{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:15:19Z","timestamp":1790399719354,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T00:00:00Z","timestamp":1235606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s00586-009-0912-1","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T08:02:50Z","timestamp":1235548970000},"page":"499-505","source":"Crossref","is-referenced-by-count":29,"title":["The effect of calmodulin antagonists on scoliosis: bipedal C57BL\/6 mice model"],"prefix":"10.1007","volume":"18","author":[{"given":"Ibrahim","family":"Akel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Demirk\u0131ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Alanay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Karahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Marcucio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Acaroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"912_CR1","doi-asserted-by":"crossref","unstructured":"Acaroglu RE, Akel I, Alanay A, Yazici M, Marcucio R (2009) Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent \u0131diopathic scoliosis. Spine J (under review)","DOI":"10.1097\/BRS.0b013e3181a3c7a2"},{"key":"912_CR2","first-page":"387","volume":"31","author":"UM Ahn","year":"2002","unstructured":"Ahn UM, Ahn NU, Nallamshetty L et al (2002) The etiology of adolescent idiopathic scoliosis. Am J Orthop 31:387\u2013395","journal-title":"Am J Orthop"},{"key":"912_CR3","doi-asserted-by":"crossref","unstructured":"Akel I, Kocak O, Bozkurt G, Alanay A, Marcucio R, Acaroglu RE (2009) The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. Spine J (in press)","DOI":"10.1097\/BRS.0b013e31818be0b1"},{"key":"912_CR4","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/00007632-200105010-00007","volume":"26","author":"KM Bagnall","year":"2001","unstructured":"Bagnall KM, Beuerlein M, Johnson P et al (2001) Pineal transplantation after pinealectomy in young chickens has no effect on the development of scoliosis. Spine 26:1022\u20131027. doi: 10.1097\/00007632-200105010-00007","journal-title":"Spine"},{"key":"912_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1126\/science.6243188","volume":"207","author":"WY Cheung","year":"1980","unstructured":"Cheung WY (1980) Calmodulin plays a pivotal role in cellular regulation. Science 207:19\u201327. doi: 10.1126\/science.6243188","journal-title":"Science"},{"key":"912_CR6","first-page":"7","volume":"7","author":"JQPTM Dubousset","year":"1983","unstructured":"Dubousset JQPTM (1983) Experimental scoliosis induced by pineal and diencephalic lesions in young chickens: its relation with clinical findings. Orthop Trans 7:7","journal-title":"Orthop Trans"},{"issue":"Suppl 1","key":"912_CR7","first-page":"S1-71","volume":"24","author":"MA Gallo","year":"1997","unstructured":"Gallo MA, Kaufman D (1997) Antagonistic and agonistic effects of tamoxifen: significance in human cancer. Semin Oncol 24(Suppl 1):S1-71\u2013S1-80","journal-title":"Semin Oncol"},{"key":"912_CR8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1748-7161-2-6","volume":"2","author":"TB Grivas","year":"2007","unstructured":"Grivas TB, Savvidou OD (2007) Melatonin the \u201clight of night\u201d in human biology and adolescent idiopathic scoliosis. Scoliosis 2:6. doi: 10.1186\/1748-7161-2-6","journal-title":"Scoliosis"},{"key":"912_CR9","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2106\/00004623-200008000-00014","volume":"82-A","author":"TG Lowe","year":"2000","unstructured":"Lowe TG, Edgar M, Margulies JY et al (2000) Etiology of idiopathic scoliosis: current trends in research. J Bone Joint Surg 82-A:1157\u20131168","journal-title":"J Bone Joint Surg"},{"key":"912_CR10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/01241398-199405000-00010","volume":"14","author":"M Machida","year":"1994","unstructured":"Machida M, Dubousset J, Imamura Y et al (1994) Pathogenesis of idiopathic scoliosis: SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis. J Pediatr Orthop 14:329\u2013335","journal-title":"J Pediatr Orthop"},{"key":"912_CR11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1302\/0301-620X.77B1.7822371","volume":"77","author":"M Machida","year":"1995","unstructured":"Machida M, Dubousset J, Imamura Y et al (1995) Role of melatonin deficiency in the development of scoliosis in pinealectomized chickens. J Bone Joint Surg Br 77:134\u2013138","journal-title":"J Bone Joint Surg Br"},{"key":"912_CR12","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/00007632-199605150-00005","volume":"21","author":"M Machida","year":"1996","unstructured":"Machida M, Dubousset J, Imamura Y et al (1996) Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis. Spine 21:1147\u20131152. doi: 10.1097\/00007632-199605150-00005","journal-title":"Spine"},{"key":"912_CR13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/00007632-199706150-00004","volume":"22","author":"M Machida","year":"1997","unstructured":"Machida