{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:41:33Z","timestamp":1790937693686,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T00:00:00Z","timestamp":1277510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00586-010-1494-7","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T12:27:04Z","timestamp":1277468824000},"page":"612-617","source":"Crossref","is-referenced-by-count":77,"title":["Perioperative complications with rhBMP-2 in transforaminal lumbar interbody fusion"],"prefix":"10.1007","volume":"20","author":[{"given":"Kirk","family":"Owens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Glassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen","family":"Djurasovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Witten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah Y.","family":"Carreon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,26]]},"reference":[{"key":"1494_CR1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-2008-1051624","volume":"120","author":"J Harms","year":"1982","unstructured":"Harms J, Rollinger H (1982) A one-stage procedure in operative treatment of spondylolisthesis: dorsal traction\u2013reposition and anterior fusion. Z Orthop Ihre Grenzgeb 120:343\u2013347","journal-title":"Z Orthop Ihre Grenzgeb"},{"key":"1494_CR2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1529-9430(01)00015-8","volume":"1","author":"RW Molinari","year":"2001","unstructured":"Molinari RW, Gerlinger T (2001) Functional outcomes of instrumented posterior lumbar interbody fusion in active-duty US servicemen: a comparison with nonoperative management. Spine J 1:215\u2013224","journal-title":"Spine J"},{"key":"1494_CR3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s00586-002-0493-8","volume":"12","author":"P Fritzell","year":"2003","unstructured":"Fritzell P, Hagg O, Nordwall A, Swedish Lumbar Spine Study Group (2003) Complications in lumbar fusion surgery for chronic low back pain: comparison of three surgical techniques used in a prospective randomized study. Eur Spine J 12:178\u2013189","journal-title":"Eur Spine J"},{"key":"1494_CR4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/17453679908997819","volume":"70","author":"K Okuyama","year":"1999","unstructured":"Okuyama K, Abe E, Suzuki T, Tamura Y, Chiba M, Sato K (1999) Posterior lumbar interbody fusion: a retrospective study of complications after facet joint excision and pedicle screw fixation in 148 cases. Acta Orthop Scand 70:329\u2013334","journal-title":"Acta Orthop Scand"},{"key":"1494_CR5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/00006123-200211000-00014","volume":"51","author":"B Barnes","year":"2002","unstructured":"Barnes B, Rodts GE Jr, Haid RW Jr, Subach BR, McLaughlin MR (2002) Allograft implants for posterior lumbar interbody fusion: results comparing cylindrical dowels and impacted wedges. Neurosurgery 51:1191\u20131198","journal-title":"Neurosurgery"},{"key":"1494_CR6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.2009.956","volume":"302","author":"KS Cahill","year":"2008","unstructured":"Cahill KS, Chi JH, Day A, Claus EB (2008) Prevalence, complications and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures. JAMA 302:58\u201366","journal-title":"JAMA"},{"key":"1494_CR7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3171\/spi.2005.3.6.0436","volume":"3","author":"AT Villavicencio","year":"2005","unstructured":"Villavicencio AT, Burneikiene S, Nelson EL, Bulsara KR, Favors M, Thramann J (2005) Safety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2. J Neurosurg Spine 3:436\u2013443","journal-title":"J Neurosurg Spine"},{"key":"1494_CR8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00007632-200002010-00020","volume":"25","author":"SD Boden","year":"2000","unstructured":"Boden SD, Zdeblick TA, Sandhu HS, Heim SE (2000) The use of rhBMP-2 in interbody fusion cages: definitive evidence of osteoinduction in humans: a preliminary report. Spine (Phila Pa 1976) 25:376\u2013381","journal-title":"Spine (Phila Pa 1976)"},{"key":"1494_CR9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.spinee.2006.06.381","volume":"7","author":"SD Glassman","year":"2007","unstructured":"Glassman SD, Carreon L, Djurasovic M, Campbell MJ, Puno RM, Johnson JR, Dimar JR (2007) Posterolateral lumbar spine fusion with infuse bone graft. Spine J 7:44\u201349","journal-title":"Spine J"},{"key":"1494_CR10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00024720-200608000-00008","volume":"19","author":"K Singh","year":"2006","unstructured":"Singh K, Smucker JD, Gill S, Boden SD (2006) Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion: a prospective CT-scan analysis at one and two years. J Spinal Disord Tech 19:416\u2013423","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR11","unstructured":"Alexander DI, Abraham