{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:07:13Z","timestamp":1782058033712,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","award":["JP23H24428"],"award-info":[{"award-number":["JP23H24428"]}]},{"name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","award":["JP21K08976"],"award-info":[{"award-number":["JP21K08976"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Anesth"],"DOI":"10.1007\/s00540-026-03753-5","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:11:42Z","timestamp":1777392702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transmembrane protein 45b in peripheral sensory neurons selectively mediates IL-31-dependent chemical itch"],"prefix":"10.1007","author":[{"given":"Tomoyuki","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Sunami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1535-6715","authenticated-orcid":false,"given":"Tomoyuki","family":"Kawamata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"3753_CR1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121989119","volume":"119","author":"T Tanioku","year":"2022","unstructured":"Tanioku T, Nishibata M, Tokinaga Y, Konno K, Watanabe M, Hemmi H, Ohta YF, Kaisyo T, Furue H, Kawamata T. Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity. Proc Natl Acad Sci U S A. 2022;119:e2121989119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3753_CR2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1126\/science.aaf8933","volume":"354","author":"C Peirs","year":"2016","unstructured":"Peirs C, Seal RP. Neural circuits for pain: recent advances and current view. Science. 2016;354:578\u201384.","journal-title":"Science"},{"key":"3753_CR3","doi-asserted-by":"publisher","first-page":"9075","DOI":"10.1073\/pnas.0901507106","volume":"106","author":"DJ Cavanaugh","year":"2009","unstructured":"Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci USA. 2009;106:9075\u201380.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3753_CR4","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.3390\/ph16121707","volume":"16","author":"MG Tsagareli","year":"2023","unstructured":"Tsagareli MG, Follansbee T, Carstens MI, Carstens E. Targeting transient receptor potential (TRP) channels, mas-related G-protein coupled receptors (Mergers), and protease-activated receptors (PARs) to relieve itch. Pharmaceuticals (Basel). 2023;16:1707.","journal-title":"Pharmaceuticals (Basel)"},{"key":"3753_CR5","doi-asserted-by":"publisher","first-page":"11330","DOI":"10.1073\/pnas.0905605106","volume":"106","author":"N Imamachi","year":"2009","unstructured":"Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci USA. 2009;106:11330\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3753_CR6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI160807","volume":"133","author":"O Chen","year":"2023","unstructured":"Chen O, He Q, Han Q, Furutani K, Gu Y, Olexa M, Ji RR. Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma. J Clin Invest. 2023;133:e160807.","journal-title":"J Clin Invest"},{"key":"3753_CR7","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.1233765","volume":"340","author":"SK Mishra","year":"2013","unstructured":"Mishra SK, Hoon MA. The cell and circuitry for itch responses in mice. Science. 2013;340:968\u201371.","journal-title":"Science"},{"key":"3753_CR8","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","volume":"133","author":"F Cevikbas","year":"2014","unstructured":"Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Ferld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum AI, Steinhoff M. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014;133:448\u201360.","journal-title":"J Allergy Clin Immunol"},{"key":"3753_CR9","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1073\/pnas.1019755108","volume":"108","author":"SJ Kim","year":"2011","unstructured":"Kim SJ, Park GH, Kim D, Han SK. Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanillin 1 (TRPV1)-expressing neurons. Proc Natl Acad Sci USA. 2011;108:3371\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3753_CR10","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.2147\/JIR.S470094","volume":"17","author":"QY Liu","year":"2024","unstructured":"Liu QY, Liu HF, Ye LQ, Li T, Chen ZM, Wang Y, Peng Z, Wan L. Vascular endothelial growth factor a promotes chronic itch via VEGFA-VEGFR2-PI3K-TRPV1 axis in allergic contact dermatitis. J Inflamm Res. 2024;17:7423\u201339.","journal-title":"J Inflamm Res"},{"key":"3753_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1708686","volume":"16","author":"SS Wang","year":"2025","unstructured":"Wang SS, Liang C, Wang RL, Sun ZL, Ren PY, Wu B, Sun JJ, Fu L, Xiao LZ, Sun WP, Li CL. Tmem45b modulates itch via endoplasmic reticulum calcium regulation. Front Physiol. 