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Patients who were placed on PTH analogues for one year in conjunction with surgery were included in the study. Ultimately, 41 patients who had pre- and two-year post-operative CT scans for review were included in this study. Hounsfield units were measured off of the L1\u2013L3 levels for all patients before and after surgery on pre-op and post-op CT scans.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>The mean age of patients in this study was 70 (52\u201384, SD 7). Mean follow-up was 66 (24\u2013132, SD 33) months. Twenty-three patients met criteria for severe deformity (Cobb angle\u2009&gt;\u200950 degrees or SVA\u2009&gt;\u200995\u00a0mm or PI\/LL mismatch\u2009&gt;\u200920 or PT\u2009&gt;\u200930). Based off 2-year post-op CT scan, there were significant improvements in L1 Hounsfield units when comparing pre-op values (96; SD 55) to post-op values (185 SD 102); <jats:italic>p<\/jats:italic>.\u2009&lt;\u20090.05. There was no screw loosening or screw pull out. There were 2 patients with PJF (4.8%). Both these patients had not completed their PTH treatment: one only took PTH for 3\u00a0months (PJF at 2-year post-op) and the other one took it only for 1\u00a0month (PJF at 1-year post-op). No increase in bone density was noted (based off of Hounsfield units) in five patients (12%) despite completion of their PTH therapy. Only one patient experienced nausea from PTH therapy. There were no other PTH related adverse events.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The incidence of PTH analogues failing to increase bone density in our series was low at 12%. This study shows that PTH analogues may be a powerful adjunct for increasing bone density and may help to mitigate the risk of mechanical complications in patients undergoing deformity correction with minimally invasive techniques. Future comparative studies are warranted to confirm these latter findings and to potentially protocolize the ideal peri-operative bone health optimization strategy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00586-023-07859-2","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T20:16:25Z","timestamp":1691525785000},"page":"3651-3658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Do peri-operative parathyroid hormone (PTH) analogues improve bone density and decrease mechanical complications in spinal deformity correction?\u2014a minimum 2-year radiological study measuring Hounsfield units"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-9595","authenticated-orcid":false,"given":"Andrew","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gendelberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bardia","family":"Khandehroo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Khandehroo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Kahwaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"7859_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jspd.2016.02.003","volume":"4","author":"T Ailon","year":"2016","unstructured":"Ailon T, Scheer JK, Lafage V et al (2016) Adult spinal deformity surgeons are unable to accurately predict postoperative spinal alignment using clinical judgment alone. 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