{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:44:01Z","timestamp":1790419441559,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s00586-015-3821-5","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T08:31:46Z","timestamp":1425112306000},"page":"702-714","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The efficacy of conservative treatment of osteoporotic compression fractures on acute pain relief: a systematic review with meta-analysis"],"prefix":"10.1007","volume":"24","author":[{"given":"Magdalena","family":"Rzewuska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo C.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"3821_CR1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761\u20131767","journal-title":"Lancet"},{"key":"3821_CR2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1056\/NEJMcp1009697","volume":"364","author":"KE Ensrud","year":"2011","unstructured":"Ensrud KE, Schousboe JT (2011) Vertebral fractures. N Engl J Med 364:1634\u20131642","journal-title":"N Engl J Med"},{"key":"3821_CR3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbmr.5650070214","volume":"7","author":"C Cooper","year":"1992","unstructured":"Cooper C, Atkinson EJ, O\u2019Fallon MW, Melton JL (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985\u20131989. J Bone Miner Res 7:221\u2013227","journal-title":"J Bone Miner Res"},{"key":"3821_CR4","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1177\/0363546512449814","volume":"40","author":"SD Gertzbein","year":"2012","unstructured":"Gertzbein SD, Khoury D, Bullington A, John TAS, Larson AI (2012) Thoracic and lumbar fractures associated with skiing and snowboarding injuries according to the AO comprehensive classification. Am J Sports Med 40:1750\u20131754","journal-title":"Am J Sports Med"},{"key":"3821_CR5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1148\/radiology.172.1.2740506","volume":"172","author":"WT Yuh","year":"1989","unstructured":"Yuh WT, Zachar CK, Barloon TJ, Sato Y, Sickels WJ, Hawes DR (1989) Vertebral compression fractures: distinction between benign and malignant causes with MR imaging. Radiology 172:215\u2013218","journal-title":"Radiology"},{"key":"3821_CR6","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1097\/00007632-199512000-00007","volume":"20","author":"RE Rupp","year":"1995","unstructured":"Rupp RE, Ebraheim NA, Commbs RJ (1995) Magnetic resonance imaging differentiation of compression spine fractures or vertebral lesions caused by osteoporosis or tumor. Spine 20:2499\u20132503","journal-title":"Spine"},{"key":"3821_CR7","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/8756-3282(92)90193-Z","volume":"13","author":"S Silverman","year":"1992","unstructured":"Silverman S (1992) The clinical consequences of vertebral compression fracture. Bone 13:S27\u2013S31","journal-title":"Bone"},{"key":"3821_CR8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1359\/jbmr.1997.12.1.152","volume":"12","author":"H Burger","year":"1997","unstructured":"Burger H, Van Daele PLA, Grashuis K, Hofman A, Grobbee DE, Sch\u00fctte HE, Birkenh\u00e4ger JC, Pols HAP (1997) Vertebral deformities and functional impairment in men and women. J Bone Miner Res 12:152\u2013157","journal-title":"J Bone Miner Res"},{"key":"3821_CR9","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/archinte.159.11.1215","volume":"159","author":"DM Kado","year":"1999","unstructured":"Kado DM, Browner WS, Palermo L, Nevitt MC, Genant HK, Cummings SR (1999) Vertebral fractures and mortality in older women: a prospective study. Arch Intern Med 159:1215","journal-title":"Arch Intern Med"},{"key":"3821_CR10","first-page":"387","volume-title":"Interventional neuroradiology","author":"ME Jensen","year":"2008","unstructured":"Jensen ME (2008) Percutaneous Vertebroplasty. In: Hurst RW, Rosenwasser RH (eds) Interventional neuroradiology. Informa Healthcare USA Inc, New York, pp 387\u2013410"},{"key":"3821_CR11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1007\/s00586-008-0753-3","volume":"17","author":"N Suzuki","year":"2008","unstructured":"Suzuki N, Ogikubo O, Hansson T (2008) The course of the acute vertebral body fragility fracture: its effect on pain, disability and quality of life during 12 months. Eur Spine J 17:1380\u20131390","journal-title":"Eur Spine J"},{"key":"3821_CR12","first-page":"205","volume":"6","author":"CC Wong","year":"2013","unstructured":"Wong CC, McGirt MJ (2013) Vertebral compression fractures: a review of current management and multimodal therapy. J Multidiscip Healthc 6:205\u2013214","journal-title":"J Multidiscip Healthc"},{"key":"3821_CR13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa0900429","volume":"361","author":"R Buchbinder","year":"2009","unstructured":"Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, Graves S, Staples MP, Murphy B (2009) A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 361:557\u2013568","journal-title":"N Engl J Med"},{"key":"3821_CR14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJMoa0900563","volume":"361","author":"DF Kallmes","year":"2009","unstructured":"Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, Edwards R, Gray LA, Stout L, Owen S (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361:569\u2013579","journal-title":"N Engl J Med"},{"key":"3821_CR15","volume-title":"The treatment of symptomatic osteoporotic spinal compression fractures guideline and evidence report","author":"AAOS","year":"2010","unstructured":"AAOS (2010) The treatment of symptomatic osteoporotic spinal compression fractures guideline and evidence report. American Academy of Orthopaedic Surgeons, Rosemont (IL)"},{"key":"3821_CR16","doi-asserted-by":"crossref","first-page":"E483","DOI":"10.36076\/ppj.2013\/16\/E483","volume":"16","author":"A Hussain","year":"2013","unstructured":"Hussain A, Erdek M (2013) Vertebroplasty augmentation procedures: examining the controversy. Pain Physician 16:E483\u2013E490","journal-title":"Pain Physician"},{"key":"3821_CR17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.semarthrit.2010.06.001","volume":"40","author":"JP Jansen","year":"2011","unstructured":"Jansen JP, Bergman GJ, Huels J, Olson M (2011) The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebral-nonhip fractures in osteoporosis: a network meta-analysis. Semin Arthritis Rheum 40:275\u2013284","journal-title":"Semin Arthritis Rheum"},{"key":"3821_CR18","doi-asserted-by":"crossref","unstructured":"Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (2008) Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev 1:CD001155. doi: 10.1002\/14651858.CD001155.pub2","DOI":"10.1002\/14651858.CD001155.pub2"},{"key":"3821_CR19","doi-asserted-by":"crossref","unstructured":"Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (2008) Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev 1: CD003376. doi: 10.1002\/14651858.CD003376.pub3","DOI":"10.1002\/14651858.CD003376.pub3"},{"key":"3821_CR20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1759720X10395651","volume":"3","author":"M Rossini","year":"2011","unstructured":"Rossini M, Idolazzi L, Adami S (2011) Evidence of sustained vertebral and nonvertebral antifracture efficacy with ibandronate therapy: a systematic review. Ther Adv Musculoskelet Dis 3:67\u201379","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"3821_CR21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1345\/aph.1C350","volume":"37","author":"LA Blau","year":"2003","unstructured":"Blau LA, Hoehns JD (2003) Analgesic efficacy of calcitonin for vertebral fracture pain. Ann Pharmacother 37:564\u2013570","journal-title":"Ann Pharmacother"},{"key":"3821_CR22","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-004-1798-8","volume":"16","author":"JA Knopp","year":"2005","unstructured":"Knopp JA, Diner BM, Blitz M, Lyritis GP, Rowe BH (2005) Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials. Osteoporos Int 16:1281\u20131290","journal-title":"Osteoporos Int"},{"key":"3821_CR23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00198-011-1676-0","volume":"23","author":"J Knopp-Sihota","year":"2012","unstructured":"Knopp-Sihota J (2012) Calcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and meta analysis. Osteoporos Int 23:17\u201338","journal-title":"Osteoporos Int"},{"key":"3821_CR24","first-page":"2160","volume":"44","author":"WP Maksymowych","year":"1998","unstructured":"Maksymowych WP (1998) Managing acute osteoporotic vertebral fractures with calcitonin. Can Fam Physician 44:2160","journal-title":"Can Fam Physician"},{"key":"3821_CR25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1177\/1060028013509233","volume":"47","author":"RA Overman","year":"2013","unstructured":"Overman RA, Borse M, Gourlay ML (2013) Salmon calcitonin use and associated cancer risk. Ann Pharmacother 47:1675\u20131684","journal-title":"Ann Pharmacother"},{"key":"3821_CR26","unstructured":"MHRA (2012) Calcitonin (Miacalcic): increased risk of cancer with long-term use\u2014all intra-nasal formulations for osteoporosis to be withdrawn. In: Drug Safety Update August 2012, vol 6, issue 1: A1 http:\/\/www.mhragovuk\/Safetyinformation\/DrugSafetyUpdate\/CON180634 . Accessed 21 Oct 2013"},{"key":"3821_CR27","unstructured":"Rzewuska M, Ferreira ML, McLachlan AJ, Machado GC, Maher CG (2014) The efficacy of conservative treatment of osteoporotic vertebral compression fractures on acute pain relief: a systematic review with meta-analysis. In: PROSPERO: International prospective register of systematic reviews. p. CRD42014007562"},{"key":"3821_CR28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.injury.2007.08.010","volume":"38","author":"H Prather","year":"2007","unstructured":"Prather