{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:17:19Z","timestamp":1789831039703,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00586-021-06931-z","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T11:03:00Z","timestamp":1626778980000},"page":"3107-3114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pathological changes within two weeks following spinal cord injury in a canine model"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-4324","authenticated-orcid":false,"given":"Yuya","family":"Nakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentarou","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Omori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"6931_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/sc.1995.42","volume":"33","author":"H Shingu","year":"1995","unstructured":"Shingu H, Ohama M, Ikata T, Katoh S, Akatsu T (1995) A nationwide epidemiological survey of spinal cord injuries in Japan from January 1990 to December 1992. Spinal Cord 33:183\u2013188. https:\/\/doi.org\/10.1038\/sc.1995.42","journal-title":"Spinal Cord"},{"key":"6931_CR2","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1748-5827.2006.00106.x","volume":"47","author":"G Fluehmann","year":"2010","unstructured":"Fluehmann G, Doherr MG, Jaggy A (2010) Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland. J Small Anim Pract 47:582\u2013587. https:\/\/doi.org\/10.1111\/j.1748-5827.2006.00106.x","journal-title":"J Small Anim Pract"},{"key":"6931_CR3","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cvsm.2010.06.001","volume":"40","author":"BA Brisson","year":"2010","unstructured":"Brisson BA (2010) Intervertebral disc disease in dogs. Vet Clin North Am Small Anim Pract 40:829\u2013858. https:\/\/doi.org\/10.1016\/j.cvsm.2010.06.001","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"6931_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.12935\/jvma.71.41","volume":"71","author":"Y Nakamoto","year":"2018","unstructured":"Nakamoto Y, Nakamoto M, Ozawa T (2018) Survey of the incidence of neurological diseases in dogs at a secondary veterinary neurology facility [In Japanese]. J Jpn Vet Med Assoc 71:41\u201349","journal-title":"J Jpn Vet Med Assoc"},{"key":"6931_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.5137\/1019-5149.JTN.14502-15.2","volume":"25","author":"O Besalti","year":"2015","unstructured":"Besalti O, Can P, Akpinar E, Aktas Z, Elcin AE, Elcin YM (2015) Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in the treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease. Turk Neurosurg 25:625\u2013632. https:\/\/doi.org\/10.5137\/1019-5149.JTN.14502-15.2","journal-title":"Turk Neurosurg"},{"key":"6931_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187746.eCollection2017","volume":"12","author":"N Alisauskaite","year":"2017","unstructured":"Alisauskaite N, Spitzbarth I, Baumgartner W et al (2017) Chronic post-traumatic intramedullary lesions in dogs, a translational model. PLoS ONE 12:e0187746. https:\/\/doi.org\/10.1371\/journal.pone.0187746.eCollection2017","journal-title":"PLoS ONE"},{"key":"6931_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.tvjl.2013.04.003","volume":"198","author":"D Henke","year":"2013","unstructured":"Henke D, Vandevelde M, Doherr MG, Stockli M, Foterre F (2013) Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Vet J 198:70\u201375. https:\/\/doi.org\/10.1016\/j.tvjl.2013.04.003","journal-title":"Vet J"},{"key":"6931_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tvjl.2016.12.008","volume":"220","author":"L Langerhuus","year":"2017","unstructured":"Langerhuus L, Miles J (2017) Proportion recovery and times to ambulation for non-ambulatory dogs with thoracolumbar disc extrusions treated with hemilaminectomy or conservative treatment: A systematic review and meta-analysis of case-series studies. Vet J 220:7\u201316. https:\/\/doi.org\/10.1016\/j.tvjl.2016.12.008","journal-title":"Vet J"},{"key":"6931_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.6002\/ect.2011.0151","volume":"3","author":"K Tamura","year":"2012","unstructured":"Tamura K, Harada Y, Nagashima N (2012) Autotransplanting of bone marrow-derived mononuclear cells for complete cases of canine paraplegia and loss of pain perception secondary to intervertebral disc