{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:25:31Z","timestamp":1786980331397,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s00586-015-3998-7","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T04:26:00Z","timestamp":1431318360000},"page":"186-191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Markers of inflammation and fibrinolysis in relation to outcome after surgery for lumbar disc herniation. A prospective study on 177 patients"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-4800","authenticated-orcid":false,"given":"P.","family":"Elkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sten-Linder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hedlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Willers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ponzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gerdhem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"issue":"1","key":"3998_CR1","first-page":"32","volume":"9","author":"B Jonsson","year":"1996","unstructured":"Jonsson B, Stromqvist B (1996) Clinical appearance of contained and noncontained lumbar disc herniation. J Spinal Disord 9(1):32\u201338","journal-title":"J Spinal Disord"},{"issue":"4","key":"3998_CR2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00586-013-2758-9","volume":"22","author":"B Stromqvist","year":"2013","unstructured":"Stromqvist B et al (2013) Swespine: the Swedish spine register: the 2012 report. Eur Spine J 22(4):953\u2013974","journal-title":"Eur Spine J"},{"issue":"6","key":"3998_CR3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00007632-199503150-00006","volume":"20","author":"K Olmarker","year":"1995","unstructured":"Olmarker K et al (1995) Inflammatogenic properties of nucleus pulposus. Spine (Phila Pa 1976) 20(6):665\u2013669","journal-title":"Spine (Phila Pa 1976)"},{"issue":"21","key":"3998_CR4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1097\/BRS.0b013e3181af06b6","volume":"34","author":"GJ Scuderi","year":"2009","unstructured":"Scuderi GJ et al (2009) Epidural interferon gamma-immunoreactivity: a biomarker for lumbar nerve root irritation. Spine (Phila Pa 1976) 34(21):2311\u20132317","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"3998_CR5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1302\/0301-620X.85B8.14538","volume":"85","author":"K Sugimori","year":"2003","unstructured":"Sugimori K et al (2003) High-sensitivity analysis of serum C-reactive protein in young patients with lumbar disc herniation. J Bone Joint Surg Br 85(8):1151\u20131154","journal-title":"J Bone Joint Surg Br"},{"issue":"6","key":"3998_CR6","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/ard.2004.027045","volume":"64","author":"T Sturmer","year":"2005","unstructured":"Sturmer T et al (2005) Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain. Ann Rheum Dis 64(6):921\u2013925","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"3998_CR7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.apmr.2012.11.026","volume":"94","author":"MS Briggs","year":"2013","unstructured":"Briggs MS et al (2013) Relations of C-reactive protein and obesity to the prevalence and the odds of reporting low back pain. Arch Phys Med Rehabil 94(4):745\u2013752","journal-title":"Arch Phys Med Rehabil"},{"issue":"4 Suppl 2","key":"3998_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0049-0172(89)90020-6","volume":"18","author":"MI Jayson","year":"1989","unstructured":"Jayson MI (1989) Vascular damage, fibrosis, and chronic inflammation in mechanical back pain problems. Semin Arthritis Rheum 18(4 Suppl 2):73\u201376","journal-title":"Semin Arthritis Rheum"},{"issue":"9","key":"3998_CR9","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/00007632-199109000-00005","volume":"16","author":"RG Cooper","year":"1991","unstructured":"Cooper RG et al (1991) The role of epidural fibrosis and defective fibrinolysis in the persistence of postlaminectomy back pain. Spine (Phila Pa 1976) 16(9):1044\u20131048","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"3998_CR10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2141.2012.09074.x","volume":"157","author":"T Iwaki","year":"2012","unstructured":"Iwaki T, Urano T, Umemura K (2012) PAI-1, progress in understanding the clinical problem and its aetiology. Br J Haematol 157(3):291\u2013298","journal-title":"Br J Haematol"},{"issue":"2","key":"3998_CR11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","volume":"227","author":"AK