{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:32:32Z","timestamp":1779309152969,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T00:00:00Z","timestamp":1491609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s00586-017-5081-z","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T06:51:04Z","timestamp":1491634264000},"page":"3122-3128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Low-intensity pulsed ultrasound is effective for progressive-stage lumbar spondylolysis with MRI high-signal change"],"prefix":"10.1007","volume":"26","author":[{"given":"Hideyuki","family":"Arima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Togawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,8]]},"reference":[{"key":"5081_CR1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.blo.0000162992.25677.7b","volume":"434","author":"MJ Herman","year":"2005","unstructured":"Herman MJ, Pizzutillo PD (2005) Spondylolysis and spondylolisthesis in the child and adolescent: a new classification. Clin Orthop Relat Res 434:46\u201354","journal-title":"Clin Orthop Relat Res"},{"key":"5081_CR2","doi-asserted-by":"publisher","first-page":"E641","DOI":"10.1097\/BRS.0b013e3181c9f2a2","volume":"35","author":"T Sakai","year":"2010","unstructured":"Sakai T, Sairyo K, Mima S, Yasui N (2010) Significance of magnetic resonance imaging signal change in the pedicle in the management of pediatric lumbar spondylolysis. Spine (Phila Pa 1976) 35:E641\u2013E645. doi: 10.1097\/BRS.0b013e3181c9f2a2","journal-title":"Spine (Phila Pa 1976)"},{"key":"5081_CR3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1302\/0301-620X.86B2.14339","volume":"86","author":"K Fujii","year":"2004","unstructured":"Fujii K, Katoh S, Sairyo K, Ikata T, Yasui N (2004) Union of defects in the pars interarticularis of the lumbar spine in children and adolescents. The radiological outcome after conservative treatment. J Bone Jt Surg Br 86:225\u2013231","journal-title":"J Bone Jt Surg Br"},{"key":"5081_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001931","author":"T Sakai","year":"2016","unstructured":"Sakai T, Tezuka F, Yamashita K, Takata Y, Higashino K, Nagamachi A, Sairyo K (2016) Conservative treatment for bony healing in pediatric lumbar spondylolysis. Spine (Phila Pa 1976). doi: 10.1097\/BRS.0000000000001931","journal-title":"Spine (Phila Pa 1976)"},{"key":"5081_CR5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/01.brs.0000195161.60549.67","volume":"31","author":"K Sairyo","year":"2006","unstructured":"Sairyo K, Katoh S, Takata Y, Terai T, Yasui N, Goel VK, Masuda A, Vadapalli S, Biyani A, Ebraheim N (2006) MRI signal changes of the pedicle as an indicator for early diagnosis of spondylolysis in children and adolescents: a clinical and biomechanical study. Spine (Phila Pa 1976) 31:206\u2013211","journal-title":"Spine (Phila Pa 1976)"},{"key":"5081_CR6","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1302\/0301-620X.91B2.21256","volume":"91","author":"K Sairyo","year":"2009","unstructured":"Sairyo K, Sakai T, Yasui N (2009) Conservative treatment of lumbar spondylolysis in childhood and adolescence: the radiological signs which predict healing. J Bone Jt Surg Br 91:206\u2013209. doi: 10.1302\/0301-620X.91B2.21256","journal-title":"J Bone Jt Surg Br"},{"key":"5081_CR7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3171\/2012.2.SPINE10914","volume":"16","author":"K Sairyo","year":"2012","unstructured":"Sairyo K, Sakai T, Yasui N, Dezawa A (2012) Conservative treatment for pediatric lumbar spondylolysis to achieve bone healing using a hard brace: what type and how long?: clinical article. J Neurosurg Spine 16:610\u2013614. doi: 10.3171\/2012.2.SPINE10914","journal-title":"J Neurosurg Spine"},{"key":"5081_CR8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1302\/0301-620X.77B4.7615609","volume":"77","author":"T Morita","year":"1995","unstructured":"Morita T, Ikata T, Katoh S, Miyake R (1995) Lumbar spondylolysis in children and adolescents. J Bone Jt Surg Br 77:620\u2013625","journal-title":"J Bone Jt Surg Br"},{"key":"5081_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/0363546512464946","volume":"41","author":"A Kobayashi","year":"2013","unstructured":"Kobayashi A, Kobayashi T, Kato K, Higuchi H, Takagishi K (2013) Diagnosis of radiographically occult lumbar spondylolysis in young athletes by magnetic resonance imaging. Am J Sports Med 41:169\u2013176. doi: 10.1177\/0363546512464946","journal-title":"Am J Sports Med"},{"key":"5081_CR10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2106\/00004623-199401000-00004","volume":"76","author":"JD Heckman","year":"1994","unstructured":"Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF (1994) Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Jt Surg Am 76:26\u201334","journal-title":"J Bone Jt Surg Am"},{"key":"5081_CR11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2106\/00004623-199707000-00002","volume":"79","author":"TK Kristiansen","year":"1997","unstructured":"Kristiansen TK, Ryaby JP, McCabe J, Frey JJ, Roe LR (1997) Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, double-blind, placebo-controlled study. J Bone Jt Surg Am 79:961\u2013973","journal-title":"J Bone Jt Surg Am"},{"key":"5081_CR12","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1359\/jbmr.2001.16.4.671","volume":"16","author":"Y Azuma","year":"2001","unstructured":"Azuma Y, Ito M, Harada Y, Takagi H, Ohta T, Jingushi S (2001) Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus. J Bone Miner Res 16:671\u2013680. doi: 