{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:46:46Z","timestamp":1791258406173,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1007\/s00586-004-0845-7","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T10:47:16Z","timestamp":1106650036000},"page":"623-629","source":"Crossref","is-referenced-by-count":93,"title":["A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions"],"prefix":"10.1007","volume":"14","author":[{"given":"Alexander R","family":"Vaccaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Fischgrund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Greg.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeric","family":"Truumees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Herkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hilibrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"845_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00007632-200001010-00021","volume":"25","author":"TJ Albert","year":"2000","unstructured":"Albert TJ, Pinto M, Denis F (2000) Management of symptomatic lumbar pseudarthrosis with anteroposterior fusion (discussion 130). A functional and radiographic outcome study. Spine 25:123\u2013129","journal-title":"Spine"},{"key":"845_CR2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00007632-199505000-00012","volume":"20","author":"JC Banwart","year":"1995","unstructured":"Banwart JC, Asher MA, Hassanein RS (1995) Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. Spine 20:1055\u20131060","journal-title":"Spine"},{"key":"845_CR3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/00007632-200004010-00014","volume":"25","author":"WT Barrick","year":"2000","unstructured":"Barrick WT, Schofferman JA, Reynolds JB et al. (2000) Anterior lumbar fusion improves discogenic pain at levels of prior posterolateral fusion. Spine 25:853\u2013857","journal-title":"Spine"},{"key":"845_CR4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0901-5027(06)80053-6","volume":"25","author":"JC Beirne","year":"1996","unstructured":"Beirne JC, Barry HJ, Brady FA, Morris VB (1996) Donor site morbidity of the anterior iliac crest following cancellous bone harvest. Int J Oral Maxillofac Surg 25:268\u2013271","journal-title":"Int J Oral Maxillofac Surg"},{"key":"845_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0030-5898(05)70034-1","volume":"29","author":"SD Boden","year":"1998","unstructured":"Boden SD (1998) The biology of posterolateral lumbar spinal fusion. Orthop Clin N Am 29:603\u2013619","journal-title":"Orthop Clin N Am"},{"key":"845_CR6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/107632700418092","volume":"6","author":"SD Boden","year":"2000","unstructured":"Boden SD (2000) Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Eng 6:383\u2013399","journal-title":"Tissue Eng"},{"key":"845_CR7","doi-asserted-by":"crossref","first-page":"102S","DOI":"10.1097\/00007632-199512151-00006","volume":"20","author":"SD Boden","year":"1995","unstructured":"Boden SD, Sumner DR (1995) Biologic factors affecting spinal fusion and degeneration. Spine 20:102S\u2013112S","journal-title":"Spine"},{"key":"845_CR8","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1097\/00007632-199405310-00014","volume":"19","author":"JW Brantigan","year":"1994","unstructured":"Brantigan JW (1994) Pseudarthrosis rate after allograft posterior lumbar interbody fusion with pedicle screw and plate fixation (discussion 1280). Spine 19:1271\u20131279","journal-title":"Spine"},{"key":"845_CR9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00002517-199306060-00001","volume":"6","author":"KH Bridwell","year":"1993","unstructured":"Bridwell KH, Sedgewick TA, O\u2019Brien MF, Lenke LG, Baldus C (1993) The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis. J Spinal Disord 6:461\u2013472","journal-title":"J Spinal Disord"},{"key":"845_CR10","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/00007632-198611000-00015","volume":"11","author":"CW Brown","year":"1986","unstructured":"Brown CW, Orme TJ, Richardson HD (1986) The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine 11:942\u2013943","journal-title":"Spine"},{"key":"845_CR11","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1097\/00007632-199712010-00009","volume":"22","author":"GR Buttermann","year":"1997","unstructured":"Buttermann GR, Glazer PA, Hu SS, Bradford DS (1997) Revision of failed lumbar fusions. A comparison of anterior autograft and allograft. Spine 22:2748\u20132755","journal-title":"Spine"},{"key":"845_CR12","first-page":"479","volume":"187","author":"HU Cameron","year":"1985","unstructured":"Cameron HU, Bridges A (1985) Pseudoarthrosis in lumbar spine fusion. Prog Clin Biol Res 187:479\u2013484","journal-title":"Prog Clin Biol Res"},{"key":"845_CR13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.2106\/00004623-199605000-00011","volume":"78","author":"CT Carpenter","year":"1996","unstructured":"Carpenter CT, Dietz JW, Leung KY, Hanscom DA, Wagner TA (1996) Repair of a pseudarthrosis of the lumbar spine. A functional outcome study. J Bone Joint Surg [Am] 78:712\u2013720","journal-title":"J Bone Joint Surg [Am]"},{"issue":"1","key":"845_CR14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0736-0266(01)00060-2","volume":"20","author":"Chen","year":"2002","unstructured":"Chen et al. (2002) Osteogenic protein 1 induced bone formation in an infected segmental defect in the rat femur. J Orthop Res 20(1):s142\u2013150","journal-title":"J Orthop Res"},{"key":"845_CR15","first-page":"interbody","volume":"cages","author":"Chirossel","year":"2000","unstructured":"Chirossel JP, Gay E, Boutrand JP, Jenny P, Turner-Domergue M (2000) Stryker Spine PEEK and titanium cages: interbody fusion with OP-1 (BMP-7) vs autograft in a sheep model. EuroSpine 2000, Antwerp, pp 10\u201314","journal-title":"Stryker Spine PEEK and titanium"},{"key":"845_CR16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00003086-200002000-00006","volume":"371","author":"DB Cohen","year":"2000","unstructured":"Cohen DB, Chotivichit A, Fujita T et al. (2000) Pseudarthrosis repair. Autogenous iliac crest versus femoral ring allograft. Clin Orthop 371:46\u201355","journal-title":"Clin Orthop"},{"key":"845_CR17","first-page":"669","volume":"22","author":"SD Cook","year":"1999","unstructured":"Cook SD (1999) Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites. Orthopedics 22:669\u2013671","journal-title":"Orthopedics"},{"key":"845_CR18","unstructured":"Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC (1993) Recombinant human osteogenic protein-1 (rhOP01) heals segmental long bone defects in non-human primates. Presented at the 60th Annual meeting of the American Academy of Orthopaedic Surgeons, San Francisco"},{"key":"845_CR19","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/00007632-199408000-00002","volume":"19","author":"SD Cook","year":"1994","unstructured":"Cook SD, Dalton JE, Tan EH, Whitecloud TS, Rueger DC (1994) In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusion. Spine 19:1655\u20131663","journal-title":"Spine"},{"key":"845_CR20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00007632-199903150-00002","volume":"24","author":"BW Cunningham","year":"1999","unstructured":"Cunningham BW, Kanayama M, Parker LM et al. (1999) Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine. Spine 24:509\u2013518","journal-title":"Spine"},{"key":"845_CR21","volume-title":"Posterolateral spinal arthrodesis using osteogenic protein-1: an in-vivo time-course study using a canine model","author":"BW Cunningham","year":"2000","unstructured":"Cunningham BW, Shimanoto N, Sefter JC et al. (2000) Posterolateral spinal arthrodesis using osteogenic protein-1: an in-vivo time-course study using a canine model. NASS New Orleans"},{"key":"845_CR22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1597\/1545-1569_1999_036_0388_hibgdt_2.3.co_2","volume":"36","author":"JI Torre de la","year":"1999","unstructured":"de la Torre JI, Tenenhaus M, Gallagher PM, Sachs SA (1999) Harvesting iliac bone graft: decreasing the morbidity. Cleft Palate Craniofac J 36:388\u2013390","journal-title":"Cleft