{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:56:57Z","timestamp":1776326217134,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Sina Trauma and Surgery Research Center"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00586-016-4858-9","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T01:26:29Z","timestamp":1478741189000},"page":"958-974","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Demineralized bone matrix in anterior cervical discectomy and fusion: a systematic review"],"prefix":"10.1007","volume":"26","author":[{"given":"Shayan Abdollah","family":"Zadegan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidin","family":"Abedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Behnam","family":"Jazayeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R.","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vafa","family":"Rahimi-Movaghar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"4858_CR1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3171\/jns.1996.85.2.0206","volume":"85","author":"RC Bishop","year":"1996","unstructured":"Bishop RC, Moore KA, Hadley MN (1996) Anterior cervical interbody fusion using autogeneic and allogeneic bone graft substrate: a prospective comparative analysis. J Neurosurg 85:206\u2013210. doi: 10.3171\/jns.1996.85.2.0206","journal-title":"J Neurosurg"},{"key":"4858_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3171\/2009.2.spine08723","volume":"11","author":"TC Ryken","year":"2009","unstructured":"Ryken TC, Heary RF, Matz PG, Anderson PA, Groff MW, Holly LT, Kaiser MG, Mummaneni PV, Choudhri TF, Vresilovic EJ, Resnick DK (2009) Techniques for cervical interbody grafting. J Neurosurg Spine 11:203\u2013220. doi: 10.3171\/2009.2.spine08723","journal-title":"J Neurosurg Spine"},{"key":"4858_CR3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2106\/00004623-200205000-00003","volume":"84-a","author":"E Ahlmann","year":"2002","unstructured":"Ahlmann E, Patzakis M, Roidis N, Shepherd L, Holtom P (2002) Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes. J Bone Joint Surg Am 84-a:716\u2013720","journal-title":"J Bone Joint Surg Am"},{"issue":"Suppl 2","key":"4858_CR4","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.injury.2011.06.015","volume":"42","author":"R Dimitriou","year":"2011","unstructured":"Dimitriou R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV (2011) Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury 42(Suppl 2):S3\u2013S15. doi: 10.1016\/j.injury.2011.06.015","journal-title":"Injury"},{"key":"4858_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/01.brs.0000041587.55176.67","volume":"28","author":"JS Silber","year":"2003","unstructured":"Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ (2003) Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 28:134\u2013139. doi: 10.1097\/01.brs.0000041587.55176.67","journal-title":"Spine"},{"key":"4858_CR6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1055\/s-0034-1376917","volume":"4","author":"EO Baird","year":"2014","unstructured":"Baird EO, Egorova NN, McAnany SJ, Qureshi SA, Hecht AC, Cho SK (2014) National trends in outpatient surgical treatment of degenerative cervical spine disease. Global Spine J 4:143\u2013150. doi: 10.1055\/s-0034-1376917","journal-title":"Global Spine J"},{"key":"4858_CR7","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/brs.0000000000000165","volume":"39","author":"A Marquez-Lara","year":"2014","unstructured":"Marquez-Lara A, Nandyala SV, Fineberg SJ, Singh K (2014) Current trends in demographics, practice, and in-hospital outcomes in cervical spine surgery: a national database analysis between 2002 and 2011. Spine 39:476\u2013481. doi: 10.1097\/brs.0000000000000165","journal-title":"Spine"},{"key":"4858_CR8","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1097\/BRS.0b013e31828be75d","volume":"38","author":"M Oglesby","year":"2013","unstructured":"Oglesby M, Fineberg SJ, Patel AA, Pelton MA, Singh