03717-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03717-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:32:43Z","timestamp":1773815563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00540-026-03717-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":18,"alternative-id":["3717"],"URL":"https:\/\/doi.org\/10.1007\/s00540-026-03717-9","relation":{},"ISSN":["0913-8668","1438-8359"],"issn-type":[{"value":"0913-8668","type":"print"},{"value":"1438-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"10 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}