Palate Craniofac J"},{"key":"845_CR23","first-page":"113","volume":"59","author":"AF Palma De","year":"1968","unstructured":"DePalma AF, Rothman RH (1968) The nature of pseudoarthrosis. Clin Orthop 59:113\u2013118","journal-title":"Clin Orthop"},{"key":"845_CR24","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1097\/00007632-199712150-00003","volume":"22","author":"JS Fischgrund","year":"1997","unstructured":"Fischgrund JS, Mackay M, Herkowitz HN, Brower R, Montgomery DM, Kurz LT (1997) 1997 Volvo Award Winner in Clinical Studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine 22:2807\u20132812","journal-title":"Spine"},{"key":"845_CR25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00007632-199903150-00010","volume":"24","author":"JC France","year":"1999","unstructured":"France JC, Yaszemski MJ, Lauerman WC et al. (1999) A randomized prospective study of posterolateral lumbar fusion. Outcomes with and without pedicle screw instrumentation. Spine 24:553\u2013560","journal-title":"Spine"},{"key":"845_CR26","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.2106\/00004623-200100022-00013","volume":"83","author":"GE Friedlaender","year":"2001","unstructured":"Friedlaender GE, Perry CR, Cole JD et al. (2001) Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg [Am] 83:S151\u2013S158","journal-title":"J Bone Joint Surg [Am]"},{"key":"845_CR27","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1097\/00007632-199811010-00021","volume":"23","author":"SD Gertzbein","year":"1998","unstructured":"Gertzbein SD, Hollopeter MR, Hall S (1998) Pseudarthrosis of the lumbar spine. Outcome after circumferential fusion (discussion 2356\u20132357). Spine 23:2352\u20132356","journal-title":"Spine"},{"key":"845_CR28","unstructured":"Grauer et al. (2003) Evaluation of OP-1 in a novel model of Pseudarthrosis Repair. Presented at the Annual North American Spine Society (NASS) Meeting , San Diego"},{"key":"845_CR29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00007632-200101150-00004","volume":"26","author":"JN Grauer","year":"2000","unstructured":"Grauer JN, Patel TC, Erulkar JS, Troiano MW, Panjabi MM, Friedlaender GE (2000) Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion. Spine 26:127\u2013133","journal-title":"Spine"},{"key":"845_CR30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00007632-199802150-00015","volume":"23","author":"CG Greenough","year":"1998","unstructured":"Greenough CG, Peterson MD, Hadlow S, Fraser RD (1998) Instrumented posterolateral lumbar fusion. Results and comparison with anterior interbody fusion. Spine 23:479\u2013486","journal-title":"Spine"},{"key":"845_CR31","doi-asserted-by":"crossref","first-page":"S449","DOI":"10.1097\/00007632-199108001-00027","volume":"16","author":"MH Heggeness","year":"1991","unstructured":"Heggeness MH, Esses SI (1991) Classification of pseudarthroses of the lumbar spine. Spine 16:S449\u2013S454","journal-title":"Spine"},{"key":"845_CR32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2106\/00004623-199173060-00002","volume":"73","author":"HN Herkowitz","year":"1991","unstructured":"Herkowitz HN, Kurz LT (1991) Degenerative lumbar spondylolisthesis with spinal stenosis. A prospective study comparing decompression with decompression and intertransverse process arthrodesis. J Bone Joint Surg [Am] 73:802\u2013808","journal-title":"J Bone Joint Surg [Am]"},{"key":"845_CR33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1148\/radiology.204.3.9280271","volume":"204","author":"JA Jacobson","year":"1997","unstructured":"Jacobson JA, Starok M, Pathria MN, Garfin SR (1997) Pseudarthrosis: US evaluation after posterolateral spinal fusion: work in progress. Radiology 204:853\u2013858","journal-title":"Radiology"},{"key":"845_CR34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00007632-199804010-00004","volume":"23","author":"M Kanayama","year":"1998","unstructured":"Kanayama M, Cunningham BW, Weis JC, Parker LM, Kaneda K, McAfee PC (1998) The effects of rigid spinal instrumentation and solid bony fusion on spinal