K (2013) Epidemiological trends in cervical spine surgery for degenerative diseases between 2002 and 2009. Spine 38:1226\u20131232. doi: 10.1097\/BRS.0b013e31828be75d","journal-title":"Spine"},{"key":"4858_CR9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000658-188907000-00043","volume":"10","author":"N Senn","year":"1889","unstructured":"Senn N (1889) Senn on the healing of aseptic bone cavities by implantation of antiseptic decalcified bone. Ann Surg 10:352\u2013368","journal-title":"Ann Surg"},{"key":"4858_CR10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","volume":"150","author":"MR Urist","year":"1965","unstructured":"Urist MR (1965) Bone: formation by autoinduction. Science 150:893\u2013899","journal-title":"Science"},{"key":"4858_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-196707000-00026","volume":"53","author":"MR Urist","year":"1967","unstructured":"Urist MR, Silverman BF, Buring K, Dubuc FL, Rosenberg JM (1967) The bone induction principle. Clin Orthop Relat Res 53:243\u2013283","journal-title":"Clin Orthop Relat Res"},{"key":"4858_CR12","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1177\/00220345710500060601","volume":"50","author":"MR Urist","year":"1971","unstructured":"Urist MR, Strates BS (1971) Bone morphogenetic protein. J Dent Res 50:1392\u20131406","journal-title":"J Dent Res"},{"key":"4858_CR13","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1073\/pnas.78.12.7599","volume":"78","author":"TK Sampath","year":"1981","unstructured":"Sampath TK, Reddi AH (1981) Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci USA 78:7599\u20137603","journal-title":"Proc Natl Acad Sci USA"},{"key":"4858_CR14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3181\/00379727-173-41630","volume":"173","author":"MR Urist","year":"1983","unstructured":"Urist MR, Sato K, Brownell AG, Malinin TI, Lietze A, Huo YK, Prolo DJ, Oklund S, Finerman GA, DeLange RJ (1983) Human bone morphogenetic protein (hBMP). Proc Soc Exp Biol Med 173:194\u2013199","journal-title":"Proc Soc Exp Biol Med"},{"key":"4858_CR15","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1097\/01.brs.0000245863.52371.c2","volume":"31","author":"JD Smucker","year":"2006","unstructured":"Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG (2006) Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 31:2813\u20132819. doi: 10.1097\/01.brs.0000245863.52371.c2","journal-title":"Spine"},{"key":"4858_CR16","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","volume":"31","author":"LB Shields","year":"2006","unstructured":"Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB (2006) Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 31:542\u2013547. doi: 10.1097\/01.brs.0000201424.27509.72","journal-title":"Spine"},{"key":"4858_CR17","unstructured":"Schultz DG (2008) FDA public health notification: life-threatening complications associated with recombinant human bone morphogenetic protein in cervical spine fusion. http:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertsandNotices\/PublicHealthNotifications\/ucm062000.htm . Accessed 20 July 2016"},{"key":"4858_CR18","unstructured":"Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0. In. The Cochrane Collaboration. http:\/\/handbook.cochrane.org\/ Accessed 20 July 2016"},{"key":"4858_CR19","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1097\/brs.0000000000001061","volume":"40","author":"AD Furlan","year":"2015","unstructured":"Furlan AD, Malmivaara A, Chou R, Maher CG, Deyo RA, Schoene M, Bronfort G, van Tulder MW (2015) 2015 Updated Method Guideline for Systematic Reviews in the Cochrane Back and Neck Group. Spine 40:1660\u20131673. doi: 10.1097\/brs.0000000000001061","journal-title":"Spine"},{"key":"4858_CR20","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1097\/BRS.0b013e3181b1c99f","volume":"34","author":"AD Furlan","year":"2009","unstructured":"Furlan AD, Pennick V, Bombardier C, van Tulder M (2009) 