H, Watson JO, Gilula LA (2007) Nonoperative management of osteoporotic vertebral compression fractures. Injury 38:40\u201348","journal-title":"Injury"},{"key":"3821_CR29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ptj\/83.8.713","volume":"83","author":"CG Maher","year":"2003","unstructured":"Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M (2003) Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther 83:713\u2013721","journal-title":"Phys Ther"},{"key":"3821_CR30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0004-9514(09)70043-1","volume":"55","author":"NA Morton de","year":"2009","unstructured":"de Morton NA (2009) The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 55:129\u2013133","journal-title":"Aust J Physiother"},{"key":"3821_CR31","doi-asserted-by":"crossref","first-page":"e003342","DOI":"10.1136\/bmjopen-2013-003342","volume":"3","author":"S Hopewell","year":"2013","unstructured":"Hopewell S, Boutron I, Altman DG, Ravaud P (2013) Incorporation of assessments of risk of bias of primary studies in systematic reviews of randomised trials: a cross-sectional study. BMJ Open 3:e003342","journal-title":"BMJ Open"},{"key":"3821_CR32","doi-asserted-by":"crossref","first-page":"865","DOI":"10.7326\/0003-4819-157-12-201212180-00564","volume":"157","author":"RZ Pinto","year":"2012","unstructured":"Pinto RZ, Maher CG, Ferreira ML, Hancock M, Oliveira VC, McLachlan AJ, Koes B, Ferreira PH (2012) Epidural corticosteroid injections in the management of sciatica a systematic review and meta-analysis. Ann Intern Med 157:865\u2013877","journal-title":"Ann Intern Med"},{"key":"3821_CR33","unstructured":"Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions version 5.1. 0 [updated March 2011]. The Cochrane Collaboration"},{"key":"3821_CR34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557","journal-title":"BMJ"},{"key":"3821_CR35","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ (2008) Rating quality of evidence and strength of recommendations: GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924","journal-title":"BMJ"},{"key":"3821_CR36","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.pain.2012.04.021","volume":"153","author":"M Middelkoop van","year":"2012","unstructured":"van Middelkoop M, Rubinstein SM, Ostelo R, van Tulder MW, Peul W, Koes BW, Verhagen AP (2012) No additional value of fusion techniques on anterior discectomy for neck pain: a systematic review. Pain 153:2167\u20132173","journal-title":"Pain"},{"key":"3821_CR37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/01.PHM.0000113403.16617.93","volume":"83","author":"M Pfeifer","year":"2004","unstructured":"Pfeifer M, Begerow B, Minne HW (2004) Effects of a new spinal orthosis on posture, trunk strength, and quality of life in women with postmenopausal osteoporosis: a randomized trial. Am J Phys Med Rehabil 83:177\u2013186","journal-title":"Am J Phys Med Rehabil"},{"key":"3821_CR38","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/PHM.0b013e31821f6df3","volume":"90","author":"M Pfeifer","year":"2011","unstructured":"Pfeifer M, Kohlwey L, Begerow B, Minne HW (2011) Effects of two newly developed spinal orthoses on trunk muscle strength, posture, and quality-of-life in women with postmenopausal osteoporosis. Am J Phys Med Rehabil 90:805\u2013815","journal-title":"Am J Phys Med Rehabil"},{"key":"3821_CR39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2217\/pmt.13.5","volume":"3","author":"GJ Vorsanger","year":"2013","unstructured":"Vorsanger GJ, Farrell J, Xiang J, Chow W, Moskovitz BL, Rosenthal NR (2013) Tapentadol, oxycodone or placebo for acute pain of vertebral compression fractures: a randomized Phase IIIb study. Pain Manag 3:109\u2013118","journal-title":"Pain Manag"},{"key":"3821_CR40","author":"M Li","year":"2014","unstructured":"Li M, S-w Law, Cheng J, H-m Kee, Wong MS (2014) A comparison study on the efficacy of SpinoMed\u00ae and soft lumbar orthosis for osteoporotic vertebral fracture. Prosthet Orthot Int. doi: 10.1177\/0309364614528204","journal-title":"Prosthet Orthot Int"},{"key":"3821_CR41","unstructured":"Zhang TH, Dong YH, Yu SM, Zhang C, Yao B (2013) .Chin J Tissue Eng Res 17:6364\u20136374. doi: 10.3969\/j.issn.2095-4344.2013.35.023"},{"key":"3821_CR42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s001980050190","volume":"10","author":"B Begerow","year":"1999","unstructured":"Begerow B, Pfeifer M, Pospeschill M, Scholz M, Schlotthauer T, Lazarescu A, Pollaehne W, Minne H (1999) Time since vertebral fracture: an important variable concerning quality of life in patients with postmenopausal osteoporosis. Osteoporos Int 10:26\u201333","journal-title":"Osteoporos Int"},{"key":"3821_CR43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1302\/0301-620X.94B2.26894","volume":"94","author":"U Longo","year":"2012","unstructured":"Longo