EP, Bailey SI, et al. (2005) A new rhBMP-2 formulation in posterolateral lumbar spine fusion; a prospective, randomized study. In: Proceedings of the American Academy of Orthopaedic Surgeons Annual Meeting, vol 6, p 532"},{"key":"1494_CR12","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1097\/01.brs.0000245863.52371.c2","volume":"31","author":"JD Smucker","year":"2006","unstructured":"Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG (2006) Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 31:2813\u20132819","journal-title":"Spine"},{"key":"1494_CR13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","volume":"31","author":"LB Shields","year":"2006","unstructured":"Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB (2006) Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 31:542\u2013547","journal-title":"Spine"},{"key":"1494_CR14","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00586-007-0351-9","volume":"16","author":"R Vaidya","year":"2007","unstructured":"Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM (2007) Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J 16:1257\u20131265","journal-title":"Eur Spine J"},{"key":"1494_CR15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.bsd.0000185277.14484.4e","volume":"19","author":"AT Villavicencio","year":"2006","unstructured":"Villavicencio AT, Burneikiene S, Bulsara KR, Thramann JJ (2006) Perioperative complications in transforaminal lumbar interbody fusion versus anterior-posterior reconstruction for lumbar disc degeneration and instability. J Spinal Disord Tech 19:92\u201397","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00002517-200112000-00013","volume":"14","author":"HT Hee","year":"2001","unstructured":"Hee HT, Castro FP Jr, Majd ME, Holt RT, Myers L (2001) Anterior\/posterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors. J Spinal Disord 14:533\u2013540","journal-title":"J Spinal Disord"},{"key":"1494_CR17","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1097\/00007632-199608150-00018","volume":"21","author":"SD Gertzbein","year":"1996","unstructured":"Gertzbein SD, Betz R, Clements D, Errico T, Hammerberg K, Robbins S, Shepherd E, Weber A, Kerina M, Albin J, Wolk D, Ensor K (1996) Semirigid instrumentation in the management of lumbar spinal conditions combined with circumferential fusion. A multicenter study. Spine 21:1918\u20131926","journal-title":"Spine"},{"key":"1494_CR18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.bsd.0000166642.69189.45","volume":"18","author":"BK Potter","year":"2005","unstructured":"Potter BK, Freedman BA, Verwiebe EG, Hall JM, Polly DW Jr, Kuklo TR (2005) Transforaminal lumbar interbody fusion: clinical and radiographic results and complications in 100 consecutive patients. J Spinal Disord Tech 18:337\u2013346","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.spinee.2009.04.004","volume":"9","author":"JA Rihn","year":"2009","unstructured":"Rihn JA, Patel R, Makda J, Hong J, Anderson DG, Vaccaro AR, Hilibrand AS, Albert TJ (2009) Complications associated with single level transforaminal lumbar interbody fusion. Spine J 9:623\u2013629","journal-title":"Spine J"},{"key":"1494_CR20","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/00007632-199309000-00019","volume":"18","author":"RC Duffield","year":"1993","unstructured":"Duffield RC, Carson WL, Chen LY, Voth Bl (1993) Longitudinal element size effect on load sharing, internal loads, and fatigue life of tri-level spinal implant constructs. Spine 18:1695\u20131703","journal-title":"Spine"},{"key":"1494_CR21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00002517-200104000-00002","volume":"14","author":"TS Whitecloud","year":"2001","unstructured":"Whitecloud TS, Roesch WW, Riciardi JE (2001) Transforaminal interbody fusion versus anterior\u2013posterior interbody fusion of the lumbar spine: a financial analysis. J Spinal Disord 14:100\u2013103","journal-title":"J Spinal Disord"},{"key":"1494_CR22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00024720-200304000-00001","volume":"16","author":"KJ Burkus","year":"2003","unstructured":"Burkus KJ, Heim SE, Gornet MF, Zdeblick TA (2003) Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device. J Spinal Disord Tech 16:113\u2013122","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR23","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.brs.0000240715.78657.81","volume":"31","author":"JR Dimar","year":"2006","unstructured":"Dimar JR, Glassman SD, Burkus KJ, Carreon LY (2006) Clinical outcomes and fusion success at 2\u00a0years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2\/compression resistant matrix versus iliac crest bone graft. Spine 31:2534\u20132539","journal-title":"Spine"},{"key":"1494_CR24","unstructured":"FDA (2009) FDA public health notification: life-threatening complications