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine 34:1929\u20131941. doi: 10.1097\/BRS.0b013e3181b1c99f","journal-title":"Spine"},{"key":"4858_CR21","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. doi: 10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"4858_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4:1. doi: 10.1186\/2046-4053-4-1","journal-title":"Syst Rev"},{"key":"4858_CR23","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"349","author":"L Shamseer","year":"2015","unstructured":"Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Br Med J (Clin Res Ed) 349:g7647. doi: 10.1136\/bmj.g7647","journal-title":"Br Med J (Clin Res Ed)"},{"key":"4858_CR24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/jama.1958.02990010025006","volume":"166","author":"GL Odom","year":"1958","unstructured":"Odom GL, Finney W, Woodhall B (1958) Cervical disk lesions. JAMA 166:23\u201328","journal-title":"JAMA"},{"key":"4858_CR25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00007632-198107000-00005","volume":"6","author":"K Hirabayashi","year":"1981","unstructured":"Hirabayashi K, Miyakawa J, Satomi K, Maruyama T, Wakano K (1981) Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament. Spine 6:354\u2013364","journal-title":"Spine"},{"key":"4858_CR26","first-page":"409","volume":"14","author":"H Vernon","year":"1991","unstructured":"Vernon H, Mior S (1991) The neck disability index: a study of reliability and validity. J Manipul Physiol Ther 14:409\u2013415","journal-title":"J Manipul Physiol Ther"},{"key":"4858_CR27","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73:712\u2013716","journal-title":"ANZ J Surg"},{"key":"4858_CR28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.jclinepi.2012.09.016","volume":"66","author":"SY Kim","year":"2013","unstructured":"Kim SY, Park JE, Lee YJ, Seo HJ, Sheen SS, Hahn S, Jang BH, Son HJ (2013) Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity. J Clin Epidemiol 66:408\u2013414. doi: 10.1016\/j.jclinepi.2012.09.016","journal-title":"J Clin Epidemiol"},{"key":"4858_CR29","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1097\/00007632-199510001-00006","volume":"20","author":"HS An","year":"1995","unstructured":"An HS, Simpson JM, Glover JM, Stephany J (1995) Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine 20:2211\u20132216","journal-title":"Spine"},{"key":"4858_CR30","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00264-014-2610-9","volume":"39","author":"Y Xie","year":"2015","unstructured":"Xie Y, Li H, Yuan J, Fu L, Yang J, Zhang P (2015) A prospective randomized comparison of PEEK cage containing calcium sulphate or demineralized bone matrix with autograft in anterior cervical interbody fusion. Int Orthop 39:1129\u20131136. doi: 10.1007\/s00264-014-2610-9","journal-title":"Int Orthop"},{"key":"4858_CR31","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4184\/asj.2015.9.1.30","volume":"9","author":"J Yi","year":"2015","unstructured":"Yi J, Lee GW, Nam WD, Han KY, Kim MH, Kang JW, Won J, Kim SW, Noh W, Yeom JS (2015) A prospective randomized clinical trial comparing bone union rate following anterior cervical discectomy and fusion using a polyetheretherketone cage: Hydroxyapatite\/B-tricalcium phosphate mixture versus hydroxyapatite\/demineralized bone matrix mixture. Asian Spine J 9:30\u201338. doi: 10.4184\/asj.2015.9.1.30","journal-title":"Asian Spine J"},{"key":"4858_CR32","first-page":"461","volume":"70","author":"A Christodoulou","year":"2004","unstructured":"Christodoulou A, Ploumis A, Terzidis I, Hantzidis P, Tapsis K, Pournaras J (2004) Combined interbody cage and anterior plating in the surgical treatment of cervical disc disease. Acta Orthop Belg 70:461\u2013465","journal-title":"Acta Orthop Belg"},{"key":"4858_CR33","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jocn.2006.02.026","volume":"14","author":"MN Demircan","year":"2007","unstructured":"Demircan MN, Kutlay AM, Colak A, Kaya S, Tekin T, Kibici K, Ungoren