{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T10:14:18Z","timestamp":1793182458056,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CSTC2018jcyjAX0059"],"award-info":[{"award-number":["CSTC2018jcyjAX0059"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00586-020-06626-x","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T13:03:01Z","timestamp":1606222981000},"page":"3074-3080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The influence of topical use of tranexamic acid in reducing blood loss on early operation for thoracolumbar burst fracture: a randomized double-blinded controlled study"],"prefix":"10.1007","volume":"30","author":[{"given":"Jieliang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"6626_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2176\/nmc.oa.2017-0017","volume":"57","author":"MA AbdelFatah","year":"2017","unstructured":"AbdelFatah MA (2017) The walking recovery one year after surgical management of thoracolumbar burst fracture in paraplegic patients. Neurol Med Chir 57:467\u2013471. https:\/\/doi.org\/10.2176\/nmc.oa.2017-0017","journal-title":"Neurol Med Chir"},{"key":"6626_CR2","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.transci.2019.06.014","volume":"58","author":"S Abeysiri","year":"2019","unstructured":"Abeysiri S, Chau M, Highton D, Richards T (2019) Management of the patient presenting with anaemia in the preoperative setting. Transfus Apher Sci 58:392\u2013396. https:\/\/doi.org\/10.1016\/j.transci.2019.06.014","journal-title":"Transfus Apher Sci"},{"key":"6626_CR3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.clineuro.2017.12.003","volume":"164","author":"ZS Ali","year":"2018","unstructured":"Ali ZS, Ma TS, Ozturk AK, Malhotra NR, Schuster JM, Marcotte PJ, Grady MS, Welch WC (2018) Pre-optimization of spinal surgery patients: development of a neurosurgical enhanced recovery after surgery (ERAS) protocol. Clin Neurol Neurosurg 164:142\u2013153. https:\/\/doi.org\/10.1016\/j.clineuro.2017.12.003","journal-title":"Clin Neurol Neurosurg"},{"key":"6626_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/acem.13835","volume":"26","author":"R Beyda","year":"2019","unstructured":"Beyda R, Johari D (2019) Tranexamic acid for upper gastrointestinal bleeding. Acad Emerg Med 26:1181\u20131182. https:\/\/doi.org\/10.1111\/acem.13835","journal-title":"Acad Emerg Med"},{"key":"6626_CR5","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1097\/MCC.0b013e3282f1e78f","volume":"13","author":"K Brohi","year":"2007","unstructured":"Brohi K, Cohen MJ, Davenport RA (2007) Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13:680\u2013685. https:\/\/doi.org\/10.1097\/MCC.0b013e3282f1e78f","journal-title":"Curr Opin Crit Care"},{"key":"6626_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jor.2016.06.007","volume":"13","author":"M Cahueque","year":"2016","unstructured":"Cahueque M, Cobar A, Zuniga C, Caldera G (2016) Management of burst fractures in the thoracolumbar spine. J Orthop 13:278\u2013281. https:\/\/doi.org\/10.1016\/j.jor.2016.06.007","journal-title":"J Orthop"},{"key":"6626_CR7","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/bja\/aew434","volume":"118","author":"MJ Colomina","year":"2017","unstructured":"Colomina MJ, Koo M, Basora M, Pizones J, Mora L, Bago J (2017) Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trialdagger. Br J Anaesth 118:380\u2013390. https:\/\/doi.org\/10.1093\/bja\/aew434","journal-title":"Br J Anaesth"},{"issue":"8","key":"6626_CR8","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/00007632-198311000-00003","volume":"8","author":"F Denis","year":"1983","unstructured":"Denis F (1983) The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine 8(8):817\u2013831. https:\/\/doi.org\/10.1097\/00007632-198311000-00003","journal-title":"Spine"},{"key":"6626_CR9","first-page":"281","volume":"31","author":"JJ Egea-Guerrero","year":"2019","unstructured":"Egea-Guerrero JJ, Ballesteros MA, Quintana-Diaz M (2019) Tranexamic acid in patients with multiple injuries: good, elegant, and cheap? Emergencias 31:281\u2013282","journal-title":"Emergencias"},{"key":"6626_CR10","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.11124\/JBISRIR-2017-003978","volume":"17","author":"CG Fahrenholtz","year":"2019","unstructured":"Fahrenholtz CG, Bonanno LS, Martin JB (2019) Tranexamic