herniation. Exp Clin Transplant 3:263\u2013272. https:\/\/doi.org\/10.6002\/ect.2011.0151","journal-title":"Exp Clin Transplant"},{"key":"6931_CR10","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/sc.2014.91","volume":"52","author":"T Cheriyan","year":"2014","unstructured":"Cheriyan T, Ryan DJ, Weinreb JH et al (2014) Spinal cord injury models: a review. Spinal Cord 52:588\u2013595. https:\/\/doi.org\/10.1038\/sc.2014.91","journal-title":"Spinal Cord"},{"key":"6931_CR11","first-page":"177","volume":"24","author":"PD Purdy","year":"2003","unstructured":"Purdy PD, Duong RT, White CL et al (2003) Percutaneous translumbar spinal cord compression injury in a dog model that uses angioplasty balloon: MR imaging and histopathologic findings. AJNR Am J Neuroradiol 24:177\u2013184","journal-title":"AJNR Am J Neuroradiol"},{"key":"6931_CR12","first-page":"1435","volume":"25","author":"PD Purdy","year":"2004","unstructured":"Purdy PD, White CL 3rd, Baser DL et al (2004) Percutaneous translumbar spinal cord compression injury in dogs from an angioplasty balloon: MR and histopathologic changes with balloon sizes and compression times. AJNR Am J Neuroradiol 25:1435\u20131442","journal-title":"AJNR Am J Neuroradiol"},{"key":"6931_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.brainresprot.2005.01.001","volume":"14","author":"S Fukuda","year":"2005","unstructured":"Fukuda S, Nakamura T, Kishigami Y et al (2005) New canine spinal cord injury model free from laminectomy. Brain Res Brain Res Protoc 14:171\u2013180. https:\/\/doi.org\/10.1016\/j.brainresprot.2005.01.001","journal-title":"Brain Res Brain Res Protoc"},{"key":"6931_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.4142\/jvs.2007.8.1.89","volume":"8","author":"JH Lim","year":"2007","unstructured":"Lim JH, Jung CS, Byeon YE, Kim WH, Yoon JH, Kang KS, Kweon OK (2007) Establishment of a canine spinal cord injury model induced by epidural balloon compression. J Vet Sci 8:89\u201394. https:\/\/doi.org\/10.4142\/jvs.2007.8.1.89","journal-title":"J Vet Sci"},{"key":"6931_CR15","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jneumeth.2007.07.020","volume":"167","author":"JH Lee","year":"2008","unstructured":"Lee JH, Choi CB, Chung DJ et al (2008) Development of an improved canine model of percutaneous spinal cord compression injury by balloon catheter. J Neurosci Methods 167:310\u2013316. https:\/\/doi.org\/10.1016\/j.jneumeth.2007.07.020","journal-title":"J Neurosci Methods"},{"key":"6931_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.zool.2017.06.004","volume":"123","author":"R Nardone","year":"2017","unstructured":"Nardone R, Florea C, Holler Y et al (2017) Rodent, large animal and non-human primate models of spinal cord injury. Zoology 123:101\u2013114. https:\/\/doi.org\/10.1016\/j.zool.2017.06.004","journal-title":"Zoology"},{"key":"6931_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.595796","volume":"7","author":"I Spitzbarth","year":"2020","unstructured":"Spitzbarth I, Moore SA, Stein VM et al (2020) Current insights into the pathology of canine intervertebral disc extrusion-induced spinal cord injury. Front Vet Sci 7:595796. https:\/\/doi.org\/10.3389\/fvets.2020.595796","journal-title":"Front Vet Sci"},{"key":"6931_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1532-950X.1998.tb00105.x","volume":"27","author":"KS Schulz","year":"1998","unstructured":"Schulz KS, Walker M, Moon M, Waldron D, Slater M, McDonald DE (1998) Correlation of clinical, radiographic, and surgical localization of intervertebral disc extrusion in small-breed dogs: a prospective study of 50 cases. Vet Surg 27:105\u2013111","journal-title":"Vet Surg"},{"key":"6931_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1176\/jnp.4.2.168","volume":"4","author":"JR Stevens","year":"1992","unstructured":"Stevens JR, Casanova M, Poltorak M, Germain L, Buchan GC (1992) Comparison of immunocytochemical and Holzer\u2019s methods for detection of acute and chronic gliosis in human postmortem material. J Neuropsychiatry Clin Neurosci 4:168\u2013173. https:\/\/doi.org\/10.1176\/jnp.4.2.168","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"6931_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.rvsc.2016.05.011","volume":"107","author":"K Arai","year":"2016","unstructured":"Arai K, Harada