K (2007) Multilevel cervical fusion without plates, screws or autogenous iliac crest bone graft. J Clin Neurosci 14:723\u2013728. doi: 10.1016\/j.jocn.2006.02.026","journal-title":"J Clin Neurosci"},{"key":"4858_CR34","first-page":"1836","volume":"9","author":"O Kelany","year":"2012","unstructured":"Kelany O, Amin AH, Gamal M (2012) Results of multilevel anterior cervical discectomy and cage assisted fusion without plates. Life Sci J 9:1836\u20131845","journal-title":"Life Sci J"},{"key":"4858_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.14245\/kjs.2015.12.2.68","volume":"12","author":"S Kukreja","year":"2015","unstructured":"Kukreja S, Ahmed OI, Haydel J, Nanda A, Sin AH (2015) Complications of anterior cervical fusion using a low-dose recombinant human bone morphogenetic protein-2. Korean J Spine 12:68\u201374. doi: 10.14245\/kjs.2015.12.2.68","journal-title":"Korean J Spine"},{"key":"4858_CR36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00701-010-0879-z","volume":"153","author":"HJ Moon","year":"2011","unstructured":"Moon HJ, Kim JH, Kim JH, Kwon TH, Chung HS, Park YK (2011) The effects of anterior cervical discectomy and fusion with stand-alone cages at two contiguous levels on cervical alignment and outcomes. Acta Neurochir (Wien) 153:559\u2013565. doi: 10.1007\/s00701-010-0879-z","journal-title":"Acta Neurochir (Wien)"},{"key":"4858_CR37","doi-asserted-by":"publisher","first-page":"E591","DOI":"10.1097\/BRS.0b013e3181ab8b9a","volume":"34","author":"HW Park","year":"2009","unstructured":"Park HW, Lee JK, Moon SJ, Seo SK, Lee JH, Kim SH (2009) The efficacy of the synthetic interbody cage and Grafton for anterior cervical fusion. Spine 34:E591\u2013E595. doi: 10.1097\/BRS.0b013e3181ab8b9a","journal-title":"Spine"},{"key":"4858_CR38","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s00586-008-0869-5","volume":"18","author":"K Topuz","year":"2009","unstructured":"Topuz K, Colak A, Kaya S, Simsek H, Kutlay M, Demircan MN, Velioglu M (2009) Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up. Eur Spine J 18:238\u2013243. doi: 10.1007\/s00586-008-0869-5","journal-title":"Eur Spine J"},{"key":"4858_CR39","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00586-007-0351-9","volume":"16","author":"R Vaidya","year":"2007","unstructured":"Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM (2007) Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J 16:1257\u20131265. doi: 10.1007\/s00586-007-0351-9","journal-title":"Eur Spine J"},{"key":"4858_CR40","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1302\/0301-620x.89b3.18270","volume":"89","author":"R Vaidya","year":"2007","unstructured":"Vaidya R, Weir R, Sethi A, Meisterling S, Hakeos W, Wybo CD (2007) Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg Br 89:342\u2013345. doi: 10.1302\/0301-620x.89b3.18270","journal-title":"J Bone Joint Surg Br"},{"key":"4858_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2041731412454420","volume":"3","author":"L Jin","year":"2012","unstructured":"Jin L, Wan Y, Shimer AL, Shen FH, Li XJ (2012) Intervertebral disk-like biphasic scaffold- demineralized bone matrix cylinder and poly(polycaprolactone triol malate)-for interbody spine fusion. J Tissue Eng 3:1\u20138. doi: 10.1177\/2041731412454420","journal-title":"J Tissue Eng"},{"key":"4858_CR42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/jbm.a.10345","volume":"65","author":"S Takikawa","year":"2003","unstructured":"Takikawa S, Bauer TW, Kambic H, Togawa D (2003) Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix. J Biomed Mater Res A 65:37\u201342","journal-title":"J Biomed Mater Res A"},{"key":"4858_CR43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3171\/2013.5.spine121028","volume":"19","author":"A Yew","year":"2013","unstructured":"Yew A, Kimball J, Lu DC (2013) Surgical seroma formation following posterior cervical laminectomy and fusion without rhBMP-2: case report. J Neurosurg Spine 19:297\u2013300. doi: 