M, Miyashita Y, Murai I et al (1997) Role of serotonin for scoliotic deformity in pinealectomized chicken. Spine 22:1297\u20131301. doi: 10.1097\/00007632-199706150-00004","journal-title":"Spine"},{"key":"912_CR14","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1097\/00007632-199910010-00004","volume":"24","author":"M Machida","year":"1999","unstructured":"Machida M, Murai I, Miyashita Y et al (1999) Pathogenesis of idiopathic scoliosis. Experimental study in rats. Spine 24:1985\u20131989. doi: 10.1097\/00007632-199910010-00004","journal-title":"Spine"},{"key":"912_CR15","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1097\/00007632-199912150-00004","volume":"24","author":"M Machida","year":"1999","unstructured":"Machida M (1999) Cause of idiopathic scoliosis. Spine 24:2576\u20132583. doi: 10.1097\/00007632-199912150-00004","journal-title":"Spine"},{"key":"912_CR16","doi-asserted-by":"crossref","first-page":"E385","DOI":"10.1097\/00007632-200109010-00006","volume":"26","author":"M Machida","year":"2001","unstructured":"Machida M, Dubousset J, Satoh T et al (2001) Pathologic mechanism of experimental scoliosis in pinealectomized chickens. Spine 26:E385\u2013E391. doi: 10.1097\/00007632-200109010-00006","journal-title":"Spine"},{"issue":"1","key":"912_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2005.00312.x","volume":"41","author":"M Machida","year":"2006","unstructured":"Machida M, Dubousset J, Yamada T et al (2006) Experimental scoliosis in melatonin-deficient C57BL\/6J mice without pinealectomy. J Pineal Res 41(1):1\u20137","journal-title":"J Pineal Res"},{"key":"912_CR18","doi-asserted-by":"crossref","unstructured":"Miller NH (2002) Genetics of familial idiopathic scoliosis. Clin Orthop Relat Res 60\u201364. doi: 10.1097\/00003086-200208000-00009","DOI":"10.1097\/00003086-200208000-00009"},{"key":"912_CR19","doi-asserted-by":"crossref","unstructured":"Pan G, Vickers SM, Pickens A et al (1999) Apoptosis and tumorigenesis in human cholangiocarcinoma cells \u0131nvolvement of Fas\/APO-1 (CD95) and calmodulin. Am J Pathol 155(1)","DOI":"10.1016\/S0002-9440(10)65113-9"},{"key":"912_CR20","doi-asserted-by":"crossref","unstructured":"Poon AMS, Cheung KMC et al (2006) Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. Spine 18:2043\u20132047. doi: 10.1097\/01.brs.0000231796.49827.39","DOI":"10.1097\/01.brs.0000231796.49827.39"},{"key":"912_CR21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s005860100311","volume":"10","author":"RW Porter","year":"2001","unstructured":"Porter RW (2001) The pathogenesis of idiopathic scoliosis: uncoupled neuro-osseous growth? Eur Spine J 10:473\u2013481. doi: 10.1007\/s005860100311","journal-title":"Eur Spine J"},{"key":"912_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0030-5898(05)70092-4","volume":"30","author":"JW Roach","year":"1999","unstructured":"Roach JW (1999) Adolescent idiopathic scoliosis. Orthop Clin North Am 30:353\u2013365. doi: 10.1016\/S0030-5898(05)70092-4","journal-title":"Orthop Clin North Am"},{"key":"912_CR23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-079X.2004.00141.x","volume":"37","author":"E Soto-Vega","year":"2004","unstructured":"Soto-Vega E, Meza I, Ramirez-Rodriguez G et al (2004) Melatonin stimulates calmodulin phosphorylation by protein kinase C. J Pineal Res 37:98\u2013106. doi: 10.1111\/j.1600-079X.2004.00141.x","journal-title":"J Pineal Res"},{"key":"912_CR24","doi-asserted-by":"crossref","unstructured":"Turgut M, Yenisey C, Uysal A et al (2003) The effects of pineal gland transplantation on the production of spinal deformity and serum melatonin level following pinealectomy in the chicken. Eur Spine J","DOI":"10.1007\/s00586-003-0528-9"},{"key":"912_CR25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.brs.0000194781.53260.dc","volume":"15","author":"E Turhan","year":"2006","unstructured":"Turhan E, Acaroglu E, Bozkurt G (2006) Unilateral enucleation affects the laterality but not the incidence of scoliosis in pinealectomized chicken. Spine 15:133\u2013138","journal-title":"Spine"},{"key":"912_CR26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0959-4388(97)80068-2","volume":"7","author":"Z Xia","year":"1997","unstructured":"Xia Z, Storm DR (1997) Calmodulin-regulated adenylyl cyclases and neuromodulation. Curr Opin Neurobiol 7:391\u2013396. doi: 10.1016\/S0959-4388(97)80068-2","journal-title":"Curr Opin Neurobiol"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-009-0912-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-009-0912-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-009-0912-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T03:24:07Z","timestamp":1559100247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-009-0912-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,26]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["912"],"URL":"https:\/\/doi.org\/10.1007\/s00586-009-0912-1","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,26]]}}}