2025;16:1708686.","journal-title":"Front Physiol"},{"key":"3753_CR12","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.jaci.2019.06.031","volume":"144","author":"D Sakata","year":"2014","unstructured":"Sakata D, Uruno T, Matsubara K, Ando T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y. Selective role of neurotoxin B in IL-31-induced itch response in mice. J Allergy Clin Immunol. 2014;144:1130\u20133.","journal-title":"J Allergy Clin Immunol"},{"key":"3753_CR13","first-page":"16575","volume":"16","author":"N Inagaki","year":"2003","unstructured":"Inagaki N, Igeta K, Shiraishi N, Kim JF, Nagao M, Nakamura N, Nagai H. Evaluation and characterization of mouse scratching behavior by a new apparatus, microAct. Skin Pharmacol Appl Skin Physiol. 2003;16:16575.","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"3753_CR14","doi-asserted-by":"publisher","first-page":"922","DOI":"10.2340\/00015555-2697","volume":"97","author":"T Andoh","year":"2017","unstructured":"Andoh T, Harada A, Kuraishi Y. Involvement of leukotriene B4 released from keratinocytes in itch-associated response to intradermal interleukin-31 in mice. Acta Derm Venereol. 2017;97:922\u20137.","journal-title":"Acta Derm Venereol"},{"key":"3753_CR15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/npr2.12120","volume":"40","author":"N Kiguchi","year":"2020","unstructured":"Kiguchi N, Saika F, Fukazawa Y, Matsuzaki S, Kishioka S. Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch. Neuropsychopharmacol Rep. 2020;40:287\u201390.","journal-title":"Neuropsychopharmacol Rep"},{"key":"3753_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/08923973.2018.1510964","volume":"40","author":"NR Han","year":"2018","unstructured":"Han NR, Moon PD, Kim HM, Jeong HJ. Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis. Immunopharmacol Immunotoxicol. 2018;40:401\u20137.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"3753_CR17","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nm.3912","volume":"21","author":"M Shiratori-Hayashi","year":"2015","unstructured":"Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nat Med. 2015;21:927\u201331.","journal-title":"Nat Med"},{"key":"3753_CR18","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/s41593-018-0119-z","volume":"21","author":"J Huang","year":"2018","unstructured":"Huang J, Polg\u00e1r E, Solinski HJ, Mishra SK, Tseng PY, Iwagaki N, Biyle KA, Dickie AC, Kriegbaum MC, Wildner H, Zeilhofer HU, Watanabe M, Riddle JS, Todd AJ, Hoon MA. Circuit dissection of the role of somatostatin in itch and pain. Nat Neurosci. 2018;21:707\u201316.","journal-title":"Nat Neurosci"},{"key":"3753_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/qjmed\/hcg002","volume":"96","author":"R Twycross","year":"2003","unstructured":"Twycross R, Greaves MW, Handwerker H, Jones EA, Libretto SE, Szepietowski JC, Zylicz Z. Itch: scratching more than the surface. QJM. 2003;96:7\u201326.","journal-title":"QJM"},{"key":"3753_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071290","volume":"24","author":"DN Che","year":"2019","unstructured":"Che DN, Cho BO, Shin JY, Kang HJ, Kim JS, Oh H, Kim YS, Jang S. Apigenin inhibits IL-31 cytokine in human mast cell and mouse skin tissues. Molecules. 2019;24:1290.","journal-title":"Molecules"},{"key":"3753_CR21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/sj.bjp.0705754","volume":"142","author":"JK Bell","year":"2004","unstructured":"Bell JK, McQueen DS, Rees JL. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. Br J Pharmacol. 2004;142:374\u201380.","journal-title":"Br J Pharmacol"},{"key":"3753_CR22","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","volume":"139","author":"Q Liu","year":"2009","unstructured":"Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009;139:1353\u201365.","journal-title":"Cell"},{"key":"3753_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001925","volume":"4","author":"Q Liu","year":"2011","unstructured":"Liu Q, Weng HJ, Patel KN, Tang Z, Bai H, Steinhoff M, Dong X. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal. 2011;4:ra45.","journal-title":"Sci Signal"},{"key":"3753_CR24","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/ni1084","volume":"5","author":"SR Dillon","year":"2004","unstructured":"Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levine SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Noval J, Gross JA. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004;5:752\u201360.","journal-title":"Nat Immunol"},{"key":"3753_CR25","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/j.jid.2020.03.959","volume":"140","author":"SH Lee","year":"2020","unstructured":"Lee SH, Tonello R, Choi Y, Jung SJ, Berta T. Sensory neuron-expressed TRPC4 is a target for the relief of psoriasiform itch and skin inflammation in mice. J Invest Derm. 2020;140:2221\u20139.","journal-title":"J Invest Derm"},{"key":"3753_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nri3150","volume":"12","author":"DH Kaplan","year":"2012","unstructured":"Kaplan DH, Igyarto BZ, Gaspari AA. Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol. 2012;12:114\u201324.","journal-title":"Nat Rev Immunol"},{"key":"3753_CR27","doi-asserted-by":"publisher","first-page":"6639","DOI":"10.1038\/s41598-018-25094-4","volume":"8","author":"A Takamori","year":"2018","unstructured":"Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Toshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 2018;8:6639.","journal-title":"Sci Rep"},{"key":"3753_CR28","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","volume":"39","author":"MR Mack","year":"2018","unstructured":"Mack MR, Kim BS. The itch-scratch cycle: a neuroimmune perspective. Trends Immunol. 2018;39:980\u201391.","journal-title":"Trends Immunol"},{"key":"3753_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172702","volume":"864","author":"S Inan","year":"2019","unstructured":"Inan S, Huerta AT, Jensen LE, Dun NJ, Cowan A. Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decrease IL-31, and increases IL-10 in mice with contact dermatitis. Eur J Pharmacol. 2019;864:172702.","journal-title":"Eur J Pharmacol"},{"key":"3753_CR30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/exd.14464","volume":"31","author":"L Tang","year":"2022","unstructured":"Tang L, Gao J, Cao X, Chen L, Wang H, Ding H. TRPV1 mediates itch-associated scratching and skin barrier dysfunction in DFNB-induced atopic dermatitis mice. Exp Dermatol. 2022;31:398\u2013405.","journal-title":"Exp Dermatol"},{"key":"3753_CR31","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","volume":"171","author":"LK Oetjen","year":"2017","unstructured":"Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell. 2017;171:217\u201328.","journal-title":"Cell"},{"key":"3753_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","volume":"18","author":"D Usoskin","year":"2015","unstructured":"Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko PV, Linnarsson S, Ernfors P. Unbiased classification of sensory neuron types by large-scale single-cell sequencing. Nat Neurosci. 2015;18:145\u201353.","journal-title":"Nat Neurosci"},{"key":"3753_CR33","doi-asserted-by":"publisher","first-page":"13202","DOI":"10.1523\/JNEUROSCI.3248-09.2009","volume":"29","author":"H Wang","year":"2009","unstructured":"Wang H, Zylka MJ. Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantial gelatinous neurons. J Neurosci. 2009;29:13202\u20139.","journal-title":"J Neurosci"},{"key":"3753_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113433","volume":"42","author":"S Takahashi","year":"2023","unstructured":"Takahashi S, Ochiai S, Jin J, Takahashi N, Toshima S, Ishigame H, Kabashima K, Kubo M, Nakayama M, Shiroguchi K, Okada T. Sensory neuronal STAT3 is crucial for IL-31 receptor expression and inflammatory itch. Cell Rep. 2023;42:113433.","journal-title":"Cell Rep"},{"key":"3753_CR35","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.jaci.2017.12.1002","volume":"141","author":"J Meng","year":"2018","unstructured":"Meng J, Moriyama M, Feld M, Buddenkotte J, Buhl T, Szollosi A, Zhang J, Miller P, Ghetti A, Fisher M, Reeh PW, Shan C, Wang J, Steinhoff M. New mechanism underlying IL-31-induced atopic dermatitis. J Allergy Clin Immunol. 2018;141:1677\u201389.","journal-title":"J Allergy Clin Immunol"},{"key":"3753_CR36","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1056\/NEJMoa1606490","volume":"376","author":"T Ruzicka","year":"2017","unstructured":"Ruzicka T, Hanifin JM, Furue M, Pulka G, Mlynarczyk I, Wollenberg A, Galus R, Etoh T, Mihara R, Yoshida H, Stewart J, Kabashima K. Anti\u2013interleukin-31 receptor A antibody for atopic dermatitis. N Engl J Med. 2017;376:826\u201335.","journal-title":"N Engl J Med"}],"container-title":["Journal of Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03753-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00540-026-03753-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03753-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T06:02:23Z","timestamp":1782021743000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00540-026-03753-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":36,"alternative-id":["3753"],"URL":"https:\/\/doi.org\/10.1007\/s00540-026-03753-5","relation":{},"ISSN":["0913-8668","1438-8359"],"issn-type":[{"value":"0913-8668","type":"print"},{"value":"1438-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}