Ghosh","year":"2012","unstructured":"Ghosh AK, Vaughan DE (2012) PAI-1 in tissue fibrosis. J Cell Physiol 227(2):493\u2013507","journal-title":"J Cell Physiol"},{"issue":"4","key":"3998_CR12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1160\/TH04-12-0842","volume":"93","author":"FJ Castellino","year":"2005","unstructured":"Castellino FJ, Ploplis VA (2005) Structure and function of the plasminogen\/plasmin system. Thromb Haemost 93(4):647\u2013654","journal-title":"Thromb Haemost"},{"issue":"9","key":"3998_CR13","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/00007632-199209000-00003","volume":"17","author":"AK Haaland","year":"1992","unstructured":"Haaland AK et al (1992) Fibrinolytic activity as a predictor of the outcome of prolapsed intervertebral lumbar disc surgery with reference to background variables: results of a prospective cohort study. Spine 17(9):1022\u20131027","journal-title":"Spine"},{"issue":"3","key":"3998_CR14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00586-007-0554-0","volume":"17","author":"E Schell","year":"2008","unstructured":"Schell E et al (2008) Stress biomarkers\u2019 associations to pain in the neck, shoulder and back in healthy media workers: 12-month prospective follow-up. Eur Spine J 17(3):393\u2013405","journal-title":"Eur Spine J"},{"issue":"2","key":"3998_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/rheumatology\/32.2.132","volume":"32","author":"LN Zebouni","year":"1993","unstructured":"Zebouni LN et al (1993) Lack of evidence for abnormal fibrinolysis in chronic low back pain. Br J Rheumatol 32(2):132\u2013134","journal-title":"Br J Rheumatol"},{"issue":"21","key":"3998_CR16","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1097\/00007632-200111010-00015","volume":"26","author":"G Zanoli","year":"2001","unstructured":"Zanoli G, Stromqvist B, Jonsson B (2001) Visual analog scales for interpretation of back and leg pain intensity in patients operated for degenerative lumbar spine disorders. Spine (Phila Pa 1976) 26(21):2375\u20132380","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"3998_CR17","first-page":"271","volume":"66","author":"JC Fairbank","year":"1980","unstructured":"Fairbank JC et al (1980) The Oswestry low back pain disability questionnaire. Physiotherapy 66(8):271\u2013273","journal-title":"Physiotherapy"},{"issue":"6","key":"3998_CR18","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.spinee.2007.11.006","volume":"8","author":"AG Copay","year":"2008","unstructured":"Copay AG et al (2008) Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales. Spine J 8(6):968\u2013974","journal-title":"Spine J"},{"issue":"7","key":"3998_CR19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1023\/A:1013171831202","volume":"10","author":"K Burstrom","year":"2001","unstructured":"Burstrom K, Johannesson M, Diderichsen F (2001) Swedish population health-related quality of life results using the EQ-5D. Qual Life Res 10(7):621\u2013635","journal-title":"Qual Life Res"},{"issue":"7","key":"3998_CR20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/art.22985","volume":"57","author":"F Rannou","year":"2007","unstructured":"Rannou F et al (2007) High-sensitivity C-reactive protein in chronic low back pain with vertebral end-plate Modic signal changes. Arthritis Rheum 57(7):1311\u20131315","journal-title":"Arthritis Rheum"},{"key":"3998_CR21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/1471-2474-15-193","volume":"15","author":"YG Zhang","year":"2014","unstructured":"Zhang YG et al (2014) MALDI-TOF-MS serum protein profiling for developing diagnostic models and identifying serum markers for discogenic low back pain. BMC Musculoskelet Disord 15:193","journal-title":"BMC Musculoskelet Disord"},{"key":"3998_CR22","doi-asserted-by":"crossref","first-page":"g1340","DOI":"10.1136\/bmj.g1340","volume":"348","author":"GJ Geersing","year":"2014","unstructured":"Geersing GJ et al (2014) Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ 348:g1340","journal-title":"BMJ"},{"issue":"11","key":"3998_CR23","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00701-008-0131-2","volume":"150","author":"DB Almeida","year":"2008","unstructured":"Almeida DB et al (2008) Outcome following lumbar disc surgery: the role of fibrosis. Acta Neurochir (Wien) 150(11):1167\u20131176","journal-title":"Acta Neurochir (Wien)"},{"issue":"12","key":"3998_CR24","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1007\/s00586-008-0805-8","volume":"17","author":"K