10.3171\/2013.5.spine121028","journal-title":"J Neurosurg Spine"},{"key":"4858_CR44","doi-asserted-by":"publisher","first-page":"E1331","DOI":"10.1097\/brs.0000000000000557","volume":"39","author":"RK Eastlack","year":"2014","unstructured":"Eastlack RK, Garfin SR, Brown CR, Meyer SC (2014) Osteocel Plus cellular allograft in anterior cervical discectomy and fusion: evaluation of clinical and radiographic outcomes from a prospective multicenter study. Spine 39:E1331\u2013E1337. doi: 10.1097\/brs.0000000000000557","journal-title":"Spine"},{"key":"4858_CR45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/WNQ.0b013e3180600c27","volume":"17","author":"SS Gill","year":"2007","unstructured":"Gill SS, Sala JL, Davis RF (2007) The use of Osteotech surface-activated cortical lordotic allograft in anterior cervical discectomy and fusion. Neurosurg Q 17:161\u2013165. doi: 10.1097\/WNQ.0b013e3180600c27","journal-title":"Neurosurg Q"},{"key":"4858_CR46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4184\/asj.2013.7.3.173","volume":"7","author":"CG Kong","year":"2013","unstructured":"Kong CG, Kim YY, Ahn CY, Park JB (2013) Diagnostic usefulness of white blood cell and absolute neutrophil count for postoperative infection after anterior cervical discectomy and fusion using allograft and demineralized bone matrix. Asian Spine J 7:173\u2013177. doi: 10.4184\/asj.2013.7.3.173","journal-title":"Asian Spine J"},{"key":"4858_CR47","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1007\/s00264-012-1645-z","volume":"36","author":"CG Kong","year":"2012","unstructured":"Kong CG, Kim YY, Park JB (2012) Postoperative changes of early-phase inflammatory indices after uncomplicated anterior cervical discectomy and fusion using allograft and demineralised bone matrix. Int Orthop 36:2293\u20132297. doi: 10.1007\/s00264-012-1645-z","journal-title":"Int Orthop"},{"key":"4858_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0306-9877(95)90195-7","volume":"45","author":"JE Block","year":"1995","unstructured":"Block JE, Poser J (1995) Does xenogeneic demineralized bone matrix have clinical utility as a bone graft substitute? Med Hypotheses 45:27\u201332. doi: 10.1016\/0306-9877(95)90195-7","journal-title":"Med Hypotheses"},{"key":"4858_CR49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/neurosurgery\/47.6.1457","volume":"47","author":"S Shapiro","year":"2000","unstructured":"Shapiro S, Bindal R (2000) Femoral ring allograft for anterior cervical interbody fusion: technical note. Neurosurgery 47:1457\u20131459","journal-title":"Neurosurgery"},{"key":"4858_CR50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.arth.2005.03.025","volume":"20","author":"RL Barrack","year":"2005","unstructured":"Barrack RL (2005) Bone graft extenders, substitutes, and osteogenic proteins. J Arthroplasty 20:94\u201397","journal-title":"J Arthroplasty"},{"key":"4858_CR51","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3171\/2014.4.spine14325","volume":"21","author":"MG Kaiser","year":"2014","unstructured":"Kaiser MG, Groff MW, Watters WC 3rd, Ghogawala Z, Mummaneni PV, Dailey AT, Choudhri TF, Eck JC, Sharan A, Wang JC, Dhall SS, Resnick DK (2014) Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: bone graft extenders and substitutes as an adjunct for lumbar fusion. J Neurosurg Spine 21:106\u2013132. doi: 10.3171\/2014.4.spine14325","journal-title":"J Neurosurg Spine"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-016-4858-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-016-4858-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-016-4858-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T23:15:39Z","timestamp":1498346139000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-016-4858-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,10]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["4858"],"URL":"https:\/\/doi.org\/10.1007\/s00586-016-4858-9","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,10]]}}}