10.1359\/jbmr.2001.16.4.671","journal-title":"J Bone Miner Res"},{"key":"5081_CR13","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1007\/s00586-013-3109-6","volume":"23","author":"Y Goda","year":"2014","unstructured":"Goda Y, Sakai T, Sakamaki T, Takata Y, Higashino K, Sairyo K (2014) Analysis of MRI signal changes in the adjacent pedicle of adolescent patients with fresh lumbar spondylolysis. Eur Spine J 23:1892\u20131895. doi: 10.1007\/s00586-013-3109-6","journal-title":"Eur Spine J"},{"key":"5081_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1177\/0363546504269035","volume":"33","author":"K Sairyo","year":"2005","unstructured":"Sairyo K, Katoh S, Sasa T, Yasui N, Goel VK, Vadapalli S, Masuda A, Biyani A, Ebraheim N (2005) Athletes with unilateral spondylolysis are at risk of stress fracture at the contralateral pedicle and pars interarticularis: a clinical and biomechanical study. Am J Sports Med 33:583\u2013590. doi: 10.1177\/0363546504269035","journal-title":"Am J Sports Med"},{"key":"5081_CR15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2106\/00004623-197557010-00003","volume":"57","author":"LL Wiltse","year":"1975","unstructured":"Wiltse LL, Widell EH Jr, Jackson DW (1975) Fatigue fracture: the basic lesion is inthmic spondylolisthesis. J Bone Jt Surg Am 57:17\u201322","journal-title":"J Bone Jt Surg Am"},{"key":"5081_CR16","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1097\/BRS.0b013e3181b4abbe","volume":"34","author":"T Sakai","year":"2009","unstructured":"Sakai T, Sairyo K, Takao S, Nishitani H, Yasui N (2009) Incidence of lumbar spondylolysis in the general population in Japan based on multidetector computed tomography scans from two thousand subjects. Spine (Phila Pa 1976) 34:2346\u20132350. doi: 10.1097\/BRS.0b013e3181b4abbe","journal-title":"Spine (Phila Pa 1976)"},{"key":"5081_CR17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archpedi.1995.02170130017004","volume":"149","author":"LJ Micheli","year":"1995","unstructured":"Micheli LJ, Wood R (1995) Back pain in young athletes. Significant differences from adults in causes and patterns. Arch Pediatr Adolesc Med 149:15\u201318","journal-title":"Arch Pediatr Adolesc Med"},{"key":"5081_CR18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1302\/0301-620X.72B5.2211782","volume":"72","author":"S Seitsalo","year":"1990","unstructured":"Seitsalo S (1990) Operative and conservative treatment of moderate spondylolisthesis in young patients. J Bone Jt Surg Br 72:908\u2013913","journal-title":"J Bone Jt Surg Br"},{"key":"5081_CR19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00005131-199004030-00002","volume":"4","author":"AA Pilla","year":"1990","unstructured":"Pilla AA, Mont MA, Nasser PR, Khan SA, Figueiredo M, Kaufman JJ, Siffert RS (1990) Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. J Orthop Trauma 4:246\u2013253","journal-title":"J Orthop Trauma"},{"key":"5081_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ultras.2016.03.016","volume":"70","author":"A Harrison","year":"2016","unstructured":"Harrison A, Lin S, Pounder N, Mikuni-Takagaki Y (2016) Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair. Ultrasonics 70:45\u201352. doi: 10.1016\/j.ultras.2016.03.016","journal-title":"Ultrasonics"},{"key":"5081_CR21","doi-asserted-by":"publisher","first-page":"8898","DOI":"10.1074\/jbc.M804281200","volume":"284","author":"CM Mahoney","year":"2009","unstructured":"Mahoney CM, Morgan MR, Harrison A, Humphries MJ, Bass MD (2009) Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. J Biol Chem 284:8898\u20138909. doi: 10.1074\/jbc.M804281200","journal-title":"J Biol Chem"},{"key":"5081_CR22","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1124\/mol.105.022160","volume":"69","author":"CH Tang","year":"2006","unstructured":"Tang CH, Yang RS, Huang TH, Lu DY, Chuang WJ, Huang TF, Fu WM (2006) Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts. Mol Pharmacol 69:2047\u20132057. doi: 10.1124\/mol.105.022160","journal-title":"Mol Pharmacol"},{"key":"5081_CR23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00003086-200401000-00044","volume":"418","author":"KS Leung","year":"2004","unstructured":"Leung KS, Cheung WH, Zhang C, Lee KM, Lo HK (2004) Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells. Clin Orthop Relat Res 418:253\u2013259","journal-title":"Clin Orthop Relat Res"},{"key":"5081_CR24","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.rvw.o.00027","author":"S Rutten","year":"2016","unstructured":"Rutten S, van den Bekerom MP, Sierevelt IN, Nolte PA (2016) Enhancement of bone-healing by low-intensity pulsed ultrasound: a systematic review. JBJS Rev. doi: 10.2106\/jbjs.rvw.o.00027","journal-title":"JBJS Rev"},{"key":"5081_CR25","first-page":"17","volume":"14","author":"E Syrmou","year":"2010","unstructured":"Syrmou E, Tsitsopoulos PP, Marinopoulos D, Tsonidis C, Anagnostopoulos I, Tsitsopoulos PD (2010) Spondylolysis: a review and reappraisal. Hippokratia 14:17\u201321","journal-title":"Hippokratia"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-017-5081-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-017-5081-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-017-5081-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T20:28:41Z","timestamp":1569011321000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-017-5081-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,8]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["5081"],"URL":"https:\/\/doi.org\/10.1007\/s00586-017-5081-z","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,8]]}}}