Y, Tomiyama H et al (2016) Evaluation of the survival of bone marrow-derived mononuclear cells and the growth factors produced upon intramedullary transplantation in rat models of acute spinal cord injury. Res Vet Sci 107:88\u201394. https:\/\/doi.org\/10.1016\/j.rvsc.2016.05.011","journal-title":"Res Vet Sci"},{"key":"6931_CR21","doi-asserted-by":"publisher","first-page":"767","DOI":"10.2460\/javma.249.7.767","volume":"249","author":"J Fenn","year":"2016","unstructured":"Fenn J, Drees R, Volk HA, De Decker S (2016) Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute noncompressive nucleus pulposus extrusion. J Am Vet Med Assoc 249:767\u2013775. https:\/\/doi.org\/10.2460\/javma.249.7.767","journal-title":"J Am Vet Med Assoc"},{"key":"6931_CR22","first-page":"598","volume":"51","author":"AA Webb","year":"2010","unstructured":"Webb AA, Ngan S, Fowler D (2010) Spinal cord injury II: Prognostic indicators, standards of care, and clinical trials. Can Vet J 51:598\u2013604","journal-title":"Can Vet J"},{"key":"6931_CR23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.tvjl.2013.04.003","volume":"198","author":"D Henke","year":"2013","unstructured":"Henke D, Vandevelde M, Doherr MG, St\u00f6ckli M, Forterre F (2013) Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Vet J 198:70\u201375. https:\/\/doi.org\/10.1016\/j.tvjl.2013.04.003","journal-title":"Vet J"},{"key":"6931_CR24","doi-asserted-by":"publisher","first-page":"762","DOI":"10.2460\/javma.2003.222.762","volume":"222","author":"N Olby","year":"2003","unstructured":"Olby N, Levine J, Harris T, Mu\u00f1ana K, Skeen T, Sharp N (2003) Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996\u20132001). J Am Vet Med Assoc 222:762\u2013769. https:\/\/doi.org\/10.2460\/javma.2003.222.762","journal-title":"J Am Vet Med Assoc"},{"key":"6931_CR25","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3171\/jns.1997.86.3.0483","volume":"86","author":"CH Tator","year":"1997","unstructured":"Tator CH, Koyanagi I (1997) Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 86:483\u2013492. https:\/\/doi.org\/10.3171\/jns.1997.86.3.0483","journal-title":"J Neurosurg"},{"key":"6931_CR26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fncel.2016.00098","volume":"10","author":"MA Anwar","year":"2016","unstructured":"Anwar MA, Al Shehab TS, Eid AH (2016) Inflammogenesis of secondary spinal cord injury. Front Cell Neurosci 10:98. https:\/\/doi.org\/10.3389\/fncel.2016.00098","journal-title":"Front Cell Neurosci"},{"key":"6931_CR27","unstructured":"Vandevelde M, Higgins RJ, Oevermann A (2002) Trauma. In: Veterinary neuropathology: essentials of theory and practice, 1st edn. Wiley-Blackwell, West Sussex, pp 81\u201391"},{"key":"6931_CR28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.spinee.2015.09.018","volume":"16","author":"D Henke","year":"2016","unstructured":"Henke D, Gorgas D, Doherr MG, Howard J, Forterre F, Vandevelde M (2016) Longitudinal extension of myelomalacia by intramedullary and subdural haemorrhage in a canine model of spinal cord injury. Spine J 16:82\u201390. https:\/\/doi.org\/10.1016\/j.spinee.2015.09.018","journal-title":"Spine J"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-021-06931-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-021-06931-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-021-06931-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T02:32:21Z","timestamp":1632450741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-021-06931-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["6931"],"URL":"https:\/\/doi.org\/10.1007\/s00586-021-06931-z","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"value":"0940-6719","type":"print"},{"value":"1432-0932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]},"assertion":[{"value":"23 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yuya Nakamoto, Gentarou Tsujimoto, Akito Ikemoto, Koichi Omori, and Tatsuo Nakamura declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were performed in accordance with the Guidelines for Animal Experiments of Kyoto University (1989; approval number, R-16\u201328; approval date, 01 April, 2016) and the principles of laboratory animal care (NIH publication No. 86\u201323, revised 1985).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}