U, Loppini M, Denaro L, Maffulli N, Denaro V (2012) Conservative management of patients with an osteoporotic vertebral fracture A review of the literature. J Bone Jt Surg Br 94:152\u2013157","journal-title":"J Bone Jt Surg Br"},{"key":"3821_CR44","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.3171\/2014.4.FOCUS14159","volume":"37","author":"J Bakhsheshian","year":"2014","unstructured":"Bakhsheshian J, Dahdaleh NS, Fakurnejad S, Scheer JK, Smith ZA (2014) Evidence-based management of traumatic thoracolumbar burst fractures: a systematic review of nonoperative management. Neurosurg Focus 37:E1","journal-title":"Neurosurg Focus"},{"issue":"8","key":"3821_CR45","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/BOT.0b013e3181a18728","volume":"23","author":"A Stadhouder","year":"2009","unstructured":"Stadhouder A, Buskens E, Vergroesen DA, Fidler MW, Nies F, Oner FC (2009) Nonoperative treatment of thoracic and lumbar spine fractures: a prospective randomized study of different treatment options. J Orthop Trauma 23(8):588\u2013594","journal-title":"J Orthop Trauma"},{"issue":"11","key":"3821_CR46","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.spinee.2013.10.017","volume":"14","author":"CS Bailey","year":"2014","unstructured":"Bailey CS, Urquhart JC, Dvorak MF, Nadeau M, Boyd MC, Thomas KC, Kwon BK, Gurr KR, Bailey SI, Fisher CG (2014) Orthosis versus no orthosis for the treatment of thoracolumbar burst fractures without neurologic injury: a multicenter prospective randomized equivalence trial. Spine J 14(11):2557\u20132564","journal-title":"Spine J"},{"key":"3821_CR47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.spinee.2009.01.003","volume":"9","author":"MJ McGirt","year":"2009","unstructured":"McGirt MJ, Parker SL, Wolinsky J-P, Witham TF, Bydon A, Gokaslan ZL (2009) Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature. Spine J 9:501\u2013508","journal-title":"Spine J"},{"key":"3821_CR48","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00586-012-2314-z","volume":"21","author":"ID Papanastassiou","year":"2012","unstructured":"Papanastassiou ID, Phillips FM, Van Meirhaeghe J, Berenson JR, Andersson GB, Chung G, Small BJ, Aghayev K, Vrionis FD (2012) Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J 21:1826\u20131843","journal-title":"Eur Spine J"},{"key":"3821_CR49","first-page":"455","volume":"16","author":"M Xiaochun Li","year":"2013","unstructured":"Xiaochun Li M, Min Yao M, Penfei YuM, Xiang Qian M (2013) Comparing pain reduction following vertebroplasty and conservative treatment for osteoporotic vertebral compression fractures: a meta-analysis of randomized controlled trials. Pain Physician 16:455\u2013464","journal-title":"Pain Physician"},{"key":"3821_CR50","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(09)60010-6","volume":"373","author":"D Wardlaw","year":"2009","unstructured":"Wardlaw D, Cummings SR, Van Meirhaeghe J, Bastian L, Tillman JB, Ranstam J, Eastell R, Shabe P, Talmadge K, Boonen S (2009) Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet 373:1016\u20131024","journal-title":"Lancet"},{"key":"3821_CR51","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00198-006-0169-z","volume":"17","author":"T Armingeat","year":"2006","unstructured":"Armingeat T, Brondino R, Pham T, Legr\u00e9 V, Lafforgue P (2006) Intravenous pamidronate for pain relief in recent osteoporotic vertebral compression fracture: a randomized double-blind controlled study. Osteoporos Int 17:1659\u20131665","journal-title":"Osteoporos Int"},{"key":"3821_CR52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10067-005-0159-0","volume":"25","author":"M Laroche","year":"2006","unstructured":"Laroche M, Cantogrel S, Jamard B, Constantin A, Zabraniecki L, Cantagrel A, Mazi\u00e8res B (2006) Comparison of the analgesic efficacy of pamidronate and synthetic human calcitonin in osteoporotic vertebral fractures: a double-blind controlled study. Clin Rheumatol 25:683\u2013686","journal-title":"Clin Rheumatol"},{"key":"3821_CR53","doi-asserted-by":"crossref","first-page":"e5913","DOI":"10.1136\/bmj.e5913","volume":"345","author":"ML Ferreira","year":"2012","unstructured":"Ferreira ML, Herbert RD, Crowther MJ, Verhagen A, Sutton AJ (2012) When is a further clinical trial justified? BMJ 345:e5913","journal-title":"BMJ"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-015-3821-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-015-3821-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-015-3821-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T22:28:59Z","timestamp":1651357739000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-015-3821-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["3821"],"URL":"https:\/\/doi.org\/10.1007\/s00586-015-3821-5","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}