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Experiments were conducted in strict accordance with the ARRIVE guidelines and the Guidelines for Proper Conduct of Animal Experiments issued by the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the Science Council of Japan.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors acknowledge the use of artificial intelligence tools, including ChatGPT (OpenAI), Genspark AI documents, and AI-powered fact-checking systems, for language refinement, literature organization, and content structuring during the preparation of this manuscript. All scientific content, clinical interpretations, and conclusions were independently verified, critically evaluated, and finalized by the authors, who take full responsibility for the accuracy and integrity of this work. No AI tool except for Fig.\u00a0\n                      \n                      was used for the generation, modification, or enhancement of any figures, images, or original data presented in this manuscript, in strict compliance with Springer Nature editorial policies on the use of AI in scientific publishing. Figure preparation (Fig.\u00a0\n                      \n                      ): An AI-based image generation tool (Gemini Nano Banana Pro, Google DeepMind) was used to generate an initial conceptual layout for the mechanistic schematic. The final figure was subsequently redrawn and finalized by the authors using BioRender.com (Science Suite Inc., Toronto, Canada). All scientific content, biological pathways, anatomical structures, and textual labels were designed, reviewed, and verified by the authors. Figure\u00a0\n                      \n                      is presented as a conceptual schematic of the hypothesized mechanism and does not depict original experimental data.","order":4,"name":"Ethics","label":"Use of artificial intelligence tools (author declarations)","group":{"name":"EthicsHeading","label":"Declarations"}}]}}