Ronnberg","year":"2008","unstructured":"Ronnberg K et al (2008) Peridural scar and its relation to clinical outcome: a randomised study on surgically treated lumbar disc herniation patients. Eur Spine J 17(12):1714\u20131720","journal-title":"Eur Spine J"},{"issue":"4","key":"3998_CR25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1227\/00006123-199604000-00053","volume":"38","author":"JS Ross","year":"1996","unstructured":"Ross JS et al (1996) Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery 38(4):855\u2013861 discussion 861-3","journal-title":"Neurosurgery"},{"issue":"13","key":"3998_CR26","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/00007632-199807010-00007","volume":"23","author":"R Dullerud","year":"1998","unstructured":"Dullerud R et al (1998) Influence of fibrinolytic factors on scar formation after lumbar discectomy. A magnetic resonance imaging follow-up study with clinical correlation performed 7\u00a0years after surgery. Spine 23(13):1464\u20131469","journal-title":"Spine"},{"issue":"2","key":"3998_CR27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1538-7836.2007.02311.x","volume":"5","author":"FW Asselbergs","year":"2007","unstructured":"Asselbergs FW et al (2007) Gender-specific correlations of plasminogen activator inhibitor-1 and tissue plasminogen activator levels with cardiovascular disease-related traits. J Thromb Haemost 5(2):313\u2013320","journal-title":"J Thromb Haemost"},{"issue":"5","key":"3998_CR28","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/17453670810016669","volume":"79","author":"F Stromqvist","year":"2008","unstructured":"Stromqvist F et al (2008) Gender differences in lumbar disc herniation surgery. Acta Orthop 79(5):643\u2013649","journal-title":"Acta Orthop"},{"issue":"5","key":"3998_CR29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/BRS.0b013e318270b243","volume":"38","author":"B Knutsson","year":"2013","unstructured":"Knutsson B, Michaelsson K, Sanden B (2013) Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register. Spine (Phila Pa 1976) 38(5):435\u2013441","journal-title":"Spine (Phila Pa 1976)"},{"issue":"23","key":"3998_CR30","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1097\/BRS.0b013e31825e21b2","volume":"37","author":"JA Rihn","year":"2012","unstructured":"Rihn JA et al (2012) Does obesity affect outcomes of treatment for lumbar stenosis and degenerative spondylolisthesis? Analysis of the Spine Patient Outcomes Research Trial (SPORT). Spine (Phila Pa 1976) 37(23):1933\u20131946","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"3998_CR31","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/ALN.0b013e318210f560","volume":"114","author":"A Turan","year":"2011","unstructured":"Turan A et al (2011) Smoking and perioperative outcomes. Anesthesiology 114(4):837\u2013846","journal-title":"Anesthesiology"},{"issue":"7","key":"3998_CR32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1302\/0301-620X.87B7.16240","volume":"87","author":"KA Jansson","year":"2005","unstructured":"Jansson KA et al (2005) Health-related quality of life in patients before and after surgery for a herniated lumbar disc. J Bone Joint Surg Br 87(7):959\u2013964","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"3998_CR33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/BRS.0b013e31815e3a42","volume":"33","author":"CB Dewing","year":"2008","unstructured":"Dewing CB et al (2008) The outcomes of lumbar microdiscectomy in a young, active population: correlation by herniation type and level. Spine (Phila Pa 1976) 33(1):33\u201338","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"3998_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3171\/2013.9.SPINE13344","volume":"20","author":"JC Fairbank","year":"2014","unstructured":"Fairbank JC (2014) Why are there different versions of the Oswestry Disability Index? J Neurosurg Spine 20(1):83\u201386","journal-title":"J Neurosurg Spine"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-015-3998-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-015-3998-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-015-3998-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T18:16:09Z","timestamp":1566670569000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-015-3998-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["3998"],"URL":"https:\/\/doi.org\/10.1007\/s00586-015-3998-7","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}