acid as adjuvant treatment for postpartum hemorrhage: a systematic review protocol. JBI Database Syst Rev Implement Rep 17:1565\u20131572. https:\/\/doi.org\/10.11124\/JBISRIR-2017-003978","journal-title":"JBI Database Syst Rev Implement Rep"},{"key":"6626_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.knee.2017.11.006","volume":"25","author":"J George","year":"2018","unstructured":"George J, Eachempati KK, Subramanyam KN, Gurava Reddy AV (2018) The comparative efficacy and safety of topical and intravenous tranexamic acid for reducing perioperative blood loss in total knee arthroplasty\u2014a randomized controlled non-inferiority trial. Knee 25:185\u2013191. https:\/\/doi.org\/10.1016\/j.knee.2017.11.006","journal-title":"Knee"},{"key":"6626_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1345\/aph.1Q383","volume":"46","author":"HJ Ipema","year":"2012","unstructured":"Ipema HJ, Tanzi MG (2012) Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. Ann Pharmacother 46:97\u2013107. https:\/\/doi.org\/10.1345\/aph.1Q383","journal-title":"Ann Pharmacother"},{"key":"6626_CR13","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1177\/0300060518772422","volume":"46","author":"CL Lin","year":"2018","unstructured":"Lin CL, Chou PH, Fang JJ, Huang KY, Lin RM (2018) Short-segment decompression and fixation for thoracolumbar osteoporotic fractures with neurological deficits. J Int Med Res 46:3104\u20133113. https:\/\/doi.org\/10.1177\/0300060518772422","journal-title":"J Int Med Res"},{"issue":"Suppl 4","key":"6626_CR14","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/BOT.0000000000000950","volume":"31","author":"C Oner","year":"2017","unstructured":"Oner C, Rajasekaran S, Chapman JR, Fehlings MG, Vaccaro AR, Schroeder GD, Sadiqi S, Harrop J (2017) Spine trauma-what are the current controversies? J Orthop Trauma 31(Suppl 4):S1\u2013S6. https:\/\/doi.org\/10.1097\/BOT.0000000000000950","journal-title":"J Orthop Trauma"},{"key":"6626_CR15","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.spinee.2019.06.012","volume":"19","author":"T Raman","year":"2019","unstructured":"Raman T, Varlotta C, Vasquez-Montes D, Buckland AJ, Errico TJ (2019) The use of tranexamic acid in adult spinal deformity: is there an optimal dosing strategy? Spine J 19:1690\u20131697. https:\/\/doi.org\/10.1016\/j.spinee.2019.06.012","journal-title":"Spine J"},{"key":"6626_CR16","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s11999-016-5133-4","volume":"475","author":"TT Roberts","year":"2017","unstructured":"Roberts TT, Leonard GR, Cepela DJ (2017) Classifications in brief: American spinal injury association (Asia) impairment scale. Clin Orthop Relat Res 475:1499\u20131504. https:\/\/doi.org\/10.1007\/s11999-016-5133-4","journal-title":"Clin Orthop Relat Res"},{"key":"6626_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/BSD.0000000000000634","volume":"31","author":"BD Rosenthal","year":"2018","unstructured":"Rosenthal BD, Boody BS, Jenkins TJ, Hsu WK, Patel AA, Savage JW (2018) Thoracolumbar burst fractures. Clin Spine Surg 31:143\u2013151. https:\/\/doi.org\/10.1097\/BSD.0000000000000634","journal-title":"Clin Spine Surg"},{"key":"6626_CR18","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1182\/blood-2017-06-789032","volume":"130","author":"AL Samson","year":"2017","unstructured":"Samson AL, Alwis I, Maclean JAA, Priyananda P, Hawkett B, Schoenwaelder SM, Jackson SP (2017) Endogenous fibrinolysis facilitates clot retraction in vivo. Blood 130:2453\u20132462. https:\/\/doi.org\/10.1182\/blood-2017-06-789032","journal-title":"Blood"},{"issue":"Suppl 4","key":"6626_CR19","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1097\/BOT.0000000000000947","volume":"31","author":"KJ Schnake","year":"2017","unstructured":"Schnake KJ, Schroeder GD, Vaccaro AR, Oner C (2017) AOSpine classification systems (subaxial, thoracolumbar). J Orthop Trauma 31(Suppl 4):S14\u2013S23. https:\/\/doi.org\/10.1097\/BOT.0000000000000947","journal-title":"J Orthop Trauma"},{"key":"6626_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jocn.2020.03.046","volume":"75","author":"SR Shin","year":"2020","unstructured":"Shin SR, Lee SS, Kim JH, Jung JH, Lee SK, Lee GJ, Ju Moon B, Lee JK (2020) Thoracolumbar burst fractures in patients with neurological deficit: anterior approach versus posterior percutaneous