associated with recombinant human bone morphogenetic protein in cervical spine fusion, issued: 1 July 2008. http:\/\/www.fda.gov\/cdrh\/safety\/070108-rhbmp.html . Accessed on-line 12 August 2009"},{"key":"1494_CR25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.spinee.2004.03.025","volume":"4","author":"RW Haid Jr","year":"2004","unstructured":"Haid RW Jr, Branch CL Jr, Alexander JT, Burkus JK (2004) Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages. Spine J 4:527\u2013538","journal-title":"Spine J"},{"key":"1494_CR26","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1097\/BRS.0b013e31815b7596","volume":"32","author":"V Joseph","year":"2007","unstructured":"Joseph V, Rampersaud YR (2007) Heterotopic bone formation with the use of rhBMP-2 in posterior minimal access interbody fusion. Spine 32:2885\u20132890","journal-title":"Spine"},{"key":"1494_CR27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00024720-200210000-00001","volume":"15","author":"JK Burkus","year":"2002","unstructured":"Burkus JK, Gornet MF, Dickman CA, Zdeblick TA (2002) Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337\u2013349","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00264-008-0531-1","volume":"33","author":"Z Chen","year":"2009","unstructured":"Chen Z, Zhao J, Liu A, Yuan J, Li Z (2009) Surgical treatment of recurrent lumbar disc herniation by transforaminal lumbar interbody fusion. Int Orthop 33:197\u2013201","journal-title":"Int Orthop"},{"key":"1494_CR29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00586-004-0830-1","volume":"14","author":"L Hackenberg","year":"2005","unstructured":"Hackenberg L, Halm H, Bullman V, Vieth V, Schneider M, Liljenqvist U (2005) Transforaminal lumbar interbody fusion: a safe technique with satisfactory three to five year results. Eur Spine J 14:551\u2013558","journal-title":"Eur Spine J"},{"key":"1494_CR30","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1097\/01.brs.0000224530.08481.4e","volume":"31","author":"S Lauber","year":"2006","unstructured":"Lauber S, Schulte TL, Liljenqvist U, Halm H, Hackenberg L (2006) Clinical and radiologic 2\u20134-year results of transforaminal lumbar interbody fusion in degenerative and isthmic spondylolisthesis grades 1 and 2. Spine 31:1693\u20131698","journal-title":"Spine"},{"key":"1494_CR31","first-page":"19","volume":"1","author":"PV Mummaneni","year":"2004","unstructured":"Mummaneni PV, Pan J, Haid RW, Rodts GE (2004) Contribution of recombinant human bone morphogenetic protein-2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. J Neurosurg 1:19\u201323","journal-title":"J Neurosurg"},{"key":"1494_CR32","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/BRS.0b013e3181a396a1","volume":"34","author":"SA Mindea","year":"2009","unstructured":"Mindea SA, Shih P, Song JK (2009) Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions. Spine 34:1480\u20131484","journal-title":"Spine"},{"key":"1494_CR33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/BRS.0b013e3181952695","volume":"34","author":"JM Toth","year":"2009","unstructured":"Toth JM, Boden SD, Burkus JK, Badura JM, Peckham SM, McKay WF (2009) Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein\u20132 in a cancellous bone environment. Spine 34:539\u2013550","journal-title":"Spine"},{"key":"1494_CR34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/BSD.0b013e31815ea897","volume":"21","author":"R Vaidya","year":"2008","unstructured":"Vaidya R, Sethi A, Bartol S, Jacobson M, Coe C, Craig JG (2008) Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions. J Spinal Disord Tech 21:557\u2013562","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/01.bsd.0000211231.83716.4b","volume":"19","author":"JW McClellan","year":"2006","unstructured":"McClellan JW, Mulconrey DS, Forbes RJ et al (2006) Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2). J Spinal Disord Tech 19:483\u2013486","journal-title":"J Spinal Disord Tech"},{"key":"1494_CR36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.spinee.2007.01.011","volume":"7","author":"KU Lewandrowski","year":"2007","unstructured":"Lewandrowski KU, Nanson C, Calderon R (2007) Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases. Spine J 7:609\u2013614","journal-title":"Spine J"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-010-1494-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-010-1494-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-010-1494-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T04:02:12Z","timestamp":1591416132000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-010-1494-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,26]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["1494"],"URL":"https:\/\/doi.org\/10.1007\/s00586-010-1494-7","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,26]]}}}