{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:54:30Z","timestamp":1761519270645},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Silicate-substituted calcium phosphate-enhanced porosity (SiCaP EP, Inductigraft\u2122, Altapore) is a synthetic bone graft material with enhanced strut porosity of 31\u201347%. SiCaP EP remains to be fully clinically evaluated in patients undergoing instrumented posterolateral fusion (PLF) surgery. We conducted a prospective, open-label, non-randomised, multicentre clinical study to evaluate efficacy of SiCaP EP as bone grafting material in PLF surgery with instrumentation for treatment of spinal disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with degenerative disc disease, spondylolisthesis or spinal stenosis underwent PLF surgery with SiCaP EP. The primary endpoint was evaluated in the per protocol population (<jats:italic>N<\/jats:italic>\u2009=\u2009102) as solid fusion at postoperative month 12 assessed using computed tomography scans, with motion assessed using flexion\u2013extension radiographs. Clinical outcomes included the Oswestry Disability Index, 36-item short-form health survey for quality-of-life, visual analog scale for pain scores and neurological assessments. Adverse events were recorded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Successful fusion was achieved in 59\/89 (66.3%) patients at month 6, 88\/102 patients (86.3%) at month 12 (primary endpoint) and 87\/96 (90.6%) patients at month 24. Disability and pain reduced following surgery. Quality-of-life improved and neurological function was maintained postoperatively. Forty-three (33.3%) of the 129 patients who underwent surgery experienced adverse events; back pain was most frequent (<jats:italic>n<\/jats:italic>\u2009=\u200910); nine and 14 patients experienced serious adverse events judged related to device and procedure, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Enhanced strut porosity SiCaP EP provided high (month 12: 86.3%) spinal fusion success rates in PLF surgery. Fusion success was associated with improved clinical outcomes in patients within 12\u00a0months, relative to baseline.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>ClinicalTrials.gov identifier<\/jats:title>\n                <jats:p>NCT01452022<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                <jats:p>These slides can be retrieved under Electronic Supplementary Material.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00586-019-05926-1","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T10:14:11Z","timestamp":1551780851000},"page":"1733-1742","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of an increased strut porosity silicate-substituted calcium phosphate, SiCaP\u00a0EP, as a synthetic bone graft substitute in spinal fusion surgery: a prospective, open-label study"],"prefix":"10.1007","volume":"28","clinical-trial-number":[{"clinical-trial-number":"nct01452022","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ciaran","family":"Bolger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Czop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"issue":"24 Suppl","key":"5926_CR1","doi-asserted-by":"publisher","first-page":"78S","DOI":"10.1097\/00007632-199512151-00002","volume":"20","author":"JN Katz","year":"1995","unstructured":"Katz JN (1995) Lumbar spinal fusion. 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