fixation with laminotomy. J Clin Neurosci 75:11\u201318. https:\/\/doi.org\/10.1016\/j.jocn.2020.03.046","journal-title":"J Clin Neurosci"},{"key":"6626_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bpa.2015.11.007","volume":"30","author":"OM Theusinger","year":"2016","unstructured":"Theusinger OM, Spahn DR (2016) Perioperative blood conservation strategies for major spine surgery. Best Pract Res Clin Anaesthesiol 30:41\u201352. https:\/\/doi.org\/10.1016\/j.bpa.2015.11.007","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"6626_CR22","doi-asserted-by":"publisher","first-page":"E462","DOI":"10.1097\/BSD.0000000000000851","volume":"32","author":"N Wanderman","year":"2019","unstructured":"Wanderman N, Robinson W, Carlson B, Bydon M, Currier B, Huddleston P, Nassr A, Freedman B (2019) Tranexamic acid in thoracic and lumbar fusions and perioperative blood loss. Clin Spine Surg 32:E462\u2013E468. https:\/\/doi.org\/10.1097\/BSD.0000000000000851","journal-title":"Clin Spine Surg"},{"key":"6626_CR23","doi-asserted-by":"publisher","first-page":"e1185","DOI":"10.1016\/j.wneu.2019.04.095","volume":"127","author":"X Wang","year":"2019","unstructured":"Wang X, Yang R, Sun H, Zhang Y (2019) Different effects of intravenous, topical, and combined application of tranexamic acid on patients with thoracolumbar fracture. World Neurosurg 127:e1185\u2013e1189. https:\/\/doi.org\/10.1016\/j.wneu.2019.04.095","journal-title":"World Neurosurg"},{"key":"6626_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.thromres.2017.03.009","volume":"153","author":"J Xie","year":"2017","unstructured":"Xie J, Hu Q, Huang Q, Ma J, Lei Y, Pei F (2017) Comparison of intravenous versus topical tranexamic acid in primary total hip and knee arthroplasty: an updated meta-analysis. Thromb Res 153:28\u201336. https:\/\/doi.org\/10.1016\/j.thromres.2017.03.009","journal-title":"Thromb Res"},{"key":"6626_CR25","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1007\/s00586-012-2624-1","volume":"22","author":"D Xing","year":"2013","unstructured":"Xing D, Chen Y, Ma JX, Song DH, Wang J, Yang Y, Feng R, Lu J, Ma XL (2013) A methodological systematic review of early versus late stabilization of thoracolumbar spine fractures. Eur Spine J 22:2157\u20132166. https:\/\/doi.org\/10.1007\/s00586-012-2624-1","journal-title":"Eur Spine J"},{"key":"6626_CR26","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13018-017-0672-2","volume":"12","author":"D Xu","year":"2017","unstructured":"Xu D, Zhuang Q, Li Z, Ren Z, Chen X, Li S (2017) A randomized controlled trial on the effects of collagen sponge and topical tranexamic acid in posterior spinal fusion surgeries. J Orthop Surg Res 12:166. https:\/\/doi.org\/10.1186\/s13018-017-0672-2","journal-title":"J Orthop Surg Res"},{"key":"6626_CR27","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jocn.2018.10.121","volume":"61","author":"K Yerneni","year":"2019","unstructured":"Yerneni K, Burke JF, Tuchman A, Li XJ, Metz LN, Lehman RA Jr, Lenke LG, Tan LA (2019) Topical tranexamic acid in spinal surgery: a systematic review and meta-analysis. J Clin Neurosci 61:114\u2013119. https:\/\/doi.org\/10.1016\/j.jocn.2018.10.121","journal-title":"J Clin Neurosci"},{"key":"6626_CR28","doi-asserted-by":"publisher","first-page":"e14983","DOI":"10.1097\/MD.0000000000014983","volume":"98","author":"M Yin","year":"2019","unstructured":"Yin M, Chen G, Yang J, Tong Z, Xu J, Huang Q, Ma J, Mo W (2019) Hidden blood loss during perioperative period and the influential factors after surgery of thoracolumbar burst fracture: a retrospective case series. Medicine 98:e14983. https:\/\/doi.org\/10.1097\/MD.0000000000014983","journal-title":"Medicine"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-020-06626-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-020-06626-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-020-06626-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:59:29Z","timestamp":1744181969000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-020-06626-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["6626"],"URL":"https:\/\/doi.org\/10.1007\/s00586-020-06626-x","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]},"assertion":[{"value":"15 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no confict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}