kinematics. A posterolateral spinal arthrodesis model. Spine 23:767\u2013773","journal-title":"Spine"},{"key":"845_CR35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00002517-200108000-00004","volume":"14","author":"I Kimura","year":"2001","unstructured":"Kimura I, Shingu H, Murata M, Hashiguchi H (2001) Lumbar posterolateral fusion alone or with transpedicular instrumentation in L4\u2013L5 degenerative spondylolisthesis. J Spinal Disord 14:301\u2013310","journal-title":"J Spinal Disord"},{"key":"845_CR36","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00007632-200005010-00015","volume":"25","author":"KM Kuntz","year":"2000","unstructured":"Kuntz KM, Snider RK, Weinstein JN, Pope MH, Katz JN (2000) Cost-effectiveness of fusion with and without instrumentation for patients with degenerative spondylolisthesis and spinal stenosis. Spine 25:1132\u20131139","journal-title":"Spine"},{"key":"845_CR37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00007632-200103010-00009","volume":"26","author":"M Magin","year":"2001","unstructured":"Magin M, Delling G (2001) Improved lumbar vertebral interbody fusion using rhOP-1. Spine 26:469\u2013478","journal-title":"Spine"},{"key":"845_CR38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00007632-200103010-00009","volume":"26","author":"MN Magin","year":"2001","unstructured":"Magin MN (2001) Enhancement of lumbar vertebral interbody fusion by human recombinant osteogenic protein-1 (BMP-7), in a sheep model. Spine 26:469\u2013478","journal-title":"Spine"},{"key":"845_CR39","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1097\/00007632-199810150-00020","volume":"23","author":"JA McCulloch","year":"1998","unstructured":"McCulloch JA (1998) Microdecompression and uninstrumented single-level fusion for spinal canal stenosis with degenerative spondylolisthesis. Spine 23:2243\u20132252","journal-title":"Spine"},{"issue":"6","key":"845_CR40","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00007632-200003150-00006","volume":"25","author":"Moller","year":"2000","unstructured":"Moller et al. (2000) Symptoms, signs, and functional disability in adult spondylolisthesis. Spine 25(6):683\u2013689","journal-title":"Spine"},{"key":"845_CR41","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/00007632-199608010-00023","volume":"21","author":"A Nachemson","year":"1996","unstructured":"Nachemson A, Zdeblick TA, O\u2019Brien JP (1996) Lumbar disc disease with discogenic pain. What surgical treatment is most effective? Spine 21:1835\u20131838","journal-title":"Spine"},{"key":"845_CR42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00007632-199903150-00012","volume":"24","author":"SE Nork","year":"1999","unstructured":"Nork SE, Hu SS, Workman KL, Glazer PA, Bradford DS (1999) Patient outcomes after decompression and instrumented posterior spinal fusion for degenerative spondylolisthesis. Spine 24:561\u2013569","journal-title":"Spine"},{"key":"845_CR43","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/00006123-199905000-00134","volume":"44","author":"CG Paramore","year":"1999","unstructured":"Paramore CG, Lauryssen C, Rauzzino J et al. (1999) The safety of OP-1 for lumbar fusion with decompression\u2014a canine study. Neurosurgery 44:1151\u20131156","journal-title":"Neurosurgery"},{"issue":"15","key":"845_CR44","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1097\/00007632-200108010-00004","volume":"26","author":"Patel","year":"2001","unstructured":"Patel et al. (2001) Osteogenic protein 1 overcomes the inhibitory effect of nicotine on posterolateral fusion. Spine 26(15):1656\u20131661","journal-title":"Spine"},{"key":"845_CR45","volume-title":"OP-1 overcomes the inhibitory effects of nicotine on lumbar fusion","author":"TC Patel","year":"2000","unstructured":"Patel TC, Erulkar JS, Grauer JS (2000) OP-1 overcomes the inhibitory effects of nicotine on lumbar fusion. NASS, New Orleans"},{"key":"845_CR46","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF02416992","volume":"23","author":"PV Quagliano","year":"1993","unstructured":"Quagliano