{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:52:46Z","timestamp":1791255166708,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08897"],"award-info":[{"award-number":["18K08897"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Anesth"],"DOI":"10.1007\/s00540-026-03917-3","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:25:49Z","timestamp":1791253549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a low-level superoxide-containing environment on SOD activity and cerebral ischemia\u2013reperfusion injury"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3934-7024","authenticated-orcid":false,"given":"Keiko","family":"Uemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"3917_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ng1295-376","volume":"11","author":"Y Li","year":"1995","unstructured":"Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995;11:376\u201381.","journal-title":"Nat Genet"},{"key":"3917_CR2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1749-6632.1999.tb07820.x","volume":"893","author":"TT Huang","year":"1999","unstructured":"Huang TT, Carlson EJ, Raineri I, Gillespie AM, Kozy H, Epstein CJ. The use of transgenic and mutant mice to study oxygen free radical metabolism. Ann N Y Acad Sci. 1999;893:95\u2013112.","journal-title":"Ann N Y Acad Sci"},{"key":"3917_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1161\/01.STR.25.1.165","volume":"25","author":"G Yang","year":"1994","unstructured":"Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, et al. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke. 1994;25:165\u201370.","journal-title":"Stroke"},{"key":"3917_CR4","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1161\/hs0302.103745","volume":"33","author":"GW Kim","year":"2002","unstructured":"Kim GW, Kondo T, Noshita N, Chan PH. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia\/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke. 2002;33:809\u201315.","journal-title":"Stroke"},{"key":"3917_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0014-5793(97)00651-0","volume":"410","author":"EA Kosenko","year":"1997","unstructured":"Kosenko EA, Kaminsky YuG, Stavrovskaya IG, Sirota TV, Kondrashova MN. The stimulatory effect of negative air ions and hydrogen peroxide on the activity of superoxide dismutase. FEBS Lett. 1997;410:309\u201312.","journal-title":"FEBS Lett"},{"key":"3917_CR6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1600-0668.2004.00254.x","volume":"14","author":"H Iwama","year":"2004","unstructured":"Iwama H. Negative air ions created by water shearing improve erythrocyte deformability and aerobic metabolism. Indoor Air. 2004;14:293\u20137.","journal-title":"Indoor Air"},{"key":"3917_CR7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1097\/00003246-200206000-00014","volume":"30","author":"H Iwama","year":"2002","unstructured":"Iwama H, Ohmizo H, Furuta S, Ohmori S, Watanabe K, Kaneko T, et al. Inspired superoxide anions attenuate blood lactate concentrations in postoperative patients. Crit Care Med. 2002;30:1246\u20139.","journal-title":"Crit Care Med"},{"key":"3917_CR8","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S1474-4422(09)70054-7","volume":"8","author":"U Dirnagl","year":"2009","unstructured":"Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 2009;8:398\u2013412.","journal-title":"Lancet Neurol"},{"key":"3917_CR9","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1002\/jnr.23005","volume":"90","author":"K Kitagawa","year":"2012","unstructured":"Kitagawa K. Ischemic tolerance in the brain: endogenous adaptive machinery against ischemic stress. J Neurosci Res. 2012;90:1043\u201354.","journal-title":"J Neurosci Res"},{"key":"3917_CR10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.advms.2016.11.006","volume":"62","author":"K Stokfisz","year":"2017","unstructured":"Stokfisz K, Ledakowicz-Polak A, Zagorski M, Zielinska M. Ischaemic preconditioning-Current knowledge and potential future applications after 30 years of experience. Adv Med Sci. 2017;62:307\u201316.","journal-title":"Adv Med Sci"},{"key":"3917_CR11","doi-asserted-by":"publisher","first-page":"590","DOI":"10.2176\/nmc.ra.2017-0062","volume":"57","author":"M Yunoki","year":"2017","unstructured":"Yunoki M, Kanda T, Suzuki K, Uneda A, Hirashita K, Yoshino K. Ischemic tolerance of the brain and spinal cord: a review. Neurol Med Chir (Tokyo). 2017;57:590\u2013600.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"3917_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/nen.0b013e3181630ba6","volume":"67","author":"C Sommer","year":"2008","unstructured":"Sommer C. Ischemic preconditioning: postischemic structural changes in the brain. J Neuropathol Exp Neurol. 2008;67:85\u201392.","journal-title":"J Neuropathol Exp Neurol"},{"key":"3917_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121872","volume":"12","author":"T Guan","year":"2022","unstructured":"Guan T, Guo Y, Li C, Zhou T, Yu Q, Yang C, et al. Cerebral ischemic preconditioning aggravates death of oligodendrocytes. Biomolecules. 2022;12:1872.","journal-title":"Biomolecules"},{"key":"3917_CR14","first-page":"164","volume":"89","author":"K Nishikawa","year":"2013","unstructured":"Nishikawa K. Air purification technology of positively and negatively charged cluster ions by plasma discharge at atmospheric pressure. J Plasma Fusion Res. 2013;89:164\u20138.","journal-title":"J Plasma Fusion Res"},{"key":"3917_CR15","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/bja\/aem220","volume":"99","author":"M Iwata","year":"2007","unstructured":"Iwata M, Inoue S, Kawaguchi M, Nakamura M, Konishi N, Furuya H. Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia. Br J Anaesth. 2007;99:538\u201346.","journal-title":"Br J Anaesth"},{"key":"3917_CR16","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.medin.2018.05.007","volume":"43","author":"K Yamanaka","year":"2019","unstructured":"Yamanaka K, Inoue S, Naito Y, Kawaguchi M. Amiodarone does not affect brain injury in a rat model of transient forebrain ischemia. Med Intensiva. 2019;43:457\u201363.","journal-title":"Med Intensiva"},{"key":"3917_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s44371-025-00275-z","volume":"2","author":"WA Ansari","year":"2025","unstructured":"Ansari WA, Srivastava K, Nasibullah M, Khan MF. Reactive oxygen species (ROS): sources, generation, disease pathophysiology, and antioxidants. Discov Chem. 2025;2:191.","journal-title":"Discov Chem"}],"container-title":["Journal of Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03917-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00540-026-03917-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00540-026-03917-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:25:50Z","timestamp":1791253550000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00540-026-03917-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":17,"alternative-id":["3917"],"URL":"https:\/\/doi.org\/10.1007\/s00540-026-03917-3","relation":{},"ISSN":["0913-8668","1438-8359"],"issn-type":[{"value":"0913-8668","type":"print"},{"value":"1438-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"13 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}