PV, Hayes CW, Palmer WE (1993) Vertebral pseudoarthrosis associated with diffuse idiopathic skeletal hyperostosis. Skeletal Radiol 23:353\u2013355","journal-title":"Skeletal Radiol"},{"key":"845_CR47","first-page":"513","volume":"29","author":"R Raiszadeh","year":"2000","unstructured":"Raiszadeh R, Heggeness M, Esses SI (2000) Thoracolumbar pseudarthrosis. Am J Orthop 29:513\u2013520","journal-title":"Am J Orthop"},{"key":"845_CR48","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00002517-199610000-00004","volume":"9","author":"GR Rechtine","year":"1996","unstructured":"Rechtine GR, Sutterlin CE, Wood GW, Boyd RJ, Mansfield FL (1996) The efficacy of pedicle screw\/plate fixation on lumbar\/lumbosacral autogenous bone graft fusion in adult patients with degenerative spondylolisthesis. J Spinal Disord 9:382\u2013391","journal-title":"J Spinal Disord"},{"key":"845_CR49","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/00007632-200107010-00018","volume":"26","author":"PA Robertson","year":"2001","unstructured":"Robertson PA, Wray AC (2001) Natural history of posterior iliac crest bone graft donation for spinal surgery: a prospective analysis of morbidity. Spine 26:1473\u20131476","journal-title":"Spine"},{"key":"845_CR50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0030-5898(20)31223-2","volume":"6","author":"RH Rothman","year":"1975","unstructured":"Rothman RH, Booth R (1975) Failures of spinal fusion. Orthop Clin N Am 6:299\u2013304","journal-title":"Orthop Clin N Am"},{"key":"845_CR51","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2106\/00004623-200106000-00001","volume":"83","author":"SL Salkeld","year":"2001","unstructured":"Salkeld SL, Patron LP, Barrack RL, Cook SD (2001) The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone. J Bone Joint Surg [Am] 83:803\u2013816","journal-title":"J Bone Joint Surg [Am]"},{"key":"845_CR52","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1097\/00007632-199710010-00005","volume":"22","author":"CL Schnee","year":"1997","unstructured":"Schnee CL, Freese A, Weil RJ, Marcotte PJ (1997) Analysis of harvest morbidity and radiographic outcome using autograft for anterior cervical fusion. Spine 22:2222\u20132227","journal-title":"Spine"},{"key":"845_CR53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00003086-199211000-00011","volume":"284","author":"JC Steinmann","year":"1992","unstructured":"Steinmann JC, Herkowitz HN (1992) Pseudarthrosis of the spine. Clin Orthop 284:80\u201390","journal-title":"Clin Orthop"},{"key":"845_CR54","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1302\/0301-620X.71B4.2768321","volume":"71","author":"BM Summers","year":"1989","unstructured":"Summers BM, Eisenstein SM (1989) Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg [Br] 71:677\u2013680","journal-title":"J Bone Joint Surg [Br]"},{"issue":"5","key":"845_CR55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00586-003-0561-8","volume":"12","author":"Vaccaro","year":"2003","unstructured":"Vaccaro et al. (2003) A Pilot Safety and Efficacy Study of OP-1 Putty (rhBMP-7) as an ajunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 12(5):495\u2013500","journal-title":"Eur Spine J"},{"key":"845_CR56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00005131-198909000-00002","volume":"3","author":"EM Younger","year":"1989","unstructured":"Younger EM, Chapman MW (1989) Morbidity at bone graft donor sites. J Orthop Trauma 3:192\u2013195","journal-title":"J Orthop Trauma"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-004-0845-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-004-0845-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-004-0845-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:39:53Z","timestamp":1682969993000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-004-0845-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,26]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["845"],"URL":"https:\/\/doi.org\/10.1007\/s00586-004-0845-7","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,26]]}}}